2c8l - Revision history

OCA at 14:09, 13 December 2023

2023-12-13T14:09:07Z

←Older revision		Revision as of 14:09, 13 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8L FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)~~OXY~~]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OX+Y]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [https://pdbe.org/2c8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [https://www.ebi.ac.uk/pdbsum/2c8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [https://pdbe.org/2c8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [https://www.ebi.ac.uk/pdbsum/2c8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).	+	[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Calcium-transporting ATPase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Jensen~~, A M~~]]	+	[[Category: Jensen AM]]
-	[[Category: Moller~~, J V~~]]	+	[[Category: Moller JV]]
-	[[Category: Nissen, P]]	+	[[Category: Nissen P]]
-	[[Category: Olesen, C]]	+	[[Category: Olesen C]]
-	[[Category: Sorensen~~, T L]]~~	+	[[Category: Sorensen TL]]
-	~~[[Category: Calcium transport]]~~	+
-	~~[[Category: Cation pump]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Modulatory atp~~]]	+

OCA at 06:50, 1 December 2021

2021-12-01T06:50:29Z

←Older revision		Revision as of 06:50, 1 December 2021
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	<StructureSection load='2c8l' size='340' side='right'caption='[[2c8l]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='2c8l' size='340' side='right'caption='[[2c8l]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C8L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [~~http~~://pdbe.org/2c8l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c8l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [https://pdbe.org/2c8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [https://www.ebi.ac.uk/pdbsum/2c8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).	+	[[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:07, 26 February 2020

2020-02-26T11:07:28Z

←Older revision		Revision as of 11:07, 26 February 2020
Line 1:		Line 1:

	==Crystal Structure of (SR) Calcium-ATPase E2(Tg) form==		==Crystal Structure of (SR) Calcium-ATPase E2(Tg) form==
-	<StructureSection load='2c8l' size='340' side='right' caption='[[2c8l]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='2c8l' size='340' side='right'caption='[[2c8l]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8L FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8L FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[ATPase\|ATPase]]	+	*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Calcium-transporting ATPase]]		[[Category: Calcium-transporting ATPase]]
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Jensen, A M]]		[[Category: Jensen, A M]]

OCA at 08:36, 23 May 2018

2018-05-23T08:36:06Z

←Older revision		Revision as of 08:36, 23 May 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ (SR) ~~CALCIUM~~-~~ATPASE~~ E2(TG) ~~FORM~~==	+
		+	==Crystal Structure of (SR) Calcium-ATPase E2(Tg) form==
	<StructureSection load='2c8l' size='340' side='right' caption='[[2c8l]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='2c8l' size='340' side='right' caption='[[2c8l]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [http://pdbe.org/2c8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [http://www.ebi.ac.uk/pdbsum/2c8l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [http://pdbe.org/2c8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [http://www.ebi.ac.uk/pdbsum/2c8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:18, 8 February 2016

2016-02-08T01:18:46Z

←Older revision		Revision as of 01:18, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c8l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:32, 10 September 2015

2015-09-10T06:32:50Z

←Older revision		Revision as of 06:32, 10 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [http://www.ebi.ac.uk/pdbsum/2c8l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [http://pdbe.org/2c8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [http://www.ebi.ac.uk/pdbsum/2c8l PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2c8l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 19:31, 24 December 2014

2014-12-24T19:31:08Z

←Older revision		Revision as of 19:31, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8L FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [http://www.ebi.ac.uk/pdbsum/2c8l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [http://www.ebi.ac.uk/pdbsum/2c8l PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Calcium-transporting ATPase]]		[[Category: Calcium-transporting ATPase]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Jensen, A M.]]	+	[[Category: Jensen, A M]]
-	[[Category: Moller, J V.]]	+	[[Category: Moller, J V]]
-	[[Category: Nissen, P.]]	+	[[Category: Nissen, P]]
-	[[Category: Olesen, C.]]	+	[[Category: Olesen, C]]
-	[[Category: Sorensen, T L.]]	+	[[Category: Sorensen, T L]]
	[[Category: Calcium transport]]		[[Category: Calcium transport]]
	[[Category: Cation pump]]		[[Category: Cation pump]]

