2c27 - Revision history

OCA at 14:03, 13 December 2023

2023-12-13T14:03:06Z

←Older revision		Revision as of 14:03, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2c27' size='340' side='right'caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2c27' size='340' side='right'caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ozp\|1ozp]], [[1p0h\|1p0h]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [https://pdbe.org/2c27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [https://www.ebi.ac.uk/pdbsum/2c27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c27 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [https://pdbe.org/2c27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [https://www.ebi.ac.uk/pdbsum/2c27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU]] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>	+	[https://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Blanchard~~, J S~~]]	+	[[Category: Blanchard JS]]
-	[[Category: Rendle~~, P M~~]]	+	[[Category: Rendle PM]]
-	[[Category: Vetting~~, M W~~]]	+	[[Category: Vetting MW]]
-	[[Category: Yu, M]]	+	[[Category: Yu M]]
-	~~[[Category: Acetyltransferase]]~~	+
-	~~[[Category: Des- acetylmycothiol]]~~	+
-	~~[[Category: Gcn5 related n- acetyltransferase]]~~	+
-	~~[[Category: Gnat]]~~	+
-	~~[[Category: Mycobacterium tuberculosis]]~~	+
-	~~[[Category: Mycothiol synthase]]~~	+
-	~~[[Category: Synthase~~]]	+

OCA at 14:34, 29 December 2021

2021-12-29T14:34:47Z

←Older revision		Revision as of 14:34, 29 December 2021
Line 3:		Line 3:
	<StructureSection load='2c27' size='340' side='right'caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2c27' size='340' side='right'caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ozp\|1ozp]], [[1p0h\|1p0h]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [~~http~~://pdbe.org/2c27 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c27 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c27 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [https://pdbe.org/2c27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [https://www.ebi.ac.uk/pdbsum/2c27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU]] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>	+	[[https://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU]] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:02, 27 March 2020

2020-03-27T11:02:42Z

←Older revision		Revision as of 11:02, 27 March 2020
Line 1:		Line 1:

	==The Structure of Mycothiol Synthase in Complex with des- AcetylMycothiol and CoenzymeA.==		==The Structure of Mycothiol Synthase in Complex with des- AcetylMycothiol and CoenzymeA.==
-	<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2c27' size='340' side='right'caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Blanchard, J S]]		[[Category: Blanchard, J S]]

OCA at 06:01, 20 June 2018

2018-06-20T06:01:27Z

←Older revision		Revision as of 06:01, 20 June 2018
Line 1:		Line 1:

-	==The ~~structure~~ of Mycothiol Synthase in ~~complex~~ with des- AcetylMycothiol and CoenzymeA.==	+	==The Structure of Mycothiol Synthase in Complex with des- AcetylMycothiol and CoenzymeA.==
	<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 07:56, 23 May 2018

2018-05-23T07:56:18Z

←Older revision		Revision as of 07:56, 23 May 2018
Line 1:		Line 1:
-	==~~THE STRUCTURE OF MYCOTHIOL SYNTHASE IN COMPLEX WITH DES~~-~~ACETYLMYCOTHIOL AND COENZYMEA~~.==	+
		+	==The structure of Mycothiol Synthase in complex with des- AcetylMycothiol and CoenzymeA.==
	<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://pdbe.org/2c27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://pdbe.org/2c27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c27_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c27_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:07, 7 February 2016

2016-02-07T12:07:40Z

←Older revision		Revision as of 12:07, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c27 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:21, 10 September 2015

2015-09-10T01:21:35Z

←Older revision		Revision as of 01:21, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://pdbe.org/2c27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU]] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c27" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Blanchard, J S]]		[[Category: Blanchard, J S]]
	[[Category: Rendle, P M]]		[[Category: Rendle, P M]]
Line 38:		Line 41:
	[[Category: Gcn5 related n- acetyltransferase]]		[[Category: Gcn5 related n- acetyltransferase]]
	[[Category: Gnat]]		[[Category: Gnat]]
		+	[[Category: Mycobacterium tuberculosis]]
	[[Category: Mycothiol synthase]]		[[Category: Mycothiol synthase]]
	[[Category: Synthase]]		[[Category: Synthase]]

OCA at 17:21, 15 January 2015

2015-01-15T17:21:53Z

←Older revision		Revision as of 17:21, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Blanchard, J S.]]	+	[[Category: Blanchard, J S]]
-	[[Category: Rendle, P M.]]	+	[[Category: Rendle, P M]]
-	[[Category: Vetting, M W.]]	+	[[Category: Vetting, M W]]
-	[[Category: Yu, M.]]	+	[[Category: Yu, M]]
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Des- acetylmycothiol]]		[[Category: Des- acetylmycothiol]]
	[[Category: Gcn5 related n- acetyltransferase]]		[[Category: Gcn5 related n- acetyltransferase]]
	[[Category: Gnat]]		[[Category: Gnat]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Mycothiol synthase]]		[[Category: Mycothiol synthase]]
	[[Category: Synthase]]		[[Category: Synthase]]

OCA at 00:38, 30 September 2014

2014-09-30T00:38:24Z

←Older revision		Revision as of 00:38, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2c27.~~png~~\|~~left~~\|200px]]	+	==THE STRUCTURE OF MYCOTHIOL SYNTHASE IN COMPLEX WITH DES-ACETYLMYCOTHIOL AND COENZYMEA.==
		+	<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ozp\|1ozp]], [[1p0h\|1p0h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c27_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of the ternary complex of mycothiol synthase from Mycobacterium tuberculosis with bound desacetylmycothiol and CoA was determined to 1.8 A resolution. The structure of the acetyl-CoA-binary complex had shown an active site groove that was several times larger than its substrate. The structure of the ternary complex reveals that mycothiol synthase undergoes a large conformational change in which the two acetyltransferase domains are brought together through shared interactions with the functional groups of desacetylmycothiol, thereby decreasing the size of this large central groove. A comparison of the binary and ternary structures illustrates many of the features that promote catalysis. Desacetylmycothiol is positioned with its primary amine in close proximity and in the proper orientation for direct nucleophilic attack on the si-face of the acetyl group of acetyl-CoA. Glu-234 and Tyr-294 are positioned to act as a general base and general acid to promote acetyl transfer. In addition, this structure provides further evidence that the N-terminal acetyltransferase domain no longer has enzymatic activity and is vestigial in nature.

-	~~{{STRUCTURE_2c27\| PDB=2c27 \| SCENE= }}~~	+	The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase.,Vetting MW, Yu M, Rendle PM, Blanchard JS J Biol Chem. 2006 Feb 3;281(5):2795-802. Epub 2005 Dec 2. PMID:16326705<ref>PMID:16326705</ref>

-	~~===THE STRUCTURE OF MYCOTHIOL SYNTHASE IN COMPLEX WITH DES-ACETYLMYCOTHIOL AND COENZYMEA.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16326705}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2c27]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016326705<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Blanchard, J S.]]		[[Category: Blanchard, J S.]]

OCA: Protected "2c27" [edit=sysop:move=sysop]

2013-01-06T10:00:08Z

Protected "2c27" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:00, 6 January 2013