2h4t - Revision history

OCA at 09:31, 14 February 2024

2024-02-14T09:31:01Z

←Older revision		Revision as of 09:31, 14 February 2024
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	<StructureSection load='2h4t' size='340' side='right'caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2h4t' size='340' side='right'caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4T FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=D12:DODECANE'>D12</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Cpt2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10116 Buffalo rat])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [https://pdbe.org/2h4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [https://www.ebi.ac.uk/pdbsum/2h4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [https://pdbe.org/2h4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [https://www.ebi.ac.uk/pdbsum/2h4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CPT2_RAT CPT2_RAT]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h4t ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h4t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the beta-oxidation of long-chain fatty acids in mitochondria. We report here the crystal structure of rat CPT-II at 1.9A resolution. The overall structure shares strong similarity to those of short- and medium-chain carnitine acyltransferases, although detailed structural differences in the active site region have a significant impact on the substrate selectivity of CPT-II. Three aliphatic chains, possibly from a detergent that is used for the crystallization, were found in the structure. Two of them are located in the carnitine and CoA binding sites, respectively. The third aliphatic chain may mimic the long-chain acyl group in the substrate of CPT-II. The binding site for this aliphatic chain does not exist in the short- and medium-chain carnitine acyltransferases, due to conformational differences among the enzymes. A unique insert in CPT-II is positioned on the surface of the enzyme, with a highly hydrophobic surface. It is likely that this surface patch mediates the association of CPT-II with the inner membrane of the mitochondria.
-
-	Crystal structure of rat carnitine palmitoyltransferase II (CPT-II).,Hsiao YS, Jogl G, Esser V, Tong L Biochem Biophys Res Commun. 2006 Aug 4;346(3):974-80. Epub 2006 Jun 9. PMID:16781677<ref>PMID:16781677</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2h4t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Carnitine palmitoyltransferase\|Carnitine palmitoyltransferase]]		*[[Carnitine palmitoyltransferase\|Carnitine palmitoyltransferase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
-	[[Category: Carnitine O-palmitoyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Esser, V]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Hsiao~~, Y S~~]]	+	[[Category: Esser V]]
-	[[Category: Jogl, G]]	+	[[Category: Hsiao YS]]
-	[[Category: Tong, L]]	+	[[Category: Jogl G]]
-	~~[[Category: Carnitine acyltransferase]]~~	+	[[Category: Tong L]]
-	~~[[Category: Transferase~~]]	+

OCA at 07:31, 17 March 2021

2021-03-17T07:31:26Z

←Older revision		Revision as of 07:31, 17 March 2021
Line 1:		Line 1:

	==Crystal structure of rat carnitine palmitoyltransferase II==		==Crystal structure of rat carnitine palmitoyltransferase II==
-	<StructureSection load='2h4t' size='340' side='right' caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2h4t' size='340' side='right'caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2H4T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [~~http~~://pdbe.org/2h4t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2h4t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [https://pdbe.org/2h4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [https://www.ebi.ac.uk/pdbsum/2h4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4t ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/2h4t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/2h4t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2h4t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2h4t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carnitine palmitoyltransferase\|Carnitine palmitoyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Carnitine O-palmitoyltransferase]]		[[Category: Carnitine O-palmitoyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Esser, V]]		[[Category: Esser, V]]
	[[Category: Hsiao, Y S]]		[[Category: Hsiao, Y S]]

OCA at 08:06, 18 October 2017

2017-10-18T08:06:14Z

←Older revision		Revision as of 08:06, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of rat carnitine palmitoyltransferase II==		==Crystal structure of rat carnitine palmitoyltransferase II==
	<StructureSection load='2h4t' size='340' side='right' caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2h4t' size='340' side='right' caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [http://pdbe.org/2h4t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [http://www.ebi.ac.uk/pdbsum/2h4t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [http://pdbe.org/2h4t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [http://www.ebi.ac.uk/pdbsum/2h4t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4t ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h4t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2h4t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2h4t" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Carnitine palmitoyltransferase\|Carnitine palmitoyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:24, 11 September 2015

2015-09-11T13:24:29Z

←Older revision		Revision as of 13:24, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2h4t' size='340' side='right' caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2h4t' size='340' side='right' caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H4T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H4T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [http://www.ebi.ac.uk/pdbsum/2h4t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [http://pdbe.org/2h4t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [http://www.ebi.ac.uk/pdbsum/2h4t PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2h4t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Carnitine O-palmitoyltransferase]]		[[Category: Carnitine O-palmitoyltransferase]]
-	[[Category: Rattus norvegicus]]
	[[Category: Esser, V]]		[[Category: Esser, V]]
	[[Category: Hsiao, Y S]]		[[Category: Hsiao, Y S]]

OCA at 09:31, 16 January 2015

2015-01-16T09:31:41Z

←Older revision		Revision as of 09:31, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H4T FirstGlance]. <br>		<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H4T FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [http://www.ebi.ac.uk/pdbsum/2h4t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [http://www.ebi.ac.uk/pdbsum/2h4t PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Carnitine O-palmitoyltransferase]]		[[Category: Carnitine O-palmitoyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Esser, V.]]	+	[[Category: Esser, V]]
-	[[Category: Hsiao, Y S.]]	+	[[Category: Hsiao, Y S]]
-	[[Category: Jogl, G.]]	+	[[Category: Jogl, G]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
	[[Category: Carnitine acyltransferase]]		[[Category: Carnitine acyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 04:20, 29 September 2014

