2il8 - Revision history

OCA at 11:18, 31 March 2021

2021-03-31T11:18:13Z

←Older revision		Revision as of 11:18, 31 March 2021
Line 1:		Line 1:

	==THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION==		==THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION==
-	<StructureSection load='2il8' size='340' side='right' caption='[[2il8]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>	+	<StructureSection load='2il8' size='340' side='right'caption='[[2il8]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2il8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2il8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IL8 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1il8\|1il8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [~~http~~://pdbe.org/2il8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2il8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2il8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [https://pdbe.org/2il8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [https://www.ebi.ac.uk/pdbsum/2il8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN]] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref>	+	[[https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN]] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Clore, G M]]		[[Category: Clore, G M]]
	[[Category: Cytokine]]		[[Category: Cytokine]]

OCA at 08:07, 4 July 2018

2018-07-04T08:07:55Z

←Older revision		Revision as of 08:07, 4 July 2018
Line 1:		Line 1:
		+
	==THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION==		==THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION==
	<StructureSection load='2il8' size='340' side='right' caption='[[2il8]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2il8' size='340' side='right' caption='[[2il8]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [http://pdbe.org/2il8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [http://www.ebi.ac.uk/pdbsum/2il8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [http://pdbe.org/2il8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [http://www.ebi.ac.uk/pdbsum/2il8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2il8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/2il8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/2il8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2il8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:53, 11 September 2015

2015-09-11T12:53:25Z

←Older revision		Revision as of 12:53, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2il8' size='340' side='right' caption='[[2il8]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>		<StructureSection load='2il8' size='340' side='right' caption='[[2il8]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2il8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2il8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL8 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [http://www.ebi.ac.uk/pdbsum/2il8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [http://pdbe.org/2il8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [http://www.ebi.ac.uk/pdbsum/2il8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2il8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Clore, G M]]		[[Category: Clore, G M]]
	[[Category: Cytokine]]		[[Category: Cytokine]]

OCA at 16:43, 25 December 2014

2014-12-25T16:43:41Z

←Older revision		Revision as of 16:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2il8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2il8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [http://www.ebi.ac.uk/pdbsum/2il8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [http://www.ebi.ac.uk/pdbsum/2il8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN]] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Clore, G M.]]	+	[[Category: Clore, G M]]
	[[Category: Cytokine]]		[[Category: Cytokine]]

OCA at 04:00, 29 September 2014

2014-09-29T04:00:13Z

←Older revision		Revision as of 04:00, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2il8.~~png~~\|~~left~~\|200px]]	+	==THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION==
		+	<StructureSection load='2il8' size='340' side='right' caption='[[2il8]], [[NMR_Ensembles_of_Models \| 30 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2il8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IL8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1il8\|1il8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2il8 RCSB], [http://www.ebi.ac.uk/pdbsum/2il8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/2il8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The solution structure of the interleukin 8 (IL-8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-dynamical simulated annealing calculations. The structure determination is based on a total of 1880 experimental distance restraints (of which 82 are intersubunit) and 362 torsion angle restraints (comprising phi, psi, and chi 1 torsion angles). A total of 30 simulated annealing structures were calculated, and the atomic rms distribution about the mean coordinate positions (excluding residues 1-5 of each subunit) is 0.41 +/- 0.08 A for the backbone atoms and 0.90 +/- 0.08 A for all atoms. The three-dimensional solution structure of the IL-8 dimer reveals a structural motif in which two symmetry-related antiparallel alpha-helices, approximately 24 A long and separated by about 14 A, lie on top of a six-stranded antiparallel beta-sheet platform derived from two three-stranded Greek keys, one from each monomer unit. The general architecture is similar to that of the alpha 1/alpha 2 domains of the human class I histocompatibility antigen HLA-A2. It is suggested that the two alpha-helices form the binding site for the cellular receptor and that the specificity of IL-8, as well as that of a number of related proteins involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response, is achieved by the distinct distribution of charged and polar residues at the surface of the helices.

