2e7q - Revision history

OCA at 08:36, 25 October 2023

2023-10-25T08:36:02Z

←Older revision		Revision as of 08:36, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~GLC~~:ALPHA-D-~~GLUCOSE~~'>~~GLC~~</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~FUC~~:ALPHA-~~L-FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~GLA~~:~~ALPHA~~+~~D-GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [https://pdbe.org/2e7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [https://www.ebi.ac.uk/pdbsum/2e7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [https://pdbe.org/2e7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [https://www.ebi.ac.uk/pdbsum/2e7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LEC1_PSOTE LEC1_PSOTE]] Lectin.	+	[https://www.uniprot.org/uniprot/LEC1_PSOTE LEC1_PSOTE] Lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Psophocarpus tetragonolobus]]		[[Category: Psophocarpus tetragonolobus]]
-	[[Category: Katiyar, S]]	+	[[Category: Katiyar S]]
-	[[Category: Kulkarni~~, K A~~]]	+	[[Category: Kulkarni KA]]
-	[[Category: Suguna, K]]	+	[[Category: Suguna K]]
-	[[Category: Surolia, A]]	+	[[Category: Surolia A]]
-	[[Category: Vijayan, M]]	+	[[Category: Vijayan M]]
-	~~[[Category: Jelly roll]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: Winged bean~~]]	+

OCA at 17:21, 15 December 2021

2021-12-15T17:21:30Z

←Older revision		Revision as of 17:21, 15 December 2021
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	<StructureSection load='2e7q' size='340' side='right'caption='[[2e7q]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2e7q' size='340' side='right'caption='[[2e7q]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~FUC~~:ALPHA-L-~~FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA-D-GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~GLA~~:ALPHA+D-~~GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=~~GLC~~:~~ALPHA~~-D-~~GLUCOSE~~'>~~GLC~~</scene>, <scene name='pdbligand=MN:~~MANGANESE~~+~~(II)+ION~~'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [~~http~~://pdbe.org/2e7q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2e7q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [https://pdbe.org/2e7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [https://www.ebi.ac.uk/pdbsum/2e7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LEC1_PSOTE LEC1_PSOTE]] Lectin.	+	[[https://www.uniprot.org/uniprot/LEC1_PSOTE LEC1_PSOTE]] Lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:28, 11 March 2020

2020-03-11T08:28:43Z

←Older revision		Revision as of 08:28, 11 March 2020
Line 1:		Line 1:

	==Crystal structure of basic winged bean lectin in complex with b blood group trisaccharide==		==Crystal structure of basic winged bean lectin in complex with b blood group trisaccharide==
-	<StructureSection load='2e7q' size='340' side='right' caption='[[2e7q]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='2e7q' size='340' side='right'caption='[[2e7q]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Agglutinin\|Agglutinin]]	+	*[[Agglutinin 3D structures\|Agglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Psophocarpus tetragonolobus]]		[[Category: Psophocarpus tetragonolobus]]
	[[Category: Katiyar, S]]		[[Category: Katiyar, S]]

OCA at 07:11, 6 June 2018

2018-06-06T07:11:45Z

←Older revision		Revision as of 07:11, 6 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of basic winged bean lectin in complex with b blood group trisaccharide==		==Crystal structure of basic winged bean lectin in complex with b blood group trisaccharide==
	<StructureSection load='2e7q' size='340' side='right' caption='[[2e7q]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2e7q' size='340' side='right' caption='[[2e7q]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=~~GLC~~:ALPHA-D-~~GLUCOSE~~'>~~GLC~~</scene>, <scene name='pdbligand=MN:~~MANGANESE+(II)+ION~~'>MN</scene>, <scene name='pdbligand=~~FUC~~:ALPHA-~~L-FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~GLA~~:~~ALPHA~~+~~D-GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [http://pdbe.org/2e7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [http://www.ebi.ac.uk/pdbsum/2e7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [http://pdbe.org/2e7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [http://www.ebi.ac.uk/pdbsum/2e7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e7q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2e7q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2e7q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Agglutinin\|Agglutinin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:51, 8 February 2016

2016-02-08T20:51:21Z

←Older revision		Revision as of 20:51, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e7q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:16, 10 September 2015

2015-09-10T15:16:53Z

←Older revision		Revision as of 15:16, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [http://www.ebi.ac.uk/pdbsum/2e7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [http://pdbe.org/2e7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [http://www.ebi.ac.uk/pdbsum/2e7q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2e7q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:04, 25 December 2014

2014-12-25T02:04:12Z

←Older revision		Revision as of 02:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [http://www.ebi.ac.uk/pdbsum/2e7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [http://www.ebi.ac.uk/pdbsum/2e7q PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEC1_PSOTE LEC1_PSOTE]] Lectin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Psophocarpus tetragonolobus]]		[[Category: Psophocarpus tetragonolobus]]
-	[[Category: Katiyar, S.]]	+	[[Category: Katiyar, S]]
-	[[Category: Kulkarni, K A.]]	+	[[Category: Kulkarni, K A]]
-	[[Category: Suguna, K.]]	+	[[Category: Suguna, K]]
-	[[Category: Surolia, A.]]	+	[[Category: Surolia, A]]
-	[[Category: Vijayan, M.]]	+	[[Category: Vijayan, M]]
	[[Category: Jelly roll]]		[[Category: Jelly roll]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
	[[Category: Winged bean]]		[[Category: Winged bean]]

