2cr4 - Revision history

OCA at 16:33, 13 December 2023

2023-12-13T16:33:44Z

←Older revision		Revision as of 16:33, 13 December 2023
Line 1:		Line 1:

	==Solution structure of the SH2 domain of human SH3BP2 protein==		==Solution structure of the SH2 domain of human SH3BP2 protein==
-	<StructureSection load='2cr4' size='340' side='right'caption='[[2cr4~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2cr4' size='340' side='right'caption='[[2cr4]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SH3BP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [https://pdbe.org/2cr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [https://pdbe.org/2cr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[https://omim.org/entry/118400 118400]]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref> <ref>PMID:12900899</ref> <ref>PMID:14577811</ref>	+	[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[https://omim.org/entry/118400 118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref> <ref>PMID:12900899</ref> <ref>PMID:14577811</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.	+	[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hatta, R]]	+	[[Category: Hatta R]]
-	[[Category: Hayashi, F]]	+	[[Category: Hayashi F]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Tomizawa T]]
-	[[Category: Tomizawa, T]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+	[[Category: Yoshida M]]
-	[[Category: Yoshida, M]]	+
-	~~[[Category: 3bp-2]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Sh2 domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 11:47, 3 February 2021

2021-02-03T11:47:43Z

←Older revision		Revision as of 11:47, 3 February 2021
Line 1:		Line 1:

	==Solution structure of the SH2 domain of human SH3BP2 protein==		==Solution structure of the SH2 domain of human SH3BP2 protein==
-	<StructureSection load='2cr4' size='340' side='right' caption='[[2cr4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2cr4' size='340' side='right'caption='[[2cr4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SH3BP2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SH3BP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [~~http~~://pdbe.org/2cr4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr4 ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [https://pdbe.org/2cr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[~~http~~://omim.org/entry/118400 118400]]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref> <ref>PMID:12900899</ref> <ref>PMID:14577811</ref>	+	[[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[https://omim.org/entry/118400 118400]]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref> <ref>PMID:12900899</ref> <ref>PMID:14577811</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.	+	[[https://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
	== References ==		== References ==
	<references/>		<references/>
Line 16:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hatta, R]]		[[Category: Hatta, R]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]

OCA at 08:03, 23 May 2018

2018-05-23T08:03:17Z

←Older revision		Revision as of 08:03, 23 May 2018
Line 1:		Line 1:
		+
	==Solution structure of the SH2 domain of human SH3BP2 protein==		==Solution structure of the SH2 domain of human SH3BP2 protein==
	<StructureSection load='2cr4' size='340' side='right' caption='[[2cr4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cr4' size='340' side='right' caption='[[2cr4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SH3BP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SH3BP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [http://pdbe.org/2cr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [http://pdbe.org/2cr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr4 ProSAT], [http://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 06:00, 11 September 2015

2015-09-11T06:00:30Z

←Older revision		Revision as of 06:00, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cr4' size='340' side='right' caption='[[2cr4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2cr4' size='340' side='right' caption='[[2cr4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SH3BP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SH3BP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [http://pdbe.org/2cr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hatta, R]]		[[Category: Hatta, R]]
	[[Category: Hayashi, F]]		[[Category: Hayashi, F]]

OCA at 11:36, 18 December 2014

2014-12-18T11:36:47Z

←Older revision		Revision as of 11:36, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2cr4\| PDB=2cr4 \| SCENE= }}~~	+	==Solution structure of the SH2 domain of human SH3BP2 protein==
-	===Solution structure of the SH2 domain of human SH3BP2 protein===	+	<StructureSection load='2cr4' size='340' side='right' caption='[[2cr4]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CR4 FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[http://omim.org/entry/118400 118400]]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref><ref>PMID:12900899</ref><ref>PMID:14577811</ref>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SH3BP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2cr4 PDBsum], [http://www.topsan.org/Proteins/RSGI/2cr4 TOPSAN]</span></td></tr>
-	==Function==	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[http://omim.org/entry/118400 118400]]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref> <ref>PMID:12900899</ref> <ref>PMID:14577811</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.		[[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hatta, R.]]	+	[[Category: Hatta, R]]
-	[[Category: Hayashi, F.]]	+	[[Category: Hayashi, F]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Tomizawa, T.]]	+	[[Category: Tomizawa, T]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
-	[[Category: Yoshida, M.]]	+	[[Category: Yoshida, M]]
	[[Category: 3bp-2]]		[[Category: 3bp-2]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-	[[Category: Structural genomic]]

OCA at 01:04, 25 March 2013

2013-03-25T01:04:41Z

←Older revision		Revision as of 01:04, 25 March 2013
Line 1:		Line 1:
-	[[Image:2cr4.png\|left\|200px]]
-
	{{STRUCTURE_2cr4\| PDB=2cr4 \| SCENE= }}		{{STRUCTURE_2cr4\| PDB=2cr4 \| SCENE= }}
-
	===Solution structure of the SH2 domain of human SH3BP2 protein===		===Solution structure of the SH2 domain of human SH3BP2 protein===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:[http://omim.org/entry/118400 118400]]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.<ref>PMID:11381256</ref><ref>PMID:12900899</ref><ref>PMID:14577811</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/3BP2_HUMAN 3BP2_HUMAN]] Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.

	==About this Structure==		==About this Structure==
	[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].		[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hatta, R.]]		[[Category: Hatta, R.]]

OCA: Protected "2cr4" [edit=sysop:move=sysop]

2013-01-06T10:51:05Z

Protected "2cr4" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:51, 6 January 2013

OCA at 10:51, 6 January 2013

2013-01-06T10:51:02Z

←Older revision		Revision as of 10:51, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2cr4.png\|left\|200px]]		[[Image:2cr4.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2cr4\| PDB=2cr4 \| SCENE= }}		{{STRUCTURE_2cr4\| PDB=2cr4 \| SCENE= }}

	===Solution structure of the SH2 domain of human SH3BP2 protein===		===Solution structure of the SH2 domain of human SH3BP2 protein===

-
-	==Disease==
-	Known disease associated with this structure: Cherubism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602104 602104]]

	==About this Structure==		==About this Structure==
-	~~2CR4~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].	+	[[2cr4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hatta, R.]]		[[Category: Hatta, R.]]
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	[[Category: Rsgi]]		[[Category: Rsgi]]
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
		+	[[Category: Signaling protein]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:01:39 2008''

OCA at 10:01, 16 November 2008

2008-11-16T10:01:42Z

←Older revision		Revision as of 10:01, 16 November 2008
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	==About this Structure==		==About this Structure==
-	2CR4 is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].	+	2CR4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Hatta, R.]]		[[Category: Hatta, R.]]
	[[Category: Hayashi, F.]]		[[Category: Hayashi, F.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~Sep 28 18~~:34:50 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:01:39 2008''

OCA at 15:34, 28 September 2008

2008-09-28T15:34:54Z

←Older revision		Revision as of 15:34, 28 September 2008
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-	[[Image:2cr4.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2cr4.png\|left\|200px]]

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	{{STRUCTURE_2cr4\| PDB=2cr4 \| SCENE= }}		{{STRUCTURE_2cr4\| PDB=2cr4 \| SCENE= }}

-	~~'''~~Solution structure of the SH2 domain of human SH3BP2 protein~~'''~~	+	===Solution structure of the SH2 domain of human SH3BP2 protein===


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	==About this Structure==		==About this Structure==
-	2CR4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].	+	2CR4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR4 OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Single protein]]		[[Category: Single protein]]
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	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 22~~:51:24 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 18:34:50 2008''