2htv - Revision history

OCA at 08:48, 11 October 2023

2023-10-11T08:48:34Z

←Older revision		Revision as of 08:48, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='2htv' size='340' side='right'caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2htv' size='340' side='right'caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus~~ Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HTV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2ht5\|2ht5]]~~, ~~[[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [https://pdbe.org/2htv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [https://www.ebi.ac.uk/pdbsum/2htv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2htv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [https://pdbe.org/2htv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [https://www.ebi.ac.uk/pdbsum/2htv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2htv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q6XV46_9INFA Q6XV46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication (By similarity).[SAAS:SAAS00234776]	+	[https://www.uniprot.org/uniprot/Q6XV46_9INFA Q6XV46_9INFA] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication (By similarity).[SAAS:SAAS00234776]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Influenza a virus]]	+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blackburn~~, G M~~]]	+	[[Category: Blackburn GM]]
-	[[Category: Collins~~, P J~~]]	+	[[Category: Collins PJ]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Haire~~, L F~~]]	+	[[Category: Haire LF]]
-	[[Category: Hay~~, A J~~]]	+	[[Category: Hay AJ]]
-	[[Category: Lin~~, Y P~~]]	+	[[Category: Lin YP]]
-	[[Category: Russell~~, R J~~]]	+	[[Category: Russell RJ]]
-	[[Category: Skehel~~, J J~~]]	+	[[Category: Skehel JJ]]
-	[[Category: Stevens~~, D J]]~~	+	[[Category: Stevens DJ]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: N4]]~~	+
-	~~[[Category: Neuraminidase~~]]	+

OCA at 11:13, 5 January 2022

2022-01-05T11:13:12Z

←Older revision		Revision as of 11:13, 5 January 2022
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	<StructureSection load='2htv' size='340' side='right'caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2htv' size='340' side='right'caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2HTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HTV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [~~http~~://pdbe.org/2htv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2htv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2htv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [https://pdbe.org/2htv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [https://www.ebi.ac.uk/pdbsum/2htv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2htv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q6XV46_9INFA Q6XV46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication (By similarity).[SAAS:SAAS00234776]	+	[[https://www.uniprot.org/uniprot/Q6XV46_9INFA Q6XV46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication (By similarity).[SAAS:SAAS00234776]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:15, 1 April 2020

2020-04-01T10:15:34Z

←Older revision		Revision as of 10:15, 1 April 2020
Line 1:		Line 1:

	==N4 neuraminidase==		==N4 neuraminidase==
-	<StructureSection load='2htv' size='340' side='right' caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2htv' size='340' side='right'caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
		+	[[Category: Large Structures]]
	[[Category: Blackburn, G M]]		[[Category: Blackburn, G M]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]

OCA at 06:30, 27 June 2018

2018-06-27T06:30:08Z

←Older revision		Revision as of 06:30, 27 June 2018
Line 1:		Line 1:
		+
	==N4 neuraminidase==		==N4 neuraminidase==
	<StructureSection load='2htv' size='340' side='right' caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2htv' size='340' side='right' caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~9infa 9infa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [http://pdbe.org/2htv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [http://www.ebi.ac.uk/pdbsum/2htv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [http://pdbe.org/2htv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [http://www.ebi.ac.uk/pdbsum/2htv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2htv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Influenza a virus]]
	[[Category: Blackburn, G M]]		[[Category: Blackburn, G M]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]

OCA at 02:18, 12 September 2015

2015-09-12T02:18:22Z

←Older revision		Revision as of 02:18, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='2htv' size='340' side='right' caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2htv' size='340' side='right' caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus Influenza a virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [http://www.ebi.ac.uk/pdbsum/2htv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [http://pdbe.org/2htv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [http://www.ebi.ac.uk/pdbsum/2htv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q6XV46_9INFA Q6XV46_9INFA]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication (By similarity).[SAAS:SAAS00234776]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2htv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Influenza a virus]]
	[[Category: Blackburn, G M]]		[[Category: Blackburn, G M]]
	[[Category: Collins, P J]]		[[Category: Collins, P J]]

