2c0d - Revision history

OCA at 14:00, 13 December 2023

2023-12-13T14:00:29Z

←Older revision		Revision as of 14:00, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2c0d' size='340' side='right'caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2c0d' size='340' side='right'caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Peroxidase Peroxidase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~1.~~11.1.7 1.11.1.7] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [https://pdbe.org/2c0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [https://www.ebi.ac.uk/pdbsum/2c0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [https://pdbe.org/2c0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [https://www.ebi.ac.uk/pdbsum/2c0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0d ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8I5Q6_PLAF7 Q8I5Q6_PLAF7] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.[PIRNR:PIRNR000239]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Peroxidase]]~~	+	[[Category: Plasmodium falciparum 3D7]]
-	~~[[Category: Plaf7~~]]	+	[[Category: Boucher IW]]
-	[[Category: Boucher~~, I W~~]]	+	[[Category: Brannigan JA]]
-	[[Category: Brannigan~~, J A~~]]	+	[[Category: Brzozowski AM]]
-	[[Category: Brzozowski~~, A M~~]]	+	[[Category: Muller S]]
-	[[Category: Muller, S]]	+	[[Category: Wilkinson AJ]]
-	[[Category: Wilkinson~~, A J]]~~	+
-	~~[[Category: 2-cy]]~~	+
-	~~[[Category: Antioxidant]]~~	+
-	~~[[Category: Mitochondrial]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Peroxiredoxin]]~~	+
-	~~[[Category: Redox-active center]]~~	+
-	~~[[Category: Thioredoxin dependant~~]]	+

OCA at 13:21, 24 November 2021

2021-11-24T13:21:55Z

←Older revision		Revision as of 13:21, 24 November 2021
Line 3:		Line 3:
	<StructureSection load='2c0d' size='340' side='right'caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2c0d' size='340' side='right'caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C0D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [~~http~~://pdbe.org/2c0d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c0d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [https://pdbe.org/2c0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [https://www.ebi.ac.uk/pdbsum/2c0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:01, 19 February 2020

2020-02-19T08:01:41Z

←Older revision		Revision as of 08:01, 19 February 2020
Line 1:		Line 1:

	==Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum==		==Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum==
-	<StructureSection load='2c0d' size='340' side='right' caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='2c0d' size='340' side='right'caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Peroxiredoxin\|Peroxiredoxin]]	+	*[[Peroxiredoxin 3D structures\|Peroxiredoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Peroxidase]]		[[Category: Peroxidase]]
	[[Category: Plaf7]]		[[Category: Plaf7]]

OCA at 06:24, 16 May 2018

2018-05-16T06:24:40Z

←Older revision		Revision as of 06:24, 16 May 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF THE MITOCHONDRIAL~~ 2-~~CYS PEROXIREDOXIN FROM PLASMODIUM FALCIPARUM~~==	+
		+	==Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum==
	<StructureSection load='2c0d' size='340' side='right' caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2c0d' size='340' side='right' caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://pdbe.org/2c0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://pdbe.org/2c0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:37, 9 February 2016

2016-02-09T07:37:23Z

←Older revision		Revision as of 07:37, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:02, 10 September 2015

2015-09-10T20:02:57Z

←Older revision		Revision as of 20:02, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2c0d' size='340' side='right' caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2c0d' size='340' side='right' caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://pdbe.org/2c0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c0d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Peroxidase]]		[[Category: Peroxidase]]
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plaf7]]
	[[Category: Boucher, I W]]		[[Category: Boucher, I W]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]

