2dwf - Revision history

OCA at 16:34, 13 December 2023

2023-12-13T16:34:39Z

←Older revision		Revision as of 16:34, 13 December 2023
Line 1:		Line 1:

	==NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles==		==NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles==
-	<StructureSection load='2dwf' size='340' side='right'caption='[[2dwf~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='2dwf' size='340' side='right'caption='[[2dwf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWF FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [https://pdbe.org/2dwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [https://www.ebi.ac.uk/pdbsum/2dwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [https://pdbe.org/2dwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [https://www.ebi.ac.uk/pdbsum/2dwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[https://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[https://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>	+	[https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[https://omim.org/entry/265120 265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[https://omim.org/entry/267450 267450]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	+	[https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Booth, V]]	+	[[Category: Booth V]]
-	[[Category: Keough~~, K M.W~~]]	+	[[Category: Keough KMW]]
-	[[Category: Sarker, M]]	+	[[Category: Sarker M]]
-	[[Category: Waring~~, A J]]~~	+	[[Category: Waring AJ]]
-	~~[[Category: Lipid associated protein]]~~	+
-	~~[[Category: Mini-b]]~~	+
-	~~[[Category: Sp-b]]~~	+
-	~~[[Category: Surface active protein]]~~	+
-	~~[[Category: Surfactant protein b~~]]	+

OCA at 17:17, 15 December 2021

2021-12-15T17:17:42Z

←Older revision		Revision as of 17:17, 15 December 2021
Line 3:		Line 3:
	<StructureSection load='2dwf' size='340' side='right'caption='[[2dwf]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2dwf' size='340' side='right'caption='[[2dwf]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2DWF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWF FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [~~http~~://pdbe.org/2dwf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2dwf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [https://pdbe.org/2dwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [https://www.ebi.ac.uk/pdbsum/2dwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[~~http~~://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[~~http~~://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>	+	[[https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[https://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[https://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.	+	[[https://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:22, 11 March 2020

2020-03-11T08:22:33Z

←Older revision		Revision as of 08:22, 11 March 2020
Line 1:		Line 1:

	==NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles==		==NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles==
-	<StructureSection load='2dwf' size='340' side='right' caption='[[2dwf]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='2dwf' size='340' side='right'caption='[[2dwf]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWF FirstGlance]. <br>
Line 15:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Booth, V]]		[[Category: Booth, V]]
	[[Category: Keough, K M.W]]		[[Category: Keough, K M.W]]

OCA at 07:17, 6 June 2018

2018-06-06T07:17:29Z

←Older revision		Revision as of 07:17, 6 June 2018
Line 1:		Line 1:
		+
	==NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles==		==NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles==
	<StructureSection load='2dwf' size='340' side='right' caption='[[2dwf]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='2dwf' size='340' side='right' caption='[[2dwf]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [http://pdbe.org/2dwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [http://www.ebi.ac.uk/pdbsum/2dwf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [http://pdbe.org/2dwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [http://www.ebi.ac.uk/pdbsum/2dwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 13:07, 10 September 2015

2015-09-10T13:07:10Z

←Older revision		Revision as of 13:07, 10 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [http://www.ebi.ac.uk/pdbsum/2dwf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [http://pdbe.org/2dwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [http://www.ebi.ac.uk/pdbsum/2dwf PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 12:58, 18 December 2014

2014-12-18T12:58:35Z

←Older revision		Revision as of 12:58, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2dwf\| PDB=2dwf \| SCENE= }}~~	+	==NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles==
-	===NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles===	+	<StructureSection load='2dwf' size='340' side='right' caption='[[2dwf]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_017845058}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DWF FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a2h\|2a2h]], [[1rg3\|1rg3]], [[1rg4\|1rg4]]</td></tr>
-	[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[http://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[http://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dwf RCSB], [http://www.ebi.ac.uk/pdbsum/2dwf PDBsum]</span></td></tr>
-		+	</table>
-	==Function==	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[http://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[http://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.		[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
-		+	== References ==
-	~~==About this Structure==~~	+	<references/>
-	~~[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA].~~	+	__TOC__
-		+	</StructureSection>
-	==~~Reference~~==	+	[[Category: Booth, V]]
-	<references ~~group="xtra"~~/><~~references~~/>	+	[[Category: Keough, K M.W]]
-	[[Category: Booth, V.]]	+	[[Category: Sarker, M]]
-	[[Category: Keough, K M.W.]]	+	[[Category: Waring, A J]]
-	[[Category: Sarker, M.]]	+
-	[[Category: Waring, A J.]]	+
	[[Category: Lipid associated protein]]		[[Category: Lipid associated protein]]
	[[Category: Mini-b]]		[[Category: Mini-b]]