OCA at 02:10, 30 September 2014

2014-09-30T02:10:50Z

←Older revision		Revision as of 02:10, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2e7q.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of basic winged bean lectin in complex with b blood group trisaccharide==
		+	<StructureSection load='2e7q' size='340' side='right' caption='[[2e7q]], [[Resolution\|resolution]] 2.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2e7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E7Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wbl\|1wbl]], [[1wbf\|1wbf]], [[2e7t\|2e7t]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e7q RCSB], [http://www.ebi.ac.uk/pdbsum/2e7q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/2e7q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Basic winged bean agglutinin binds A-blood group substance with higher affinity and B-blood group substance with lesser affinity. It does not bind the O substance. The crystal structures of the lectin, complexed with A-reactive and B-reactive di and tri saccharides, have been determined. In addition, the complexes of the lectin with fucosylated A-trisaccharides and B-trisaccharides and with a variant of the A-trisaccharide have been modeled. These structures and models provide valuable insights into the structural basis of blood group specificities. All the four carbohydrate binding loops of the lectin contribute to the primary combining site while the loop of variable length contributes to the secondary binding site. In a significant advance to the current understanding, the interactions at the secondary binding site also contribute substantially, albeit in a subtle manner, to determine the blood group specificity. Compared with the interactions of the B-trisaccharide with the lectin, the third sugar residue of the A-reactive trisacharide forms an additional hydrogen bond with a lysine residue in the variable loop. In the former, the formation of such a hydrogen bond is prevented by a shift in the orientation of third sugar resulting from an internal hydrogen bond in it. The formation of this bond is also facilitated by an interaction dependent change in the rotamer conformation of the lysyl residue of the variable loop. Thus, the difference in the interactions at the secondary site is generated by coordinated movements in the ligand as well as the protein. A comparison of the crystal structure and the model of the complex involving the variant of the A-trisaccharide results in the delineation of the relative contributions of the interactions at the primary and the secondary sites in determining blood group specificity.

-	~~{{STRUCTURE_2e7q\| PDB=2e7q \| SCENE= }}~~	+	Generation of blood group specificity: new insights from structural studies on the complexes of A- and B-reactive saccharides with basic winged bean agglutinin.,Kulkarni KA, Katiyar S, Surolia A, Vijayan M, Suguna K Proteins. 2007 Aug 15;68(3):762-9. PMID:17510954<ref>PMID:17510954</ref>

-	~~===Crystal structure~~ of ~~basic winged bean lectin in complex with b blood group trisaccharide===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17510954}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2e7q]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Psophocarpus_tetragonolobus Psophocarpus tetragonolobus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2E7Q OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017510954<~~/~~ref~~><~~ref group="xtra">PMID:017057334</ref><ref group="xtra">PMID:009500920</ref><references group="xtra"~~/>	+
	[[Category: Psophocarpus tetragonolobus]]		[[Category: Psophocarpus tetragonolobus]]
	[[Category: Katiyar, S.]]		[[Category: Katiyar, S.]]

OCA at 12:30, 23 January 2013

2013-01-23T12:30:56Z

←Older revision		Revision as of 12:30, 23 January 2013
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	[[Image:2e7q.png\|left\|200px]]		[[Image:2e7q.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2e7q\| PDB=2e7q \| SCENE= }}		{{STRUCTURE_2e7q\| PDB=2e7q \| SCENE= }}

	===Crystal structure of basic winged bean lectin in complex with b blood group trisaccharide===		===Crystal structure of basic winged bean lectin in complex with b blood group trisaccharide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17510954}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17510954 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17510954}}		{{ABSTRACT_PUBMED_17510954}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17510954~~</ref><ref group="xtra">PMID:~~17057334~~</ref><ref group="xtra">PMID:~~9500920~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017510954</ref><ref group="xtra">PMID:017057334</ref><ref group="xtra">PMID:009500920</ref><references group="xtra"/>
	[[Category: Psophocarpus tetragonolobus]]		[[Category: Psophocarpus tetragonolobus]]
	[[Category: Katiyar, S.]]		[[Category: Katiyar, S.]]
Line 29:		Line 18:
	[[Category: Surolia, A.]]		[[Category: Surolia, A.]]
	[[Category: Vijayan, M.]]		[[Category: Vijayan, M.]]
		+	[[Category: Jelly roll]]
		+	[[Category: Sugar binding protein]]
		+	[[Category: Winged bean]]

OCA: Protected "2e7q" [edit=sysop:move=sysop]

2011-02-09T05:35:40Z

Protected "2e7q" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:35, 9 February 2011