2grv - Revision history

OCA at 19:15, 10 March 2021

2021-03-10T19:15:06Z

←Older revision		Revision as of 19:15, 10 March 2021
Line 1:		Line 1:

	==Crystal Structure of LpqW==		==Crystal Structure of LpqW==
-	<StructureSection load='2grv' size='340' side='right' caption='[[2grv]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2grv' size='340' side='right'caption='[[2grv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2GRV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GRV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [~~http~~://pdbe.org/2grv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2grv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2grv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [https://pdbe.org/2grv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [https://www.ebi.ac.uk/pdbsum/2grv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2grv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]
	[[Category: Marland, Z]]		[[Category: Marland, Z]]

OCA at 07:59, 18 October 2017

2017-10-18T07:59:21Z

←Older revision		Revision as of 07:59, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of LpqW==		==Crystal Structure of LpqW==
	<StructureSection load='2grv' size='340' side='right' caption='[[2grv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2grv' size='340' side='right' caption='[[2grv]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRV FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [http://pdbe.org/2grv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [http://www.ebi.ac.uk/pdbsum/2grv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [http://pdbe.org/2grv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [http://www.ebi.ac.uk/pdbsum/2grv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2grv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 04:19, 10 February 2016

2016-02-10T04:19:41Z

←Older revision		Revision as of 04:19, 10 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2grv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:19, 11 September 2015

2015-09-11T05:19:16Z

←Older revision		Revision as of 05:19, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2grv' size='340' side='right' caption='[[2grv]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2grv' size='340' side='right' caption='[[2grv]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRV FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 ~~Mycobacterium smegmatis str. MC2 155~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [http://www.ebi.ac.uk/pdbsum/2grv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [http://pdbe.org/2grv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [http://www.ebi.ac.uk/pdbsum/2grv PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2grv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium smegmatis str. mc2 155~~]]	+	[[Category: Mycs2]]
	[[Category: Marland, Z]]		[[Category: Marland, Z]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]
	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]
	[[Category: Substrate-binding protein scaffold]]		[[Category: Substrate-binding protein scaffold]]

OCA at 08:55, 16 January 2015

2015-01-16T08:55:16Z

←Older revision		Revision as of 08:55, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 Mycobacterium smegmatis str. MC2 155])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 Mycobacterium smegmatis str. MC2 155])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [http://www.ebi.ac.uk/pdbsum/2grv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [http://www.ebi.ac.uk/pdbsum/2grv PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium smegmatis str. mc2 155]]		[[Category: Mycobacterium smegmatis str. mc2 155]]
-	[[Category: Marland, Z.]]	+	[[Category: Marland, Z]]
-	[[Category: Rossjohn, J.]]	+	[[Category: Rossjohn, J]]
	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]
	[[Category: Substrate-binding protein scaffold]]		[[Category: Substrate-binding protein scaffold]]

OCA at 08:32, 30 September 2014

2014-09-30T08:32:45Z

←Older revision		Revision as of 08:32, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2grv.~~png\|left~~\|200px]]	+	==Crystal Structure of LpqW==
		+	<StructureSection load='2grv' size='340' side='right' caption='[[2grv]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GRV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpqW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 Mycobacterium smegmatis str. MC2 155])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2grv RCSB], [http://www.ebi.ac.uk/pdbsum/2grv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2grv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The waxy cell wall is crucial to the survival of mycobacteria within the infected host. The cell wall is a complex structure rich in unusual molecules that includes two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Many proteins implicated in the PIM/LAM biosynthetic pathway, while attractive therapeutic targets, are poorly defined. The 2.4A resolution crystal structure of an essential lipoprotein, LpqW, implicated in LAM biosynthesis is reported here. LpqW adopts a scaffold reminiscent of the distantly related, promiscuous substrate-binding proteins of the ATP-binding cassette import system. Nevertheless, the unique closed conformation of LpqW suggests that mycobacteria and other closely related pathogens have hijacked this scaffold for use in key processes of cell wall biosynthesis. In silico docking provided a plausible model in which the candidate PIM ligand binds within a marked electronegative region located on the surface of LpqW. We suggest that LpqW represents an archetypal lipoprotein that channels intermediates from a pathway for mature PIM production into a pathway for LAM biosynthesis, thus controlling the relative abundance of these two important components of the cell wall.

-	~~{{STRUCTURE_2grv\| PDB=2grv \| SCENE= }}~~	+	Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis.,Marland Z, Beddoe T, Zaker-Tabrizi L, Lucet IS, Brammananth R, Whisstock JC, Wilce MC, Coppel RL, Crellin PK, Rossjohn J J Mol Biol. 2006 Jun 16;359(4):983-97. Epub 2006 Apr 25. PMID:16698034<ref>PMID:16698034</ref>

-	~~===Crystal Structure~~ of ~~LpqW===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16698034}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2grv]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_smegmatis_str~~.~~_mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016698034<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium smegmatis str. mc2 155]]		[[Category: Mycobacterium smegmatis str. mc2 155]]
	[[Category: Marland, Z.]]		[[Category: Marland, Z.]]

