2c7p - Revision history

OCA at 14:07, 13 December 2023

2023-12-13T14:07:58Z

←Older revision		Revision as of 14:07, 13 December 2023
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	<StructureSection load='2c7p' size='340' side='right'caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2c7p' size='340' side='right'caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett~~ and ~~stillman 1919~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>~~, ~~<scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-~~1~~-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [https://pdbe.org/2c7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [https://www.ebi.ac.uk/pdbsum/2c7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [https://pdbe.org/2c7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [https://www.ebi.ac.uk/pdbsum/2c7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH]] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.	+	[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus x pritchett and stillman 1919~~]]	+	[[Category: Haemophilus haemolyticus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Daujotyte, D]]	+	[[Category: Synthetic construct]]
-	[[Category: Dryden~~, D T.F~~]]	+	[[Category: Daujotyte D]]
-	[[Category: Grazulis, S]]	+	[[Category: Dryden DTF]]
-	[[Category: Jones~~, A C~~]]	+	[[Category: Grazulis S]]
-	[[Category: Klimasauskas, S]]	+	[[Category: Jones AC]]
-	[[Category: Magennis~~, S W~~]]	+	[[Category: Klimasauskas S]]
-	[[Category: Neely~~, R K]]~~	+	[[Category: Magennis SW]]
-	~~[[Category: Base flipping]]~~	+	[[Category: Neely RK]]
-	~~[[Category: Restriction system]]~~	+
-	~~[[Category: Transferase-dna complex~~]]	+

OCA at 09:46, 5 May 2021

2021-05-05T09:46:17Z

OCA at 07:14, 24 July 2019

2019-07-24T07:14:34Z

←Older revision		Revision as of 07:14, 24 July 2019
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	==HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH==		==HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH==
-	<StructureSection load='2c7p' size='340' side='right' caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2c7p' size='340' side='right'caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7P FirstGlance]. <br>
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	==See Also==		==See Also==
-	*[[DNA methyltransferase\|DNA methyltransferase]]	+	*[[DNA methyltransferase 3D structures\|DNA methyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus x pritchett and stillman 1919]]		[[Category: Bacillus x pritchett and stillman 1919]]
		+	[[Category: Large Structures]]
	[[Category: Daujotyte, D]]		[[Category: Daujotyte, D]]
	[[Category: Dryden, D T.F]]		[[Category: Dryden, D T.F]]

OCA at 08:48, 23 May 2018

2018-05-23T08:48:26Z

←Older revision		Revision as of 08:48, 23 May 2018
Line 1:		Line 1:
		+
	==HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH==		==HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH==
	<StructureSection load='2c7p' size='340' side='right' caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2c7p' size='340' side='right' caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [http://pdbe.org/2c7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [http://www.ebi.ac.uk/pdbsum/2c7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [http://pdbe.org/2c7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [http://www.ebi.ac.uk/pdbsum/2c7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c7p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[DNA methyltransferase\|DNA methyltransferase]]		*[[DNA methyltransferase\|DNA methyltransferase]]
-	*[[HhaI DNA methyltransferase\|HhaI DNA methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:57, 12 September 2015

2015-09-12T01:57:52Z

←Older revision		Revision as of 01:57, 12 September 2015
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [http://www.ebi.ac.uk/pdbsum/2c7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [http://pdbe.org/2c7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [http://www.ebi.ac.uk/pdbsum/2c7p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c7p" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 22:21, 25 December 2014

2014-12-25T22:21:26Z

←Older revision		Revision as of 22:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7P FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [http://www.ebi.ac.uk/pdbsum/2c7p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [http://www.ebi.ac.uk/pdbsum/2c7p PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH]] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus x pritchett and stillman 1919]]		[[Category: Bacillus x pritchett and stillman 1919]]
-	[[Category: Daujotyte, D.]]	+	[[Category: Daujotyte, D]]
-	[[Category: Dryden, D T.F.]]	+	[[Category: Dryden, D T.F]]
-	[[Category: Grazulis, S.]]	+	[[Category: Grazulis, S]]
-	[[Category: Jones, A C.]]	+	[[Category: Jones, A C]]
-	[[Category: Klimasauskas, S.]]	+	[[Category: Klimasauskas, S]]
-	[[Category: Magennis, S W.]]	+	[[Category: Magennis, S W]]
-	[[Category: Neely, R K.]]	+	[[Category: Neely, R K]]
	[[Category: Base flipping]]		[[Category: Base flipping]]
	[[Category: Restriction system]]		[[Category: Restriction system]]
	[[Category: Transferase-dna complex]]		[[Category: Transferase-dna complex]]

OCA at 05:39, 3 October 2014

2014-10-03T05:39:56Z

←Older revision		Revision as of 05:39, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2c7p\| PDB=2c7p \| SCENE= }}~~	+	==HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH==
-	===HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH===	+	<StructureSection load='2c7p' size='340' side='right' caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16340006}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [http://www.ebi.ac.uk/pdbsum/2c7p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DNA base flipping is an important mechanism in molecular enzymology, but its study is limited by the lack of an accessible and reliable diagnostic technique. A series of crystalline complexes of a DNA methyltransferase, M.HhaI, and its cognate DNA, in which a fluorescent nucleobase analogue, 2-aminopurine (AP), occupies defined positions with respect the target flipped base, have been prepared and their structures determined at higher than 2 A resolution. From time-resolved fluorescence measurements of these single crystals, we have established that the fluorescence decay function of AP shows a pronounced, characteristic response to base flipping: the loss of the very short (approximately 100 ps) decay component and the large increase in the amplitude of the long (approximately 10 ns) component. When AP is positioned at sites other than the target site, this response is not seen. Most significantly, we have shown that the same clear response is apparent when M.HhaI complexes with DNA in solution, giving an unambiguous signal of base flipping. Analysis of the AP fluorescence decay function reveals conformational heterogeneity in the DNA-enzyme complexes that cannot be discerned from the present X-ray structures.