OCA at 18:02, 24 March 2013

2013-03-24T18:02:12Z

←Older revision		Revision as of 18:02, 24 March 2013
Line 1:		Line 1:
-	[[Image:2dwf.png\|left\|200px]]
-
	{{STRUCTURE_2dwf\| PDB=2dwf \| SCENE= }}		{{STRUCTURE_2dwf\| PDB=2dwf \| SCENE= }}
-
	===NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles===		===NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles===
-
	{{ABSTRACT_PUBMED_017845058}}		{{ABSTRACT_PUBMED_017845058}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[http://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[http://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

	==About this Structure==		==About this Structure==
	[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA].		[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Booth, V.]]		[[Category: Booth, V.]]
	[[Category: Keough, K M.W.]]		[[Category: Keough, K M.W.]]

OCA: Protected "2dwf" [edit=sysop:move=sysop]

2012-10-24T07:59:56Z

Protected "2dwf" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:59, 24 October 2012

OCA at 07:59, 24 October 2012

2012-10-24T07:59:52Z

←Older revision		Revision as of 07:59, 24 October 2012
Line 1:		Line 1:
-	[[Image:2dwf.~~jpg~~\|left\|200px]]	+	[[Image:2dwf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2dwf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2dwf\| PDB=2dwf \| SCENE= }}		{{STRUCTURE_2dwf\| PDB=2dwf \| SCENE= }}

-	~~'''~~NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles~~'''~~	+	===NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles===

		+	{{ABSTRACT_PUBMED_017845058}}

	==About this Structure==		==About this Structure==
-	~~2DWF is a~~ [[~~Single protein~~]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA].	+	[[2dwf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA].
-	~~[[Category: Single protein]]~~	+
	[[Category: Booth, V.]]		[[Category: Booth, V.]]
	[[Category: Keough, K M.W.]]		[[Category: Keough, K M.W.]]
Line 22:		Line 16:
	[[Category: Mini-b]]		[[Category: Mini-b]]
	[[Category: Sp-b]]		[[Category: Sp-b]]
		+	[[Category: Surface active protein]]
	[[Category: Surfactant protein b]]		[[Category: Surfactant protein b]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:31:00 2008''

OCA at 22:31, 3 May 2008

2008-05-03T22:31:02Z

←Older revision		Revision as of 22:31, 3 May 2008
Line 1:		Line 1:
	[[Image:2dwf.jpg\|left\|200px]]		[[Image:2dwf.jpg\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 2dwf \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>2dwf</scene>~~	+	The line below this paragraph, containing "STRUCTURE_2dwf", creates the "Structure Box" on the page.
-	~~\|SITE=~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND=~~	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	~~\|ACTIVITY=~~	+	or leave the SCENE parameter empty for the default display.
-	~~\|GENE=~~	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_2dwf\| PDB=2dwf \| SCENE= }}
-	~~\|RELATEDENTRY=[[2a2h\|2A2H]]~~, ~~[[1rg3\|1RG3]], [[1rg4\|1RG4]]~~	+
-	~~\|RESOURCES=<span class='plainlinks'>[http://oca~~.~~weizmann.ac.il/oca~~-~~docs/fgij/fg.htm?mol=2dwf FirstGlance], [http://oca.weizmann.ac.il/oca~~-~~bin/ocaids?id~~=2dwf ~~OCA], [http://www.ebi.ac.uk/pdbsum/2dwf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId~~=~~2dwf RCSB]</span>~~	+
-	}}	+

	'''NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles'''		'''NMR structure of Mini-B, an N-terminal- C-terminal construct from human Surfactant Protein B (SP-B), in Sodium dodecyl sulfate (SDS) micelles'''
Line 16:		Line 13:

	==About this Structure==		==About this Structure==
-	2DWF is a [[Single protein]] structure ~~of sequence from [http://en.wikipedia.org/wiki/ ]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA].	+	2DWF is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWF OCA].
	[[Category: Single protein]]		[[Category: Single protein]]
	[[Category: Booth, V.]]		[[Category: Booth, V.]]
Line 22:		Line 19:
	[[Category: Sarker, M.]]		[[Category: Sarker, M.]]
	[[Category: Waring, A J.]]		[[Category: Waring, A J.]]
-	[[Category: ~~lipid~~ associated protein]]	+	[[Category: Lipid associated protein]]
-	[[Category: ~~mini~~-b]]	+	[[Category: Mini-b]]
-	[[Category: sp-b]]	+	[[Category: Sp-b]]
-	[[Category: ~~surfactant~~ protein b]]	+	[[Category: Surfactant protein b]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:31:00 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 02~~:40:26 2008''	+