OCA: Protected "2grv" [edit=sysop:move=sysop]

2013-01-07T10:56:53Z

Protected "2grv" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:56, 7 January 2013

OCA at 10:56, 7 January 2013

2013-01-07T10:56:47Z

←Older revision		Revision as of 10:56, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2grv.png\|left\|200px]]		[[Image:2grv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2grv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2grv\| PDB=2grv \| SCENE= }}		{{STRUCTURE_2grv\| PDB=2grv \| SCENE= }}

	===Crystal Structure of LpqW===		===Crystal Structure of LpqW===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16698034}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16698034 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16698034}}		{{ABSTRACT_PUBMED_16698034}}

	==About this Structure==		==About this Structure==
-	~~2GRV~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis~~ Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA].	+	[[2grv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16698034~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016698034</ref><references group="xtra"/>
-	[[Category: Mycobacterium smegmatis]]	+	[[Category: Mycobacterium smegmatis str. mc2 155]]
	[[Category: Marland, Z.]]		[[Category: Marland, Z.]]
	[[Category: Rossjohn, J.]]		[[Category: Rossjohn, J.]]
		+	[[Category: Biosynthetic protein]]
	[[Category: Substrate-binding protein scaffold]]		[[Category: Substrate-binding protein scaffold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:22:50 2009''

OCA at 13:22, 17 February 2009

2009-02-17T13:22:51Z

←Older revision		Revision as of 13:22, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2GRV is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA].	+	2GRV is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRV OCA].

	==Reference==		==Reference==
-	Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis., Marland Z, Beddoe T, Zaker-Tabrizi L, Lucet IS, Brammananth R, Whisstock JC, Wilce MC, Coppel RL, Crellin PK, Rossjohn J, J Mol Biol. 2006 Jun 16;359(4):983-97. Epub 2006 Apr 25. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16698034 16698034]~~	+	<ref group="xtra">PMID:16698034</ref><references group="xtra"/>
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
-	[[Category: Single protein]]
	[[Category: Marland, Z.]]		[[Category: Marland, Z.]]
	[[Category: Rossjohn, J.]]		[[Category: Rossjohn, J.]]
	[[Category: Substrate-binding protein scaffold]]		[[Category: Substrate-binding protein scaffold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 21~~:00:~~38 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:22:50 2009''

OCA at 18:00, 28 July 2008

2008-07-28T18:00:39Z

←Older revision		Revision as of 18:00, 28 July 2008
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-	[[Image:2grv.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2grv.png\|left\|200px]]

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	{{STRUCTURE_2grv\| PDB=2grv \| SCENE= }}		{{STRUCTURE_2grv\| PDB=2grv \| SCENE= }}

-	~~'''~~Crystal Structure of LpqW~~'''~~	+	===Crystal Structure of LpqW===


-	~~==Overview==~~	+	<!--
-	The ~~waxy cell wall is crucial~~ to the ~~survival of mycobacteria within the infected host. The cell wall is a complex structure rich in unusual molecules that includes two related lipoglycans, the phosphatidylinositol mannosides~~ (~~PIMs) and lipoarabinomannans (LAMs). Many proteins implicated in the PIM~~/~~LAM biosynthetic pathway, while attractive therapeutic targets, are poorly defined~~. ~~The 2~~.~~4A resolution crystal structure of an essential lipoprotein, LpqW~~, ~~implicated in LAM biosynthesis~~ is ~~reported here~~. ~~LpqW adopts a scaffold reminiscent of the distantly related, promiscuous substrate~~-~~binding proteins of the ATP~~-binding cassette import system. Nevertheless, the unique closed conformation of LpqW suggests that mycobacteria and other closely related pathogens have hijacked this scaffold for use in key processes of cell wall biosynthesis. In silico docking provided a plausible model in which the candidate PIM ligand binds within a marked electronegative region located on the surface of LpqW. We suggest that LpqW represents an archetypal lipoprotein that channels intermediates from a pathway for mature PIM production into a pathway for LAM biosynthesis, thus controlling the relative abundance of these two important components of the cell wall.	+	The line below this paragraph, {{ABSTRACT_PUBMED_16698034}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 16698034 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_16698034}}

	==About this Structure==		==About this Structure==
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	[[Category: Rossjohn, J.]]		[[Category: Rossjohn, J.]]
	[[Category: Substrate-binding protein scaffold]]		[[Category: Substrate-binding protein scaffold]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:26:51 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:00:38 2008''