2ggd - Revision history

OCA at 09:40, 30 August 2023

2023-08-30T09:40:29Z

←Older revision		Revision as of 09:40, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2ggd' size='340' side='right'caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ggd' size='340' side='right'caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Agrsc Agrsc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_sp._CP4 Agrobacterium sp. CP4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>~~, ~~<scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>aroA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~268951 AGRSC])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/3-phosphoshikimate_1~~-~~carboxyvinyltransferase~~ 3-~~phosphoshikimate 1-carboxyvinyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [https://pdbe.org/2ggd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [https://www.ebi.ac.uk/pdbsum/2ggd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [https://pdbe.org/2ggd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [https://www.ebi.ac.uk/pdbsum/2ggd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AROA_AGRSC AROA_AGRSC]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[EPSP synthase\|EPSP synthase]]	+	*[[EPSP synthase 3D structures\|EPSP synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~3-phosphoshikimate 1-carboxyvinyltransferase]]~~	+	[[Category: Agrobacterium sp. CP4]]
-	~~[[Category: Agrsc~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Funke, T]]	+	[[Category: Funke T]]
-	[[Category: Schonbrunn, E]]	+	[[Category: Schonbrunn E]]
-	~~[[Category: Inside-out alpha/beta barrel]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Two domain structure~~]]	+

OCA at 19:02, 10 March 2021

2021-03-10T19:02:17Z

←Older revision		Revision as of 19:02, 10 March 2021
Line 1:		Line 1:

	==CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate==		==CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate==
-	<StructureSection load='2ggd' size='340' side='right' caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2ggd' size='340' side='right'caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Agrsc Agrsc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GGD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrsc Agrsc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 AGRSC])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 AGRSC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [~~http~~://pdbe.org/2ggd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ggd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [https://pdbe.org/2ggd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [https://www.ebi.ac.uk/pdbsum/2ggd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 38:		Line 38:
	[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]		[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]
	[[Category: Agrsc]]		[[Category: Agrsc]]
		+	[[Category: Large Structures]]
	[[Category: Funke, T]]		[[Category: Funke, T]]
	[[Category: Schonbrunn, E]]		[[Category: Schonbrunn, E]]

OCA at 06:54, 20 June 2018

2018-06-20T06:54:22Z

←Older revision		Revision as of 06:54, 20 June 2018
Line 1:		Line 1:
		+
	==CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate==		==CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate==
	<StructureSection load='2ggd' size='340' side='right' caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ggd' size='340' side='right' caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 AGRSC])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 AGRSC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [http://pdbe.org/2ggd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [http://www.ebi.ac.uk/pdbsum/2ggd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [http://pdbe.org/2ggd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [http://www.ebi.ac.uk/pdbsum/2ggd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:35, 9 February 2016

2016-02-09T18:35:49Z

←Older revision		Revision as of 18:35, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ggd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:56, 11 September 2015

2015-09-11T00:56:59Z

←Older revision		Revision as of 00:56, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ggd' size='340' side='right' caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ggd' size='340' side='right' caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Agrobacterium_sp._cp4 Agrobacterium sp. cp4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GGD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrsc Agrsc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GGD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 ~~Agrobacterium sp. CP4~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 AGRSC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [http://www.ebi.ac.uk/pdbsum/2ggd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [http://pdbe.org/2ggd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [http://www.ebi.ac.uk/pdbsum/2ggd PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ggd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[EPSP synthase\|EPSP synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]		[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]
-	[[Category: ~~Agrobacterium sp. cp4~~]]	+	[[Category: Agrsc]]
	[[Category: Funke, T]]		[[Category: Funke, T]]
	[[Category: Schonbrunn, E]]		[[Category: Schonbrunn, E]]

OCA at 08:59, 16 January 2015

2015-01-16T08:59:25Z

OCA at 10:30, 30 September 2014

2014-09-30T10:30:20Z

←Older revision		Revision as of 10:30, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ggd.~~png~~\|~~left~~\|200px]]	+	==CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate==
		+	<StructureSection load='2ggd' size='340' side='right' caption='[[2ggd]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp._cp4 Agrobacterium sp. cp4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GGD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 Agrobacterium sp. CP4])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [http://www.ebi.ac.uk/pdbsum/2ggd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/2ggd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The engineering of transgenic crops resistant to the broad-spectrum herbicide glyphosate has greatly improved agricultural efficiency worldwide. Glyphosate-based herbicides, such as Roundup, target the shikimate pathway enzyme 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, the functionality of which is absolutely required for the survival of plants. Roundup Ready plants carry the gene coding for a glyphosate-insensitive form of this enzyme, obtained from Agrobacterium sp. strain CP4. Once incorporated into the plant genome, the gene product, CP4 EPSP synthase, confers crop resistance to glyphosate. Although widely used, the molecular basis for this glyphosate-resistance has remained obscure. We generated a synthetic gene coding for CP4 EPSP synthase and characterized the enzyme using kinetics and crystallography. The CP4 enzyme has unexpected kinetic and structural properties that render it unique among the known EPSP synthases. Glyphosate binds to the CP4 EPSP synthase in a condensed, noninhibitory conformation. Glyphosate sensitivity can be restored through a single-site mutation in the active site (Ala-100-Gly), allowing glyphosate to bind in its extended, inhibitory conformation.

