2geg - Revision history

OCA at 14:43, 29 December 2021

2021-12-29T14:43:46Z

←Older revision		Revision as of 14:43, 29 December 2021
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	<StructureSection load='2geg' size='340' side='right'caption='[[2geg]]' scene=''>		<StructureSection load='2geg' size='340' side='right'caption='[[2geg]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GEG FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GEG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2geg FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/2geg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2geg ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2geg FirstGlance], [https://www.ebi.ac.uk/pdbsum/2geg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2geg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:13, 27 March 2020

2020-03-27T11:13:38Z

←Older revision		Revision as of 11:13, 27 March 2020
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	==THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.==		==THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.==
-	<StructureSection load='2geg' size='340' side='right' caption='[[2geg]]' scene=''>	+	<StructureSection load='2geg' size='340' side='right'caption='[[2geg]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEG FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEG FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Carlsson, J]]		[[Category: Carlsson, J]]
	[[Category: Persson, B]]		[[Category: Persson, B]]

OCA at 07:26, 20 June 2018

2018-06-20T07:26:07Z

←Older revision		Revision as of 07:26, 20 June 2018
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEG FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2geg FirstGlance], [http://www.ebi.ac.uk/pdbsum/2geg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2geg FirstGlance], [http://www.ebi.ac.uk/pdbsum/2geg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2geg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:40, 11 February 2016

2016-02-11T10:40:17Z

←Older revision		Revision as of 10:40, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.==		==THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.==
	<StructureSection load='2geg' size='340' side='right' caption='[[2geg]]' scene=''>		<StructureSection load='2geg' size='340' side='right' caption='[[2geg]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Carlsson, J]]		[[Category: Carlsson, J]]
	[[Category: Persson, B]]		[[Category: Persson, B]]

OCA at 08:10, 10 September 2015

2015-09-10T08:10:09Z

←Older revision		Revision as of 08:10, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2geg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:30, 16 January 2015

2015-01-16T09:30:05Z

←Older revision		Revision as of 09:30, 16 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEG FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2geg FirstGlance], [http://www.ebi.ac.uk/pdbsum/2geg PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2geg FirstGlance], [http://www.ebi.ac.uk/pdbsum/2geg PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:24, 29 September 2014

2014-09-29T05:24:26Z

←Older revision		Revision as of 05:24, 29 September 2014
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-	~~{{Theoretical_model}}~~	+	==THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.==
		+	<StructureSection load='2geg' size='340' side='right' caption='[[2geg]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GEG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2geg FirstGlance], [http://www.ebi.ac.uk/pdbsum/2geg PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enhanced understanding of structure-function relationships of human 21-hydroxylase, CYP21, is required to better understand the molecular causes of congenital adrenal hyperplasia. To this end, a structural model of human CYP21 was calculated based on the crystal structure of rabbit CYP2C5. All but two known allelic variants of missense type, a total of 60 disease-causing mutations and six normal variants, were analyzed using this model. A structural explanation for the corresponding phenotype was found for all but two mutants for which available clinical data are also discrepant with in vitro enzyme activity. Calculations of protein stability of modeled mutants were found to correlate inversely with the corresponding clinical severity. Putative structurally important residues were identified to be involved in heme and substrate binding, redox partner interaction, and enzyme catalysis using docking calculations and analysis of structurally determined homologous cytochrome P450s (CYPs). Functional and structural consequences of seven novel mutations, V139E, C147R, R233G, T295N, L308F, R366C, and M473I, detected in Scandinavian patients with suspected congenital adrenal hyperplasia of different severity, were predicted using molecular modeling. Structural features deduced from the models are in good correlation with clinical severity of CYP21 mutants, which shows the applicability of a modeling approach in assessment of new CYP21 mutations.

-	~~[[Image~~:~~2geg~~.~~png\|left\|200px]]~~	+	Molecular model of human CYP21 based on mammalian CYP2C5: structural features correlate with clinical severity of mutations causing congenital adrenal hyperplasia.,Robins T, Carlsson J, Sunnerhagen M, Wedell A, Persson B Mol Endocrinol. 2006 Nov;20(11):2946-64. Epub 2006 Jun 20. PMID:16788163<ref>PMID:16788163</ref>

-	~~{{STRUCTURE_2geg\| PDB=2geg \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~===THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450~~, ~~21- HYDROXYLASE) BASED ON RABBIT CYP2C5~~.~~===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_16788163}}~~	+	__TOC__
-		+	</StructureSection>
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016788163<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Carlsson, J]]		[[Category: Carlsson, J]]
	[[Category: Persson, B]]		[[Category: Persson, B]]

OCA: Protected "2geg" [edit=sysop:move=sysop]

2012-10-21T10:03:18Z

Protected "2geg" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:03, 21 October 2012

OCA at 10:03, 21 October 2012

2012-10-21T10:03:16Z

←Older revision		Revision as of 10:03, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:2geg.png\|left\|200px]]		[[Image:2geg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2geg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2geg\| PDB=2geg \| SCENE= }}		{{STRUCTURE_2geg\| PDB=2geg \| SCENE= }}

	===THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.===		===THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16788163}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16788163 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16788163}}		{{ABSTRACT_PUBMED_16788163}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16788163~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016788163</ref><references group="xtra"/>
	[[Category: Carlsson, J]]		[[Category: Carlsson, J]]
	[[Category: Persson, B]]		[[Category: Persson, B]]
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	[[Category: Sunnerhagen, M]]		[[Category: Sunnerhagen, M]]
	[[Category: Wedell, A]]		[[Category: Wedell, A]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:28:20 2010''

OCA at 06:28, 8 April 2010

2010-04-08T06:28:21Z

←Older revision		Revision as of 06:28, 8 April 2010
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-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:2geg.png\|left\|200px]]

-	The ~~entry 2GEG is a Theoretical Model titled 'Theoretical model of human CYP21 (cytochrome p450~~, ~~21-hydroxylase) based~~ on ~~rabbit CYP2C5~~.'.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2geg", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2geg\| PDB=2geg \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===THEORETICAL MODEL OF HUMAN CYP21 (CYTOCHROME P450, 21- HYDROXYLASE) BASED ON RABBIT CYP2C5.===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30~~ 09:56:~~53 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_16788163}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16788163 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16788163}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GEG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:16788163</ref><references group="xtra"/>
		+	[[Category: Carlsson, J]]
		+	[[Category: Persson, B]]
		+	[[Category: Robins, T]]
		+	[[Category: Sunnerhagen, M]]
		+	[[Category: Wedell, A]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 09:28:20 2010''