2go9 - Revision history

OCA at 18:59, 29 May 2024

2024-05-29T18:59:39Z

←Older revision		Revision as of 18:59, 29 May 2024
Line 1:		Line 1:

	==RRM domains 1 and 2 of Prp24 from S. cerevisiae==		==RRM domains 1 and 2 of Prp24 from S. cerevisiae==
-	<StructureSection load='2go9' size='340' side='right'caption='[[2go9~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='2go9' size='340' side='right'caption='[[2go9]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PRP24 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~4932 ATCC 18824])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [https://pdbe.org/2go9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [https://www.ebi.ac.uk/pdbsum/2go9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2go9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [https://pdbe.org/2go9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [https://www.ebi.ac.uk/pdbsum/2go9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2go9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PRP24_YEAST PRP24_YEAST]] Binds preferentially to the U4/U6 hybrid snRNAs. Can stimulate the annealing of U4 and U6. Could participate in both the formation and disassembly of the U4/U6 hybrid during splicing.	+	[https://www.uniprot.org/uniprot/PRP24_YEAST PRP24_YEAST] Binds preferentially to the U4/U6 hybrid snRNAs. Can stimulate the annealing of U4 and U6. Could participate in both the formation and disassembly of the U4/U6 hybrid during splicing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brow~~, D A~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Butcher~~, S E~~]]	+	[[Category: Brow DA]]
-	[[Category: Kwan~~, S K~~]]	+	[[Category: Butcher SE]]
-	[[Category: Lee~~, D H~~]]	+	[[Category: Kwan SK]]
-	[[Category: Reiter~~, N J~~]]	+	[[Category: Lee DH]]
-	[[Category: Tonelli, M]]	+	[[Category: Reiter NJ]]
-	~~[[Category: Beta-alpha-beta]]~~	+	[[Category: Tonelli M]]
-	~~[[Category: Rbd]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rrm~~]]	+

OCA at 19:11, 10 March 2021

2021-03-10T19:11:31Z

←Older revision		Revision as of 19:11, 10 March 2021
Line 1:		Line 1:

	==RRM domains 1 and 2 of Prp24 from S. cerevisiae==		==RRM domains 1 and 2 of Prp24 from S. cerevisiae==
-	<StructureSection load='2go9' size='340' side='right' caption='[[2go9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='2go9' size='340' side='right'caption='[[2go9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [~~http~~://pdbe.org/2go9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2go9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2go9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [https://pdbe.org/2go9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [https://www.ebi.ac.uk/pdbsum/2go9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2go9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PRP24_YEAST PRP24_YEAST]] Binds preferentially to the U4/U6 hybrid snRNAs. Can stimulate the annealing of U4 and U6. Could participate in both the formation and disassembly of the U4/U6 hybrid during splicing.	+	[[https://www.uniprot.org/uniprot/PRP24_YEAST PRP24_YEAST]] Binds preferentially to the U4/U6 hybrid snRNAs. Can stimulate the annealing of U4 and U6. Could participate in both the formation and disassembly of the U4/U6 hybrid during splicing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Pre-mRNA-splicing ~~factor~~\|Pre-mRNA-splicing ~~factor~~]]	+	*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Brow, D A]]		[[Category: Brow, D A]]
	[[Category: Butcher, S E]]		[[Category: Butcher, S E]]

OCA at 07:26, 20 June 2018

2018-06-20T07:26:52Z

←Older revision		Revision as of 07:26, 20 June 2018
Line 1:		Line 1:
		+
	==RRM domains 1 and 2 of Prp24 from S. cerevisiae==		==RRM domains 1 and 2 of Prp24 from S. cerevisiae==
	<StructureSection load='2go9' size='340' side='right' caption='[[2go9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2go9' size='340' side='right' caption='[[2go9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [http://pdbe.org/2go9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [http://www.ebi.ac.uk/pdbsum/2go9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [http://pdbe.org/2go9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [http://www.ebi.ac.uk/pdbsum/2go9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2go9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2go9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2go9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:20, 9 February 2016

2016-02-09T12:20:41Z

←Older revision		Revision as of 12:20, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2go9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:11, 10 September 2015

2015-09-10T22:11:57Z

←Older revision		Revision as of 22:11, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2go9' size='340' side='right' caption='[[2go9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2go9' size='340' side='right' caption='[[2go9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [http://www.ebi.ac.uk/pdbsum/2go9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [http://pdbe.org/2go9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [http://www.ebi.ac.uk/pdbsum/2go9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2go9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Brow, D A]]		[[Category: Brow, D A]]
	[[Category: Butcher, S E]]		[[Category: Butcher, S E]]

