2bi4 - Revision history

OCA at 13:38, 13 December 2023

2023-12-13T13:38:39Z

←Older revision		Revision as of 13:38, 13 December 2023
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	<StructureSection load='2bi4' size='340' side='right'caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2bi4' size='340' side='right'caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1rrm\|1rrm]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [https://pdbe.org/2bi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bi4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [https://pdbe.org/2bi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bi4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FUCO_ECOLI FUCO_ECOLI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Lactaldehyde reductase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aguilar, J]]	+	[[Category: Aguilar J]]
-	[[Category: Badia, J]]	+	[[Category: Badia J]]
-	[[Category: Baldoma, L]]	+	[[Category: Baldoma L]]
-	[[Category: Bellsolell, L]]	+	[[Category: Bellsolell L]]
-	[[Category: Coll, M]]	+	[[Category: Coll M]]
-	[[Category: Montella, C]]	+	[[Category: Montella C]]
-	[[Category: Perez, R]]	+	[[Category: Perez R]]
-	~~[[Category: Dinucleotide cofactor specificity]]~~	+
-	~~[[Category: Fuco]]~~	+
-	~~[[Category: Group iii dehydrogenase]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Metalo-enzyme]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 13:10, 24 November 2021

2021-11-24T13:10:26Z

←Older revision		Revision as of 13:10, 24 November 2021
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	<StructureSection load='2bi4' size='340' side='right'caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2bi4' size='340' side='right'caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rrm\|1rrm]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [~~http~~://pdbe.org/2bi4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bi4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bi4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [https://pdbe.org/2bi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bi4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:15, 19 February 2020

2020-02-19T08:15:52Z

←Older revision		Revision as of 08:15, 19 February 2020
Line 1:		Line 1:

	==Lactaldehyde:1,2-propanediol oxidoreductase of Escherichia coli==		==Lactaldehyde:1,2-propanediol oxidoreductase of Escherichia coli==
-	<StructureSection load='2bi4' size='340' side='right' caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>	+	<StructureSection load='2bi4' size='340' side='right'caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>
Line 34:		Line 34:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Lactaldehyde reductase]]		[[Category: Lactaldehyde reductase]]
		+	[[Category: Large Structures]]
	[[Category: Aguilar, J]]		[[Category: Aguilar, J]]
	[[Category: Badia, J]]		[[Category: Badia, J]]

OCA at 06:46, 16 May 2018

2018-05-16T06:46:19Z

←Older revision		Revision as of 06:46, 16 May 2018
Line 1:		Line 1:
-	==~~LACTALDEHYDE~~:1,2-~~PROPANEDIOL OXIDOREDUCTASE OF ESCHERICHIA COLI~~==	+
		+	==Lactaldehyde:1,2-propanediol oxidoreductase of Escherichia coli==
	<StructureSection load='2bi4' size='340' side='right' caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2bi4' size='340' side='right' caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [http://pdbe.org/2bi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [http://pdbe.org/2bi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bi4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/2bi4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/2bi4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:50, 8 February 2016

2016-02-08T04:50:50Z

←Older revision		Revision as of 04:50, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bi4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:02, 10 September 2015

2015-09-10T08:02:37Z

←Older revision		Revision as of 08:02, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bi4' size='340' side='right' caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2bi4' size='340' side='right' caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [http://pdbe.org/2bi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bi4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Lactaldehyde reductase]]		[[Category: Lactaldehyde reductase]]
	[[Category: Aguilar, J]]		[[Category: Aguilar, J]]

OCA at 10:34, 8 January 2015

2015-01-08T10:34:17Z

←Older revision		Revision as of 10:34, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Lactaldehyde reductase]]		[[Category: Lactaldehyde reductase]]
-	[[Category: Aguilar, J.]]	+	[[Category: Aguilar, J]]
-	[[Category: Badia, J.]]	+	[[Category: Badia, J]]
-	[[Category: Baldoma, L.]]	+	[[Category: Baldoma, L]]
-	[[Category: Bellsolell, L.]]	+	[[Category: Bellsolell, L]]
-	[[Category: Coll, M.]]	+	[[Category: Coll, M]]
-	[[Category: Montella, C.]]	+	[[Category: Montella, C]]
-	[[Category: Perez, R.]]	+	[[Category: Perez, R]]
	[[Category: Dinucleotide cofactor specificity]]		[[Category: Dinucleotide cofactor specificity]]
	[[Category: Fuco]]		[[Category: Fuco]]

