2elk - Revision history

OCA at 18:51, 29 May 2024

2024-05-29T18:51:38Z

←Older revision		Revision as of 18:51, 29 May 2024
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	==Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein==		==Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein==
-	<StructureSection load='2elk' size='340' side='right'caption='[[2elk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2elk' size='340' side='right'caption='[[2elk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELK FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SPCC24B10.08c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~4896 CBS 356])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [https://pdbe.org/2elk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [https://www.ebi.ac.uk/pdbsum/2elk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2elk ProSAT], [https://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [https://pdbe.org/2elk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [https://www.ebi.ac.uk/pdbsum/2elk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2elk ProSAT], [https://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ADA2_SCHPO ADA2_SCHPO]] Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (By similarity). Required for full activation of chromatin alteration and meiotic recombination at meiotic recombination hot spot ade6-M26. Also required for the regulation of transcription and chromatin structure around ade6-M26 in response to osmotic stress. Needed for hyperacetylation of histone H3 around ade6-M26.<ref>PMID:18199689</ref> [UniProtKB:Q02336]	+	[https://www.uniprot.org/uniprot/ADA2_SCHPO ADA2_SCHPO] Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (By similarity). Required for full activation of chromatin alteration and meiotic recombination at meiotic recombination hot spot ade6-M26. Also required for the regulation of transcription and chromatin structure around ade6-M26 in response to osmotic stress. Needed for hyperacetylation of histone H3 around ade6-M26.<ref>PMID:18199689</ref> [UniProtKB:Q02336]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Harada, T~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: ~~Kigawa,~~ T]]	+	[[Category: Harada T]]
-	[[Category: ~~Koshiba, S~~]]	+	[[Category: Kigawa T]]
-	[[Category: ~~Structural genomic~~]]	+	[[Category: Koshiba S]]
-	[[Category: Tanaka, A]]	+	[[Category: Tanaka A]]
-	[[Category: Tochio, N]]	+	[[Category: Tochio N]]
-	[[Category: Umehara, T]]	+	[[Category: Umehara T]]
-	[[Category: Watanabe, S]]	+	[[Category: Watanabe S]]
-	[[Category: Yokoyama, S]]	+	[[Category: Yokoyama S]]
-	~~[[Category: Hypothetical protein]]~~	+
-	~~[[Category: National project on protein structural and functional analyse]]~~	+
-	~~[[Category: Nppsfa]]~~	+
-	~~[[Category: Rsgi]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 12:11, 10 February 2021

2021-02-10T12:11:55Z

←Older revision		Revision as of 12:11, 10 February 2021
Line 1:		Line 1:

	==Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein==		==Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein==
-	<StructureSection load='2elk' size='340' side='right' caption='[[2elk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2elk' size='340' side='right'caption='[[2elk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ELK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [~~http~~://pdbe.org/2elk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2elk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2elk ProSAT], [~~http~~://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [https://pdbe.org/2elk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [https://www.ebi.ac.uk/pdbsum/2elk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2elk ProSAT], [https://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ADA2_SCHPO ADA2_SCHPO]] Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (By similarity). Required for full activation of chromatin alteration and meiotic recombination at meiotic recombination hot spot ade6-M26. Also required for the regulation of transcription and chromatin structure around ade6-M26 in response to osmotic stress. Needed for hyperacetylation of histone H3 around ade6-M26.<ref>PMID:18199689</ref> [UniProtKB:Q02336]	+	[[https://www.uniprot.org/uniprot/ADA2_SCHPO ADA2_SCHPO]] Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (By similarity). Required for full activation of chromatin alteration and meiotic recombination at meiotic recombination hot spot ade6-M26. Also required for the regulation of transcription and chromatin structure around ade6-M26 in response to osmotic stress. Needed for hyperacetylation of histone H3 around ade6-M26.<ref>PMID:18199689</ref> [UniProtKB:Q02336]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Cbs 356]]		[[Category: Cbs 356]]
		+	[[Category: Large Structures]]
	[[Category: Harada, T]]		[[Category: Harada, T]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 07:04, 6 June 2018

2018-06-06T07:04:00Z

←Older revision		Revision as of 07:04, 6 June 2018
Line 1:		Line 1:
		+
	==Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein==		==Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein==
	<StructureSection load='2elk' size='340' side='right' caption='[[2elk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2elk' size='340' side='right' caption='[[2elk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELK FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [http://pdbe.org/2elk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [http://www.ebi.ac.uk/pdbsum/2elk PDBsum], [http://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [http://pdbe.org/2elk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [http://www.ebi.ac.uk/pdbsum/2elk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2elk ProSAT], [http://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2elk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2elk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:55, 10 February 2016

2016-02-10T01:55:21Z

←Older revision		Revision as of 01:55, 10 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2elk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	== References ==		== References ==