OCA at 04:12, 29 September 2014

2014-09-29T04:12:27Z

←Older revision		Revision as of 04:12, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2c8l.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF (SR) CALCIUM-ATPASE E2(TG) FORM==
		+	<StructureSection load='2c8l' size='340' side='right' caption='[[2c8l]], [[Resolution\|resolution]] 3.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2c8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fqu\|1fqu]], [[1iwo\|1iwo]], [[1kju\|1kju]], [[1su4\|1su4]], [[1t5s\|1t5s]], [[1t5t\|1t5t]], [[1vfp\|1vfp]], [[1wpe\|1wpe]], [[1wpg\|1wpg]], [[1xp5\|1xp5]], [[2agv\|2agv]], [[2by4\|2by4]], [[2c88\|2c88]], [[2c8k\|2c8k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8l RCSB], [http://www.ebi.ac.uk/pdbsum/2c8l PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present crystal structures of the calcium-free E2 state of the sarcoplasmic reticulum Ca2+ -ATPase, stabilized by the inhibitor thapsigargin and the ATP analog AMPPCP. The structures allow us to describe the ATP binding site in a modulatory mode uncoupled from the Asp351 phosphorylation site. The Glu439 side chain interacts with AMPPCP via an Mg2+ ion in accordance with previous Fe2+ -cleavage studies implicating this residue in the ATPase cycle and in magnesium binding. Functional data on Ca2+ mediated activation indicate that the crystallized state represents an initial stage of ATP modulated deprotonation of E2, preceding the binding of Ca2+ ions in the membrane from the cytoplasmic side. We propose a mechanism of Ca2+ activation of phosphorylation leading directly from the compact E2-ATP form to the Ca2E1-ATP state. In addition, a role of Glu439 in ATP modulation of other steps of the functional cycle is suggested.

-	~~{{STRUCTURE_2c8l\| PDB=2c8l \| SCENE= }}~~	+	Modulatory and catalytic modes of ATP binding by the calcium pump.,Jensen AM, Sorensen TL, Olesen C, Moller JV, Nissen P EMBO J. 2006 Jun 7;25(11):2305-14. Epub 2006 May 18. PMID:16710301<ref>PMID:16710301</ref>

-	~~===CRYSTAL STRUCTURE OF (SR) CALCIUM-ATPASE E2(TG) FORM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16710301}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2c8l]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA].~~	+

	==See Also==		==See Also==
	*[[ATPase\|ATPase]]		*[[ATPase\|ATPase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016710301<~~/~~ref~~><~~ref group="xtra">PMID:016272562</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Calcium-transporting ATPase]]		[[Category: Calcium-transporting ATPase]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]

OCA at 08:25, 20 October 2012

2012-10-20T08:25:45Z

←Older revision		Revision as of 08:25, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2c8l]] is a 1 chain structure ~~of [[ATPase]]~~ with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA].	+	[[2c8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8L OCA].

	==See Also==		==See Also==

OCA at 19:29, 25 July 2012

2012-07-25T19:29:37Z

←Older revision		Revision as of 19:29, 25 July 2012
Line 1:		Line 1:
	[[Image:2c8l.png\|left\|200px]]		[[Image:2c8l.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2c8l\| PDB=2c8l \| SCENE= }}		{{STRUCTURE_2c8l\| PDB=2c8l \| SCENE= }}

	===CRYSTAL STRUCTURE OF (SR) CALCIUM-ATPASE E2(TG) FORM===		===CRYSTAL STRUCTURE OF (SR) CALCIUM-ATPASE E2(TG) FORM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16710301}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16710301 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16710301}}		{{ABSTRACT_PUBMED_16710301}}

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	==See Also==		==See Also==
-	*[[ATPase]]	+	*[[ATPase\|ATPase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16710301~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016710301</ref><ref group="xtra">PMID:016272562</ref><references group="xtra"/>
	[[Category: Calcium-transporting ATPase]]		[[Category: Calcium-transporting ATPase]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
Line 33:		Line 22:
	[[Category: Olesen, C.]]		[[Category: Olesen, C.]]
	[[Category: Sorensen, T L.]]		[[Category: Sorensen, T L.]]
		+	[[Category: Calcium transport]]
		+	[[Category: Cation pump]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane protein]]
		+	[[Category: Modulatory atp]]