2cjh - Revision history

OCA at 11:26, 22 May 2024

2024-05-22T11:26:57Z

←Older revision		Revision as of 11:26, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2cjh' size='340' side='right'caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2cjh' size='340' side='right'caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AKG:2~~-~~OXOGLUTARIC+ACID'>AKG</scene>~~, ~~<scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [https://pdbe.org/2cjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [https://www.ebi.ac.uk/pdbsum/2cjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [https://pdbe.org/2cjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [https://www.ebi.ac.uk/pdbsum/2cjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LAT_MYCTU LAT_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-lysine 6-transaminase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Ramachandran, R]]	+	[[Category: Ramachandran R]]
-	[[Category: Tripathi~~, S M]]~~	+	[[Category: Tripathi SM]]
-	~~[[Category: Aminotransferase]]~~	+
-	~~[[Category: Internal aldimine]]~~	+
-	~~[[Category: Rv3290c]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 20:35, 20 October 2021

2021-10-20T20:35:51Z

←Older revision		Revision as of 20:35, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2cjh' size='340' side='right'caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2cjh' size='340' side='right'caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [~~http~~://pdbe.org/2cjh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cjh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [https://pdbe.org/2cjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [https://www.ebi.ac.uk/pdbsum/2cjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:16, 11 December 2019

2019-12-11T19:16:02Z

←Older revision		Revision as of 19:16, 11 December 2019
Line 1:		Line 1:

	==Lysine aminotransferase from M. tuberculosis in the internal aldimine form with bound substrate 2-ketoglutarate==		==Lysine aminotransferase from M. tuberculosis in the internal aldimine form with bound substrate 2-ketoglutarate==
-	<StructureSection load='2cjh' size='340' side='right' caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2cjh' size='340' side='right'caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJH FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2cjh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cjh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]

OCA at 18:47, 24 January 2018

2018-01-24T18:47:32Z

←Older revision		Revision as of 18:47, 24 January 2018
Line 1:		Line 1:
-	==~~LYSINE AMINOTRANSFERASE FROM~~ M. ~~TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM WITH BOUND SUBSTRATE~~ 2-~~KETOGLUTARATE~~==	+
		+	==Lysine aminotransferase from M. tuberculosis in the internal aldimine form with bound substrate 2-ketoglutarate==
	<StructureSection load='2cjh' size='340' side='right' caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2cjh' size='340' side='right' caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [http://pdbe.org/2cjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [http://www.ebi.ac.uk/pdbsum/2cjh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [http://pdbe.org/2cjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [http://www.ebi.ac.uk/pdbsum/2cjh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2cjh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cjh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:29, 10 February 2016

2016-02-10T04:29:35Z

←Older revision		Revision as of 04:29, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cjh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2cjh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cjh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:23, 11 September 2015

2015-09-11T05:23:38Z

←Older revision		Revision as of 05:23, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cjh' size='340' side='right' caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2cjh' size='340' side='right' caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [http://www.ebi.ac.uk/pdbsum/2cjh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [http://pdbe.org/2cjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [http://www.ebi.ac.uk/pdbsum/2cjh PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cjh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]
	[[Category: Tripathi, S M]]		[[Category: Tripathi, S M]]

OCA at 17:44, 15 January 2015

2015-01-15T17:44:04Z

←Older revision		Revision as of 17:44, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [http://www.ebi.ac.uk/pdbsum/2cjh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [http://www.ebi.ac.uk/pdbsum/2cjh PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Ramachandran, R.]]	+	[[Category: Ramachandran, R]]
-	[[Category: Tripathi, S M.]]	+	[[Category: Tripathi, S M]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Internal aldimine]]		[[Category: Internal aldimine]]
	[[Category: Rv3290c]]		[[Category: Rv3290c]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 00:53, 30 September 2014

2014-09-30T00:53:46Z

←Older revision		Revision as of 00:53, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2cjh.~~png~~\|~~left~~\|200px]]	+	==LYSINE AMINOTRANSFERASE FROM M. TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM WITH BOUND SUBSTRATE 2-KETOGLUTARATE==
		+	<StructureSection load='2cjh' size='340' side='right' caption='[[2cjh]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cin\|2cin]], [[2cjd\|2cjd]], [[2cjg\|2cjg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjh RCSB], [http://www.ebi.ac.uk/pdbsum/2cjh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysine epsilon-aminotransferase (LAT) is a PLP-dependent enzyme that is highly up-regulated in nutrient-starved tuberculosis models. It catalyzes an overall reaction involving the transfer of the epsilon-amino group of L-lysine to alpha-ketoglutarate to yield L-glutamate and alpha-aminoadipate-delta-semialdehyde. We have cloned and characterized the enzyme from Mycobacterium tuberculosisH37Rv. We report here the crystal structures of the enzyme, the first from any source, in the unliganded form, external aldimine with L-lysine, with bound PMP and with its C5 substrate alpha-ketoglutarate. In addition to interaction details in the active site, the structures reveal a Glu243 "switch" through which the enzyme changes substrate specificities. The unique substrate L-lysine is recognized specifically when Glu243 maintains a salt-bridge with Arg422. On the other hand, the binding of the common C5 substrates L-glutamate and alpha-ketoglutarate is enabled when Glu243 switches away and unshields Arg422. The structures reported here, sequence conservation and earlier mutational studies suggest that the "glutamate switch" is an elegant solution devised by a subgroup of fold type I aminotransferases for recognition of structurally diverse substrates in the same binding site and provides for reaction specificity.

-	~~{{STRUCTURE_2cjh\| PDB=2cjh \| SCENE= }}~~	+	Direct evidence for a glutamate switch necessary for substrate recognition: crystal structures of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv.,Mani Tripathi S, Ramachandran R J Mol Biol. 2006 Oct 6;362(5):877-86. Epub 2006 Aug 11. PMID:16950391<ref>PMID:16950391</ref>

-	~~===LYSINE AMINOTRANSFERASE FROM M. TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM WITH BOUND SUBSTRATE 2-KETOGLUTARATE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16950391}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2cjh]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016950391<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "2cjh" [edit=sysop:move=sysop]

2013-01-06T10:12:35Z

Protected "2cjh" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:12, 6 January 2013

OCA at 10:12, 6 January 2013

2013-01-06T10:12:31Z

←Older revision		Revision as of 10:12, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2cjh.png\|left\|200px]]		[[Image:2cjh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cjh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2cjh\| PDB=2cjh \| SCENE= }}		{{STRUCTURE_2cjh\| PDB=2cjh \| SCENE= }}

	===LYSINE AMINOTRANSFERASE FROM M. TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM WITH BOUND SUBSTRATE 2-KETOGLUTARATE===		===LYSINE AMINOTRANSFERASE FROM M. TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM WITH BOUND SUBSTRATE 2-KETOGLUTARATE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16950391}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16950391 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16950391}}		{{ABSTRACT_PUBMED_16950391}}

	==About this Structure==		==About this Structure==
-	~~2CJH~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA].	+	[[2cjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16950391~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016950391</ref><references group="xtra"/>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 32:		Line 20:
	[[Category: Rv3290c]]		[[Category: Rv3290c]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:01:24 2009''