2bk4 - Revision history

OCA at 13:41, 13 December 2023

2023-12-13T13:41:56Z

←Older revision		Revision as of 13:41, 13 December 2023
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	<StructureSection load='2bk4' size='340' side='right'caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bk4' size='340' side='right'caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-~~1~~-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~1~~.4.~~3.4 1~~.4.3.4]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [https://pdbe.org/2bk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bk4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [https://pdbe.org/2bk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bk4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Monoamine oxidase]]~~	+	[[Category: Binda C]]
-	[[Category: Binda, C]]	+	[[Category: Castagnoli N]]
-	[[Category: Castagnoli, N]]	+	[[Category: Edmondson DE]]
-	[[Category: Edmondson~~, D E~~]]	+	[[Category: Hubalek F]]
-	[[Category: Hubalek, F]]	+	[[Category: Khalil A]]
-	[[Category: Khalil, A]]	+	[[Category: Li M]]
-	[[Category: Li, M]]	+	[[Category: Mattevi A]]
-	[[Category: Mattevi, A]]	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Fad-containing amine oxidase]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Maob]]~~	+
-	~~[[Category: Maob acetylation]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 13:11, 24 November 2021

2021-11-24T13:11:53Z

←Older revision		Revision as of 13:11, 24 November 2021
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	<StructureSection load='2bk4' size='340' side='right'caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bk4' size='340' side='right'caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [~~http~~://pdbe.org/2bk4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bk4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bk4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [https://pdbe.org/2bk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bk4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:57, 19 February 2020

2020-02-19T07:57:05Z

←Older revision		Revision as of 07:57, 19 February 2020
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	==Human Monoamine Oxidase B: I199F mutant in complex with rasagiline==		==Human Monoamine Oxidase B: I199F mutant in complex with rasagiline==
-	<StructureSection load='2bk4' size='340' side='right' caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2bk4' size='340' side='right'caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Monoamine oxidase]]		[[Category: Monoamine oxidase]]
	[[Category: Binda, C]]		[[Category: Binda, C]]

OCA at 06:17, 16 May 2018

2018-05-16T06:17:02Z

←Older revision		Revision as of 06:17, 16 May 2018
Line 1:		Line 1:
		+
	==Human Monoamine Oxidase B: I199F mutant in complex with rasagiline==		==Human Monoamine Oxidase B: I199F mutant in complex with rasagiline==
	<StructureSection load='2bk4' size='340' side='right' caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bk4' size='340' side='right' caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [http://pdbe.org/2bk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [http://pdbe.org/2bk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bk4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bk4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bk4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:24, 9 February 2016

2016-02-09T07:24:42Z

←Older revision		Revision as of 07:24, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bk4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:56, 10 September 2015

2015-09-10T19:56:46Z

←Older revision		Revision as of 19:56, 10 September 2015
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	<StructureSection load='2bk4' size='340' side='right' caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2bk4' size='340' side='right' caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [http://pdbe.org/2bk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2bk4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Monoamine oxidase]]		[[Category: Monoamine oxidase]]
	[[Category: Binda, C]]		[[Category: Binda, C]]

OCA at 10:02, 8 January 2015

2015-01-08T10:02:11Z

←Older revision		Revision as of 10:02, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Monoamine oxidase]]		[[Category: Monoamine oxidase]]
-	[[Category: Binda, C.]]	+	[[Category: Binda, C]]
-	[[Category: Castagnoli, N.]]	+	[[Category: Castagnoli, N]]
-	[[Category: Edmondson, D E.]]	+	[[Category: Edmondson, D E]]
-	[[Category: Hubalek, F.]]	+	[[Category: Hubalek, F]]
-	[[Category: Khalil, A.]]	+	[[Category: Khalil, A]]
-	[[Category: Li, M.]]	+	[[Category: Li, M]]
-	[[Category: Mattevi, A.]]	+	[[Category: Mattevi, A]]
	[[Category: Fad]]		[[Category: Fad]]
	[[Category: Fad-containing amine oxidase]]		[[Category: Fad-containing amine oxidase]]

