2g7b - Revision history

OCA at 18:49, 10 March 2021

2021-03-10T18:49:54Z

←Older revision		Revision as of 18:49, 10 March 2021
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	==Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution==		==Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution==
-	<StructureSection load='2g7b' size='340' side='right' caption='[[2g7b]], [[Resolution\|resolution]] 1.18Å' scene=''>	+	<StructureSection load='2g7b' size='340' side='right'caption='[[2g7b]], [[Resolution\|resolution]] 1.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g7b]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2G7B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G7B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [~~http~~://pdbe.org/2g7b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2g7b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [https://pdbe.org/2g7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [https://www.ebi.ac.uk/pdbsum/2g7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.	+	[[https://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2g7b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2g7b" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein 3D structures\|Cellular retinoic acid-binding protein 3D structures]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 41:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Geiger, J H]]		[[Category: Geiger, J H]]
	[[Category: Vaezeslami, S]]		[[Category: Vaezeslami, S]]

OCA at 07:48, 18 October 2017

2017-10-18T07:48:54Z

←Older revision		Revision as of 07:48, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution==		==Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution==
	<StructureSection load='2g7b' size='340' side='right' caption='[[2g7b]], [[Resolution\|resolution]] 1.18Å' scene=''>		<StructureSection load='2g7b' size='340' side='right' caption='[[2g7b]], [[Resolution\|resolution]] 1.18Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [http://pdbe.org/2g7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [http://www.ebi.ac.uk/pdbsum/2g7b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [http://pdbe.org/2g7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [http://www.ebi.ac.uk/pdbsum/2g7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g7b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2g7b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2g7b" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
-	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
-	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
-	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:49, 11 September 2015

2015-09-11T15:49:38Z

←Older revision		Revision as of 15:49, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2g7b' size='340' side='right' caption='[[2g7b]], [[Resolution\|resolution]] 1.18Å' scene=''>		<StructureSection load='2g7b' size='340' side='right' caption='[[2g7b]], [[Resolution\|resolution]] 1.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2g7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G7B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2g7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G7B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [http://www.ebi.ac.uk/pdbsum/2g7b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [http://pdbe.org/2g7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [http://www.ebi.ac.uk/pdbsum/2g7b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2g7b" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Geiger, J H]]		[[Category: Geiger, J H]]
	[[Category: Vaezeslami, S]]		[[Category: Vaezeslami, S]]

OCA at 18:36, 25 December 2014

2014-12-25T18:36:39Z

←Older revision		Revision as of 18:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2g7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2g7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G7B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [http://www.ebi.ac.uk/pdbsum/2g7b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [http://www.ebi.ac.uk/pdbsum/2g7b PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RABP2_HUMAN RABP2_HUMAN]] Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Geiger, J H.]]	+	[[Category: Geiger, J H]]
-	[[Category: Vaezeslami, S.]]	+	[[Category: Vaezeslami, S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]

OCA at 06:03, 29 September 2014

2014-09-29T06:03:14Z

←Older revision		Revision as of 06:03, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2g7b.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution==
		+	<StructureSection load='2g7b' size='340' side='right' caption='[[2g7b]], [[Resolution\|resolution]] 1.18Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2g7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G7B FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZE:ALL-TRANS+AXEROPHTHENE'>AZE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g7a\|2g7a]], [[2g79\|2g79]], [[2g78\|2g78]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CRABP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g7b RCSB], [http://www.ebi.ac.uk/pdbsum/2g7b PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rational redesign of the binding pocket of Cellular Retinoic Acid Binding Protein II (CRABPII) has provided a mutant that can bind retinal as a protonated Schiff base, mimicking the binding observed in rhodopsin. The reengineering was accomplished through a series of choreographed manipulations to ultimately orient the reactive species (the epsilon-amino group of Lys132 and the carbonyl of retinal) in the proper geometry for imine formation. The guiding principle was to achieve the appropriate Burgi-Dunitz trajectory for the reaction to ensue. Through crystallographic analysis of protein mutants incapable of forming the requisite Schiff base, a highly ordered water molecule was identified as a key culprit in orienting retinal in a nonconstructive manner. Removal of the ordered water, along with placing reinforcing mutations to favor the desired orientation of retinal, led to a triple mutant CRABPII protein capable of nanomolar binding of retinal as a protonated Schiff base. The high-resolution crystal structure of all-trans-retinal bound to the CRABPII triple mutant (1.2 A resolution) unequivocally illustrates the imine formed between retinal and the protein.

-	~~{{STRUCTURE_2g7b\| PDB=2g7b \| SCENE= }}~~	+	Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic.,Vasileiou C, Vaezeslami S, Crist RM, Rabago-Smith M, Geiger JH, Borhan B J Am Chem Soc. 2007 May 16;129(19):6140-8. Epub 2007 Apr 21. PMID:17447762<ref>PMID:17447762</ref>

-	~~===Crystal Structure~~ of the ~~R132K:R111L:L121E mutant~~ of ~~Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1~~.~~18 Angstroms Resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17447762}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2g7b]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA].~~	+

	==See Also==		==See Also==
Line 15:		Line 32:
	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]		*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]		*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017447762<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]

OCA at 20:04, 20 October 2012

2012-10-20T20:04:33Z

←Older revision		Revision as of 20:04, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2g7b]] is a 1 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA].	+	[[2g7b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA].