-	~~{{STRUCTURE_2il8\| PDB=2il8 \| SCENE= }}~~	+	Three-dimensional structure of interleukin 8 in solution.,Clore GM, Appella E, Yamada M, Matsushima K, Gronenborn AM Biochemistry. 1990 Feb 20;29(7):1689-96. PMID:2184886<ref>PMID:2184886</ref>

-	~~===THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_2184886}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2il8]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].~~	+

	==See Also==		==See Also==
	*[[Interleukin\|Interleukin]]		*[[Interleukin\|Interleukin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:002184886<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Clore, G M.]]		[[Category: Clore, G M.]]
	[[Category: Cytokine]]		[[Category: Cytokine]]

OCA at 19:02, 20 October 2012

2012-10-20T19:02:53Z

←Older revision		Revision as of 19:02, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2il8]] is a 2 chain structure ~~of [[Interleukin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].	+	[[2il8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].

	==See Also==		==See Also==

OCA: Protected "2il8" [edit=sysop:move=sysop]

2012-07-27T06:06:02Z

Protected "2il8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:06, 27 July 2012

OCA at 06:06, 27 July 2012

2012-07-27T06:06:00Z

←Older revision		Revision as of 06:06, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2il8.png\|left\|200px]]		[[Image:2il8.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2il8", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2il8\| PDB=2il8 \| SCENE= }}		{{STRUCTURE_2il8\| PDB=2il8 \| SCENE= }}

	===THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION===		===THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 2184886 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_2184886}}		{{ABSTRACT_PUBMED_2184886}}

	==About this Structure==		==About this Structure==
-	~~2IL8~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].	+	[[2il8]] is a 2 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].
		+
		+	==See Also==
		+	*[[Interleukin\|Interleukin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~2184886~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:002184886</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Clore, G M.]]		[[Category: Clore, G M.]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:04:24 2009''

OCA at 20:04, 17 February 2009

2009-02-17T20:04:25Z

←Older revision		Revision as of 20:04, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2IL8 is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].	+	2IL8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].

	==Reference==		==Reference==
-	~~Three-dimensional structure of interleukin 8 in solution., Clore GM, Appella E, Yamada M, Matsushima K, Gronenborn AM, Biochemistry. 1990 Feb 20;29(7):1689-96.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/2184886 2184886]~~	+	<ref group="xtra">PMID:2184886</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Clore, G M.]]		[[Category: Clore, G M.]]
	[[Category: Cytokine]]		[[Category: Cytokine]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:18:~~17 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:04:24 2009''

OCA at 03:18, 29 July 2008

2008-07-29T03:18:18Z

←Older revision		Revision as of 03:18, 29 July 2008
Line 1:		Line 1:
-	[[Image:2il8.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2il8.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2il8\| PDB=2il8 \| SCENE= }}		{{STRUCTURE_2il8\| PDB=2il8 \| SCENE= }}

-	~~'''~~THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION~~'''~~	+	===THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION===


-	~~==Overview==~~	+	<!--
-	~~The solution structure of the interleukin 8 (IL~~-~~8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry~~-~~dynamical simulated annealing calculations.~~ The ~~structure determination is based on a total of 1880 experimental distance restraints (of which 82 are intersubunit) and 362 torsion angle restraints (comprising phi~~, ~~psi, and chi 1 torsion angles). A total of 30 simulated annealing structures were calculated~~, ~~and~~ the ~~atomic rms distribution about~~ the ~~mean coordinate positions~~ (~~excluding residues 1-5 of each subunit) is 0.41 +~~/~~- 0.08 A for the backbone atoms and 0.90 +~~/~~- 0~~.~~08 A for all atoms~~. ~~The three-dimensional solution structure of the IL-8 dimer reveals a structural motif in which two symmetry-related antiparallel alpha-helices~~, approximately 24 A long and separated by about 14 A, lie on top of a six-stranded antiparallel beta-sheet platform derived from two three-stranded Greek keys, one from each monomer unit. The general architecture is ~~similar to that of~~ the ~~alpha 1/alpha 2 domains of the human class I histocompatibility antigen HLA-A2~~. ~~It is suggested that the two alpha~~-~~helices form the binding site for the cellular receptor and that the specificity of IL~~-8, as well as that of a number of related proteins involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response, is achieved by the distinct distribution of charged and polar residues at the surface of the helices.	+	The line below this paragraph, {{ABSTRACT_PUBMED_2184886}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 2184886 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_2184886}}

	==About this Structure==		==About this Structure==
-	2IL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].	+	2IL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].

	==Reference==		==Reference==
Line 24:		Line 28:
	[[Category: Clore, G M.]]		[[Category: Clore, G M.]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 07~~:37:27 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:18:17 2008''