2ho7 - Revision history

OCA at 09:33, 14 February 2024

2024-02-14T09:33:32Z

←Older revision		Revision as of 09:33, 14 February 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [https://pdbe.org/2ho7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ho7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [https://pdbe.org/2ho7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ho7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho7 ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
-
-	Structural basis of glmS ribozyme activation by glucosamine-6-phosphate.,Klein DJ, Ferre-D'Amare AR Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543<ref>PMID:16990543</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2ho7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribozyme 3D structures\|Ribozyme 3D structures]]		*[[Ribozyme 3D structures\|Ribozyme 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:48, 11 October 2023

2023-10-11T08:48:25Z

←Older revision		Revision as of 08:48, 11 October 2023
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	<StructureSection load='2ho7' size='340' side='right'caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2ho7' size='340' side='right'caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=G6P:ALPHA~~-~~D-GLUCOSE-6-PHOSPHATE'>G6P</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class="sblockDat"><div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2ho6\|2ho6]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [https://pdbe.org/2ho7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ho7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [https://pdbe.org/2ho7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ho7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho7 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 19:

	==See Also==		==See Also==
-	*[[Ribozyme\|Ribozyme]]	+	*[[Ribozyme 3D structures\|Ribozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Amare, A R.~~Ferre-D]]	+	[[Category: Ferre-D'Amare AR]]
-	[[Category: Klein~~, D J]]~~	+	[[Category: Klein DJ]]
-	~~[[Category: Helix]]~~	+
-	~~[[Category: Pseudoknot]]~~	+
-	~~[[Category: Ribozyme]]~~	+
-	~~[[Category: Rna~~]]	+

OCA at 11:11, 5 January 2022

2022-01-05T11:11:07Z

←Older revision		Revision as of 11:11, 5 January 2022
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	<StructureSection load='2ho7' size='340' side='right'caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2ho7' size='340' side='right'caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ho6\|2ho6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [~~http~~://pdbe.org/2ho7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ho7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [https://pdbe.org/2ho7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ho7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:13, 1 April 2020

2020-04-01T10:13:04Z

←Older revision		Revision as of 10:13, 1 April 2020
Line 1:		Line 1:

	==Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate==		==Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate==
-	<StructureSection load='2ho7' size='340' side='right' caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2ho7' size='340' side='right'caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Amare, A R.Ferre-D]]		[[Category: Amare, A R.Ferre-D]]
	[[Category: Klein, D J]]		[[Category: Klein, D J]]

OCA at 06:40, 27 June 2018

2018-06-27T06:40:12Z

←Older revision		Revision as of 06:40, 27 June 2018
Line 1:		Line 1:
		+
	==Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate==		==Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate==
	<StructureSection load='2ho7' size='340' side='right' caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2ho7' size='340' side='right' caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [http://pdbe.org/2ho7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [http://pdbe.org/2ho7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ho7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:23, 10 September 2015

2015-09-10T10:23:33Z

←Older revision		Revision as of 10:23, 10 September 2015
Line 6:		Line 6:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [http://pdbe.org/2ho7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho7 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ho7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:28, 16 January 2015

2015-01-16T08:28:23Z

←Older revision		Revision as of 08:28, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Amare, A R.Ferre-D.]]	+	[[Category: Amare, A R.Ferre-D]]
-	[[Category: Klein, D J.]]	+	[[Category: Klein, D J]]
	[[Category: Helix]]		[[Category: Helix]]
	[[Category: Pseudoknot]]		[[Category: Pseudoknot]]
	[[Category: Ribozyme]]		[[Category: Ribozyme]]
	[[Category: Rna]]		[[Category: Rna]]

OCA at 02:30, 29 September 2014

2014-09-29T02:30:42Z

←Older revision		Revision as of 02:30, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ho7.~~png~~\|~~left~~\|~~200px~~]]	+	==Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate==
		+	<StructureSection load='2ho7' size='340' side='right' caption='[[2ho7]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HO7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G6P:ALPHA-D-GLUCOSE-6-PHOSPHATE'>G6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ho6\|2ho6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ho7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ho7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ho7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ho7 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.

-	~~{{STRUCTURE_2ho7\| PDB=2ho7 \| SCENE= }}~~	+	Structural basis of glmS ribozyme activation by glucosamine-6-phosphate.,Klein DJ, Ferre-D'Amare AR Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543<ref>PMID:16990543</ref>

-	~~===Pre-cleavage state~~ of the ~~Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16990543}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2ho7]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2HO7 OCA].~~	+

	==See Also==		==See Also==
	*[[Ribozyme\|Ribozyme]]		*[[Ribozyme\|Ribozyme]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016990543<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Amare, A R.Ferre-D.]]		[[Category: Amare, A R.Ferre-D.]]
	[[Category: Klein, D J.]]		[[Category: Klein, D J.]]

OCA at 09:45, 20 October 2012

2012-10-20T09:45:51Z

←Older revision		Revision as of 09:45, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2ho7]] is a 2 chain structure ~~of [[Ribozyme]]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA].	+	[[2ho7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HO7 OCA].

	==See Also==		==See Also==

OCA: Protected "2ho7" [edit=sysop:move=sysop]

2012-07-25T23:52:31Z

Protected "2ho7" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:52, 25 July 2012