-	~~==Function==~~	+	Time-resolved fluorescence of 2-aminopurine as a probe of base flipping in M.HhaI-DNA complexes.,Neely RK, Daujotyte D, Grazulis S, Magennis SW, Dryden DT, Klimasauskas S, Jones AC Nucleic Acids Res. 2005 Dec 9;33(22):6953-60. Print 2005. PMID:16340006<ref>PMID:16340006</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH]] This methylase recognizes the double~~-~~stranded sequence GCGC~~, ~~causes specific methylation on C-2 on both strands~~, ~~and protects the DNA from cleavage by the HhaI endonuclease~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2c7p]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[DNA methyltransferase\|DNA methyltransferase]]		*[[DNA methyltransferase\|DNA methyltransferase]]
	*[[HhaI DNA methyltransferase\|HhaI DNA methyltransferase]]		*[[HhaI DNA methyltransferase\|HhaI DNA methyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016340006</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus x pritchett and stillman 1919]]		[[Category: Bacillus x pritchett and stillman 1919]]
	[[Category: Daujotyte, D.]]		[[Category: Daujotyte, D.]]

OCA at 06:28, 29 January 2014

2014-01-29T06:28:31Z

←Older revision		Revision as of 06:28, 29 January 2014
Line 1:		Line 1:
-	[[Image:2c7p.png\|left\|200px]]
-
	{{STRUCTURE_2c7p\| PDB=2c7p \| SCENE= }}		{{STRUCTURE_2c7p\| PDB=2c7p \| SCENE= }}
		+	===HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH===
		+	{{ABSTRACT_PUBMED_16340006}}

-	===~~HHAI DNA METHYLTRANSFERASE COMPLEX WITH OLIGONUCLEOTIDE CONTAINING 2~~-~~AMINOPURINE OPPOSITE TO THE TARGET BASE (~~GCGC~~:GMPC) AND SAH===~~	+	==Function==
-		+	[[http://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH]] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
-	~~{{ABSTRACT_PUBMED_16340006}}~~	+

	==About this Structure==		==About this Structure==
-	[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haemophilus_haemolyticus Haemophilus haemolyticus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA].	+	[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA].

	==See Also==		==See Also==
	*[[DNA methyltransferase\|DNA methyltransferase]]		*[[DNA methyltransferase\|DNA methyltransferase]]
		+	*[[HhaI DNA methyltransferase\|HhaI DNA methyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016340006</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016340006</ref><references group="xtra"/><references/>
-	[[Category: ~~Haemophilus haemolyticus~~]]	+	[[Category: Bacillus x pritchett and stillman 1919]]
	[[Category: Daujotyte, D.]]		[[Category: Daujotyte, D.]]
		+	[[Category: Dryden, D T.F.]]
	[[Category: Grazulis, S.]]		[[Category: Grazulis, S.]]
		+	[[Category: Jones, A C.]]
		+	[[Category: Klimasauskas, S.]]
		+	[[Category: Magennis, S W.]]
		+	[[Category: Neely, R K.]]
	[[Category: Base flipping]]		[[Category: Base flipping]]
-	[[Category: Dna methyltransferase]]
-	[[Category: Methyltransferase]]
	[[Category: Restriction system]]		[[Category: Restriction system]]
-	[[Category: Transferase]]	+	[[Category: Transferase-dna complex]]

OCA at 22:20, 20 October 2012

2012-10-20T22:20:23Z

←Older revision		Revision as of 22:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2c7p]] is a 3 chain structure ~~of [[DNA methyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA].	+	[[2c7p]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA].

	==See Also==		==See Also==

OCA: Protected "2c7p" [edit=sysop:move=sysop]

2012-07-27T15:59:09Z

Protected "2c7p" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:59, 27 July 2012

←Older revision		Revision as of 09:46, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2c7p' size='340' side='right'caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2c7p' size='340' side='right'caption='[[2c7p]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C7P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c7p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_x"_pritchett_and_stillman_1919 "bacillus x" pritchett and stillman 1919]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PR:2-AMINO-9-[2-DEOXYRIBOFURANOSYL]-9H-PURINE-5-MONOPHOSPHATE'>2PR</scene>, <scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[10mh\|10mh]], [[1fjx\|1fjx]], [[1hmy\|1hmy]], [[1m0e\|1m0e]], [[1mht\|1mht]], [[1skm\|1skm]], [[1svu\|1svu]], [[2hmy\|2hmy]], [[3mht\|3mht]], [[4mht\|4mht]], [[5mht\|5mht]], [[6mht\|6mht]], [[7mht\|7mht]], [[8mht\|8mht]], [[9mht\|9mht]], [[2c7o\|2c7o]], [[2c7q\|2c7q]], [[2c7r\|2c7r]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [~~http~~://pdbe.org/2c7p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c7p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7p OCA], [https://pdbe.org/2c7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7p RCSB], [https://www.ebi.ac.uk/pdbsum/2c7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH]] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.	+	[[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH]] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]