OCA at 05:02, 29 September 2014

2014-09-29T05:02:05Z

←Older revision		Revision as of 05:02, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2bk4.~~png~~\|~~left~~\|200px]]	+	==Human Monoamine Oxidase B: I199F mutant in complex with rasagiline==
		+	<StructureSection load='2bk4' size='340' side='right' caption='[[2bk4]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RAS:(1R)-N-(PROP-2-EN-1-YL)-2,3-DIHYDRO-1H-INDEN-1-AMINE'>RAS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1gos\|1gos]], [[1h8r\|1h8r]], [[1oj9\|1oj9]], [[1oja\|1oja]], [[1ojb\|1ojb]], [[1ojc\|1ojc]], [[1ojd\|1ojd]], [[1s2q\|1s2q]], [[1s2y\|1s2y]], [[1s3b\|1s3b]], [[1s3e\|1s3e]], [[2bk3\|2bk3]], [[2bk5\|2bk5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bk4 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bk4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several reversible inhibitors selective for human monoamine oxidase B (MAO B) that do not inhibit MAO A have been described in the literature. The following compounds: 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene, and trans,trans-farnesol are shown to inhibit competitively human, horse, rat, and mouse MAO B with K(i) values in the low micromolar range but are without effect on either bovine or sheep MAO B or human MAO A. In contrast, the reversible competitive inhibitor isatin binds to all known MAO B and MAO A with similar affinities. Sequence alignments and the crystal structures of human MAO B in complex with 1,4-diphenyl-2-butene or with trans,trans-farnesol provide molecular insights into these specificities. These inhibitors span the substrate and entrance cavities with the side chain of Ile-199 rotated out of its normal conformation suggesting that Ile-199 is gating the substrate cavity. Ile-199 is conserved in all known MAO B sequences except bovine MAO B, which has Phe in this position (the sequence of sheep MAO B is unknown). Phe is conserved in the analogous position in MAO A sequences. The human MAO B I199F mutant protein of MAO B binds to isatin (K(i) = 3 microM) but not to the three inhibitors listed above. The crystal structure of this mutant demonstrates that the side chain of Phe-199 interferes with the binding of those compounds. This suggests that the Ile-199 "gate" is a determinant for the specificity of these MAO B inhibitors and provides a molecular basis for the development of MAO B-specific reversible inhibitors without interference with MAO A function in neurotransmitter metabolism.

-	~~{{STRUCTURE_2bk4\| PDB=2bk4 \| SCENE= }}~~	+	Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.,Hubalek F, Binda C, Khalil A, Li M, Mattevi A, Castagnoli N, Edmondson DE J Biol Chem. 2005 Apr 22;280(16):15761-6. Epub 2005 Feb 14. PMID:15710600<ref>PMID:15710600</ref>

-	~~===Human Monoamine Oxidase B: I199F mutant in complex with rasagiline===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15710600}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2bk4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA].~~	+

	==See Also==		==See Also==
	*[[Monoamine oxidase\|Monoamine oxidase]]		*[[Monoamine oxidase\|Monoamine oxidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015710600<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Monoamine oxidase]]		[[Category: Monoamine oxidase]]

OCA at 13:06, 20 October 2012

2012-10-20T13:06:23Z

←Older revision		Revision as of 13:06, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2bk4]] is a 2 chain structure ~~of [[Monoamine oxidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA].	+	[[2bk4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK4 OCA].

	==See Also==		==See Also==

OCA at 10:55, 26 July 2012

2012-07-26T10:55:17Z

←Older revision		Revision as of 10:55, 26 July 2012
Line 1:		Line 1:
	[[Image:2bk4.png\|left\|200px]]		[[Image:2bk4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2bk4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2bk4\| PDB=2bk4 \| SCENE= }}		{{STRUCTURE_2bk4\| PDB=2bk4 \| SCENE= }}

	===Human Monoamine Oxidase B: I199F mutant in complex with rasagiline===		===Human Monoamine Oxidase B: I199F mutant in complex with rasagiline===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15710600}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15710600 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15710600}}		{{ABSTRACT_PUBMED_15710600}}

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	==See Also==		==See Also==
-	*[[Monoamine oxidase]]	+	*[[Monoamine oxidase\|Monoamine oxidase]]

	==Reference==		==Reference==