2i2y - Revision history

OCA at 19:03, 29 May 2024

2024-05-29T19:03:35Z

←Older revision		Revision as of 19:03, 29 May 2024
Line 1:		Line 1:

	==Solution structure of the RRM of SRp20 bound to the RNA CAUC==		==Solution structure of the RRM of SRp20 bound to the RNA CAUC==
-	<StructureSection load='2i2y' size='340' side='right'caption='[[2i2y~~]], [[NMR_Ensembles_of_Models \| 28 NMR models~~]]' scene=''>	+	<StructureSection load='2i2y' size='340' side='right'caption='[[2i2y]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strsg Strsg~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>spg and SFRS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1320 STRSG])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [https://pdbe.org/2i2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [https://www.ebi.ac.uk/pdbsum/2i2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [https://pdbe.org/2i2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [https://www.ebi.ac.uk/pdbsum/2i2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG] [https://www.uniprot.org/uniprot/SRSF3_HUMAN SRSF3_HUMAN] Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).<ref>PMID:11336712</ref> <ref>PMID:17036044</ref> <ref>PMID:18364396</ref> <ref>PMID:26876937</ref> <ref>PMID:28984244</ref> <ref>PMID:32440474</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strsg~~]]	+	[[Category: Streptococcus sp. 'group G']]
-	[[Category: Allain~~, F H~~]]	+	[[Category: Allain FH]]
-	[[Category: Hargous~~, Y F]]~~	+	[[Category: Hargous YF]]
-	~~[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]~~	+
-	~~[[Category: Rna binding protein-chimera-rna complex~~]]	+

OCA at 07:26, 24 March 2021

2021-03-24T07:26:51Z

←Older revision		Revision as of 07:26, 24 March 2021
Line 1:		Line 1:

	==Solution structure of the RRM of SRp20 bound to the RNA CAUC==		==Solution structure of the RRM of SRp20 bound to the RNA CAUC==
-	<StructureSection load='2i2y' size='340' side='right' caption='[[2i2y]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>	+	<StructureSection load='2i2y' size='340' side='right'caption='[[2i2y]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [~~http~~://pdbe.org/2i2y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2i2y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [https://pdbe.org/2i2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [https://www.ebi.ac.uk/pdbsum/2i2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Pre-mRNA-splicing ~~factor~~\|Pre-mRNA-splicing ~~factor]]~~	+	*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
-	*[[Srp20-Human Alternative Splicing Factor\|Srp20-Human Alternative Splicing Factor]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Strsg]]		[[Category: Strsg]]
	[[Category: Allain, F H]]		[[Category: Allain, F H]]

OCA at 07:57, 4 July 2018

2018-07-04T07:57:35Z

←Older revision		Revision as of 07:57, 4 July 2018
Line 1:		Line 1:
		+
	==Solution structure of the RRM of SRp20 bound to the RNA CAUC==		==Solution structure of the RRM of SRp20 bound to the RNA CAUC==
	<StructureSection load='2i2y' size='340' side='right' caption='[[2i2y]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>		<StructureSection load='2i2y' size='340' side='right' caption='[[2i2y]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [http://pdbe.org/2i2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [http://www.ebi.ac.uk/pdbsum/2i2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [http://pdbe.org/2i2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [http://www.ebi.ac.uk/pdbsum/2i2y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2y ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/2i2y_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/2i2y_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i2y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	==See Also==		==See Also==
	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]		*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
		+	*[[Srp20-Human Alternative Splicing Factor\|Srp20-Human Alternative Splicing Factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:02, 11 September 2015

2015-09-11T09:02:58Z

←Older revision		Revision as of 09:02, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2i2y' size='340' side='right' caption='[[2i2y]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>		<StructureSection load='2i2y' size='340' side='right' caption='[[2i2y]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_sp._'group_g' Streptococcus sp. 'group g'~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strsg Strsg]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 ~~Streptococcus sp. 'group G'~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 STRSG])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [http://www.ebi.ac.uk/pdbsum/2i2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [http://pdbe.org/2i2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [http://www.ebi.ac.uk/pdbsum/2i2y PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2i2y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus sp. 'group g'~~]]	+	[[Category: Strsg]]
	[[Category: Allain, F H]]		[[Category: Allain, F H]]
	[[Category: Hargous, Y F]]		[[Category: Hargous, Y F]]
	[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]		[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]
	[[Category: Rna binding protein-chimera-rna complex]]		[[Category: Rna binding protein-chimera-rna complex]]

OCA at 08:02, 16 January 2015

2015-01-16T08:02:58Z

←Older revision		Revision as of 08:02, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._'group_g' Streptococcus sp. 'group g']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._'group_g' Streptococcus sp. 'group g']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 Streptococcus sp. 'group G'])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 Streptococcus sp. 'group G'])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [http://www.ebi.ac.uk/pdbsum/2i2y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [http://www.ebi.ac.uk/pdbsum/2i2y PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Streptococcus sp. 'group g']]		[[Category: Streptococcus sp. 'group g']]
-	[[Category: Allain, F H.]]	+	[[Category: Allain, F H]]
-	[[Category: Hargous, Y F.]]	+	[[Category: Hargous, Y F]]
	[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]		[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]
	[[Category: Rna binding protein-chimera-rna complex]]		[[Category: Rna binding protein-chimera-rna complex]]

