2f5i - Revision history

OCA at 13:50, 13 March 2024

2024-03-13T13:50:26Z

←Older revision		Revision as of 13:50, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='2f5i' size='340' side='right'caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2f5i' size='340' side='right'caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Diamine_N~~-~~acetyltransferase Diamine N-acetyltransferase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.3~~.1.57 2.3.1.57] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [https://pdbe.org/2f5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [https://www.ebi.ac.uk/pdbsum/2f5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [https://pdbe.org/2f5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [https://www.ebi.ac.uk/pdbsum/2f5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5i ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[https://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>	+	[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[https://omim.org/entry/308800 308800]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.	+	[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Diamine N-acetyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Vonrhein, C]]	+	[[Category: Vonrhein C]]
-	[[Category: Wang~~, D C~~]]	+	[[Category: Wang DC]]
-	[[Category: Zhu~~, D Y~~]]	+	[[Category: Zhu DY]]
-	[[Category: Zhu~~, Y Q]]~~	+	[[Category: Zhu YQ]]
-	~~[[Category: Beta-alpha-barrel]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:01, 22 December 2021

2021-12-22T16:01:22Z

←Older revision		Revision as of 16:01, 22 December 2021
Line 3:		Line 3:
	<StructureSection load='2f5i' size='340' side='right'caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2f5i' size='340' side='right'caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2F5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [~~http~~://pdbe.org/2f5i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2f5i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [https://pdbe.org/2f5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [https://www.ebi.ac.uk/pdbsum/2f5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5i ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[~~http~~://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>	+	[[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[https://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.	+	[[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:46, 18 March 2020

2020-03-18T10:46:00Z

←Older revision		Revision as of 10:46, 18 March 2020
Line 1:		Line 1:

	==X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens==		==X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens==
-	<StructureSection load='2f5i' size='340' side='right' caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2f5i' size='340' side='right'caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
Line 30:		Line 30:
	[[Category: Diamine N-acetyltransferase]]		[[Category: Diamine N-acetyltransferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Vonrhein, C]]		[[Category: Vonrhein, C]]
	[[Category: Wang, D C]]		[[Category: Wang, D C]]

OCA at 09:14, 14 June 2018

2018-06-14T09:14:48Z

←Older revision		Revision as of 09:14, 14 June 2018
Line 1:		Line 1:
		+
	==X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens==		==X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens==
	<StructureSection load='2f5i' size='340' side='right' caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2f5i' size='340' side='right' caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [http://pdbe.org/2f5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [http://www.ebi.ac.uk/pdbsum/2f5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [http://pdbe.org/2f5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [http://www.ebi.ac.uk/pdbsum/2f5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5i ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:26, 9 February 2016

2016-02-09T08:26:57Z

←Older revision		Revision as of 08:26, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f5i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 20:27, 10 September 2015

2015-09-10T20:27:03Z

←Older revision		Revision as of 20:27, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2f5i' size='340' side='right' caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2f5i' size='340' side='right' caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [http://www.ebi.ac.uk/pdbsum/2f5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [http://pdbe.org/2f5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [http://www.ebi.ac.uk/pdbsum/2f5i PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Diamine N-acetyltransferase]]		[[Category: Diamine N-acetyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Vonrhein, C]]		[[Category: Vonrhein, C]]
	[[Category: Wang, D C]]		[[Category: Wang, D C]]

OCA at 09:23, 16 January 2015

2015-01-16T09:23:40Z

←Older revision		Revision as of 09:23, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>		<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [http://www.ebi.ac.uk/pdbsum/2f5i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [http://www.ebi.ac.uk/pdbsum/2f5i PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[http://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>		[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[http://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>
Line 29:		Line 29:
	[[Category: Diamine N-acetyltransferase]]		[[Category: Diamine N-acetyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Vonrhein, C.]]	+	[[Category: Vonrhein, C]]
-	[[Category: Wang, D C.]]	+	[[Category: Wang, D C]]
-	[[Category: Zhu, D Y.]]	+	[[Category: Zhu, D Y]]
-	[[Category: Zhu, Y Q.]]	+	[[Category: Zhu, Y Q]]
	[[Category: Beta-alpha-barrel]]		[[Category: Beta-alpha-barrel]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 01:18, 30 September 2014

2014-09-30T01:18:47Z

←Older revision		Revision as of 01:18, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2f5i\| PDB=2f5i \| SCENE= }}~~	+	==X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens==
-	===X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens===	+	<StructureSection load='2f5i' size='340' side='right' caption='[[2f5i]], [[Resolution\|resolution]] 2.30Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[http://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref><ref>PMID:12215835</ref>	+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diamine_N-acetyltransferase Diamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.57 2.3.1.57] </span></td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [http://www.ebi.ac.uk/pdbsum/2f5i PDBsum]</span></td></tr>
-	==Function==	+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[http://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.		[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
-		+	== Evolutionary Conservation ==
-	==~~About this Structure~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	[[~~2f5i~~]] ~~is a 2 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2F5I OCA~~].	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Spermidine/spermine N-acetyltransferase\|Spermidine/spermine N-acetyltransferase]]		*[[Spermidine/spermine N-acetyltransferase\|Spermidine/spermine N-acetyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:016544326</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Diamine N-acetyltransferase]]		[[Category: Diamine N-acetyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 05:02, 25 March 2013

2013-03-25T05:02:56Z

←Older revision		Revision as of 05:02, 25 March 2013
Line 1:		Line 1:
-	[[Image:2f5i.png\|left\|200px]]
-
	{{STRUCTURE_2f5i\| PDB=2f5i \| SCENE= }}		{{STRUCTURE_2f5i\| PDB=2f5i \| SCENE= }}
		+	===X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens===

-	===X-~~ray structure of spermidine/spermine N1-acetyltransferase~~ (~~SAT~~) ~~from Homo sapiens===~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[http://omim.org/entry/308800 308800]]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref><ref>PMID:12215835</ref>

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN]] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.

	==About this Structure==		==About this Structure==
Line 13:		Line 15:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:016544326</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016544326</ref><references group="xtra"/><references/>
	[[Category: Diamine N-acetyltransferase]]		[[Category: Diamine N-acetyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 13:16, 20 October 2012

2012-10-20T13:16:24Z

←Older revision		Revision as of 13:16, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2f5i]] is a 2 chain structure ~~of [[Spermidine/spermine N-acetyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA].	+	[[2f5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA].

	==See Also==		==See Also==