2014-09-29T04:20:03Z

←Older revision		Revision as of 04:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2h4t.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of rat carnitine palmitoyltransferase II==
		+	<StructureSection load='2h4t' size='340' side='right' caption='[[2h4t]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2h4t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H4T FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cpt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h4t RCSB], [http://www.ebi.ac.uk/pdbsum/2h4t PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/2h4t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the beta-oxidation of long-chain fatty acids in mitochondria. We report here the crystal structure of rat CPT-II at 1.9A resolution. The overall structure shares strong similarity to those of short- and medium-chain carnitine acyltransferases, although detailed structural differences in the active site region have a significant impact on the substrate selectivity of CPT-II. Three aliphatic chains, possibly from a detergent that is used for the crystallization, were found in the structure. Two of them are located in the carnitine and CoA binding sites, respectively. The third aliphatic chain may mimic the long-chain acyl group in the substrate of CPT-II. The binding site for this aliphatic chain does not exist in the short- and medium-chain carnitine acyltransferases, due to conformational differences among the enzymes. A unique insert in CPT-II is positioned on the surface of the enzyme, with a highly hydrophobic surface. It is likely that this surface patch mediates the association of CPT-II with the inner membrane of the mitochondria.

-	~~{{STRUCTURE_2h4t\| PDB=2h4t \| SCENE= }}~~	+	Crystal structure of rat carnitine palmitoyltransferase II (CPT-II).,Hsiao YS, Jogl G, Esser V, Tong L Biochem Biophys Res Commun. 2006 Aug 4;346(3):974-80. Epub 2006 Jun 9. PMID:16781677<ref>PMID:16781677</ref>

-	~~===Crystal structure~~ of ~~rat carnitine palmitoyltransferase II===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16781677}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2h4t]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA].~~	+

	==See Also==		==See Also==
	*[[Carnitine palmitoyltransferase\|Carnitine palmitoyltransferase]]		*[[Carnitine palmitoyltransferase\|Carnitine palmitoyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016781677<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carnitine O-palmitoyltransferase]]		[[Category: Carnitine O-palmitoyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA at 19:12, 20 October 2012

2012-10-20T19:12:44Z

←Older revision		Revision as of 19:12, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2h4t]] is a 2 chain structure ~~of [[Carnitine palmitoyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA].	+	[[2h4t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA].

	==See Also==		==See Also==

OCA: Protected "2h4t" [edit=sysop:move=sysop]

2012-07-27T06:38:05Z

Protected "2h4t" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 27 July 2012

OCA at 06:38, 27 July 2012

2012-07-27T06:38:03Z

←Older revision		Revision as of 06:38, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2h4t.png\|left\|200px]]		[[Image:2h4t.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2h4t", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2h4t\| PDB=2h4t \| SCENE= }}		{{STRUCTURE_2h4t\| PDB=2h4t \| SCENE= }}

	===Crystal structure of rat carnitine palmitoyltransferase II===		===Crystal structure of rat carnitine palmitoyltransferase II===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16781677}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16781677 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16781677}}		{{ABSTRACT_PUBMED_16781677}}

	==About this Structure==		==About this Structure==
-	~~2H4T~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA].	+	[[2h4t]] is a 2 chain structure of [[Carnitine palmitoyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA].
		+
		+	==See Also==
		+	*[[Carnitine palmitoyltransferase\|Carnitine palmitoyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16781677~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016781677</ref><references group="xtra"/>
	[[Category: Carnitine O-palmitoyltransferase]]		[[Category: Carnitine O-palmitoyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 31:		Line 22:
	[[Category: Tong, L.]]		[[Category: Tong, L.]]
	[[Category: Carnitine acyltransferase]]		[[Category: Carnitine acyltransferase]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 22:42:54 2009''~~	+

OCA at 20:43, 17 February 2009

2009-02-17T20:43:06Z

←Older revision		Revision as of 20:43, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2H4T is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA].	+	2H4T is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4T OCA].

	==Reference==		==Reference==
-	~~Crystal structure of rat carnitine palmitoyltransferase II (CPT-II)., Hsiao YS, Jogl G, Esser V, Tong L, Biochem Biophys Res Commun. 2006 Aug 4;346(3):974-80. Epub 2006 Jun 9.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16781677 16781677]~~	+	<ref group="xtra">PMID:16781677</ref><references group="xtra"/>
	[[Category: Carnitine O-palmitoyltransferase]]		[[Category: Carnitine O-palmitoyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Esser, V.]]		[[Category: Esser, V.]]
	[[Category: Hsiao, Y S.]]		[[Category: Hsiao, Y S.]]
Line 33:		Line 32:
	[[Category: Carnitine acyltransferase]]		[[Category: Carnitine acyltransferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:47:~~57 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:42:54 2009''