2e5r - Revision history

OCA at 18:47, 29 May 2024

2024-05-29T18:47:25Z

←Older revision		Revision as of 18:47, 29 May 2024
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	==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==		==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
-	<StructureSection load='2e5r' size='340' side='right'caption='[[2e5r~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2e5r' size='340' side='right'caption='[[2e5r]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~DTNA ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [https://pdbe.org/2e5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [https://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [https://pdbe.org/2e5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [https://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[https://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>	+	[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[https://omim.org/entry/604169 604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.	+	[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dang, W]]	+	[[Category: Dang W]]
-	[[Category: Inoue, M]]	+	[[Category: Inoue M]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Muto, Y]]	+	[[Category: Muto Y]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Shirouzu M]]
-	[[Category: Shirouzu, M]]	+	[[Category: Terada T]]
-	[[Category: Terada, T]]	+	[[Category: Yokoyama S]]
-	[[Category: Yokoyama, S]]	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dystrobrevin alpha]]~~	+
-	~~[[Category: Dystrobrevin-alpha]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Zz domain~~]]	+

OCA at 11:48, 10 February 2021

2021-02-10T11:48:45Z

←Older revision		Revision as of 11:48, 10 February 2021
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	==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==		==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
-	<StructureSection load='2e5r' size='340' side='right' caption='[[2e5r]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2e5r' size='340' side='right'caption='[[2e5r]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E5R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [~~http~~://pdbe.org/2e5r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [https://pdbe.org/2e5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [https://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[~~http~~://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>	+	[[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[https://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.	+	[[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dang, W]]		[[Category: Dang, W]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 07:15, 6 June 2018

2018-06-06T07:15:23Z

←Older revision		Revision as of 07:15, 6 June 2018
Line 1:		Line 1:
		+
	==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==		==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
	<StructureSection load='2e5r' size='340' side='right' caption='[[2e5r]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2e5r' size='340' side='right' caption='[[2e5r]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://pdbe.org/2e5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://pdbe.org/2e5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5r_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5r_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:50, 7 February 2016

2016-02-07T19:50:52Z

←Older revision		Revision as of 19:50, 7 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e5r ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 04:29, 10 September 2015

2015-09-10T04:29:30Z

←Older revision		Revision as of 04:29, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2e5r' size='340' side='right' caption='[[2e5r]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2e5r' size='340' side='right' caption='[[2e5r]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://pdbe.org/2e5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dang, W]]		[[Category: Dang, W]]
	[[Category: Inoue, M]]		[[Category: Inoue, M]]

OCA at 17:15, 15 January 2015

2015-01-15T17:15:07Z

←Older revision		Revision as of 17:15, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5R FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[http://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>		[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[http://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dang, W.]]	+	[[Category: Dang, W]]
-	[[Category: Inoue, M.]]	+	[[Category: Inoue, M]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Muto, Y.]]	+	[[Category: Muto, Y]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Shirouzu, M.]]	+	[[Category: Shirouzu, M]]
-	[[Category: Terada, T.]]	+	[[Category: Terada, T]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dystrobrevin alpha]]		[[Category: Dystrobrevin alpha]]
Line 39:		Line 39:
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Zz domain]]		[[Category: Zz domain]]

OCA at 00:34, 30 September 2014

2014-09-30T00:34:32Z

←Older revision		Revision as of 00:34, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2e5r\| PDB=2e5r \| SCENE= }}~~	+	==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
-	===Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)===	+	<StructureSection load='2e5r' size='340' side='right' caption='[[2e5r]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[http://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	==Function==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[http://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.		[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
-		+	== Evolutionary Conservation ==
-	==~~About this Structure~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	[[~~2e5r~~]] ~~is a 1 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full experimental information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2E5R OCA~~].	+	Check<jmol>
-		+	<jmolCheckbox>
-	==~~Reference~~==	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5r_consurf.spt"</scriptWhenChecked>
-	<references ~~group="xtra"~~/><~~references~~/>	+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dang, W.]]		[[Category: Dang, W.]]

OCA at 23:37, 24 March 2013

2013-03-24T23:37:56Z

←Older revision		Revision as of 23:37, 24 March 2013
Line 1:		Line 1:
-	[[Image:2e5r.png\|left\|200px]]
-
	{{STRUCTURE_2e5r\| PDB=2e5r \| SCENE= }}		{{STRUCTURE_2e5r\| PDB=2e5r \| SCENE= }}
-
	===Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)===		===Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[http://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.

	==About this Structure==		==About this Structure==
	[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA].		[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dang, W.]]		[[Category: Dang, W.]]

OCA: Protected "2e5r" [edit=sysop:move=sysop]

2013-01-06T09:56:38Z

Protected "2e5r" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:56, 6 January 2013

OCA at 09:56, 6 January 2013

2013-01-06T09:56:33Z

←Older revision		Revision as of 09:56, 6 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2e5r.png\|left\|200px]]		[[Image:2e5r.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2e5r", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2e5r\| PDB=2e5r \| SCENE= }}		{{STRUCTURE_2e5r\| PDB=2e5r \| SCENE= }}

	===Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)===		===Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)===

-
-	==Disease==
-	Known disease associated with this structure: Left ventricular noncompaction with congenital heart defects OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601239 601239]], Left ventricular noncompaction, familial isolated, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601239 601239]]

	==About this Structure==		==About this Structure==
-	~~2E5R~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA].	+	[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dang, W.]]		[[Category: Dang, W.]]
Line 31:		Line 21:
	[[Category: Dystrobrevin-alpha]]		[[Category: Dystrobrevin-alpha]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
-	[[Category: Nmr]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
	[[Category: Riken structural genomics/proteomics initiative]]		[[Category: Riken structural genomics/proteomics initiative]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Zz domain]]		[[Category: Zz domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 11:28:28 2009''