2e6f - Revision history

OCA at 08:35, 25 October 2023

2023-10-25T08:35:43Z

←Older revision		Revision as of 08:35, 25 October 2023
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	<StructureSection load='2e6f' size='340' side='right'caption='[[2e6f]], [[Resolution\|resolution]] 1.26Å' scene=''>		<StructureSection load='2e6f' size='340' side='right'caption='[[2e6f]], [[Resolution\|resolution]] 1.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6F FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.26Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2djl\|2djl]], [[2djx\|2djx]], [[2e68\|2e68]], [[2e6a\|2e6a]], [[2e6d\|2e6d]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">TCDHOD2~~ (~~[https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR]~~)~~</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [https://pdbe.org/2e6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [https://www.ebi.ac.uk/pdbsum/2e6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [https://pdbe.org/2e6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [https://www.ebi.ac.uk/pdbsum/2e6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.	+	[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trycr~~]]	+	[[Category: Trypanosoma cruzi]]
-	[[Category: Aoki, T]]	+	[[Category: Aoki T]]
-	[[Category: Harada, S]]	+	[[Category: Harada S]]
-	[[Category: Inaoka~~, D K~~]]	+	[[Category: Inaoka DK]]
-	[[Category: Kita, K]]	+	[[Category: Kita K]]
-	[[Category: Kurisu, G]]	+	[[Category: Kurisu G]]
-	[[Category: Nara, T]]	+	[[Category: Nara T]]
-	[[Category: Sakamoto, K]]	+	[[Category: Sakamoto K]]
-	[[Category: Shiba, T]]	+	[[Category: Shiba T]]
-	[[Category: Shimizu, H]]	+	[[Category: Shimizu H]]
-	~~[[Category: Chagas disease]]~~	+
-	~~[[Category: Dihydroorotate dehydrogenase]]~~	+
-	~~[[Category: Energy metabolism]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Fumarate reductase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pyrimidine biosynthesis]]~~	+
-	~~[[Category: Redox homeostasis~~]]	+

OCA at 11:49, 10 February 2021

2021-02-10T11:49:50Z

←Older revision		Revision as of 11:49, 10 February 2021
Line 1:		Line 1:

	==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate==		==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate==
-	<StructureSection load='2e6f' size='340' side='right' caption='[[2e6f]], [[Resolution\|resolution]] 1.26Å' scene=''>	+	<StructureSection load='2e6f' size='340' side='right'caption='[[2e6f]], [[Resolution\|resolution]] 1.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e6f]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E6F FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6F FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2djl\|2djl]], [[2djx\|2djx]], [[2e68\|2e68]], [[2e6a\|2e6a]], [[2e6d\|2e6d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2djl\|2djl]], [[2djx\|2djx]], [[2e68\|2e68]], [[2e6a\|2e6a]], [[2e6d\|2e6d]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [~~http~~://pdbe.org/2e6f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e6f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6f ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [https://pdbe.org/2e6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [https://www.ebi.ac.uk/pdbsum/2e6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.	+	[[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]	+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Trycr]]		[[Category: Trycr]]
	[[Category: Aoki, T]]		[[Category: Aoki, T]]

OCA at 07:11, 6 June 2018

2018-06-06T07:11:07Z

←Older revision		Revision as of 07:11, 6 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate==		==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate==
	<StructureSection load='2e6f' size='340' side='right' caption='[[2e6f]], [[Resolution\|resolution]] 1.26Å' scene=''>		<StructureSection load='2e6f' size='340' side='right' caption='[[2e6f]], [[Resolution\|resolution]] 1.26Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [http://pdbe.org/2e6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [http://www.ebi.ac.uk/pdbsum/2e6f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [http://pdbe.org/2e6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [http://www.ebi.ac.uk/pdbsum/2e6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e6f_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e6f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:30, 10 February 2016

2016-02-10T00:30:38Z

←Older revision		Revision as of 00:30, 10 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e6f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 03:34, 11 September 2015

2015-09-11T03:34:33Z

←Older revision		Revision as of 03:34, 11 September 2015
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [http://www.ebi.ac.uk/pdbsum/2e6f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [http://pdbe.org/2e6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [http://www.ebi.ac.uk/pdbsum/2e6f PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:32, 25 December 2014