OCA at 17:45, 15 January 2015

2015-01-15T17:45:56Z

←Older revision		Revision as of 17:45, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Peroxidase]]		[[Category: Peroxidase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Boucher, I W.]]	+	[[Category: Boucher, I W]]
-	[[Category: Brannigan, J A.]]	+	[[Category: Brannigan, J A]]
-	[[Category: Brzozowski, A M.]]	+	[[Category: Brzozowski, A M]]
-	[[Category: Muller, S.]]	+	[[Category: Muller, S]]
-	[[Category: Wilkinson, A J.]]	+	[[Category: Wilkinson, A J]]
	[[Category: 2-cy]]		[[Category: 2-cy]]
	[[Category: Antioxidant]]		[[Category: Antioxidant]]
	[[Category: Mitochondrial]]		[[Category: Mitochondrial]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Peroxidase]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]
	[[Category: Redox-active center]]		[[Category: Redox-active center]]
	[[Category: Thioredoxin dependant]]		[[Category: Thioredoxin dependant]]

OCA at 05:05, 29 September 2014

2014-09-29T05:05:34Z

←Older revision		Revision as of 05:05, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2c0d.~~png\|left~~\|200px]]	+	==STRUCTURE OF THE MITOCHONDRIAL 2-CYS PEROXIREDOXIN FROM PLASMODIUM FALCIPARUM==
		+	<StructureSection load='2c0d' size='340' side='right' caption='[[2c0d]], [[Resolution\|resolution]] 1.78Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C0D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c0d RCSB], [http://www.ebi.ac.uk/pdbsum/2c0d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium falciparum possesses a single mitochondrion with a functional electron transport chain. During respiration, reactive oxygen species are generated that need to be removed to protect the organelle from oxidative damage. In the absence of catalase and glutathione peroxidase, the parasites rely primarily on peroxiredoxin-linked systems for protection. We have analysed the biochemical and structural features of the mitochondrial peroxiredoxin and thioredoxin of P. falciparum. The mitochondrial localization of both proteins was confirmed by expressing green fluorescent protein fusions in parasite erythrocytic stages. Recombinant protein was kinetically characterized using the cytosolic and the mitochondrial thioredoxin (PfTrx1 and PfTrx2 respectively). The peroxiredoxin clearly preferred PfTrx2 to PfTrx1 as a reducing partner, reflected by the KM values of 11.6 microM and 130.4 microM respectively. Substitution of the two dyads asparagine-62/tyrosine-63 and phenylalanine-139/alanine-140 residues by aspartate-phenylalaine and valine-serine, respectively, reduced the KM for Trx1 but had no effect on the KM of Trx2 suggesting some role for these residues in the discrimination between the two substrates. Solution studies suggest that the protein exists primarily in a homodecameric form. The crystal structure of the mitochondrial peroxiredoxin reveals a fold typical of the 2-Cys class peroxiredoxins and a dimeric form with an intermolecular disulphide bridge between Cys67 and Cys187. These results show that the mitochondrial peroxiredoxin of P. falciparum occurs in both dimeric and decameric forms when purified under non-reducing conditions.

-	~~{{STRUCTURE_2c0d\| PDB=2c0d \| SCENE= }}~~	+	Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum.,Boucher IW, McMillan PJ, Gabrielsen M, Akerman SE, Brannigan JA, Schnick C, Brzozowski AM, Wilkinson AJ, Muller S Mol Microbiol. 2006 Aug;61(4):948-59. PMID:16879648<ref>PMID:16879648</ref>

-	~~===STRUCTURE OF THE MITOCHONDRIAL 2-CYS PEROXIREDOXIN FROM PLASMODIUM FALCIPARUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16879648}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2c0d]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA].~~	+

	==See Also==		==See Also==
	*[[Peroxiredoxin\|Peroxiredoxin]]		*[[Peroxiredoxin\|Peroxiredoxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016879648<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Peroxidase]]		[[Category: Peroxidase]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]

OCA at 13:08, 20 October 2012

2012-10-20T13:08:16Z

←Older revision		Revision as of 13:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2c0d]] is a 2 chain structure ~~of [[Peroxiredoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA].	+	[[2c0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0D OCA].

	==See Also==		==See Also==

OCA: Protected "2c0d" [edit=sysop:move=sysop]

2012-07-26T11:01:07Z

Protected "2c0d" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:01, 26 July 2012