-	~~{{STRUCTURE_2ggd\| PDB=2ggd \| SCENE= }}~~	+	Molecular basis for the herbicide resistance of Roundup Ready crops.,Funke T, Han H, Healy-Fried ML, Fischer M, Schonbrunn E Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13010-5. Epub 2006 Aug 17. PMID:16916934<ref>PMID:16916934</ref>

-	~~===CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16916934}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ggd]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Agrobacterium_sp~~.~~_cp4 Agrobacterium sp. cp4]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016916934<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]		[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]
	[[Category: Agrobacterium sp. cp4]]		[[Category: Agrobacterium sp. cp4]]

OCA: Protected "2ggd" [edit=sysop:move=sysop]

2013-01-07T12:21:17Z

Protected "2ggd" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:21, 7 January 2013

OCA at 12:21, 7 January 2013

2013-01-07T12:21:13Z

←Older revision		Revision as of 12:21, 7 January 2013
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-	{{Seed}}
	[[Image:2ggd.png\|left\|200px]]		[[Image:2ggd.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ggd", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ggd\| PDB=2ggd \| SCENE= }}		{{STRUCTURE_2ggd\| PDB=2ggd \| SCENE= }}

	===CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate===		===CP4 EPSP synthase Ala100Gly liganded with S3P and Glyphosate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16916934}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16916934 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16916934}}		{{ABSTRACT_PUBMED_16916934}}

	==About this Structure==		==About this Structure==
-	~~2GGD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA].	+	[[2ggd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp._cp4 Agrobacterium sp. cp4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16916934~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016916934</ref><references group="xtra"/>
	[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]		[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]
-	[[Category: Agrobacterium sp.]]	+	[[Category: Agrobacterium sp. cp4]]
	[[Category: Funke, T.]]		[[Category: Funke, T.]]
	[[Category: Schonbrunn, E.]]		[[Category: Schonbrunn, E.]]
	[[Category: Inside-out alpha/beta barrel]]		[[Category: Inside-out alpha/beta barrel]]
		+	[[Category: Transferase]]
	[[Category: Two domain structure]]		[[Category: Two domain structure]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:53:16 2009''

OCA at 09:53, 17 February 2009

2009-02-17T09:53:17Z

←Older revision		Revision as of 09:53, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2GGD is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA].	+	2GGD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA].

	==Reference==		==Reference==
-	~~Molecular basis for the herbicide resistance of Roundup Ready crops., Funke T, Han H, Healy-Fried ML, Fischer M, Schonbrunn E, Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13010-5. Epub 2006 Aug 17.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16916934 16916934]~~	+	<ref group="xtra">PMID:16916934</ref><references group="xtra"/>
	[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]		[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]
	[[Category: Agrobacterium sp.]]		[[Category: Agrobacterium sp.]]
-	[[Category: Single protein]]
	[[Category: Funke, T.]]		[[Category: Funke, T.]]
	[[Category: Schonbrunn, E.]]		[[Category: Schonbrunn, E.]]
Line 32:		Line 31:
	[[Category: Two domain structure]]		[[Category: Two domain structure]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 16~~:03:~~48 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:53:16 2009''

←Older revision		Revision as of 08:59, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp._cp4 Agrobacterium sp. cp4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GGD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ggd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp._cp4 Agrobacterium sp. cp4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GGD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GPJ:GLYPHOSATE'>GPJ</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g6t\|1g6t]], [[1g6s\|1g6s]], [[1q36\|1q36]], [[1mi4\|1mi4]], [[1rf5\|1rf5]], [[1rf6\|1rf6]], [[2gg4\|2gg4]], [[2gg6\|2gg6]], [[2gga\|2gga]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 Agrobacterium sp. CP4])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aroA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=268951 Agrobacterium sp. CP4])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [http://www.ebi.ac.uk/pdbsum/2ggd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ggd RCSB], [http://www.ebi.ac.uk/pdbsum/2ggd PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]		[[Category: 3-phosphoshikimate 1-carboxyvinyltransferase]]
	[[Category: Agrobacterium sp. cp4]]		[[Category: Agrobacterium sp. cp4]]
-	[[Category: Funke, T.]]	+	[[Category: Funke, T]]
-	[[Category: Schonbrunn, E.]]	+	[[Category: Schonbrunn, E]]
	[[Category: Inside-out alpha/beta barrel]]		[[Category: Inside-out alpha/beta barrel]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Two domain structure]]		[[Category: Two domain structure]]