2f12 - Revision history

OCA at 08:44, 25 October 2023

2023-10-25T08:44:29Z

←Older revision		Revision as of 08:44, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HTM:6~~-~~(3-HYDROXYPROPOXY)-5-ACETAMIDO-5~~,~~6-DIHYDRO-4-HYDROXY-4H-PYRAN-~~2~~-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.27Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [https://pdbe.org/2f12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [https://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [https://pdbe.org/2f12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [https://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.	+	[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN] Hydrolyzes sialylated compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Exo-alpha-sialidase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chavas~~, L M.G~~]]	+	[[Category: Chavas LMG]]
-	[[Category: Dyason~~, J C~~]]	+	[[Category: Dyason JC]]
-	[[Category: Fusi, P]]	+	[[Category: Fusi P]]
-	~~[[Category: Itzstein, M von~~]]	+	[[Category: Kato R]]
-	[[Category: Kato, R]]	+	[[Category: Mann MC]]
-	[[Category: Mann~~, M C~~]]	+	[[Category: Monti E]]
-	[[Category: Monti, E]]	+	[[Category: Tettamanti G]]
-	[[Category: Tettamanti, G]]	+	[[Category: Thomson RJ]]
-	[[Category: Thomson~~, R J~~]]	+	[[Category: Tringali C]]
-	[[Category: Tringali, C]]	+	[[Category: Venerando B]]
-	[[Category: Venerando, B]]	+	[[Category: Wakatsuki S]]
-	[[Category: Wakatsuki, S]]	+	[[Category: Von Itzstein M]]
-	[[Category: ~~Drug design]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Influenza virus]]~~	+
-	~~[[Category: Neuraminidase]]~~	+
-	~~[[Category: Sialidase~~]]	+

OCA at 16:00, 22 December 2021

2021-12-22T16:00:09Z

←Older revision		Revision as of 16:00, 22 December 2021
Line 3:		Line 3:
	<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2F12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [~~http~~://pdbe.org/2f12 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [https://pdbe.org/2f12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [https://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.	+	[[https://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f12 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f12 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:44, 18 March 2020

2020-03-18T10:44:18Z

←Older revision		Revision as of 10:44, 18 March 2020
Line 1:		Line 1:

	==Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor==		==Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor==
-	<StructureSection load='2f12' size='340' side='right' caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>	+	<StructureSection load='2f12' size='340' side='right'caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f12 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f12 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Neuraminidase\|Neuraminidase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chavas, L M.G]]		[[Category: Chavas, L M.G]]
	[[Category: Dyason, J C]]		[[Category: Dyason, J C]]

OCA at 09:03, 14 June 2018

2018-06-14T09:03:20Z

←Older revision		Revision as of 09:03, 14 June 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor==		==Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor==
	<StructureSection load='2f12' size='340' side='right' caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='2f12' size='340' side='right' caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://pdbe.org/2f12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://pdbe.org/2f12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f12 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f12_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f12_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f12 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 13:06, 11 September 2015

2015-09-11T13:06:07Z

←Older revision		Revision as of 13:06, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2f12' size='340' side='right' caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='2f12' size='340' side='right' caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://pdbe.org/2f12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chavas, L M.G]]		[[Category: Chavas, L M.G]]
	[[Category: Dyason, J C]]		[[Category: Dyason, J C]]

OCA at 16:50, 25 December 2014

2014-12-25T16:50:52Z

←Older revision		Revision as of 16:50, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NEUR2_HUMAN NEUR2_HUMAN]] Hydrolyzes sialylated compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chavas, L M.G.]]	+	[[Category: Chavas, L M.G]]
-	[[Category: Dyason, J C.]]	+	[[Category: Dyason, J C]]
-	[[Category: Fusi, P.]]	+	[[Category: Fusi, P]]
-	[[Category: Itzstein, M von.]]	+	[[Category: Itzstein, M von]]
-	[[Category: Kato, R.]]	+	[[Category: Kato, R]]
-	[[Category: Mann, M C.]]	+	[[Category: Mann, M C]]
-	[[Category: Monti, E.]]	+	[[Category: Monti, E]]
-	[[Category: Tettamanti, G.]]	+	[[Category: Tettamanti, G]]
-	[[Category: Thomson, R J.]]	+	[[Category: Thomson, R J]]
-	[[Category: Tringali, C.]]	+	[[Category: Tringali, C]]
-	[[Category: Venerando, B.]]	+	[[Category: Venerando, B]]
-	[[Category: Wakatsuki, S.]]	+	[[Category: Wakatsuki, S]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 04:07, 29 September 2014

2014-09-29T04:07:35Z

←Older revision		Revision as of 04:07, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:2f12.png\|left\|200px]]~~	+	==Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor==
-		+	<StructureSection load='2f12' size='340' side='right' caption='[[2f12]], [[Resolution\|resolution]] 2.27Å' scene=''>
-	~~{{STRUCTURE_2f12\| PDB=2f12 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F12 FirstGlance]. <br>
-	===Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTM:6-(3-HYDROXYPROPOXY)-5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-4H-PYRAN-2-CARBOXYLIC+ACID'>HTM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1snt\|1snt]], [[1so7\|1so7]], [[1vcu\|1vcu]], [[2f0z\|2f0z]], [[2f10\|2f10]], [[2f11\|2f11]], [[2f13\|2f13]], [[2f24\|2f24]], [[2f25\|2f25]], [[2f26\|2f26]], [[2f27\|2f27]], [[2f28\|2f28]], [[2f29\|2f29]]</td></tr>
-	~~{{ABSTRACT_PUBMED_020222714}}~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f12 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f12 RCSB], [http://www.ebi.ac.uk/pdbsum/2f12 PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f12_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:020222714</ref>~~<~~references group="xtra"~~/>	+
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 19:07, 20 October 2012

2012-10-20T19:07:12Z

←Older revision		Revision as of 19:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2f12]] is a 1 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA].	+	[[2f12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA].

	==See Also==		==See Also==

OCA: Protected "2f12" [edit=sysop:move=sysop]

2012-07-27T06:20:28Z

Protected "2f12" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:20, 27 July 2012

OCA at 06:20, 27 July 2012

2012-07-27T06:20:27Z

←Older revision		Revision as of 06:20, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2f12.png\|left\|200px]]		[[Image:2f12.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2f12", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2f12\| PDB=2f12 \| SCENE= }}		{{STRUCTURE_2f12\| PDB=2f12 \| SCENE= }}

	===Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor===		===Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor===

		+	{{ABSTRACT_PUBMED_020222714}}

	==About this Structure==		==About this Structure==
-	~~2F12~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA].	+	[[2f12]] is a 1 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F12 OCA].
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020222714</ref><references group="xtra"/>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 30:		Line 30:
	[[Category: Wakatsuki, S.]]		[[Category: Wakatsuki, S.]]
	[[Category: Drug design]]		[[Category: Drug design]]
		+	[[Category: Hydrolase]]
	[[Category: Influenza virus]]		[[Category: Influenza virus]]
	[[Category: Neuraminidase]]		[[Category: Neuraminidase]]
	[[Category: Sialidase]]		[[Category: Sialidase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:14:18 2009''