2cjr - Revision history

OCA at 09:26, 9 May 2024

2024-05-09T09:26:22Z

←Older revision		Revision as of 09:26, 9 May 2024
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	<StructureSection load='2cjr' size='340' side='right'caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2cjr' size='340' side='right'caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Sars_coronavirus_tw1 Sars~~ coronavirus ~~tw1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_TW1 SARS coronavirus TW1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJR FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1ssk\|1ssk]]~~, [[~~1x7q~~\|~~1x7q~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [https://pdbe.org/2cjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [https://www.ebi.ac.uk/pdbsum/2cjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [https://pdbe.org/2cjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [https://www.ebi.ac.uk/pdbsum/2cjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NCAP_SARS NCAP_SARS] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455).[HAMAP-Rule:MF_04096]<ref>PMID:17210170</ref> <ref>PMID:18055455</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Sars~~ coronavirus ~~tw1~~]]	+	[[Category: SARS coronavirus TW1]]
-	[[Category: Chen, C Y]]	+	[[Category: Chen C-Y]]
-	[[Category: Hsiao, C D]]	+	[[Category: Hsiao C-D]]
-	~~[[Category: Coronavirus]]~~	+
-	~~[[Category: Nucleocapsid protein]]~~	+
-	~~[[Category: Oligomerization domain]]~~	+
-	~~[[Category: Sar]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 06:56, 1 December 2021

2021-12-01T06:56:52Z

←Older revision		Revision as of 06:56, 1 December 2021
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	<StructureSection load='2cjr' size='340' side='right'caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2cjr' size='340' side='right'caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sars_coronavirus_tw1 Sars coronavirus tw1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Sars_coronavirus_tw1 Sars coronavirus tw1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJR FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ssk\|1ssk]], [[1x7q\|1x7q]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [~~http~~://pdbe.org/2cjr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cjr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [https://pdbe.org/2cjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [https://www.ebi.ac.uk/pdbsum/2cjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:52, 26 February 2020

2020-02-26T10:52:16Z

←Older revision		Revision as of 10:52, 26 February 2020
Line 1:		Line 1:

	==Crystal structure of oligomerization domain of SARS coronavirus nucleocapsid protein.==		==Crystal structure of oligomerization domain of SARS coronavirus nucleocapsid protein.==
-	<StructureSection load='2cjr' size='340' side='right' caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2cjr' size='340' side='right'caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_tw1 Sars coronavirus tw1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_tw1 Sars coronavirus tw1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Sars coronavirus tw1]]		[[Category: Sars coronavirus tw1]]
	[[Category: Chen, C Y]]		[[Category: Chen, C Y]]

OCA at 08:09, 23 May 2018

2018-05-23T08:09:59Z

←Older revision		Revision as of 08:09, 23 May 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF OLIGOMERIZATION DOMAIN OF~~ SARS ~~CORONAVIRUS NUCLEOCAPSID PROTEIN~~.==	+
		+	==Crystal structure of oligomerization domain of SARS coronavirus nucleocapsid protein.==
	<StructureSection load='2cjr' size='340' side='right' caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2cjr' size='340' side='right' caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_tw1 Sars coronavirus tw1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_tw1 Sars coronavirus tw1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [http://pdbe.org/2cjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [http://www.ebi.ac.uk/pdbsum/2cjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [http://pdbe.org/2cjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [http://www.ebi.ac.uk/pdbsum/2cjr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:13, 9 February 2016

2016-02-09T20:13:27Z

←Older revision		Revision as of 20:13, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cjr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:39, 11 September 2015

2015-09-11T01:39:36Z

←Older revision		Revision as of 01:39, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cjr' size='340' side='right' caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2cjr' size='340' side='right' caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sars_coronavirus~~ Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_tw1 Sars coronavirus tw1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [http://www.ebi.ac.uk/pdbsum/2cjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [http://pdbe.org/2cjr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [http://www.ebi.ac.uk/pdbsum/2cjr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2cjr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Sars coronavirus]]	+	[[Category: Sars coronavirus tw1]]
	[[Category: Chen, C Y]]		[[Category: Chen, C Y]]
	[[Category: Hsiao, C D]]		[[Category: Hsiao, C D]]

