2gov - Revision history

OCA at 18:59, 29 May 2024

2024-05-29T18:59:43Z

←Older revision		Revision as of 18:59, 29 May 2024
Line 1:		Line 1:

	==Solution structure of Murine p22HBP==		==Solution structure of Murine p22HBP==
-	<StructureSection load='2gov' size='340' side='right'caption='[[2gov~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2gov' size='340' side='right'caption='[[2gov]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOV FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Hebp1, Hbp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [https://pdbe.org/2gov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [https://www.ebi.ac.uk/pdbsum/2gov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gov ProSAT], [https://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [https://pdbe.org/2gov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [https://www.ebi.ac.uk/pdbsum/2gov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gov ProSAT], [https://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HEBP1_MOUSE HEBP1_MOUSE]] May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.<ref>PMID:12413491</ref> <ref>PMID:16905545</ref>	+	[https://www.uniprot.org/uniprot/HEBP1_MOUSE HEBP1_MOUSE] May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.<ref>PMID:12413491</ref> <ref>PMID:16905545</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Dias JS]]
-	[[Category: Dias~~, J S~~]]	+	[[Category: Goodfellow BJ]]
-	[[Category: Goodfellow~~, B J~~]]	+	[[Category: Peterson FC]]
-	[[Category: Peterson~~, F C~~]]	+	[[Category: Volkman BF]]
-	[[Category: Volkman~~, B F]]~~	+
-	~~[[Category: Cesg]]~~	+
-	~~[[Category: Heme binding]]~~	+
-	~~[[Category: Heme binding protein]]~~	+
-	~~[[Category: P22hbp]]~~	+
-	~~[[Category: PSI, Protein structure initiative~~]]	+

OCA at 19:11, 10 March 2021

2021-03-10T19:11:58Z

←Older revision		Revision as of 19:11, 10 March 2021
Line 1:		Line 1:

	==Solution structure of Murine p22HBP==		==Solution structure of Murine p22HBP==
-	<StructureSection load='2gov' size='340' side='right' caption='[[2gov]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2gov' size='340' side='right'caption='[[2gov]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [~~http~~://pdbe.org/2gov PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gov PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gov ProSAT], [~~http~~://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [https://pdbe.org/2gov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [https://www.ebi.ac.uk/pdbsum/2gov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gov ProSAT], [https://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HEBP1_MOUSE HEBP1_MOUSE]] May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.<ref>PMID:12413491</ref> <ref>PMID:16905545</ref>	+	[[https://www.uniprot.org/uniprot/HEBP1_MOUSE HEBP1_MOUSE]] May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.<ref>PMID:12413491</ref> <ref>PMID:16905545</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 07:08, 20 June 2018

2018-06-20T07:08:03Z

←Older revision		Revision as of 07:08, 20 June 2018
Line 1:		Line 1:
		+
	==Solution structure of Murine p22HBP==		==Solution structure of Murine p22HBP==
	<StructureSection load='2gov' size='340' side='right' caption='[[2gov]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2gov' size='340' side='right' caption='[[2gov]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOV FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [http://pdbe.org/2gov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [http://www.ebi.ac.uk/pdbsum/2gov PDBsum], [http://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [http://pdbe.org/2gov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [http://www.ebi.ac.uk/pdbsum/2gov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gov ProSAT], [http://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2gov_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2gov_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:43, 9 February 2016

2016-02-09T11:43:04Z

←Older revision		Revision as of 11:43, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gov ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:53, 10 September 2015

2015-09-10T21:53:22Z

←Older revision		Revision as of 21:53, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2gov' size='340' side='right' caption='[[2gov]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2gov' size='340' side='right' caption='[[2gov]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [http://www.ebi.ac.uk/pdbsum/2gov PDBsum], [http://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [http://pdbe.org/2gov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [http://www.ebi.ac.uk/pdbsum/2gov PDBsum], [http://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2gov" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Dias, J S]]		[[Category: Dias, J S]]

OCA at 06:34, 25 December 2014

2014-12-25T06:34:41Z

←Older revision		Revision as of 06:34, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [http://www.ebi.ac.uk/pdbsum/2gov PDBsum], [http://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [http://www.ebi.ac.uk/pdbsum/2gov PDBsum], [http://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEBP1_MOUSE HEBP1_MOUSE]] May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.<ref>PMID:12413491</ref> <ref>PMID:16905545</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: ~~CESG, Center for Eukaryotic~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Dias, J S.]]	+	[[Category: Dias, J S]]
-	[[Category: Goodfellow, B J.]]	+	[[Category: Goodfellow, B J]]
-	[[Category: Peterson, F C.]]	+	[[Category: Peterson, F C]]
-	[[Category: Volkman, B F~~.]]~~	+	[[Category: Volkman, B F]]
-	~~[[Category: Center for eukaryotic structural genomic~~]]	+
	[[Category: Cesg]]		[[Category: Cesg]]
	[[Category: Heme binding]]		[[Category: Heme binding]]
	[[Category: Heme binding protein]]		[[Category: Heme binding protein]]
	[[Category: P22hbp]]		[[Category: P22hbp]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 10:41, 30 September 2014

