2cet - Revision history

OCA at 14:15, 13 December 2023

2023-12-13T14:15:25Z

←Older revision		Revision as of 14:15, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2cet' size='340' side='right'caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='2cet' size='340' side='right'caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CET FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CET FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [https://pdbe.org/2cet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [https://www.ebi.ac.uk/pdbsum/2cet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cet ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [https://pdbe.org/2cet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [https://www.ebi.ac.uk/pdbsum/2cet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cet ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43589]]
-	[[Category: Beta-glucosidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Davies, G J~~]]	+	[[Category: Thermotoga maritima]]
-	[[Category: ~~Gloster, T M~~]]	+	[[Category: Davies GJ]]
-	[[Category: ~~Roberts, S~~]]	+	[[Category: Gloster TM]]
-	[[Category: ~~Vasella, A~~]]	+	[[Category: Roberts S]]
-	[[Category: ~~Family 1]]~~	+	[[Category: Vasella A]]
-	~~[[Category: Glycoside hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Phenethyl-substituted glucoimidazole]]~~	+
-	~~[[Category: Transition state mimic~~]]	+

OCA at 06:54, 1 December 2021

2021-12-01T06:54:11Z

←Older revision		Revision as of 06:54, 1 December 2021
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	<StructureSection load='2cet' size='340' side='right'caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='2cet' size='340' side='right'caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CET FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CET FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [~~http~~://pdbe.org/2cet PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cet PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cet ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [https://pdbe.org/2cet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [https://www.ebi.ac.uk/pdbsum/2cet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cet ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:59, 26 February 2020

2020-02-26T10:59:58Z

←Older revision		Revision as of 10:59, 26 February 2020
Line 1:		Line 1:

	==Beta-glucosidase from Thermotoga maritima in complex with phenethyl- substituted glucoimidazole==		==Beta-glucosidase from Thermotoga maritima in complex with phenethyl- substituted glucoimidazole==
-	<StructureSection load='2cet' size='340' side='right' caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='2cet' size='340' side='right'caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CET FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CET FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Beta-glucosidase\|Beta-glucosidase]]	+	*[[Beta-glucosidase 3D structures\|Beta-glucosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	[[Category: Atcc 43589]]		[[Category: Atcc 43589]]
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
		+	[[Category: Large Structures]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]
	[[Category: Gloster, T M]]		[[Category: Gloster, T M]]

OCA at 08:24, 23 May 2018

2018-05-23T08:24:01Z

←Older revision		Revision as of 08:24, 23 May 2018
Line 1:		Line 1:
-	==~~BETA~~-~~GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH PHENETHYL~~-~~SUBSTITUTED GLUCOIMIDAZOLE~~==	+
		+	==Beta-glucosidase from Thermotoga maritima in complex with phenethyl- substituted glucoimidazole==
	<StructureSection load='2cet' size='340' side='right' caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='2cet' size='340' side='right' caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [http://pdbe.org/2cet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [http://www.ebi.ac.uk/pdbsum/2cet PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [http://pdbe.org/2cet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [http://www.ebi.ac.uk/pdbsum/2cet PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cet ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/2cet_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/2cet_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cet ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:09, 11 September 2015

2015-09-11T23:09:06Z

←Older revision		Revision as of 23:09, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cet' size='340' side='right' caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='2cet' size='340' side='right' caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermotoga_maritima Thermotoga maritima~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CET FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CET FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [http://www.ebi.ac.uk/pdbsum/2cet PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [http://pdbe.org/2cet PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [http://www.ebi.ac.uk/pdbsum/2cet PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cet" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 43589]]
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
-	[[Category: Thermotoga maritima]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]
	[[Category: Gloster, T M]]		[[Category: Gloster, T M]]

OCA at 18:05, 15 January 2015

2015-01-15T18:05:12Z

←Older revision		Revision as of 18:05, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CET FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CET FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [http://www.ebi.ac.uk/pdbsum/2cet PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [http://www.ebi.ac.uk/pdbsum/2cet PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]
-	[[Category: Davies, G J.]]	+	[[Category: Davies, G J]]
-	[[Category: Gloster, T M.]]	+	[[Category: Gloster, T M]]
-	[[Category: Roberts, S.]]	+	[[Category: Roberts, S]]
-	[[Category: Vasella, A.]]	+	[[Category: Vasella, A]]
	[[Category: Family 1]]		[[Category: Family 1]]
	[[Category: Glycoside hydrolase]]		[[Category: Glycoside hydrolase]]

