2c1s - Revision history

OCA at 14:02, 13 December 2023

2023-12-13T14:02:23Z

←Older revision		Revision as of 14:02, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2c1s' size='340' side='right'caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2c1s' size='340' side='right'caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C1S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C1S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BSO:BIOTIN~~-~~D-SULFOXIDE'>BSO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2c1q\|2c1q]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [https://pdbe.org/2c1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [https://www.ebi.ac.uk/pdbsum/2c1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [https://pdbe.org/2c1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [https://www.ebi.ac.uk/pdbsum/2c1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1s ProSAT]</span></td></tr>
	</table>		</table>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Airenne~~, T T~~]]	+	[[Category: Airenne TT]]
-	[[Category: Halling~~, K K~~]]	+	[[Category: Halling KK]]
-	[[Category: Helttunen~~, K J~~]]	+	[[Category: Helttunen KJ]]
-	[[Category: Huuskonen, J]]	+	[[Category: Huuskonen J]]
-	[[Category: Hytonen~~, V P~~]]	+	[[Category: Hytonen VP]]
-	[[Category: Johnson~~, M S~~]]	+	[[Category: Johnson MS]]
-	[[Category: Kulomaa~~, M S~~]]	+	[[Category: Kulomaa MS]]
-	[[Category: Laitinen~~, O H~~]]	+	[[Category: Laitinen OH]]
-	[[Category: Maatta~~, J A.E~~]]	+	[[Category: Maatta JAE]]
-	[[Category: Niskanen~~, E A~~]]	+	[[Category: Niskanen EA]]
-	[[Category: Nordlund~~, H R~~]]	+	[[Category: Nordlund HR]]
-	[[Category: Rissanen, K]]	+	[[Category: Rissanen K]]
-	[[Category: Salminen~~, T A~~]]	+	[[Category: Salminen TA]]
-	[[Category: Slotte~~, J P]]~~	+	[[Category: Slotte JP]]
-	~~[[Category: Biotin binding protein~~]]	+

OCA at 20:32, 20 October 2021

2021-10-20T20:32:29Z

←Older revision		Revision as of 20:32, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2c1s' size='340' side='right'caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2c1s' size='340' side='right'caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C1S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C1S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c1q\|2c1q]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [~~http~~://pdbe.org/2c1s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c1s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [https://pdbe.org/2c1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [https://www.ebi.ac.uk/pdbsum/2c1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:21, 11 December 2019

2019-12-11T19:21:46Z

←Older revision		Revision as of 19:21, 11 December 2019
Line 1:		Line 1:

	==X-ray structure of biotin binding protein from chicken==		==X-ray structure of biotin binding protein from chicken==
-	<StructureSection load='2c1s' size='340' side='right' caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='2c1s' size='340' side='right'caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1S FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1S FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Airenne, T T]]		[[Category: Airenne, T T]]
	[[Category: Halling, K K]]		[[Category: Halling, K K]]

OCA at 07:20, 17 January 2018

2018-01-17T07:20:19Z

←Older revision		Revision as of 07:20, 17 January 2018
Line 1:		Line 1:
-	==X-~~RAY STRUCTURE OF BIOTIN BINDING PROTEIN FROM CHICKEN~~==	+
		+	==X-ray structure of biotin binding protein from chicken==
	<StructureSection load='2c1s' size='340' side='right' caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2c1s' size='340' side='right' caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [http://pdbe.org/2c1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [http://www.ebi.ac.uk/pdbsum/2c1s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [http://pdbe.org/2c1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [http://www.ebi.ac.uk/pdbsum/2c1s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c1s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c1s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:54, 7 February 2016

2016-02-07T14:54:10Z

←Older revision		Revision as of 14:54, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c1s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:33, 10 September 2015

2015-09-10T02:33:39Z

←Older revision		Revision as of 02:33, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2c1s' size='340' side='right' caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='2c1s' size='340' side='right' caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [http://www.ebi.ac.uk/pdbsum/2c1s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [http://pdbe.org/2c1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [http://www.ebi.ac.uk/pdbsum/2c1s PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c1s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Airenne, T T]]		[[Category: Airenne, T T]]
	[[Category: Halling, K K]]		[[Category: Halling, K K]]

