2hi2 - Revision history

OCA at 09:58, 30 August 2023

2023-08-30T09:58:13Z

←Older revision		Revision as of 09:58, 30 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HTO:HEPTANE~~-1,2,3~~-TRIOL'~~>~~HTO~~</~~scene~~>, <~~scene name~~='~~pdbligand~~=~~OPE~~:~~PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'~~>~~OPE~~</~~scene~~>, <scene name='pdbligand=DT6:2,4-BIS(ACETYLAMINO)-2,4-DIDEOXY-BETA-D-GLUCOPYRANOSE'>DT6</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id~~='~~NonStdRes'><td class~~=~~"sblockLbl"><b>[[Non~~-~~Standard_Residue\|NonStd Res:]]</b~~></~~td><td class="sblockDat"~~><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DT6:2,4-BIS(ACETYLAMINO)-2,4-DIDEOXY-BETA-D-GLUCOPYRANOSE'>DT6</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[2hil\|2hil]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [https://pdbe.org/2hi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [https://www.ebi.ac.uk/pdbsum/2hi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [https://pdbe.org/2hi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [https://www.ebi.ac.uk/pdbsum/2hi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FMM1_NEIGO FMM1_NEIGO]] This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells.	+	[https://www.uniprot.org/uniprot/FMM1_NEIGO FMM1_NEIGO] This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: Arvai~~, A S~~]]	+	[[Category: Arvai AS]]
-	[[Category: Craig, L]]	+	[[Category: Craig L]]
-	[[Category: Tainer~~, J A]]~~	+	[[Category: Tainer JA]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Fiber-forming protein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Type iv pilin~~]]	+

OCA at 11:09, 5 January 2022

2022-01-05T11:09:04Z

←Older revision		Revision as of 11:09, 5 January 2022
Line 3:		Line 3:
	<StructureSection load='2hi2' size='340' side='right'caption='[[2hi2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2hi2' size='340' side='right'caption='[[2hi2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~DT6~~:~~2,4-BIS(ACETYLAMINO)~~-2,4-~~DIDEOXY-BETA-D-GLUCOPYRANOSE~~'>~~DT6~~</scene>, <scene name='pdbligand=~~GLA~~:~~ALPHA~~+D-~~GALACTOSE~~'>~~GLA~~</scene>, <scene name='pdbligand=~~HTO~~:~~HEPTANE-1~~,2,3-~~TRIOL~~'>~~HTO~~</scene>, <scene name='pdbligand=~~OPE~~:~~PHOSPHORIC~~+~~ACID+MONO~~-~~(2-AMINO-ETHYL)+ESTER~~'>~~OPE~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=DT6:2,4-BIS(ACETYLAMINO)-2,4-DIDEOXY-BETA-D-GLUCOPYRANOSE'>DT6</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hil\|2hil]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [~~http~~://pdbe.org/2hi2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2hi2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [https://pdbe.org/2hi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [https://www.ebi.ac.uk/pdbsum/2hi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FMM1_NEIGO FMM1_NEIGO]] This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells.	+	[[https://www.uniprot.org/uniprot/FMM1_NEIGO FMM1_NEIGO]] This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:10, 1 April 2020

2020-04-01T10:10:00Z

←Older revision		Revision as of 10:10, 1 April 2020
Line 1:		Line 1:

	==Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution==		==Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution==
-	<StructureSection load='2hi2' size='340' side='right' caption='[[2hi2]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2hi2' size='340' side='right'caption='[[2hi2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Pilin\|Pilin]]	+	*[[Pilin 3D structures\|Pilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
	[[Category: Arvai, A S]]		[[Category: Arvai, A S]]

OCA at 06:20, 27 June 2018

2018-06-27T06:20:08Z

←Older revision		Revision as of 06:20, 27 June 2018
Line 1:		Line 1:
		+
	==Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution==		==Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution==
	<StructureSection load='2hi2' size='340' side='right' caption='[[2hi2]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2hi2' size='340' side='right' caption='[[2hi2]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~HTO~~:~~HEPTANE-1~~,2,3-~~TRIOL~~'>~~HTO~~</scene>, <scene name='pdbligand=~~OPE~~:~~PHOSPHORIC~~+~~ACID+MONO~~-~~(2-AMINO-ETHYL)+ESTER~~'>~~OPE~~</scene>, <scene name='pdbligand=~~DT6~~:~~2,4-BIS(ACETYLAMINO)~~-2,~~4-DIDEOXY-BETA-D~~-~~GLUCOPYRANOSE~~'>~~DT6~~</scene>, <scene name='pdbligand=~~GLA~~:~~ALPHA~~+D-~~GALACTOSE~~'>~~GLA~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DT6:2,4-BIS(ACETYLAMINO)-2,4-DIDEOXY-BETA-D-GLUCOPYRANOSE'>DT6</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [http://pdbe.org/2hi2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [http://pdbe.org/2hi2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hi2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hi2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:09, 10 February 2016

