2bel - Revision history

OCA at 06:37, 1 May 2024

2024-05-01T06:37:53Z

←Older revision		Revision as of 06:37, 1 May 2024
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	<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.11Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1xu7\|1xu7]], [[1xu9\|1xu9]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/11~~-~~beta~~-~~hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [https://pdbe.org/2bel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [https://www.ebi.ac.uk/pdbsum/2bel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [https://pdbe.org/2bel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [https://www.ebi.ac.uk/pdbsum/2bel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~11-beta-hydroxysteroid dehydrogenase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abrahmsen, L]]	+	[[Category: Abrahmsen L]]
-	[[Category: Arrowsmith, C]]	+	[[Category: Arrowsmith C]]
-	[[Category: Bray, J]]	+	[[Category: Bray J]]
-	[[Category: Debreczeni~~, J E]]~~	+	[[Category: Debreczeni JE]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Elleby B]]
-	[[Category: Elleby, B]]	+	[[Category: Kavanagh K]]
-	[[Category: Kavanagh, K]]	+	[[Category: Oppermann U]]
-	[[Category: Oppermann, U]]	+	[[Category: Sharma S]]
-	[[Category: Sharma, S]]	+	[[Category: Sundstrom M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Svensson S]]
-	[[Category: Svensson, S]]	+	[[Category: Wu X]]
-	[[Category: Wu, X]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Drug target]]~~	+
-	~~[[Category: Glucocorticoid activation]]~~	+
-	~~[[Category: Hormone metabolism]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Microsome]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Short-chain dehydrogenase/reductase]]~~	+
-	~~[[Category: Steroid metabolism~~]]	+

OCA at 13:37, 13 October 2021

2021-10-13T13:37:29Z

←Older revision		Revision as of 13:37, 13 October 2021
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	<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xu7\|1xu7]], [[1xu9\|1xu9]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [~~http~~://pdbe.org/2bel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [https://pdbe.org/2bel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [https://www.ebi.ac.uk/pdbsum/2bel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:05, 11 December 2019

2019-12-11T19:05:52Z

←Older revision		Revision as of 19:05, 11 December 2019
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	==Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone==		==Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone==
-	<StructureSection load='2bel' size='340' side='right' caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>	+	<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Hydroxysteroid dehydrogenase 3D structures\|Hydroxysteroid dehydrogenase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: 11-beta-hydroxysteroid dehydrogenase]]		[[Category: 11-beta-hydroxysteroid dehydrogenase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Abrahmsen, L]]		[[Category: Abrahmsen, L]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]

OCA at 18:44, 24 January 2018

2018-01-24T18:44:31Z

←Older revision		Revision as of 18:44, 24 January 2018
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-	==~~STRUCTURE OF HUMAN~~ 11-~~BETA~~-~~HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH~~ NADP ~~AND CARBENOXOLONE~~==	+
		+	==Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone==
	<StructureSection load='2bel' size='340' side='right' caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2bel' size='340' side='right' caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://pdbe.org/2bel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://pdbe.org/2bel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bel_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bel_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
Line 29:		Line 27:
	[[Category: Bray, J]]		[[Category: Bray, J]]
	[[Category: Debreczeni, J E]]		[[Category: Debreczeni, J E]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Elleby, B]]		[[Category: Elleby, B]]

OCA at 08:53, 8 February 2016

2016-02-08T08:53:06Z

←Older revision		Revision as of 08:53, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 09:55, 10 September 2015

2015-09-10T09:55:38Z

←Older revision		Revision as of 09:55, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bel' size='340' side='right' caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>		<StructureSection load='2bel' size='340' side='right' caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://pdbe.org/2bel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: 11-beta-hydroxysteroid dehydrogenase]]		[[Category: 11-beta-hydroxysteroid dehydrogenase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Abrahmsen, L]]		[[Category: Abrahmsen, L]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]

OCA at 08:53, 8 January 2015

2015-01-08T08:53:27Z

←Older revision		Revision as of 08:53, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	[[Category: 11-beta-hydroxysteroid dehydrogenase]]		[[Category: 11-beta-hydroxysteroid dehydrogenase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Abrahmsen, L.]]	+	[[Category: Abrahmsen, L]]
-	[[Category: Arrowsmith, C.]]	+	[[Category: Arrowsmith, C]]
-	[[Category: Bray, J.]]	+	[[Category: Bray, J]]
-	[[Category: Debreczeni, J E.]]	+	[[Category: Debreczeni, J E]]
-	[[Category: Delft, F Von.]]	+	[[Category: Delft, F Von]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Elleby, B.]]	+	[[Category: Elleby, B]]
-	[[Category: Kavanagh, K.]]	+	[[Category: Kavanagh, K]]
-	[[Category: Oppermann, U.]]	+	[[Category: Oppermann, U]]
-	[[Category: Sharma, S.]]	+	[[Category: Sharma, S]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Svensson, S.]]	+	[[Category: Svensson, S]]
-	[[Category: Wu, X.]]	+	[[Category: Wu, X]]
	[[Category: Drug target]]		[[Category: Drug target]]
	[[Category: Glucocorticoid activation]]		[[Category: Glucocorticoid activation]]

OCA at 23:47, 29 September 2014

2014-09-29T23:47:23Z

←Older revision		Revision as of 23:47, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2bel\| PDB=2bel \| SCENE= }}~~	+	==STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE==
-	===STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE===	+	<StructureSection load='2bel' size='340' side='right' caption='[[2bel]], [[Resolution\|resolution]] 2.11Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
-	[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA].	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xu7\|1xu7]], [[1xu9\|1xu9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [http://www.ebi.ac.uk/pdbsum/2bel PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bel_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]		*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: 11-beta-hydroxysteroid dehydrogenase]]		[[Category: 11-beta-hydroxysteroid dehydrogenase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 08:57, 24 March 2013

2013-03-24T08:57:35Z

←Older revision		Revision as of 08:57, 24 March 2013
Line 1:		Line 1:
-	[[Image:2bel.png\|left\|200px]]
-
	{{STRUCTURE_2bel\| PDB=2bel \| SCENE= }}		{{STRUCTURE_2bel\| PDB=2bel \| SCENE= }}
-
	===STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE===		===STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE===
-

	==About this Structure==		==About this Structure==

OCA at 09:36, 20 October 2012

2012-10-20T09:36:36Z

←Older revision		Revision as of 09:36, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2bel]] is a 4 chain structure ~~of [[Hydroxysteroid dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA].	+	[[2bel]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA].

	==See Also==		==See Also==