2cgr - Revision history

OCA at 11:26, 22 May 2024

2024-05-22T11:26:43Z

←Older revision		Revision as of 11:26, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2cgr' size='340' side='right'caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2cgr' size='340' side='right'caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CGR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [https://pdbe.org/2cgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [https://www.ebi.ac.uk/pdbsum/2cgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cgr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [https://pdbe.org/2cgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [https://www.ebi.ac.uk/pdbsum/2cgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cgr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A2P1G9_MOUSE A2P1G9_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Edmundson~~, A B~~]]	+	[[Category: Edmundson AB]]
-	[[Category: Guddat~~, L W~~]]	+	[[Category: Guddat LW]]
-	[[Category: Shan, L]]	+	[[Category: Shan L]]
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 20:35, 20 October 2021

2021-10-20T20:35:15Z

←Older revision		Revision as of 20:35, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2cgr' size='340' side='right'caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2cgr' size='340' side='right'caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CGR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [~~http~~://pdbe.org/2cgr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cgr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cgr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [https://pdbe.org/2cgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [https://www.ebi.ac.uk/pdbsum/2cgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cgr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:31, 11 December 2019

2019-12-11T19:31:06Z

←Older revision		Revision as of 19:31, 11 December 2019
Line 1:		Line 1:

	==LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB==		==LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB==
-	<StructureSection load='2cgr' size='340' side='right' caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2cgr' size='340' side='right'caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/2cgr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/2cgr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Edmundson, A B]]		[[Category: Edmundson, A B]]

OCA at 07:05, 29 November 2017

2017-11-29T07:05:17Z

←Older revision		Revision as of 07:05, 29 November 2017
Line 1:		Line 1:
		+
	==LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB==		==LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB==
	<StructureSection load='2cgr' size='340' side='right' caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2cgr' size='340' side='right' caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [http://pdbe.org/2cgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [http://www.ebi.ac.uk/pdbsum/2cgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [http://pdbe.org/2cgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [http://www.ebi.ac.uk/pdbsum/2cgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cgr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cgr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:

	==See Also==		==See Also==
-	*[[~~Antibody~~\|~~Antibody~~]]	+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:51, 12 September 2015

2015-09-12T00:51:16Z

←Older revision		Revision as of 00:51, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2cgr' size='340' side='right' caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2cgr' size='340' side='right' caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [http://www.ebi.ac.uk/pdbsum/2cgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [http://pdbe.org/2cgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [http://www.ebi.ac.uk/pdbsum/2cgr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cgr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Edmundson, A B]]		[[Category: Edmundson, A B]]
	[[Category: Guddat, L W]]		[[Category: Guddat, L W]]
	[[Category: Shan, L]]		[[Category: Shan, L]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 18:14, 15 January 2015

2015-01-15T18:14:10Z

←Older revision		Revision as of 18:14, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [http://www.ebi.ac.uk/pdbsum/2cgr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [http://www.ebi.ac.uk/pdbsum/2cgr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Edmundson, A B.]]	+	[[Category: Edmundson, A B]]
-	[[Category: Guddat, L W.]]	+	[[Category: Guddat, L W]]
-	[[Category: Shan, L.]]	+	[[Category: Shan, L]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 05:15, 29 September 2014

