2c81 - Revision history

OCA at 14:08, 13 December 2023

2023-12-13T14:08:31Z

←Older revision		Revision as of 14:08, 13 December 2023
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	<StructureSection load='2c81' size='340' side='right'caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2c81' size='340' side='right'caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_24 Atcc 24~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Niallia_circulans Niallia circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [https://pdbe.org/2c81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [https://www.ebi.ac.uk/pdbsum/2c81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c81 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [https://pdbe.org/2c81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [https://www.ebi.ac.uk/pdbsum/2c81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~GLDSA_BACCI GLDSA_BACCI]~~] Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (DOI) to form 2-deoxy-scyllo-inosamine (DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (~~amino~~-~~DOI~~) into 2-deoxystreptamine (DOS)~~. Is also able to catalyze the transamination of scyllo-inosose to form scyllo-inosamine, although this reaction may be not physiological~~.<ref>PMID:12374384</ref> <ref>PMID:12478783</ref> <ref>PMID:15839685</ref>	+	[https://www.uniprot.org/uniprot/GLDSA_NIACI GLDSA_NIACI] Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (2-DOI) to form 2-deoxy-scyllo-inosamine (2-DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (keto-2-DOIA) into 2-deoxystreptamine (2-DOS).<ref>PMID:12374384</ref> <ref>PMID:12478783</ref> <ref>PMID:15839685</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 24]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blundell~~, T L~~]]	+	[[Category: Niallia circulans]]
-	[[Category: Chirgadze~~, D Y~~]]	+	[[Category: Blundell TL]]
-	[[Category: Huang, F]]	+	[[Category: Chirgadze DY]]
-	[[Category: Popovic, B]]	+	[[Category: Huang F]]
-	[[Category: Spencer~~, J B~~]]	+	[[Category: Popovic B]]
-	[[Category: Tang, X]]	+	[[Category: Spencer JB]]
-	~~[[Category: Aminoglycoside antibiotic]]~~	+	[[Category: Tang X]]
-	~~[[Category: Aminotransferase]]~~	+
-	~~[[Category: Butirosin]]~~	+
-	~~[[Category: Smat]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 20:33, 20 October 2021

2021-10-20T20:33:33Z

←Older revision		Revision as of 20:33, 20 October 2021
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	<StructureSection load='2c81' size='340' side='right'caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2c81' size='340' side='right'caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [~~http~~://pdbe.org/2c81 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c81 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c81 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [https://pdbe.org/2c81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [https://www.ebi.ac.uk/pdbsum/2c81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLDSA_BACCI GLDSA_BACCI]] Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (DOI) to form 2-deoxy-scyllo-inosamine (DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI) into 2-deoxystreptamine (DOS). Is also able to catalyze the transamination of scyllo-inosose to form scyllo-inosamine, although this reaction may be not physiological.<ref>PMID:12374384</ref> <ref>PMID:12478783</ref> <ref>PMID:15839685</ref>	+	[[https://www.uniprot.org/uniprot/GLDSA_BACCI GLDSA_BACCI]] Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (DOI) to form 2-deoxy-scyllo-inosamine (DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI) into 2-deoxystreptamine (DOS). Is also able to catalyze the transamination of scyllo-inosose to form scyllo-inosamine, although this reaction may be not physiological.<ref>PMID:12374384</ref> <ref>PMID:12478783</ref> <ref>PMID:15839685</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:40, 1 January 2020

2020-01-01T12:40:32Z

←Older revision		Revision as of 12:40, 1 January 2020
Line 1:		Line 1:

	==Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis.==		==Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis.==
-	<StructureSection load='2c81' size='340' side='right' caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2c81' size='340' side='right'caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 24]]		[[Category: Atcc 24]]
		+	[[Category: Large Structures]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]
	[[Category: Chirgadze, D Y]]		[[Category: Chirgadze, D Y]]