2014-09-30T10:41:07Z

←Older revision		Revision as of 10:41, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2gov.~~png\|left~~\|200px]]	+	==Solution structure of Murine p22HBP==
		+	<StructureSection load='2gov' size='340' side='right' caption='[[2gov]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GOV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hebp1, Hbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gov RCSB], [http://www.ebi.ac.uk/pdbsum/2gov PDBsum], [http://www.topsan.org/Proteins/CESG/2gov TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/2gov_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Murine p22HBP, a 22-kDa monomer originally identified as a cytosolic heme-binding protein ubiquitously expressed in various tissues, has 27% sequence identity to murine SOUL, a heme-binding hexamer specifically expressed in the retina. In contrast to murine SOUL, which binds one heme per subunit via coordination of the Fe(III)-heme to a histidine, murine p22HBP binds one heme molecule per subunit with no specific axial ligand coordination of the Fe(III)-heme. Using intrinsic protein fluorescence quenching, the values for the dissociation constants of p22HBP for hemin and protoporphyrin-IX were determined to be in the low nanomolar range. The three-dimensional structure of murine p22HBP, the first for a protein from the SOUL/HBP family, was determined by NMR methods to consist of a 9-stranded distorted beta-barrel flanked by two long alpha-helices. Although homologous domains have been found in three bacterial proteins, two of which are transcription factors, the fold determined for p22HBP corresponds to a novel alpha plus beta fold in a eukaryotic protein. Chemical shift mapping localized the tetrapyrrole binding site to a hydrophobic cleft formed by residues from helix alphaA and an extended loop. In an attempt to assess the structural basis for tetrapyrrole binding in the SOUL/HBP family, models for the p22HBP-protoporphyrin-IX complex and the SOUL protein were generated by manual docking and automated methods.

-	~~{{STRUCTURE_2gov\| PDB=2gov \| SCENE= }}~~	+	The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP.,Dias JS, Macedo AL, Ferreira GC, Peterson FC, Volkman BF, Goodfellow BJ J Biol Chem. 2006 Oct 20;281(42):31553-61. Epub 2006 Aug 10. PMID:16905545<ref>PMID:16905545</ref>

-	~~===Solution structure~~ of ~~Murine p22HBP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16905545}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2gov]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016905545<~~/~~ref~~><~~ref group="xtra">PMID:016211492</ref><references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: CESG, Center for Eukaryotic Structural Genomics.]]		[[Category: CESG, Center for Eukaryotic Structural Genomics.]]

OCA at 12:12, 23 January 2013

2013-01-23T12:12:34Z

←Older revision		Revision as of 12:12, 23 January 2013
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	[[Image:2gov.png\|left\|200px]]		[[Image:2gov.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2gov\| PDB=2gov \| SCENE= }}		{{STRUCTURE_2gov\| PDB=2gov \| SCENE= }}

	===Solution structure of Murine p22HBP===		===Solution structure of Murine p22HBP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16905545}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16905545 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16905545}}		{{ABSTRACT_PUBMED_16905545}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16905545~~</ref><ref group="xtra">PMID:~~16211492~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016905545</ref><ref group="xtra">PMID:016211492</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: CESG, Center for Eukaryotic Structural Genomics.]]		[[Category: CESG, Center for Eukaryotic Structural Genomics.]]

OCA: Protected "2gov" [edit=sysop:move=sysop]

2011-03-14T23:55:34Z

Protected "2gov" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:55, 14 March 2011

OCA at 23:55, 14 March 2011

2011-03-14T23:55:32Z

←Older revision		Revision as of 23:55, 14 March 2011
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-	{{Seed}}
	[[Image:2gov.png\|left\|200px]]		[[Image:2gov.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2GOV~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA].	+	[[2gov]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOV OCA].

	==Reference==		==Reference==
Line 33:		Line 32:
	[[Category: Cesg]]		[[Category: Cesg]]
	[[Category: Heme binding]]		[[Category: Heme binding]]
		+	[[Category: Heme binding protein]]
	[[Category: P22hbp]]		[[Category: P22hbp]]
	[[Category: Protein structure initiative]]		[[Category: Protein structure initiative]]
	[[Category: Psi]]		[[Category: Psi]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:30:26 2009''