2cdu - Revision history

OCA at 11:49, 1 February 2024

2024-02-01T11:49:03Z

←Older revision		Revision as of 11:49, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fructilactobacillus_sanfranciscensis Fructilactobacillus sanfranciscensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fructilactobacillus_sanfranciscensis Fructilactobacillus sanfranciscensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [https://pdbe.org/2cdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [https://www.ebi.ac.uk/pdbsum/2cdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [https://pdbe.org/2cdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [https://www.ebi.ac.uk/pdbsum/2cdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:14, 26 October 2022

2022-10-26T06:14:11Z

←Older revision		Revision as of 06:14, 26 October 2022
Line 3:		Line 3:
	<StructureSection load='2cdu' size='340' side='right'caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2cdu' size='340' side='right'caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"lactobacillus_sanfrancisco"_kline_and_sugihara_1971 "lactobacillus sanfrancisco" kline and sugihara 1971~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fructilactobacillus_sanfranciscensis Fructilactobacillus sanfranciscensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=~~FAD~~:~~FLAVIN~~-~~ADENINE~~+~~DINUCLEOTIDE~~'>~~FAD~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~CSX~~:S-~~OXY~~+~~CYSTEINE~~'>~~CSX~~</scene></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [https://pdbe.org/2cdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [https://www.ebi.ac.uk/pdbsum/2cdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [https://pdbe.org/2cdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [https://www.ebi.ac.uk/pdbsum/2cdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9F1X5_FRUSA Q9F1X5_FRUSA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2cdu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cdu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[NADPH oxidase 3D structures\|NADPH oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lactobacillus sanfrancisco kline and sugihara 1971~~]]	+	[[Category: Fructilactobacillus sanfranciscensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bommarius~~, A S~~]]	+	[[Category: Bommarius AS]]
-	[[Category: Jiang, R]]	+	[[Category: Jiang R]]
-	[[Category: Lountos~~, G T~~]]	+	[[Category: Lountos GT]]
-	[[Category: Orville~~, A M~~]]	+	[[Category: Orville AM]]
-	[[Category: Thaler~~, T L~~]]	+	[[Category: Thaler TL]]
-	[[Category: Wellborn~~, W B]]~~	+	[[Category: Wellborn WB]]
-	~~[[Category: Flavoenzyme]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 06:53, 1 December 2021

2021-12-01T06:53:45Z

←Older revision		Revision as of 06:53, 1 December 2021
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	<StructureSection load='2cdu' size='340' side='right'caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2cdu' size='340' side='right'caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"lactobacillus_sanfrancisco"_kline_and_sugihara_1971 "lactobacillus sanfrancisco" kline and sugihara 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CDU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"lactobacillus_sanfrancisco"_kline_and_sugihara_1971 "lactobacillus sanfrancisco" kline and sugihara 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [~~http~~://pdbe.org/2cdu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cdu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [https://pdbe.org/2cdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [https://www.ebi.ac.uk/pdbsum/2cdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:57, 26 February 2020

2020-02-26T10:57:07Z

←Older revision		Revision as of 10:57, 26 February 2020
Line 1:		Line 1:

	==The Crystal Structure of Water-forming NAD(P)H Oxidase from Lactobacillus sanfranciscensis==		==The Crystal Structure of Water-forming NAD(P)H Oxidase from Lactobacillus sanfranciscensis==
-	<StructureSection load='2cdu' size='340' side='right' caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2cdu' size='340' side='right'caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"lactobacillus_sanfrancisco"_kline_and_sugihara_1971 "lactobacillus sanfrancisco" kline and sugihara 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"lactobacillus_sanfrancisco"_kline_and_sugihara_1971 "lactobacillus sanfrancisco" kline and sugihara 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDU FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Lactobacillus sanfrancisco kline and sugihara 1971]]		[[Category: Lactobacillus sanfrancisco kline and sugihara 1971]]
		+	[[Category: Large Structures]]
	[[Category: Bommarius, A S]]		[[Category: Bommarius, A S]]
	[[Category: Jiang, R]]		[[Category: Jiang, R]]