2014-09-29T05:15:20Z

←Older revision		Revision as of 05:15, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2cgr.~~png\|left~~\|200px]]	+	==LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB==
		+	<StructureSection load='2cgr' size='340' side='right' caption='[[2cgr]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CGR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAS:N-(P-CYANOPHENYL)-N-DIPHENYLMETHYL-GUANIDINE-ACETIC+ACID'>GAS</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cgr RCSB], [http://www.ebi.ac.uk/pdbsum/2cgr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/2cgr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of an Fab (NC6.8) from a murine IgG2b(kappa) antibody and its complex with a sweet-tasting, N-,N'-,N"-trisubstituted guanidine compound (NC174) have been determined by X-ray analysis. Both crystal forms are produced by a microseeding technique in polyethylene glycol (PEG) 8000 but the habits and space groups are very different. The native protein crystallizes as plates in the monoclinic space group C2 and the complex crystallizes as prisms in the orthorhombic space group P2(1)2(1)2. The structures were solved by molecular replacement methods, with the Fab fragments from the 4-4-20, HyHel-5 and BV04-01 antibodies as starting models. On binding of the ligand, N-(p-cyanophenyl)-N'-(diphenylmethyl)-N"-(carboxymethyl)g uan idine, the protein exhibits significant local conformational changes in the active site, particularly in the third complementarity-determining region (CDR3) of the heavy chain. The ligand enters the small crevice by end-on insertion with the cyanophenyl group in the lead and the diphenyl rings partially protruding from the entrance. No strict pi-pi stacking interactions are observed. However, tyrosine L32 (CDR1), tyrosine L96 (CDR3) and tryptophan H33 (CDR1) help immobilize the cyanophenyl ring and guanido group, and tyrosine H96 moves about 4.5 A to lie between the rings of the diphenyl group. The positive charge on the guanido group is compensated by glutamic acid H50 (CDR2) while the negative charge on acetic acid is neutralized by arginine H56 (CDR2) and by hydrogen bonding with asparagine H58 (CDR2). Water molecules participate in the binding process by hydrogen bonding with the cyano and guanido groups. The mechanism of binding is a clear example of induced fit. Like hemoglobin, the NC6.8 Fab can be classified as an allosteric protein, since its overall structure is altered by the binding of a small ligand. In crystals of the native Fab the elbow bend angle is 184 degrees while in crystals of the complex the elbow angle is 153 degrees. There is also a reciprocal push-pull type of change where the heavy chain is flexed and the light chain is extended. The tail of the heavy chain, which would be connected to the Fc in an intact antibody, is displaced 19 A relative to its position in the unliganded Fab. Within the limited series of sweetener-Fab complexes we have thus far examined, only the NC174 hapten has produced such results.(ABSTRACT TRUNCATED AT 400 WORDS)

-	~~{{STRUCTURE_2cgr\| PDB=2cgr \| SCENE= }}~~	+	Local and transmitted conformational changes on complexation of an anti-sweetener Fab.,Guddat LW, Shan L, Anchin JM, Linthicum DS, Edmundson AB J Mol Biol. 1994 Feb 11;236(1):247-74. PMID:7893280<ref>PMID:7893280</ref>

-	~~===LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7893280}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2cgr]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:007893280<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Edmundson, A B.]]		[[Category: Edmundson, A B.]]

OCA at 21:58, 20 October 2012

2012-10-20T21:58:09Z

←Older revision		Revision as of 21:58, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2cgr]] is a 2 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA].	+	[[2cgr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA].

	==See Also==		==See Also==

OCA: Protected "2cgr" [edit=sysop:move=sysop]

2012-07-27T14:48:19Z

Protected "2cgr" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:48, 27 July 2012

OCA at 14:48, 27 July 2012

2012-07-27T14:48:18Z

←Older revision		Revision as of 14:48, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2cgr.png\|left\|200px]]		[[Image:2cgr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cgr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2cgr\| PDB=2cgr \| SCENE= }}		{{STRUCTURE_2cgr\| PDB=2cgr \| SCENE= }}

	===LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB===		===LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7893280}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7893280 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_7893280}}		{{ABSTRACT_PUBMED_7893280}}

	==About this Structure==		==About this Structure==
-	~~2CGR~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA].	+	[[2cgr]] is a 2 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CGR OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7893280~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007893280</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Edmundson, A B.]]		[[Category: Edmundson, A B.]]
Line 29:		Line 20:
	[[Category: Shan, L.]]		[[Category: Shan, L.]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:54:38 2009''