2014-12-25T10:32:24Z

←Older revision		Revision as of 10:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e6f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E6F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e6f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E6F FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2djl\|2djl]], [[2djx\|2djx]], [[2e68\|2e68]], [[2e6a\|2e6a]], [[2e6d\|2e6d]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2djl\|2djl]], [[2djx\|2djx]], [[2e68\|2e68]], [[2e6a\|2e6a]], [[2e6d\|2e6d]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [http://www.ebi.ac.uk/pdbsum/2e6f PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [http://www.ebi.ac.uk/pdbsum/2e6f PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Trycr]]		[[Category: Trycr]]
-	[[Category: Aoki, T.]]	+	[[Category: Aoki, T]]
-	[[Category: Harada, S.]]	+	[[Category: Harada, S]]
-	[[Category: Inaoka, D K.]]	+	[[Category: Inaoka, D K]]
-	[[Category: Kita, K.]]	+	[[Category: Kita, K]]
-	[[Category: Kurisu, G.]]	+	[[Category: Kurisu, G]]
-	[[Category: Nara, T.]]	+	[[Category: Nara, T]]
-	[[Category: Sakamoto, K.]]	+	[[Category: Sakamoto, K]]
-	[[Category: Shiba, T.]]	+	[[Category: Shiba, T]]
-	[[Category: Shimizu, H.]]	+	[[Category: Shimizu, H]]
	[[Category: Chagas disease]]		[[Category: Chagas disease]]
	[[Category: Dihydroorotate dehydrogenase]]		[[Category: Dihydroorotate dehydrogenase]]

OCA at 11:24, 3 October 2014

2014-10-03T11:24:10Z

←Older revision		Revision as of 11:24, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2e6f\| PDB=2e6f \| SCENE= }}~~	+	==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate==
-	===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate===	+	<StructureSection load='2e6f' size='340' side='right' caption='[[2e6f]], [[Resolution\|resolution]] 1.26Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[2e6f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E6F FirstGlance]. <br>
-	[[~~http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC~~]] ~~Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor~~. ~~Molecular oxygen can replace fumarate in vitro.~~	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=OXC:OXONIC+ACID'>OXC</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2djl\|2djl]], [[2djx\|2djx]], [[2e68\|2e68]], [[2e6a\|2e6a]], [[2e6d\|2e6d]]</td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
-	[[2e6f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA].	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e6f RCSB], [http://www.ebi.ac.uk/pdbsum/2e6f PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e6f_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]		*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:018808149</ref><references group="xtra"/>~~<~~references~~/>	+
	[[Category: Trycr]]		[[Category: Trycr]]
	[[Category: Aoki, T.]]		[[Category: Aoki, T.]]

OCA at 08:12, 16 April 2014

2014-04-16T08:12:38Z

←Older revision		Revision as of 08:12, 16 April 2014
Line 1:		Line 1:
-	[[Image:2e6f.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2e6f", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2e6f\| PDB=2e6f \| SCENE= }}		{{STRUCTURE_2e6f\| PDB=2e6f \| SCENE= }}
-
	===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate===		===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.

-	~~<!--~~	+	==About this Structure==
-	~~The line below~~ this ~~paragraph, {{ABSTRACT_PUBMED_018808149}}, adds the Publication Abstract to the page~~	+	[[2e6f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA].
-	~~(as it appears on PubMed at~~ http://~~www~~.~~pubmed~~.~~gov), where 018808149~~ is ~~the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_018808149}}~~	+

-	==~~About this Structure~~==	+	==See Also==
-	[[~~2e6f~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6F OCA].	+	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018808149</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018808149</ref><references group="xtra"/><references/>
-	[[Category: ~~Dihydroorotate oxidase]]~~	+	[[Category: Trycr]]
-	~~[[Category: Trypanosoma cruzi~~]]	+
	[[Category: Aoki, T.]]		[[Category: Aoki, T.]]
	[[Category: Harada, S.]]		[[Category: Harada, S.]]

OCA: Protected "2e6f" [edit=sysop:move=sysop]

2012-06-02T09:43:10Z

Protected "2e6f" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:43, 2 June 2012