OCA at 16:34, 15 January 2015

2015-01-15T16:34:03Z

←Older revision		Revision as of 16:34, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1S FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [http://www.ebi.ac.uk/pdbsum/2c1s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [http://www.ebi.ac.uk/pdbsum/2c1s PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Airenne, T T.]]	+	[[Category: Airenne, T T]]
-	[[Category: Halling, K K.]]	+	[[Category: Halling, K K]]
-	[[Category: Helttunen, K J.]]	+	[[Category: Helttunen, K J]]
-	[[Category: Huuskonen, J.]]	+	[[Category: Huuskonen, J]]
-	[[Category: Hytonen, V P.]]	+	[[Category: Hytonen, V P]]
-	[[Category: Johnson, M S.]]	+	[[Category: Johnson, M S]]
-	[[Category: Kulomaa, M S.]]	+	[[Category: Kulomaa, M S]]
-	[[Category: Laitinen, O H.]]	+	[[Category: Laitinen, O H]]
-	[[Category: Maatta, J A.E.]]	+	[[Category: Maatta, J A.E]]
-	[[Category: Niskanen, E A.]]	+	[[Category: Niskanen, E A]]
-	[[Category: Nordlund, H R.]]	+	[[Category: Nordlund, H R]]
-	[[Category: Rissanen, K.]]	+	[[Category: Rissanen, K]]
-	[[Category: Salminen, T A.]]	+	[[Category: Salminen, T A]]
-	[[Category: Slotte, J P.]]	+	[[Category: Slotte, J P]]
	[[Category: Biotin binding protein]]		[[Category: Biotin binding protein]]

OCA at 01:48, 30 September 2014

2014-09-30T01:48:30Z

←Older revision		Revision as of 01:48, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2c1s.~~png~~\|~~left~~\|200px]]	+	==X-RAY STRUCTURE OF BIOTIN BINDING PROTEIN FROM CHICKEN==
		+	<StructureSection load='2c1s' size='340' side='right' caption='[[2c1s]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSO:BIOTIN-D-SULFOXIDE'>BSO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c1q\|2c1q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c1s RCSB], [http://www.ebi.ac.uk/pdbsum/2c1s PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c1s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: The chicken genome contains a BBP-A gene showing similar characteristics to avidin family genes. In a previous study we reported that the BBP-A gene may encode a biotin-binding protein due to the high sequence similarity with chicken avidin, especially at regions encoding residues known to be located at the ligand-binding site of avidin. RESULTS: Here, we expand the repertoire of known macromolecular biotin binders by reporting a novel biotin-binding protein A (BBP-A) from chicken. The BBP-A recombinant protein was expressed using two different expression systems and purified with affinity chromatography, biochemically characterized and two X-ray structures were solved - in complex with D-biotin (BTN) and in complex with D-biotin D-sulfoxide (BSO). The BBP-A protein binds free biotin with high, "streptavidin-like" affinity (Kd ~ 10-13 M), which is about 50 times lower than that of chicken avidin. Surprisingly, the affinity of BBP-A for BSO is even higher than the affinity for BTN. Furthermore, the solved structures of the BBP-A--BTN and BBP-A--BSO complexes, which share the fold with the members of the avidin and lipocalin protein families, are extremely similar to each other. CONCLUSION: BBP-A is an avidin-like protein having a beta-barrel fold and high affinity towards BTN. However, BBP-A differs from the other known members of the avidin protein family in thermal stability and immunological properties. BBP-A also has a unique ligand-binding property, the ability to bind BTN and BSO at comparable affinities. BBP-A may have use as a novel material in, e.g. modern bio(nano)technological applications.

-	~~{{STRUCTURE_2c1s\| PDB=2c1s \| SCENE= }}~~	+	Structure and characterization of a novel chicken biotin-binding protein A (BBP-A).,Hytonen VP, Maatta JA, Niskanen EA, Huuskonen J, Helttunen KJ, Halling KK, Nordlund HR, Rissanen K, Johnson MS, Salminen TA, Kulomaa MS, Laitinen OH, Airenne TT BMC Struct Biol. 2007 Mar 7;7:8. PMID:17343730<ref>PMID:17343730</ref>

-	~~===X-RAY STRUCTURE OF BIOTIN BINDING PROTEIN FROM CHICKEN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17343730}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2c1s]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017343730<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Airenne, T T.]]		[[Category: Airenne, T T.]]

OCA: Protected "2c1s" [edit=sysop:move=sysop]

2013-01-06T11:02:58Z

Protected "2c1s" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:02, 6 January 2013

OCA at 11:02, 6 January 2013

2013-01-06T11:02:53Z

←Older revision		Revision as of 11:02, 6 January 2013
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-	{{Seed}}
	[[Image:2c1s.png\|left\|200px]]		[[Image:2c1s.png\|left\|200px]]

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	{{STRUCTURE_2c1s\| PDB=2c1s \| SCENE= }}		{{STRUCTURE_2c1s\| PDB=2c1s \| SCENE= }}

	===X-RAY STRUCTURE OF BIOTIN BINDING PROTEIN FROM CHICKEN===		===X-RAY STRUCTURE OF BIOTIN BINDING PROTEIN FROM CHICKEN===

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	{{ABSTRACT_PUBMED_17343730}}		{{ABSTRACT_PUBMED_17343730}}

	==About this Structure==		==About this Structure==
-	~~2C1S~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA].	+	[[2c1s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1S OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17343730~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017343730</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Airenne, T T.]]		[[Category: Airenne, T T.]]
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	[[Category: Slotte, J P.]]		[[Category: Slotte, J P.]]
	[[Category: Biotin binding protein]]		[[Category: Biotin binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:00:58 2009''