OCA at 08:18, 23 May 2018

2018-05-23T08:18:18Z

←Older revision		Revision as of 08:18, 23 May 2018
Line 1:		Line 1:
-	==~~THE CRYSTAL STRUCTURE OF WATER~~-~~FORMING~~ NAD(P)H ~~OXIDASE FROM LACTOBACILLUS SANFRANCISCENSIS~~==	+
		+	==The Crystal Structure of Water-forming NAD(P)H Oxidase from Lactobacillus sanfranciscensis==
	<StructureSection load='2cdu' size='340' side='right' caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2cdu' size='340' side='right' caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [http://pdbe.org/2cdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [http://www.ebi.ac.uk/pdbsum/2cdu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [http://pdbe.org/2cdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [http://www.ebi.ac.uk/pdbsum/2cdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cdu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:33, 12 September 2015

2015-09-12T01:33:50Z

←Older revision		Revision as of 01:33, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2cdu' size='340' side='right' caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2cdu' size='340' side='right' caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lactobacillus_sanfranciscensis Lactobacillus sanfranciscensis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"lactobacillus_sanfrancisco"_kline_and_sugihara_1971 "lactobacillus sanfrancisco" kline and sugihara 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [http://www.ebi.ac.uk/pdbsum/2cdu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [http://pdbe.org/2cdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [http://www.ebi.ac.uk/pdbsum/2cdu PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cdu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lactobacillus ~~sanfranciscensis~~]]	+	[[Category: Lactobacillus sanfrancisco kline and sugihara 1971]]
	[[Category: Bommarius, A S]]		[[Category: Bommarius, A S]]
	[[Category: Jiang, R]]		[[Category: Jiang, R]]

OCA at 16:33, 15 January 2015

2015-01-15T16:33:52Z

←Older revision		Revision as of 16:33, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_sanfranciscensis Lactobacillus sanfranciscensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_sanfranciscensis Lactobacillus sanfranciscensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [http://www.ebi.ac.uk/pdbsum/2cdu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [http://www.ebi.ac.uk/pdbsum/2cdu PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Lactobacillus sanfranciscensis]]		[[Category: Lactobacillus sanfranciscensis]]
-	[[Category: Bommarius, A S.]]	+	[[Category: Bommarius, A S]]
-	[[Category: Jiang, R.]]	+	[[Category: Jiang, R]]
-	[[Category: Lountos, G T.]]	+	[[Category: Lountos, G T]]
-	[[Category: Orville, A M.]]	+	[[Category: Orville, A M]]
-	[[Category: Thaler, T L.]]	+	[[Category: Thaler, T L]]
-	[[Category: Wellborn, W B.]]	+	[[Category: Wellborn, W B]]
	[[Category: Flavoenzyme]]		[[Category: Flavoenzyme]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 01:48, 30 September 2014

