2fwj - Revision history

OCA at 09:32, 30 August 2023

2023-08-30T09:32:37Z

←Older revision		Revision as of 09:32, 30 August 2023
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	<StructureSection load='2fwj' size='340' side='right'caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2fwj' size='340' side='right'caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"acetimonas_aceti"_(pasteur_1864)_orla-jensen_1909 "acetimonas~~ aceti~~" (pasteur 1864) orla-jensen 1909~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AIR:5~~-~~AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1u11\|1u11]]~~</~~div~~>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 "Acetimonas aceti" (Pasteur 1864) Orla-Jensen 1909])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [https://pdbe.org/2fwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [https://www.ebi.ac.uk/pdbsum/2fwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fwj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [https://pdbe.org/2fwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [https://www.ebi.ac.uk/pdbsum/2fwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fwj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q2QJL3_ACEAC Q2QJL3_ACEAC]] Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity).[PIRNR:PIRNR001338]	+	[https://www.uniprot.org/uniprot/Q2QJL3_ACEAC Q2QJL3_ACEAC] Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity).[PIRNR:PIRNR001338]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acetobacter aceti]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kappock~~, T J~~]]	+	[[Category: Kappock TJ]]
-	[[Category: Starks~~, C M]]~~	+	[[Category: Starks CM]]
-	~~[[Category: Acidophile]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Pure]]~~	+
-	~~[[Category: Purine biosynthesis~~]]	+

OCA at 15:34, 3 March 2021

2021-03-03T15:34:52Z

←Older revision		Revision as of 15:34, 3 March 2021
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	==Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from the acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)==		==Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from the acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)==
-	<StructureSection load='2fwj' size='340' side='right' caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2fwj' size='340' side='right'caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"acetimonas_aceti"_(pasteur_1864)_orla-jensen_1909 "acetimonas aceti" (pasteur 1864) orla-jensen 1909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"acetimonas_aceti"_(pasteur_1864)_orla-jensen_1909 "acetimonas aceti" (pasteur 1864) orla-jensen 1909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u11\|1u11]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 "Acetimonas aceti" (Pasteur 1864) Orla-Jensen 1909])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 "Acetimonas aceti" (Pasteur 1864) Orla-Jensen 1909])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [~~http~~://pdbe.org/2fwj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2fwj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2fwj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [https://pdbe.org/2fwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [https://www.ebi.ac.uk/pdbsum/2fwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fwj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q2QJL3_ACEAC Q2QJL3_ACEAC]] Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity).[PIRNR:PIRNR001338]	+	[[https://www.uniprot.org/uniprot/Q2QJL3_ACEAC Q2QJL3_ACEAC]] Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity).[PIRNR:PIRNR001338]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Phosphoribosylaminoimidazole carboxylase\|Phosphoribosylaminoimidazole carboxylase]]	+	*[[Phosphoribosylaminoimidazole carboxylase 3D structures\|Phosphoribosylaminoimidazole carboxylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kappock, T J]]		[[Category: Kappock, T J]]
	[[Category: Starks, C M]]		[[Category: Starks, C M]]

OCA at 07:18, 20 June 2018

2018-06-20T07:18:55Z

←Older revision		Revision as of 07:18, 20 June 2018
Line 1:		Line 1:
		+
	==Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from the acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)==		==Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from the acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)==
	<StructureSection load='2fwj' size='340' side='right' caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2fwj' size='340' side='right' caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 "Acetimonas aceti" (Pasteur 1864) Orla-Jensen 1909])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 "Acetimonas aceti" (Pasteur 1864) Orla-Jensen 1909])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [http://pdbe.org/2fwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [http://www.ebi.ac.uk/pdbsum/2fwj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [http://pdbe.org/2fwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [http://www.ebi.ac.uk/pdbsum/2fwj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fwj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fwj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fwj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:16, 10 February 2016

2016-02-10T05:16:03Z

←Older revision		Revision as of 05:16, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fwj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:44, 11 September 2015

2015-09-11T05:44:19Z

←Older revision		Revision as of 05:44, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2fwj' size='340' side='right' caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2fwj' size='340' side='right' caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Acetobacter_aceti Acetobacter~~ aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"acetimonas_aceti"_(pasteur_1864)_orla-jensen_1909 "acetimonas aceti" (pasteur 1864) orla-jensen 1909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 ~~Acetobacter~~ aceti])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 "Acetimonas aceti" (Pasteur 1864) Orla-Jensen 1909])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [http://www.ebi.ac.uk/pdbsum/2fwj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [http://pdbe.org/2fwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [http://www.ebi.ac.uk/pdbsum/2fwj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2fwj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetobacter aceti]]
	[[Category: Kappock, T J]]		[[Category: Kappock, T J]]
	[[Category: Starks, C M]]		[[Category: Starks, C M]]

OCA at 12:04, 25 December 2014

2014-12-25T12:04:39Z

←Older revision		Revision as of 12:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 Acetobacter aceti])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 Acetobacter aceti])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [http://www.ebi.ac.uk/pdbsum/2fwj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [http://www.ebi.ac.uk/pdbsum/2fwj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q2QJL3_ACEAC Q2QJL3_ACEAC]] Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity).[PIRNR:PIRNR001338]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Acetobacter aceti]]		[[Category: Acetobacter aceti]]
-	[[Category: Kappock, T J.]]	+	[[Category: Kappock, T J]]
-	[[Category: Starks, C M.]]	+	[[Category: Starks, C M]]
	[[Category: Acidophile]]		[[Category: Acidophile]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Pure]]		[[Category: Pure]]
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