	==See Also==		==See Also==

OCA: Protected "2g7b" [edit=sysop:move=sysop]

2012-07-27T09:20:12Z

Protected "2g7b" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:20, 27 July 2012

OCA at 09:20, 27 July 2012

2012-07-27T09:20:11Z

←Older revision		Revision as of 09:20, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2g7b.png\|left\|200px]]		[[Image:2g7b.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2g7b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2g7b\| PDB=2g7b \| SCENE= }}		{{STRUCTURE_2g7b\| PDB=2g7b \| SCENE= }}

	===Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution===		===Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17447762}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17447762 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17447762}}		{{ABSTRACT_PUBMED_17447762}}

	==About this Structure==		==About this Structure==
-	~~2G7B~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA].	+	[[2g7b]] is a 1 chain structure of [[CRABP I ( Cellular Retinoic Acid Binding Protein )]], [[Cellular retinoic acid-binding protein]], [[Gustavo Elberto Epalza Sanchez/Sandbox 1]] and [[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA].
		+
		+	==See Also==
		+	*[[CRABP I ( Cellular Retinoic Acid Binding Protein )\|CRABP I ( Cellular Retinoic Acid Binding Protein )]]
		+	*[[Cellular retinoic acid-binding protein\|Cellular retinoic acid-binding protein]]
		+	*[[Gustavo Elberto Epalza Sanchez/Sandbox 1\|Gustavo Elberto Epalza Sanchez/Sandbox 1]]
		+	*[[Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)\|Molecular Playground/CRABP I (Cellular Retinoic Acid Binding Protein)]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17447762~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017447762</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]
Line 29:		Line 23:
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Crabpii]]		[[Category: Crabpii]]
-	[[Category: Crystallography]]
	[[Category: High resolution]]		[[Category: High resolution]]
	[[Category: Protonated schiff base]]		[[Category: Protonated schiff base]]
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	[[Category: Retinoid]]		[[Category: Retinoid]]
	[[Category: Schiff base]]		[[Category: Schiff base]]
-	[[Category: ~~X-ray~~]]	+	[[Category: Transport protein]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:42:00 2009''~~	+

OCA at 00:42, 18 February 2009

2009-02-18T00:42:01Z

←Older revision		Revision as of 00:42, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2G7B is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA].	+	2G7B is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7B OCA].

	==Reference==		==Reference==
-	Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic., Vasileiou C, Vaezeslami S, Crist RM, Rabago-Smith M, Geiger JH, Borhan B, J Am Chem Soc. 2007 May 16;129(19):6140-8. Epub 2007 Apr 21. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17447762 17447762]~~	+	<ref group="xtra">PMID:17447762</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Geiger, J H.]]		[[Category: Geiger, J H.]]
	[[Category: Vaezeslami, S.]]		[[Category: Vaezeslami, S.]]
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	[[Category: X-ray]]		[[Category: X-ray]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 09~~:19:~~01 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:42:00 2009''

OCA at 06:19, 29 July 2008

2008-07-29T06:19:07Z

←Older revision		Revision as of 06:19, 29 July 2008
Line 1:		Line 1:
-	[[Image:2g7b.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2g7b.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2g7b\| PDB=2g7b \| SCENE= }}		{{STRUCTURE_2g7b\| PDB=2g7b \| SCENE= }}

-	~~'''~~Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution~~'''~~	+	===Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution===


-	~~==Overview==~~	+	<!--
-	~~Rational redesign of the binding pocket of Cellular Retinoic Acid Binding Protein II (CRABPII) has provided a mutant that can bind retinal as a protonated Schiff base~~, ~~mimicking~~ the ~~binding observed in rhodopsin. The reengineering was accomplished through a series of choreographed manipulations~~ to ~~ultimately orient~~ the ~~reactive species~~ (~~the epsilon-amino group of Lys132 and the carbonyl of retinal) in the proper geometry for imine formation~~. ~~The guiding principle was to achieve the appropriate Burgi-Dunitz trajectory for the reaction to ensue~~. ~~Through crystallographic analysis of protein mutants incapable of forming the requisite Schiff base~~, ~~a highly ordered water molecule was identified as a key culprit in orienting retinal in a nonconstructive manner. Removal of~~ the ordered water, along with placing reinforcing mutations to favor the desired orientation of retinal, led to a triple mutant CRABPII protein capable of nanomolar binding of retinal as a protonated Schiff base. ~~The high~~-~~resolution crystal structure of all~~-~~trans-retinal bound to the CRABPII triple mutant (1.2 A resolution) unequivocally illustrates the imine formed between retinal and the protein.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_17447762}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17447762 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17447762}}

	==About this Structure==		==About this Structure==
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	[[Category: Schiff base]]		[[Category: Schiff base]]
	[[Category: X-ray]]		[[Category: X-ray]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:46:20 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:19:01 2008''