OCA at 16:22, 15 January 2015

2015-01-15T16:22:15Z

←Older revision		Revision as of 16:22, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [http://www.ebi.ac.uk/pdbsum/2cjr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [http://www.ebi.ac.uk/pdbsum/2cjr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
-	[[Category: Chen, C Y.]]	+	[[Category: Chen, C Y]]
-	[[Category: Hsiao, C D.]]	+	[[Category: Hsiao, C D]]
	[[Category: Coronavirus]]		[[Category: Coronavirus]]
	[[Category: Nucleocapsid protein]]		[[Category: Nucleocapsid protein]]

OCA at 23:57, 29 September 2014

2014-09-29T23:57:30Z

←Older revision		Revision as of 23:57, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2cjr.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF OLIGOMERIZATION DOMAIN OF SARS CORONAVIRUS NUCLEOCAPSID PROTEIN.==
		+	<StructureSection load='2cjr' size='340' side='right' caption='[[2cjr]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ssk\|1ssk]], [[1x7q\|1x7q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjr RCSB], [http://www.ebi.ac.uk/pdbsum/2cjr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Coronavirus nucleocapsid proteins are basic proteins that encapsulate viral genomic RNA to form part of the virus structure. The nucleocapsid protein of SARS-CoV is highly antigenic and associated with several host-cell interactions. Our previous studies using nuclear magnetic resonance revealed the domain organization of the SARS-CoV nucleocapsid protein. RNA has been shown to bind to the N-terminal domain (NTD), although recently the C-terminal half of the protein has also been implicated in RNA binding. Here, we report that the C-terminal domain (CTD), spanning residues 248-365 (NP248-365), had stronger nucleic acid-binding activity than the NTD. To determine the molecular basis of this activity, we have also solved the crystal structure of the NP248-365 region. Residues 248-280 form a positively charged groove similar to that found in the infectious bronchitis virus (IBV) nucleocapsid protein. Furthermore, the positively charged surface area is larger in the SARS-CoV construct than in the IBV. Interactions between residues 248-280 and the rest of the molecule also stabilize the formation of an octamer in the asymmetric unit. Packing of the octamers in the crystal forms two parallel, basic helical grooves, which may be oligonucleotide attachment sites, and suggests a mechanism for helical RNA packaging in the virus.

-	~~{{STRUCTURE_2cjr\| PDB=2cjr \| SCENE= }}~~	+	Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA.,Chen CY, Chang CK, Chang YW, Sue SC, Bai HI, Riang L, Hsiao CD, Huang TH J Mol Biol. 2007 May 11;368(4):1075-86. Epub 2007 Mar 2. PMID:17379242<ref>PMID:17379242</ref>

-	~~===CRYSTAL STRUCTURE OF OLIGOMERIZATION DOMAIN OF SARS CORONAVIRUS NUCLEOCAPSID PROTEIN.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17379242}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2cjr]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sars_coronavirus Sars coronavirus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017379242<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
	[[Category: Chen, C Y.]]		[[Category: Chen, C Y.]]

OCA: Protected "2cjr" [edit=sysop:move=sysop]

2013-01-06T09:25:36Z

Protected "2cjr" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:25, 6 January 2013

OCA at 09:25, 6 January 2013

2013-01-06T09:25:34Z

←Older revision		Revision as of 09:25, 6 January 2013
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-	{{Seed}}
	[[Image:2cjr.png\|left\|200px]]		[[Image:2cjr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2cjr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2cjr\| PDB=2cjr \| SCENE= }}		{{STRUCTURE_2cjr\| PDB=2cjr \| SCENE= }}

	===CRYSTAL STRUCTURE OF OLIGOMERIZATION DOMAIN OF SARS CORONAVIRUS NUCLEOCAPSID PROTEIN.===		===CRYSTAL STRUCTURE OF OLIGOMERIZATION DOMAIN OF SARS CORONAVIRUS NUCLEOCAPSID PROTEIN.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17379242}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17379242 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17379242}}		{{ABSTRACT_PUBMED_17379242}}

	==About this Structure==		==About this Structure==
-	~~2CJR~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA].	+	[[2cjr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJR OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17379242~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017379242</ref><references group="xtra"/>
	[[Category: Sars coronavirus]]		[[Category: Sars coronavirus]]
	[[Category: Chen, C Y.]]		[[Category: Chen, C Y.]]
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	[[Category: Sar]]		[[Category: Sar]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:48:42 2009''