2014-09-30T01:48:20Z

←Older revision		Revision as of 01:48, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2cdu.~~png~~\|~~left~~\|200px]]	+	==THE CRYSTAL STRUCTURE OF WATER-FORMING NAD(P)H OXIDASE FROM LACTOBACILLUS SANFRANCISCENSIS==
		+	<StructureSection load='2cdu' size='340' side='right' caption='[[2cdu]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_sanfranciscensis Lactobacillus sanfranciscensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdu RCSB], [http://www.ebi.ac.uk/pdbsum/2cdu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The FAD-dependent NAD(P)H oxidase from Lactobacillus sanfrancisensis (L.san-Nox2) catalyzes the oxidation of 2 equivalents of either NADH or NADPH and reduces 1 equivalent of O(2) to yield 2 equivalents of water. During steady-state turnover only 0.5% of the reducing equivalents are detected in solution as hydrogen peroxide, suggesting that it is not released from the enzyme after the oxidation of the first equivalent of NAD(P)H and reaction with O(2). Here we report the crystal structure of L.san-Nox2 to 1.8 A resolution. The enzyme crystallizes as a dimer with each monomer consisting of a FAD binding domain (residues 1-120), a NAD(P)H binding domain (residues 150-250), and a dimerization domain (residues 325-451). The electron density for the redox-active Cys42 residue located adjacent to the si-face FAD is consistent with oxidation to the sulfenic acid (Cys-SOH) state. The side chain of Cys42 is also observed in two conformations; in one the sulfenic acid is hydrogen bonded to His10 and in the other it hydrogen bonds with the FAD O2' atom. Surprisingly, the NAD(P)H binding domains each contain an ADP ligand as established by electron density maps and MALDI-TOF analysis of the ligands released from heat-denatured enzyme. The ADP ligand copurifies with the enzyme, and its presence does not inhibit enzyme activity. Consequently, we hypothesize that either NADPH or NADH substrates bind via a long channel that extends from the enzyme exterior and terminates at the FAD re-face. A homology model of the NADH oxidase from Lactococcus lactis (L.lac-Nox2) was also generated using the crystal structure of L.san-Nox2, which reveals several important similarities and differences between the two enzymes. HPLC analysis of ligands released from denatured L.lac-Nox2 indicates that it does not bind ADP, which correlates with the specificity of the enzyme for oxidation of NADH.

-	~~{{STRUCTURE_2cdu\| PDB=2cdu \| SCENE= }}~~	+	The crystal structure of NAD(P)H oxidase from Lactobacillus sanfranciscensis: insights into the conversion of O2 into two water molecules by the flavoenzyme.,Lountos GT, Jiang R, Wellborn WB, Thaler TL, Bommarius AS, Orville AM Biochemistry. 2006 Aug 15;45(32):9648-59. PMID:16893166<ref>PMID:16893166</ref>

-	~~===THE CRYSTAL STRUCTURE OF WATER-FORMING NAD(P)H OXIDASE FROM LACTOBACILLUS SANFRANCISCENSIS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16893166}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2cdu]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lactobacillus_sanfranciscensis Lactobacillus sanfranciscensis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CDU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016893166<~~/~~ref~~><~~ref group="xtra">PMID:015502322</ref><references group="xtra"~~/>	+
	[[Category: Lactobacillus sanfranciscensis]]		[[Category: Lactobacillus sanfranciscensis]]
	[[Category: Bommarius, A S.]]		[[Category: Bommarius, A S.]]

OCA at 12:34, 23 January 2013

2013-01-23T12:34:52Z

←Older revision		Revision as of 12:34, 23 January 2013
Line 1:		Line 1:
	[[Image:2cdu.png\|left\|200px]]		[[Image:2cdu.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cdu", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2cdu\| PDB=2cdu \| SCENE= }}		{{STRUCTURE_2cdu\| PDB=2cdu \| SCENE= }}

	===THE CRYSTAL STRUCTURE OF WATER-FORMING NAD(P)H OXIDASE FROM LACTOBACILLUS SANFRANCISCENSIS===		===THE CRYSTAL STRUCTURE OF WATER-FORMING NAD(P)H OXIDASE FROM LACTOBACILLUS SANFRANCISCENSIS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16893166}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16893166 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16893166}}		{{ABSTRACT_PUBMED_16893166}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16893166~~</ref><ref group="xtra">PMID:~~15502322~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016893166</ref><ref group="xtra">PMID:015502322</ref><references group="xtra"/>
	[[Category: Lactobacillus sanfranciscensis]]		[[Category: Lactobacillus sanfranciscensis]]
	[[Category: Bommarius, A S.]]		[[Category: Bommarius, A S.]]

OCA: Protected "2cdu" [edit=sysop:move=sysop]

2011-03-14T21:58:09Z

Protected "2cdu" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:58, 14 March 2011