OCA at 06:51, 28 March 2018

2018-03-28T06:51:47Z

←Older revision		Revision as of 06:51, 28 March 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURES OF THE~~ PLP- ~~AND~~ PMP-~~BOUND FORMS OF BTRR~~, ~~A DUAL FUNCTIONAL AMINOTRANSFERASE INVOLVED IN BUTIROSIN BIOSYNTHESIS~~.==	+
		+	==Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis.==
	<StructureSection load='2c81' size='340' side='right' caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2c81' size='340' side='right' caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [http://pdbe.org/2c81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [http://www.ebi.ac.uk/pdbsum/2c81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [http://pdbe.org/2c81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [http://www.ebi.ac.uk/pdbsum/2c81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c81_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c81_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c81 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:31, 11 September 2015

2015-09-11T16:31:20Z

←Older revision		Revision as of 16:31, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2c81' size='340' side='right' caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2c81' size='340' side='right' caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_circulans Bacillus circulans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_24 Atcc 24]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [http://www.ebi.ac.uk/pdbsum/2c81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [http://pdbe.org/2c81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [http://www.ebi.ac.uk/pdbsum/2c81 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLDSA_BACCI GLDSA_BACCI]] Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (DOI) to form 2-deoxy-scyllo-inosamine (DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI) into 2-deoxystreptamine (DOS). Is also able to catalyze the transamination of scyllo-inosose to form scyllo-inosamine, although this reaction may be not physiological.<ref>PMID:12374384</ref> <ref>PMID:12478783</ref> <ref>PMID:15839685</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c81" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus circulans~~]]	+	[[Category: Atcc 24]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]
	[[Category: Chirgadze, D Y]]		[[Category: Chirgadze, D Y]]

OCA at 19:02, 25 December 2014

2014-12-25T19:02:23Z

←Older revision		Revision as of 19:02, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [http://www.ebi.ac.uk/pdbsum/2c81 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [http://www.ebi.ac.uk/pdbsum/2c81 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus circulans]]		[[Category: Bacillus circulans]]
-	[[Category: Blundell, T L.]]	+	[[Category: Blundell, T L]]
-	[[Category: Chirgadze, D Y.]]	+	[[Category: Chirgadze, D Y]]
-	[[Category: Huang, F.]]	+	[[Category: Huang, F]]
-	[[Category: Popovic, B.]]	+	[[Category: Popovic, B]]
-	[[Category: Spencer, J B.]]	+	[[Category: Spencer, J B]]
-	[[Category: Tang, X.]]	+	[[Category: Tang, X]]
	[[Category: Aminoglycoside antibiotic]]		[[Category: Aminoglycoside antibiotic]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]

OCA at 23:45, 29 September 2014

2014-09-29T23:45:24Z

←Older revision		Revision as of 23:45, 29 September 2014
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-	[[~~Image~~:2c81.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURES OF THE PLP- AND PMP-BOUND FORMS OF BTRR, A DUAL FUNCTIONAL AMINOTRANSFERASE INVOLVED IN BUTIROSIN BIOSYNTHESIS.==
		+	<StructureSection load='2c81' size='340' side='right' caption='[[2c81]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C81 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c81 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c81 RCSB], [http://www.ebi.ac.uk/pdbsum/2c81 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c81_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aminotransferase (BtrR), which is involved in the biosynthesis of butirosin, a 2-deoxystreptamine (2-DOS)-containing aminoglycoside antibiotic produced by Bacillus circulans, catalyses the pyridoxal phosphate (PLP)-dependent transamination reaction both of 2-deoxy-scyllo-inosose to 2-deoxy-scyllo-inosamine and of amino-dideoxy-scyllo-inosose to 2-DOS. The high-resolution crystal structures of the PLP- and PMP-bound forms of BtrR aminotransferase from B. circulans were solved at resolutions of 2.1 A and 1.7 A with R(factor)/R(free) values of 17.4/20.6 and 19.9/21.9, respectively. BtrR has a fold characteristic of the aspartate aminotransferase family, and sequence and structure analysis categorises it as a member of SMAT (secondary metabolite aminotransferases) subfamily. It exists as a homodimer with two active sites per dimer. The active site of the BtrR protomer is located in a cleft between an alpha helical N-terminus, a central alphabetaalpha sandwich domain and an alphabeta C-terminal domain. The structures of the PLP- and PMP-bound enzymes are very similar; however BtrR-PMP lacks the covalent bond to Lys192. Furthermore, the two forms differ in the side-chain conformations of Trp92, Asp163, and Tyr342 that are likely to be important in substrate selectivity and substrate binding. This is the first three-dimensional structure of an enzyme from the butirosin biosynthesis gene cluster.