OCA at 01:17, 30 September 2014

2014-09-30T01:17:35Z

←Older revision		Revision as of 01:17, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2bi4.~~png~~\|~~left~~\|200px]]	+	==LACTALDEHYDE:1,2-PROPANEDIOL OXIDOREDUCTASE OF ESCHERICHIA COLI==
		+	<StructureSection load='2bi4' size='340' side='right' caption='[[2bi4]], [[Resolution\|resolution]] 2.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BI4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rrm\|1rrm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactaldehyde_reductase Lactaldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.77 1.1.1.77] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bi4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bi4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bi4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/2bi4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The FucO protein, a member of the group III "iron-activated" dehydrogenases, catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli. The three-dimensional structure of FucO in a complex with NAD(+) was solved, and the presence of iron in the crystals was confirmed by X-ray fluorescence. The FucO structure presented here is the first structure for a member of the group III bacterial dehydrogenases shown experimentally to contain iron. FucO forms a dimer, in which each monomer folds into an alpha/beta dinucleotide-binding N-terminal domain and an all-alpha-helix C-terminal domain that are separated by a deep cleft. The dimer is formed by the swapping (between monomers) of the first chain of the beta-sheet. The binding site for Fe(2+) is located at the face of the cleft formed by the C-terminal domain, where the metal ion is tetrahedrally coordinated by three histidine residues (His200, His263, and His277) and an aspartate residue (Asp196). The glycine-rich turn formed by residues 96 to 98 and the following alpha-helix is part of the NAD(+) recognition locus common in dehydrogenases. Site-directed mutagenesis and enzyme kinetic assays were performed to assess the role of different residues in metal, cofactor, and substrate binding. In contrast to previous assumptions, the essential His267 residue does not interact with the metal ion. Asp39 appears to be the key residue for discriminating against NADP(+). Modeling L-1,2-propanediol in the active center resulted in a close approach of the C-1 hydroxyl of the substrate to C-4 of the nicotinamide ring, implying that there is a typical metal-dependent dehydrogenation catalytic mechanism.

-	~~{{STRUCTURE_2bi4\| PDB=2bi4 \| SCENE= }}~~	+	Crystal structure of an iron-dependent group III dehydrogenase that interconverts L-lactaldehyde and L-1,2-propanediol in Escherichia coli.,Montella C, Bellsolell L, Perez-Luque R, Badia J, Baldoma L, Coll M, Aguilar J J Bacteriol. 2005 Jul;187(14):4957-66. PMID:15995211<ref>PMID:15995211</ref>

-	~~===LACTALDEHYDE:1~~,~~2-PROPANEDIOL OXIDOREDUCTASE OF ESCHERICHIA COLI===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15995211}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2bi4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015995211<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Lactaldehyde reductase]]		[[Category: Lactaldehyde reductase]]

OCA: Protected "2bi4" [edit=sysop:move=sysop]

2013-01-06T10:32:09Z

Protected "2bi4" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:32, 6 January 2013

OCA at 10:32, 6 January 2013

2013-01-06T10:32:05Z

←Older revision		Revision as of 10:32, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2bi4.png\|left\|200px]]		[[Image:2bi4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2bi4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2bi4\| PDB=2bi4 \| SCENE= }}		{{STRUCTURE_2bi4\| PDB=2bi4 \| SCENE= }}

	===LACTALDEHYDE:1,2-PROPANEDIOL OXIDOREDUCTASE OF ESCHERICHIA COLI===		===LACTALDEHYDE:1,2-PROPANEDIOL OXIDOREDUCTASE OF ESCHERICHIA COLI===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15995211}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15995211 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15995211}}		{{ABSTRACT_PUBMED_15995211}}

	==About this Structure==		==About this Structure==
-	~~2BI4~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA].	+	[[2bi4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15995211~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015995211</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Lactaldehyde reductase]]		[[Category: Lactaldehyde reductase]]
Line 29:		Line 17:
	[[Category: Badia, J.]]		[[Category: Badia, J.]]
	[[Category: Baldoma, L.]]		[[Category: Baldoma, L.]]
-	[[Category: Bellsolell]]	+	[[Category: Bellsolell, L.]]
	[[Category: Coll, M.]]		[[Category: Coll, M.]]
	[[Category: Montella, C.]]		[[Category: Montella, C.]]
Line 40:		Line 28:
	[[Category: Nad]]		[[Category: Nad]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 18:55:46 2009''