OCA at 04:05, 29 September 2014

2014-09-29T04:05:17Z

←Older revision		Revision as of 04:05, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2cet.~~png~~\|~~left~~\|200px]]	+	==BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH PHENETHYL-SUBSTITUTED GLUCOIMIDAZOLE==
		+	<StructureSection load='2cet' size='340' side='right' caption='[[2cet]], [[Resolution\|resolution]] 1.97Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CET FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PGI:(5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>PGI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1od0\|1od0]], [[1oif\|1oif]], [[1oim\|1oim]], [[1oin\|1oin]], [[1uz1\|1uz1]], [[1w3j\|1w3j]], [[2cbu\|2cbu]], [[2cbv\|2cbv]], [[2ces\|2ces]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cet OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cet RCSB], [http://www.ebi.ac.uk/pdbsum/2cet PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/2cet_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of glycosidases has great potential in the quest for highly potent and specific drugs to treat diseases such as diabetes, cancer, and viral infections. One of the most effective ways of designing such compounds is by mimicking the transition state. Here we describe the structural, kinetic, and thermodynamic dissection of binding of two glucoimidazole-derived compounds, which are among the most potent glycosidase inhibitors reported to date, with two family 1 beta-glycosidases. Provocatively, while inclusion of the phenethyl moiety improves binding by a factor of 20-80-fold, this does not appear to result from better noncovalent interactions with the enzyme; instead, improved affinity may be derived from significantly better entropic contributions to binding displayed by the phenethyl-substituted imidazole compound.

-	~~{{STRUCTURE_2cet\| PDB=2cet \| SCENE= }}~~	+	Structural, kinetic, and thermodynamic analysis of glucoimidazole-derived glycosidase inhibitors.,Gloster TM, Roberts S, Perugino G, Rossi M, Moracci M, Panday N, Terinek M, Vasella A, Davies GJ Biochemistry. 2006 Oct 3;45(39):11879-84. PMID:17002288<ref>PMID:17002288</ref>

-	~~===BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH PHENETHYL-SUBSTITUTED GLUCOIMIDAZOLE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17002288}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2cet]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermotoga_maritima Thermotoga maritima]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-glucosidase\|Beta-glucosidase]]		*[[Beta-glucosidase\|Beta-glucosidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017002288<~~/~~ref~~><~~ref group="xtra">PMID:017279749</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]

OCA at 21:21, 20 October 2012

2012-10-20T21:21:34Z

←Older revision		Revision as of 21:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2cet]] is a 2 chain structure ~~of [[Beta-glucosidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA].	+	[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA].

	==See Also==		==See Also==

OCA at 13:00, 27 July 2012

2012-07-27T13:00:57Z

←Older revision		Revision as of 13:00, 27 July 2012
Line 1:		Line 1:
	[[Image:2cet.png\|left\|200px]]		[[Image:2cet.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cet", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2cet\| PDB=2cet \| SCENE= }}		{{STRUCTURE_2cet\| PDB=2cet \| SCENE= }}

	===BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH PHENETHYL-SUBSTITUTED GLUCOIMIDAZOLE===		===BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH PHENETHYL-SUBSTITUTED GLUCOIMIDAZOLE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17002288}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17002288 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17002288}}		{{ABSTRACT_PUBMED_17002288}}

	==About this Structure==		==About this Structure==
-	[[2cet]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA].	+	[[2cet]] is a 2 chain structure of [[Beta-glucosidase]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CET OCA].
		+
		+	==See Also==
		+	*[[Beta-glucosidase\|Beta-glucosidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17002288~~</ref><ref group="xtra">PMID:~~17279749~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017002288</ref><ref group="xtra">PMID:017279749</ref><references group="xtra"/>
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
	[[Category: Thermotoga maritima]]		[[Category: Thermotoga maritima]]

OCA: Protected "2cet" [edit=sysop:move=sysop]

2011-03-14T23:52:14Z

Protected "2cet" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:52, 14 March 2011