OCA at 05:32, 29 September 2014

2014-09-29T05:32:16Z

←Older revision		Revision as of 05:32, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2i2y.~~png\|left~~\|200px]]	+	==Solution structure of the RRM of SRp20 bound to the RNA CAUC==
		+	<StructureSection load='2i2y' size='340' side='right' caption='[[2i2y]], [[NMR_Ensembles_of_Models \| 28 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._'group_g' Streptococcus sp. 'group g']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">spg and SFRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1320 Streptococcus sp. 'group G'])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i2y RCSB], [http://www.ebi.ac.uk/pdbsum/2i2y PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/2i2y_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sequence-specific RNA-binding proteins SRp20 and 9G8 are the smallest members of the serine- and arginine-rich (SR) protein family, well known for their role in splicing. They also play a role in mRNA export, in particular of histone mRNAs. We present the solution structures of the free 9G8 and SRp20 RNA recognition motifs (RRMs) and of SRp20 RRM in complex with the RNA sequence 5'CAUC3'. The SRp20-RNA structure reveals that although all 4 nt are contacted by the RRM, only the 5' cytosine is primarily recognized in a specific way. This might explain the numerous consensus sequences found by SELEX (systematic evolution of ligands by exponential enrichment) for the RRM of 9G8 and SRp20. Furthermore, we identify a short arginine-rich peptide adjacent to the SRp20 and 9G8 RRMs, which does not contact RNA but is necessary and sufficient for interaction with the export factor Tip-associated protein (TAP). Together, these results provide a molecular description for mRNA and TAP recognition by SRp20 and 9G8.

-	~~{{STRUCTURE_2i2y\| PDB=2i2y \| SCENE= }}~~	+	Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.,Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH EMBO J. 2006 Nov 1;25(21):5126-37. Epub 2006 Oct 12. PMID:17036044<ref>PMID:17036044</ref>

-	~~===Solution structure~~ of the ~~RRM of SRp20 bound to the RNA CAUC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17036044}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2i2y]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_sp~~.~~_'group_g' Streptococcus sp. 'group g']. Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].~~	+

	==See Also==		==See Also==
	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]		*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017036044<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Streptococcus sp. 'group g']]		[[Category: Streptococcus sp. 'group g']]
	[[Category: Allain, F H.]]		[[Category: Allain, F H.]]

OCA at 17:41, 20 October 2012

2012-10-20T17:41:21Z

←Older revision		Revision as of 17:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2i2y]] is a 2 chain structure ~~of [[Pre-mRNA-splicing factor]]~~ with sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._'group_g'~~,_homo_sapiens~~ Streptococcus sp. 'group g'~~, homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].	+	[[2i2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._'group_g' Streptococcus sp. 'group g']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:017036044</ref><references group="xtra"/>		<ref group="xtra">PMID:017036044</ref><references group="xtra"/>
-	[[Category: Streptococcus sp. 'group g'~~, homo sapiens~~]]	+	[[Category: Streptococcus sp. 'group g']]
	[[Category: Allain, F H.]]		[[Category: Allain, F H.]]
	[[Category: Hargous, Y F.]]		[[Category: Hargous, Y F.]]
	[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]		[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]
	[[Category: Rna binding protein-chimera-rna complex]]		[[Category: Rna binding protein-chimera-rna complex]]

OCA: Protected "2i2y" [edit=sysop:move=sysop]

2012-07-27T01:42:14Z

Protected "2i2y" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:42, 27 July 2012

OCA at 01:42, 27 July 2012

2012-07-27T01:42:12Z

←Older revision		Revision as of 01:42, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2i2y.png\|left\|200px]]		[[Image:2i2y.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2i2y", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2i2y\| PDB=2i2y \| SCENE= }}		{{STRUCTURE_2i2y\| PDB=2i2y \| SCENE= }}

	===Solution structure of the RRM of SRp20 bound to the RNA CAUC===		===Solution structure of the RRM of SRp20 bound to the RNA CAUC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17036044}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17036044 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17036044}}		{{ABSTRACT_PUBMED_17036044}}

	==About this Structure==		==About this Structure==
-	~~2I2Y~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Streptococcus_sp.~~_group_g_and_homo_sapiens~~ Streptococcus sp. group g ~~and~~ homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].	+	[[2i2y]] is a 2 chain structure of [[Pre-mRNA-splicing factor]] with sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._'group_g',_homo_sapiens Streptococcus sp. 'group g', homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].
		+
		+	==See Also==
		+	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17036044~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017036044</ref><references group="xtra"/>
-	[[Category: Streptococcus sp. group g ~~and~~ homo sapiens]]	+	[[Category: Streptococcus sp. 'group g', homo sapiens]]
	[[Category: Allain, F H.]]		[[Category: Allain, F H.]]
	[[Category: Hargous, Y F.]]		[[Category: Hargous, Y F.]]
	[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]		[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]
-		+	[[Category: Rna binding protein-chimera-rna complex]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 18:23:45 2009''~~	+

OCA at 16:23, 17 February 2009

2009-02-17T16:23:46Z

←Older revision		Revision as of 16:23, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2I2Y is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Streptococcus_sp._group_g_and_homo_sapiens Streptococcus sp. group g and homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].	+	2I2Y is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_sp._group_g_and_homo_sapiens Streptococcus sp. group g and homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2Y OCA].

	==Reference==		==Reference==
-	Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8., Hargous Y, Hautbergue GM, Tintaru AM, Skrisovska L, Golovanov AP, Stevenin J, Lian LY, Wilson SA, Allain FH, EMBO J. 2006 Nov 1;25(21):5126-37. Epub 2006 Oct 12. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17036044 17036044]~~	+	<ref group="xtra">PMID:17036044</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Streptococcus sp. group g and homo sapiens]]		[[Category: Streptococcus sp. group g and homo sapiens]]
	[[Category: Allain, F H.]]		[[Category: Allain, F H.]]
Line 30:		Line 29:
	[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]		[[Category: Protein-rna complex rrm alpha-beta sandwich beta1-alpha1-beta2-beta3-alpha2-beta4]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 02~~:20:~~40 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:23:45 2009''