-	~~{{STRUCTURE_2c81\| PDB=2c81 \| SCENE= }}~~	+	Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis.,Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB Proteins. 2006 Oct 1;65(1):220-30. PMID:16894611<ref>PMID:16894611</ref>

-	~~===CRYSTAL STRUCTURES OF THE PLP- AND PMP-BOUND FORMS OF BTRR~~, ~~A DUAL FUNCTIONAL AMINOTRANSFERASE INVOLVED IN BUTIROSIN BIOSYNTHESIS.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16894611}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2c81]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_circulans Bacillus circulans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016894611<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus circulans]]		[[Category: Bacillus circulans]]
	[[Category: Blundell, T L.]]		[[Category: Blundell, T L.]]

OCA: Protected "2c81" [edit=sysop:move=sysop]

2013-01-06T09:15:28Z

Protected "2c81" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:15, 6 January 2013

OCA at 09:15, 6 January 2013

2013-01-06T09:15:26Z

←Older revision		Revision as of 09:15, 6 January 2013
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-	{{Seed}}
	[[Image:2c81.png\|left\|200px]]		[[Image:2c81.png\|left\|200px]]

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	{{STRUCTURE_2c81\| PDB=2c81 \| SCENE= }}		{{STRUCTURE_2c81\| PDB=2c81 \| SCENE= }}

	===CRYSTAL STRUCTURES OF THE PLP- AND PMP-BOUND FORMS OF BTRR, A DUAL FUNCTIONAL AMINOTRANSFERASE INVOLVED IN BUTIROSIN BIOSYNTHESIS.===		===CRYSTAL STRUCTURES OF THE PLP- AND PMP-BOUND FORMS OF BTRR, A DUAL FUNCTIONAL AMINOTRANSFERASE INVOLVED IN BUTIROSIN BIOSYNTHESIS.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16894611}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16894611 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16894611}}		{{ABSTRACT_PUBMED_16894611}}

	==About this Structure==		==About this Structure==
-	~~2C81~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA].	+	[[2c81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16894611~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016894611</ref><references group="xtra"/>
	[[Category: Bacillus circulans]]		[[Category: Bacillus circulans]]
	[[Category: Blundell, T L.]]		[[Category: Blundell, T L.]]
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	[[Category: Smat]]		[[Category: Smat]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:50:49 2009''

OCA at 01:50, 18 February 2009

2009-02-18T01:50:50Z

←Older revision		Revision as of 01:50, 18 February 2009
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	==About this Structure==		==About this Structure==
-	2C81 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA].	+	2C81 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C81 OCA].

	==Reference==		==Reference==
-	Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis., Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB, Proteins. 2006 Oct 1;65(1):220-30. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16894611 16894611]~~	+	<ref group="xtra">PMID:16894611</ref><references group="xtra"/>
	[[Category: Bacillus circulans]]		[[Category: Bacillus circulans]]
-	[[Category: Single protein]]
	[[Category: Blundell, T L.]]		[[Category: Blundell, T L.]]
	[[Category: Chirgadze, D Y.]]		[[Category: Chirgadze, D Y.]]
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	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 10~~:02:~~28 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:50:49 2009''