OCA at 06:46, 25 December 2014

2014-12-25T06:46:42Z

←Older revision		Revision as of 06:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [http://www.ebi.ac.uk/pdbsum/2go9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [http://www.ebi.ac.uk/pdbsum/2go9 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRP24_YEAST PRP24_YEAST]] Binds preferentially to the U4/U6 hybrid snRNAs. Can stimulate the annealing of U4 and U6. Could participate in both the formation and disassembly of the U4/U6 hybrid during splicing.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Brow, D A.]]	+	[[Category: Brow, D A]]
-	[[Category: Butcher, S E.]]	+	[[Category: Butcher, S E]]
-	[[Category: Kwan, S K.]]	+	[[Category: Kwan, S K]]
-	[[Category: Lee, D H.]]	+	[[Category: Lee, D H]]
-	[[Category: Reiter, N J.]]	+	[[Category: Reiter, N J]]
-	[[Category: Tonelli, M.]]	+	[[Category: Tonelli, M]]
	[[Category: Beta-alpha-beta]]		[[Category: Beta-alpha-beta]]
	[[Category: Rbd]]		[[Category: Rbd]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rrm]]		[[Category: Rrm]]

OCA at 10:29, 29 September 2014

2014-09-29T10:29:59Z

←Older revision		Revision as of 10:29, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2go9.~~png\|left~~\|200px]]	+	==RRM domains 1 and 2 of Prp24 from S. cerevisiae==
		+	<StructureSection load='2go9' size='340' side='right' caption='[[2go9]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GO9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2go9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2go9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2go9 RCSB], [http://www.ebi.ac.uk/pdbsum/2go9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2go9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The essential Saccharomyces cerevisiae pre-messenger RNA splicing protein 24 (Prp24) has four RNA recognition motifs (RRMs) and facilitates U6 RNA base-pairing with U4 RNA during spliceosome assembly. Prp24 is a component of the free U6 small nuclear ribonucleoprotein particle (snRNP) but not the U4/U6 bi-snRNP, and so is thought to be displaced from U6 by U4/U6 base-pairing. The interaction partners of each of the four RRMs of Prp24 and how these interactions direct U4/U6 pairing are not known. Here we report the crystal structure of the first three RRMs and the solution structure of the first two RRMs of Prp24. Strikingly, RRM 2 forms extensive inter-domain contacts with RRMs 1 and 3. These contacts occupy much of the canonical RNA-binding faces (beta-sheets) of RRMs 1 and 2, but leave the beta-sheet of RRM 3 exposed. Previously identified substitutions in Prp24 that suppress mutations in U4 and U6 spliceosomal RNAs cluster primarily in the beta-sheet of RRM 3, but also in a conserved loop of RRM 2. RNA binding assays and chemical shift mapping indicate that a large basic patch evident on the surface of RRMs 1 and 2 is part of a high affinity U6 RNA binding site. Our results suggest that Prp24 binds free U6 RNA primarily with RRMs 1 and 2, which may remodel the U6 secondary structure. The beta-sheet of RRM 3 then influences U4/U6 pairing through interaction with an unidentified ligand.

-	~~{{STRUCTURE_2go9\| PDB=2go9 \| SCENE= }}~~	+	Structure and interactions of the first three RNA recognition motifs of splicing factor prp24.,Bae E, Reiter NJ, Bingman CA, Kwan SS, Lee D, Phillips GN Jr, Butcher SE, Brow DA J Mol Biol. 2007 Apr 13;367(5):1447-58. Epub 2007 Feb 7. PMID:17320109<ref>PMID:17320109</ref>

-	~~===RRM domains 1 and 2~~ of ~~Prp24 from~~ S. ~~cerevisiae===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17320109}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2go9]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA].~~	+

	==See Also==		==See Also==
	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]		*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017320109<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Brow, D A.]]		[[Category: Brow, D A.]]

OCA at 13:49, 20 October 2012

2012-10-20T13:49:07Z

←Older revision		Revision as of 13:49, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2go9]] is a 1 chain structure ~~of [[Pre-mRNA-splicing factor]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA].	+	[[2go9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA].

	==See Also==		==See Also==

OCA: Protected "2go9" [edit=sysop:move=sysop]

2012-07-26T13:12:33Z

Protected "2go9" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:12, 26 July 2012

OCA at 13:12, 26 July 2012

2012-07-26T13:12:31Z

←Older revision		Revision as of 13:12, 26 July 2012
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-	{{Seed}}
	[[Image:2go9.png\|left\|200px]]		[[Image:2go9.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2go9\| PDB=2go9 \| SCENE= }}		{{STRUCTURE_2go9\| PDB=2go9 \| SCENE= }}

	===RRM domains 1 and 2 of Prp24 from S. cerevisiae===		===RRM domains 1 and 2 of Prp24 from S. cerevisiae===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17320109}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17320109 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17320109}}		{{ABSTRACT_PUBMED_17320109}}

	==About this Structure==		==About this Structure==
-	~~2GO9~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA].	+	[[2go9]] is a 1 chain structure of [[Pre-mRNA-splicing factor]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GO9 OCA].
		+
		+	==See Also==
		+	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17320109~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017320109</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Brow, D A.]]		[[Category: Brow, D A.]]
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	[[Category: Tonelli, M.]]		[[Category: Tonelli, M.]]
	[[Category: Beta-alpha-beta]]		[[Category: Beta-alpha-beta]]
-	[[Category: Nmr]]
	[[Category: Rbd]]		[[Category: Rbd]]
		+	[[Category: Rna binding protein]]
	[[Category: Rrm]]		[[Category: Rrm]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:44:15 2009''