2gqq - Revision history

OCA at 09:29, 14 February 2024

2024-02-14T09:29:20Z

←Older revision		Revision as of 09:29, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='2gqq' size='340' side='right'caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2gqq' size='340' side='right'caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~lrp~~, ~~alsB, ihb, livR, oppI (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [https://pdbe.org/2gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [https://www.ebi.ac.uk/pdbsum/2gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gqq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [https://pdbe.org/2gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [https://www.ebi.ac.uk/pdbsum/2gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LRP_ECOLI LRP_ECOLI]] Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.	+	[https://www.uniprot.org/uniprot/LRP_ECOLI LRP_ECOLI] Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gqq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gqq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structure of Escherichia coli leucine-responsive regulatory protein (Lrp) co-crystallized with a short duplex oligodeoxynucleotide reveals a novel quaternary assembly in which the protein octamer forms an open, linear array of four dimers. In contrast, structures of the Lrp homologs LrpA, LrpC and AsnC crystallized in the absence of DNA show that these proteins instead form highly symmetrical octamers in which the four dimers form a closed ring. Although the DNA is disordered within the Lrp crystal, comparative analyses suggest that the observed differences in quaternary state may arise from DNA interactions during crystallization. Interconversion of these conformations, possibly in response to DNA or leucine binding, provides an underlying mechanism to alter the relative spatial orientation of the DNA-binding domains. Breaking of the closed octamer symmetry may be a common essential step in the formation of active DNA complexes by all members of the Lrp/AsnC family of transcriptional regulatory proteins.

-	Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly.,de los Rios S, Perona JJ J Mol Biol. 2007 Mar 9;366(5):1589-602. Epub 2006 Dec 19. PMID:17223133<ref>PMID:17223133</ref>	+	==See Also==
-		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 2gqq" style="background-color:#fffaf0;"></div>~~	+
-	== ~~References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Perona~~, J J~~]]	+	[[Category: Perona JJ]]
-	[[Category: Rios, S ~~de los]]~~	+	[[Category: De los Rios S]]
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 19:14, 10 March 2021

2021-03-10T19:14:26Z

←Older revision		Revision as of 19:14, 10 March 2021
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	==Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)==		==Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)==
-	<StructureSection load='2gqq' size='340' side='right' caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='2gqq' size='340' side='right'caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [~~http~~://pdbe.org/2gqq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2gqq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2gqq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [https://pdbe.org/2gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [https://www.ebi.ac.uk/pdbsum/2gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LRP_ECOLI LRP_ECOLI]] Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.	+	[[https://www.uniprot.org/uniprot/LRP_ECOLI LRP_ECOLI]] Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Perona, J J]]		[[Category: Perona, J J]]
	[[Category: Rios, S de los]]		[[Category: Rios, S de los]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 07:00, 20 June 2018

2018-06-20T07:00:03Z

←Older revision		Revision as of 07:00, 20 June 2018
Line 1:		Line 1:
		+
	==Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)==		==Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)==
	<StructureSection load='2gqq' size='340' side='right' caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2gqq' size='340' side='right' caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://pdbe.org/2gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://pdbe.org/2gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/2gqq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/2gqq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:45, 8 February 2016

2016-02-08T21:45:49Z

←Older revision		Revision as of 21:45, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gqq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:40, 10 September 2015

2015-09-10T15:40:40Z

←Older revision		Revision as of 15:40, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2gqq' size='340' side='right' caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2gqq' size='340' side='right' caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://pdbe.org/2gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2gqq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Perona, J J]]		[[Category: Perona, J J]]
	[[Category: Rios, S de los]]		[[Category: Rios, S de los]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 02:21, 25 December 2014

2014-12-25T02:21:25Z

←Older revision		Revision as of 02:21, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LRP_ECOLI LRP_ECOLI]] Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Perona, J J.]]	+	[[Category: Perona, J J]]
-	[[Category: Rios, S de los.]]	+	[[Category: Rios, S de los]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 10:35, 30 September 2014

2014-09-30T10:35:18Z

←Older revision		Revision as of 10:35, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2gqq.~~png\|left~~\|200px]]	+	==Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)==
		+	<StructureSection load='2gqq' size='340' side='right' caption='[[2gqq]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GQQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lrp, alsB, ihb, livR, oppI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gqq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gqq RCSB], [http://www.ebi.ac.uk/pdbsum/2gqq PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/2gqq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of Escherichia coli leucine-responsive regulatory protein (Lrp) co-crystallized with a short duplex oligodeoxynucleotide reveals a novel quaternary assembly in which the protein octamer forms an open, linear array of four dimers. In contrast, structures of the Lrp homologs LrpA, LrpC and AsnC crystallized in the absence of DNA show that these proteins instead form highly symmetrical octamers in which the four dimers form a closed ring. Although the DNA is disordered within the Lrp crystal, comparative analyses suggest that the observed differences in quaternary state may arise from DNA interactions during crystallization. Interconversion of these conformations, possibly in response to DNA or leucine binding, provides an underlying mechanism to alter the relative spatial orientation of the DNA-binding domains. Breaking of the closed octamer symmetry may be a common essential step in the formation of active DNA complexes by all members of the Lrp/AsnC family of transcriptional regulatory proteins.

-	~~{{STRUCTURE_2gqq\| PDB=2gqq \| SCENE= }}~~	+	Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly.,de los Rios S, Perona JJ J Mol Biol. 2007 Mar 9;366(5):1589-602. Epub 2006 Dec 19. PMID:17223133<ref>PMID:17223133</ref>

-	~~===Crystal Structure~~ of E. ~~coli Leucine-responsive regulatory protein (Lrp)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17223133}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2gqq]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017223133<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Perona, J J.]]		[[Category: Perona, J J.]]

OCA: Protected "2gqq" [edit=sysop:move=sysop]

2013-01-07T15:03:50Z

Protected "2gqq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:03, 7 January 2013

OCA at 15:03, 7 January 2013

2013-01-07T15:03:48Z

←Older revision		Revision as of 15:03, 7 January 2013
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-	{{Seed}}
	[[Image:2gqq.png\|left\|200px]]		[[Image:2gqq.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2gqq\| PDB=2gqq \| SCENE= }}		{{STRUCTURE_2gqq\| PDB=2gqq \| SCENE= }}

	===Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)===		===Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17223133}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17223133 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_17223133}}		{{ABSTRACT_PUBMED_17223133}}

	==About this Structure==		==About this Structure==
-	~~2GQQ~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA].	+	[[2gqq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17223133~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017223133</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Perona, J J.]]		[[Category: Perona, J J.]]
	[[Category: Rios, S de los.]]		[[Category: Rios, S de los.]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 03:43:59 2009''~~	+

OCA at 01:44, 17 February 2009

2009-02-17T01:44:00Z

←Older revision		Revision as of 01:44, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2GQQ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA].	+	2GQQ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQQ OCA].

	==Reference==		==Reference==
-	~~Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly., de los Rios S, Perona JJ, J Mol Biol. 2007 Mar 9;366(5):1589-602. Epub 2006 Dec 19.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17223133 17223133]~~	+	<ref group="xtra">PMID:17223133</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Single protein]]
	[[Category: Perona, J J.]]		[[Category: Perona, J J.]]
	[[Category: Rios, S de los.]]		[[Category: Rios, S de los.]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 07~~:06:~~46 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:43:59 2009''