OCA at 09:06, 16 January 2015

2015-01-16T09:06:42Z

←Older revision		Revision as of 09:06, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [http://www.ebi.ac.uk/pdbsum/2htv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [http://www.ebi.ac.uk/pdbsum/2htv PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Blackburn, G M.]]	+	[[Category: Blackburn, G M]]
-	[[Category: Collins, P J.]]	+	[[Category: Collins, P J]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Hay, A J.]]	+	[[Category: Hay, A J]]
-	[[Category: Lin, Y P.]]	+	[[Category: Lin, Y P]]
-	[[Category: Russell, R J.]]	+	[[Category: Russell, R J]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Stevens, D J.]]	+	[[Category: Stevens, D J]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: N4]]		[[Category: N4]]
	[[Category: Neuraminidase]]		[[Category: Neuraminidase]]

OCA at 01:04, 2 October 2014

2014-10-02T01:04:36Z

←Older revision		Revision as of 01:04, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2htv.~~png~~\|~~left~~\|~~200px~~]]	+	==N4 neuraminidase==
		+	<StructureSection load='2htv' size='340' side='right' caption='[[2htv]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HTV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ht5\|2ht5]], [[2ht7\|2ht7]], [[2ht8\|2ht8]], [[2htr\|2htr]], [[2htq\|2htq]], [[2htu\|2htu]], [[2htw\|2htw]], [[2hty\|2hty]], [[2hu0\|2hu0]], [[2hu4\|2hu4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2htv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2htv RCSB], [http://www.ebi.ac.uk/pdbsum/2htv PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for the structure-based design of current drugs. Here we show by X-ray crystallography that these two groups are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding. Our analysis suggests that it may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs.

-	~~{{STRUCTURE_2htv\| PDB=2htv \| SCENE= }}~~	+	The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.,Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235<ref>PMID:16915235</ref>

-	~~===N4 neuraminidase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16915235}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2htv]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Influenza_a_virus Influenza~~ a ~~virus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2HTV OCA].~~	+

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:016915235<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Blackburn, G M.]]		[[Category: Blackburn, G M.]]

OCA at 22:27, 20 October 2012

2012-10-20T22:27:11Z

←Older revision		Revision as of 22:27, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2htv]] is a 2 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA].	+	[[2htv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA].

	==See Also==		==See Also==

OCA: Protected "2htv" [edit=sysop:move=sysop]

2012-07-27T16:20:45Z

Protected "2htv" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:20, 27 July 2012

OCA at 16:20, 27 July 2012

2012-07-27T16:20:44Z

←Older revision		Revision as of 16:20, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2htv.png\|left\|200px]]		[[Image:2htv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2htv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2htv\| PDB=2htv \| SCENE= }}		{{STRUCTURE_2htv\| PDB=2htv \| SCENE= }}

	===N4 neuraminidase===		===N4 neuraminidase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16915235}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16915235 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_16915235}}		{{ABSTRACT_PUBMED_16915235}}

	==About this Structure==		==About this Structure==
-	~~2HTV is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA].	+	[[2htv]] is a 2 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTV OCA].
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]

	==Reference==		==Reference==
-	The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design., Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ, Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16915235 16915235]~~	+	<ref group="xtra">PMID:016915235</ref><references group="xtra"/>
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
-	[[Category: Single protein]]
	[[Category: Blackburn, G M.]]		[[Category: Blackburn, G M.]]
	[[Category: Collins, P J.]]		[[Category: Collins, P J.]]
Line 35:		Line 25:
	[[Category: Skehel, J J.]]		[[Category: Skehel, J J.]]
	[[Category: Stevens, D J.]]		[[Category: Stevens, D J.]]
		+	[[Category: Hydrolase]]
	[[Category: N4]]		[[Category: N4]]
	[[Category: Neuraminidase]]		[[Category: Neuraminidase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:13:42 2008''