2cg4 - Revision history

OCA at 06:38, 1 May 2024

2024-05-01T06:38:51Z

←Older revision		Revision as of 06:38, 1 May 2024
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	<StructureSection load='2cg4' size='340' side='right'caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cg4' size='340' side='right'caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [https://pdbe.org/2cg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cg4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [https://pdbe.org/2cg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ASNC_ECOLI ASNC_ECOLI]] Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.<ref>PMID:3909107</ref> <ref>PMID:2864330</ref> <ref>PMID:2836709</ref>	+	[https://www.uniprot.org/uniprot/ASNC_ECOLI ASNC_ECOLI] Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.<ref>PMID:3909107</ref> <ref>PMID:2864330</ref> <ref>PMID:2836709</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cg4 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cg4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus subtilis LrpC is a global regulator involved in chromosome condensation. Our AsnC-asparagine structure is the first for a regulator-effector complex and is revealed as an octameric disc. Key ligand recognition residues are identified together with a route for ligand access. The LrpC structure reveals a stable octamer supportive of a topological role in dynamic DNA packaging. The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation.

-	Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.,Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:16528101<ref>PMID:16528101</ref>	+	==See Also==
-		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 2cg4" style~~=~~"background-color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Akerboom, J]]	+	[[Category: Akerboom J]]
-	[[Category: Alonso~~, J C~~]]	+	[[Category: Alonso JC]]
-	[[Category: Ayora, S]]	+	[[Category: Ayora S]]
-	[[Category: Brinkman~~, A B~~]]	+	[[Category: Brinkman AB]]
-	[[Category: Muranova, T]]	+	[[Category: Muranova T]]
-	~~[[Category: Oost, J van der~~]]	+	[[Category: Rafferty JB]]
-	[[Category: Rafferty~~, J B~~]]	+	[[Category: Sedelnikova SE]]
-	[[Category: Sedelnikova~~, S E~~]]	+	[[Category: Thaw P]]
-	[[Category: Thaw, P]]	+	[[Category: Wiese S]]
-	[[Category: Wiese, S]]	+	[[Category: Van der Oost J]]
-	[[Category: ~~Asnc]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Ffrp]]~~	+
-	~~[[Category: Lrp family]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 05:23, 28 April 2021

2021-04-28T05:23:03Z

←Older revision		Revision as of 05:23, 28 April 2021
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	<StructureSection load='2cg4' size='340' side='right'caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cg4' size='340' side='right'caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [~~http~~://pdbe.org/2cg4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cg4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cg4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [https://pdbe.org/2cg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ASNC_ECOLI ASNC_ECOLI]] Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.<ref>PMID:3909107</ref> <ref>PMID:2864330</ref> <ref>PMID:2836709</ref>	+	[[https://www.uniprot.org/uniprot/ASNC_ECOLI ASNC_ECOLI]] Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.<ref>PMID:3909107</ref> <ref>PMID:2864330</ref> <ref>PMID:2836709</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:00, 26 February 2020

2020-02-26T11:00:16Z

←Older revision		Revision as of 11:00, 26 February 2020
Line 1:		Line 1:

	==Structure of E.coli AsnC==		==Structure of E.coli AsnC==
-	<StructureSection load='2cg4' size='340' side='right' caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2cg4' size='340' side='right'caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Akerboom, J]]		[[Category: Akerboom, J]]
	[[Category: Alonso, J C]]		[[Category: Alonso, J C]]

OCA at 08:24, 23 May 2018

2018-05-23T08:24:20Z

←Older revision		Revision as of 08:24, 23 May 2018
Line 1:		Line 1:
-	==~~STRUCTURE OF~~ E.~~COLI ASNC~~==	+
		+	==Structure of E.coli AsnC==
	<StructureSection load='2cg4' size='340' side='right' caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cg4' size='340' side='right' caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [http://pdbe.org/2cg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [http://pdbe.org/2cg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cg4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/2cg4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/2cg4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cg4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Brinkman, A B]]		[[Category: Brinkman, A B]]
	[[Category: Muranova, T]]		[[Category: Muranova, T]]
-	[[Category: Oost, J ~~Van Der~~]]	+	[[Category: Oost, J van der]]
	[[Category: Rafferty, J B]]		[[Category: Rafferty, J B]]
	[[Category: Sedelnikova, S E]]		[[Category: Sedelnikova, S E]]