2016-02-10T01:09:29Z

←Older revision		Revision as of 01:09, 10 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hi2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:52, 11 September 2015

2015-09-11T03:52:17Z

←Older revision		Revision as of 03:52, 11 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [http://pdbe.org/2hi2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2hi2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:44, 25 December 2014

2014-12-25T10:44:16Z

←Older revision		Revision as of 10:44, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=DT6:2,4-BIS(ACETYLAMINO)-2,4-DIDEOXY-BETA-D-GLUCOPYRANOSE'>DT6</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=DT6:2,4-BIS(ACETYLAMINO)-2,4-DIDEOXY-BETA-D-GLUCOPYRANOSE'>DT6</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi2 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FMM1_NEIGO FMM1_NEIGO]] This protein is the predominant Neisseria surface antigen, which allows adhesion of the bacterium to various host cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: Arvai, A S.]]	+	[[Category: Arvai, A S]]
-	[[Category: Craig, L.]]	+	[[Category: Craig, L]]
-	[[Category: Tainer, J A.]]	+	[[Category: Tainer, J A]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]

OCA at 10:27, 30 September 2014

2014-09-30T10:27:58Z

←Older revision		Revision as of 10:27, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2hi2\| PDB=2hi2 \| SCENE= }}~~	+	==Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution==
-	===Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution===	+	<StructureSection load='2hi2' size='340' side='right' caption='[[2hi2]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_16949362}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2hi2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=DT6:2,4-BIS(ACETYLAMINO)-2,4-DIDEOXY-BETA-D-GLUCOPYRANOSE'>DT6</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2hil\|2hil]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hi2 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/2hi2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type IV pili (T4P) are long, thin, flexible filaments on bacteria that undergo assembly-disassembly from inner membrane pilin subunits and exhibit astonishing multifunctionality. Neisseria gonorrhoeae (gonococcal or GC) T4P are prototypic virulence factors and immune targets for increasingly antibiotic-resistant human pathogens, yet detailed structures are unavailable for any T4P. Here, we determined a detailed experimental GC-T4P structure by quantitative fitting of a 2.3 A full-length pilin crystal structure into a 12.5 A resolution native GC-T4P reconstruction solved by cryo-electron microscopy (cryo-EM) and iterative helical real space reconstruction. Spiraling three-helix bundles form the filament core, anchor the globular heads, and provide strength and flexibility. Protruding hypervariable loops and posttranslational modifications in the globular head shield conserved functional residues in pronounced grooves, creating a surprisingly corrugated pilus surface. These results clarify T4P multifunctionality and assembly-disassembly while suggesting unified assembly mechanisms for T4P, archaeal flagella, and type II secretion system filaments.

-	~~==About this Structure==~~	+	Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions.,Craig L, Volkmann N, Arvai AS, Pique ME, Yeager M, Egelman EH, Tainer JA Mol Cell. 2006 Sep 1;23(5):651-62. PMID:16949362<ref>PMID:16949362</ref>
-	~~[[2hi2]] is a 1 chain~~ structure ~~with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2HI2 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Pilin\|Pilin]]		*[[Pilin\|Pilin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016949362<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
	[[Category: Arvai, A S.]]		[[Category: Arvai, A S.]]

OCA at 10:51, 11 March 2013

2013-03-11T10:51:52Z

←Older revision		Revision as of 10:51, 11 March 2013
Line 1:		Line 1:
-	[[Image:2hi2.png\|left\|200px]]
-
	{{STRUCTURE_2hi2\| PDB=2hi2 \| SCENE= }}		{{STRUCTURE_2hi2\| PDB=2hi2 \| SCENE= }}
-
	===Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution===		===Crystal structure of native Neisseria gonorrhoeae Type IV pilin at 2.3 Angstroms Resolution===
-
	{{ABSTRACT_PUBMED_16949362}}		{{ABSTRACT_PUBMED_16949362}}

OCA: Protected "2hi2" [edit=sysop:move=sysop]

2013-01-07T14:55:33Z

Protected "2hi2" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:55, 7 January 2013