OCA at 08:58, 30 September 2014

2014-09-30T08:58:24Z

←Older revision		Revision as of 08:58, 30 September 2014
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-	[[~~Image:~~2fwj.~~png~~\|~~left~~\|200px]]	+	==Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from the acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)==
		+	<StructureSection load='2fwj' size='340' side='right' caption='[[2fwj]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2fwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FWJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIR:5-AMINOIMIDAZOLE+RIBONUCLEOTIDE'>AIR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u11\|1u11]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">purE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=435 Acetobacter aceti])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fwj RCSB], [http://www.ebi.ac.uk/pdbsum/2fwj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fwj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) mutase (PurE) catalyzes the reversible interconversion of acid-labile compounds N5-CAIR and 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). We have examined PurE from the acidophilic bacterium Acetobacter aceti (AaPurE), focusing on its adaptation to acid pH and the roles of conserved residues His59 and His89. Both AaPurE and Escherichia coli PurE showed quasi-reversible acid-mediated inactivation, but wt AaPurE was much more stable at pH 3.5, with a > or = 20 degrees C higher thermal unfolding temperature at all pHs. His89 is not essential and does not function as part of a proton relay system. The kcat pH-rate profile was consistent with the assignment of pK1 to unproductive protonation of bound nucleotide and pK2 to deprotonation of His59. A 1.85 A resolution crystal structure of the inactive mutant H59N-AaPurE soaked in CAIR showed that protonation of CAIR C4 can occur in the absence of His59. The resulting species, modeled as isoCAIR [4(R)-carboxy-5-iminoimidazoline ribonucleotide], is strongly stabilized by extensive interactions with the enzyme and a water molecule. The carboxylate moiety is positioned in a small pocket proposed to facilitate nucleotide decarboxylation in the forward direction (N5-CAIR --> CAIR) [Meyer, E., Kappock, T. J., Osuji, C., and Stubbe, J. (1999) Biochemistry 38, 3012-3018]. Comparisons with model studies suggest that in the reverse (nonbiosynthetic) direction PurE favors protonation of CAIR C4. We suggest that the essential role of protonated His59 is to lower the barrier to decarboxylation by stabilizing a CO2-azaenolate intermediate.

-	~~{{STRUCTURE_2fwj\| PDB=2fwj \| SCENE= }}~~	+	Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti.,Constantine CZ, Starks CM, Mill CP, Ransome AE, Karpowicz SJ, Francois JA, Goodman RA, Kappock TJ Biochemistry. 2006 Jul 11;45(27):8193-208. PMID:16819818<ref>PMID:16819818</ref>

-	~~===Structure~~ of ~~PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from~~ the ~~acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_16819818}}~~	+	==See Also==
-		+	*[[Phosphoribosylaminoimidazole carboxylase\|Phosphoribosylaminoimidazole carboxylase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2fwj~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:016819818<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Acetobacter aceti]]		[[Category: Acetobacter aceti]]
	[[Category: Kappock, T J.]]		[[Category: Kappock, T J.]]

OCA: Protected "2fwj" [edit=sysop:move=sysop]

2013-01-07T11:17:58Z

Protected "2fwj" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:17, 7 January 2013

OCA at 11:17, 7 January 2013

2013-01-07T11:17:56Z

←Older revision		Revision as of 11:17, 7 January 2013
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-	{{Seed}}
	[[Image:2fwj.png\|left\|200px]]		[[Image:2fwj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2fwj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2fwj\| PDB=2fwj \| SCENE= }}		{{STRUCTURE_2fwj\| PDB=2fwj \| SCENE= }}

	===Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from the acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)===		===Structure of PurE (N5-carboxyaminoimidazole ribonucleotide mutase) from the acidophilic bacterium Acetobacter aceti, complexed with AIR (5-aminoimidazole ribonucleotide)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16819818}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16819818 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16819818}}		{{ABSTRACT_PUBMED_16819818}}

	==About this Structure==		==About this Structure==
-	~~2FWJ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA].	+	[[2fwj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16819818~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016819818</ref><references group="xtra"/>
	[[Category: Acetobacter aceti]]		[[Category: Acetobacter aceti]]
	[[Category: Kappock, T J.]]		[[Category: Kappock, T J.]]
	[[Category: Starks, C M.]]		[[Category: Starks, C M.]]
	[[Category: Acidophile]]		[[Category: Acidophile]]
		+	[[Category: Lyase]]
	[[Category: Pure]]		[[Category: Pure]]
	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:42:50 2009''

OCA at 13:42, 17 February 2009

2009-02-17T13:42:52Z

←Older revision		Revision as of 13:42, 17 February 2009
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	==About this Structure==		==About this Structure==
-	2FWJ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA].	+	2FWJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Acetobacter_aceti Acetobacter aceti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWJ OCA].

	==Reference==		==Reference==
-	Biochemical and structural studies of N5-carboxyaminoimidazole ribonucleotide mutase from the acidophilic bacterium Acetobacter aceti., Constantine CZ, Starks CM, Mill CP, Ransome AE, Karpowicz SJ, Francois JA, Goodman RA, Kappock TJ, Biochemistry. 2006 Jul 11;45(27):8193-208. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16819818 16819818]~~	+	<ref group="xtra">PMID:16819818</ref><references group="xtra"/>
	[[Category: Acetobacter aceti]]		[[Category: Acetobacter aceti]]
-	[[Category: Single protein]]
	[[Category: Kappock, T J.]]		[[Category: Kappock, T J.]]
	[[Category: Starks, C M.]]		[[Category: Starks, C M.]]
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	[[Category: Purine biosynthesis]]		[[Category: Purine biosynthesis]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 21~~:27:~~27 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:42:50 2009''