OCA at 09:17, 11 September 2015

2015-09-11T09:17:01Z

←Older revision		Revision as of 09:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cg4' size='340' side='right' caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2cg4' size='340' side='right' caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [http://pdbe.org/2cg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cg4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cg4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Akerboom, J]]		[[Category: Akerboom, J]]
	[[Category: Alonso, J C]]		[[Category: Alonso, J C]]

OCA at 14:23, 25 December 2014

2014-12-25T14:23:21Z

←Older revision		Revision as of 14:23, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cg4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cg4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ASNC_ECOLI ASNC_ECOLI]] Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.<ref>PMID:3909107</ref> <ref>PMID:2864330</ref> <ref>PMID:2836709</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Akerboom, J.]]	+	[[Category: Akerboom, J]]
-	[[Category: Alonso, J C.]]	+	[[Category: Alonso, J C]]
-	[[Category: Ayora, S.]]	+	[[Category: Ayora, S]]
-	[[Category: Brinkman, A B.]]	+	[[Category: Brinkman, A B]]
-	[[Category: Muranova, T.]]	+	[[Category: Muranova, T]]
-	[[Category: Oost, J Van Der.]]	+	[[Category: Oost, J Van Der]]
-	[[Category: Rafferty, J B.]]	+	[[Category: Rafferty, J B]]
-	[[Category: Sedelnikova, S E.]]	+	[[Category: Sedelnikova, S E]]
-	[[Category: Thaw, P.]]	+	[[Category: Thaw, P]]
-	[[Category: Wiese, S.]]	+	[[Category: Wiese, S]]
	[[Category: Asnc]]		[[Category: Asnc]]
	[[Category: Dna binding]]		[[Category: Dna binding]]

OCA at 01:55, 30 September 2014

2014-09-30T01:55:11Z

←Older revision		Revision as of 01:55, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2cg4.~~png\|left~~\|200px]]	+	==STRUCTURE OF E.COLI ASNC==
		+	<StructureSection load='2cg4' size='340' side='right' caption='[[2cg4]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cg4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/2cg4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus subtilis LrpC is a global regulator involved in chromosome condensation. Our AsnC-asparagine structure is the first for a regulator-effector complex and is revealed as an octameric disc. Key ligand recognition residues are identified together with a route for ligand access. The LrpC structure reveals a stable octamer supportive of a topological role in dynamic DNA packaging. The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation.

-	~~{{STRUCTURE_2cg4\| PDB=2cg4 \| SCENE= }}~~	+	Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family.,Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:16528101<ref>PMID:16528101</ref>

-	~~===STRUCTURE OF E.COLI ASNC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16528101}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2cg4]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016528101<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Akerboom, J.]]		[[Category: Akerboom, J.]]

OCA: Protected "2cg4" [edit=sysop:move=sysop]

2013-01-06T11:08:35Z

Protected "2cg4" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 6 January 2013

OCA at 11:08, 6 January 2013

2013-01-06T11:08:32Z

←Older revision		Revision as of 11:08, 6 January 2013
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-	{{Seed}}
	[[Image:2cg4.png\|left\|200px]]		[[Image:2cg4.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cg4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2cg4\| PDB=2cg4 \| SCENE= }}		{{STRUCTURE_2cg4\| PDB=2cg4 \| SCENE= }}

	===STRUCTURE OF E.COLI ASNC===		===STRUCTURE OF E.COLI ASNC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16528101}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16528101 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16528101}}		{{ABSTRACT_PUBMED_16528101}}

	==About this Structure==		==About this Structure==
-	~~2CG4~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA].	+	[[2cg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16528101~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016528101</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Akerboom, J.]]		[[Category: Akerboom, J.]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:36:11 2009''

OCA at 16:36, 17 February 2009

2009-02-17T16:36:13Z

←Older revision		Revision as of 16:36, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2CG4 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA].	+	2CG4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA].

	==Reference==		==Reference==
-	Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family., Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB, Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16528101 16528101]~~	+	<ref group="xtra">PMID:16528101</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Akerboom, J.]]		[[Category: Akerboom, J.]]
	[[Category: Alonso, J C.]]		[[Category: Alonso, J C.]]
Line 44:		Line 43:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 02~~:35:~~20 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:36:11 2009''