OCA at 04:13, 11 September 2015

2015-09-11T04:13:14Z

←Older revision		Revision as of 04:13, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2elk' size='340' side='right' caption='[[2elk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2elk' size='340' side='right' caption='[[2elk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELK FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 ~~Schizosaccharomyces pombe~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [http://www.ebi.ac.uk/pdbsum/2elk PDBsum], [http://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [http://pdbe.org/2elk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [http://www.ebi.ac.uk/pdbsum/2elk PDBsum], [http://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Cbs 356]]
	[[Category: Harada, T]]		[[Category: Harada, T]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]

OCA at 10:59, 25 December 2014

2014-12-25T10:59:37Z

←Older revision		Revision as of 10:59, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [http://www.ebi.ac.uk/pdbsum/2elk PDBsum], [http://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [http://www.ebi.ac.uk/pdbsum/2elk PDBsum], [http://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ADA2_SCHPO ADA2_SCHPO]] Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (By similarity). Required for full activation of chromatin alteration and meiotic recombination at meiotic recombination hot spot ade6-M26. Also required for the regulation of transcription and chromatin structure around ade6-M26 in response to osmotic stress. Needed for hyperacetylation of histone H3 around ade6-M26.<ref>PMID:18199689</ref> [UniProtKB:Q02336]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Harada, T.]]	+	[[Category: Harada, T]]
-	[[Category: Kigawa, T.]]	+	[[Category: Kigawa, T]]
-	[[Category: Koshiba, S.]]	+	[[Category: Koshiba, S]]
-	[[Category: ~~RSGI, RIKEN~~ Structural ~~Genomics/Proteomics Initiative.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Tanaka, A.]]	+	[[Category: Tanaka, A]]
-	[[Category: Tochio, N.]]	+	[[Category: Tochio, N]]
-	[[Category: Umehara, T.]]	+	[[Category: Umehara, T]]
-	[[Category: Watanabe, S.]]	+	[[Category: Watanabe, S]]
-	[[Category: Yokoyama, S.]]	+	[[Category: Yokoyama, S]]
	[[Category: Hypothetical protein]]		[[Category: Hypothetical protein]]
	[[Category: National project on protein structural and functional analyse]]		[[Category: National project on protein structural and functional analyse]]
	[[Category: Nppsfa]]		[[Category: Nppsfa]]
-	[[Category: Riken structural genomics/proteomics initiative]]
	[[Category: Rsgi]]		[[Category: Rsgi]]
-	[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 02:54, 30 September 2014

2014-09-30T02:54:34Z

←Older revision		Revision as of 02:54, 30 September 2014
Line 1:		Line 1:
-	~~[[Image:2elk.png\|left\|200px]]~~	+	==Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein==
-		+	<StructureSection load='2elk' size='340' side='right' caption='[[2elk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~{{STRUCTURE_2elk\| PDB=2elk \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELK FirstGlance]. <br>
-	===Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein===	+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPCC24B10.08c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2elk RCSB], [http://www.ebi.ac.uk/pdbsum/2elk PDBsum], [http://www.topsan.org/Proteins/RSGI/2elk TOPSAN]</span></td></tr>
-	~~{{ABSTRACT_PUBMED_019086269}}~~	+	<table>
-		+	== Evolutionary Conservation ==
-	==~~About this Structure~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA].	+	Check<jmol>
-		+	<jmolCheckbox>
-	==~~Reference~~==	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/el/2elk_consurf.spt"</scriptWhenChecked>
-	<~~ref group~~="~~xtra~~">~~PMID~~:~~019086269~~</~~ref~~><~~references group~~="~~xtra~~"/>	+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Harada, T.]]		[[Category: Harada, T.]]

OCA: Protected "2elk" [edit=sysop:move=sysop]

2013-01-06T12:05:20Z

Protected "2elk" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:05, 6 January 2013

OCA at 12:05, 6 January 2013

2013-01-06T12:05:17Z

←Older revision		Revision as of 12:05, 6 January 2013
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-	{{Seed}}
	[[Image:2elk.png\|left\|200px]]		[[Image:2elk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2elk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2elk\| PDB=2elk \| SCENE= }}		{{STRUCTURE_2elk\| PDB=2elk \| SCENE= }}

	===Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein===		===Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein===

		+	{{ABSTRACT_PUBMED_019086269}}

	==About this Structure==		==About this Structure==
-	~~2ELK~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA].	+	[[2elk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019086269</ref><references group="xtra"/>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Harada, T.]]		[[Category: Harada, T.]]
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	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:59:14 2009''

OCA at 07:59, 13 May 2009

2009-05-13T07:59:14Z

←Older revision		Revision as of 07:59, 13 May 2009
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	2ELK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full ~~experimental~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA].	+	2ELK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELK OCA].
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Harada, T.]]		[[Category: Harada, T.]]
Line 33:		Line 33:
	[[Category: Transcription]]		[[Category: Transcription]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Nov 16 18~~:39:~~10 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 13 10:59:14 2009''