2ion - Revision history

OCA at 10:14, 30 August 2023

2023-08-30T10:14:23Z

←Older revision		Revision as of 10:14, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='2ion' size='340' side='right'caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='2ion' size='340' side='right'caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ION FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ION FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.57Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2iol\|2iol]], [[2ios\|2ios]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Pdcd4, MA-3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [https://pdbe.org/2ion PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [https://www.ebi.ac.uk/pdbsum/2ion PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ion ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [https://pdbe.org/2ion PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [https://www.ebi.ac.uk/pdbsum/2ion PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ion ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.	+	[https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE] Note=Decreases benign tumor development and malignant progression.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref>	+	[https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: LaRonde-LeBlanc~~, N A~~]]	+	[[Category: LaRonde-LeBlanc NA]]
-	[[Category: Wlodawer, A]]	+	[[Category: Wlodawer A]]
-	~~[[Category: Alpha-helical]]~~	+
-	~~[[Category: Antitumor protein~~]]	+

OCA at 11:20, 31 March 2021

2021-03-31T11:20:02Z

←Older revision		Revision as of 11:20, 31 March 2021
Line 1:		Line 1:

	==Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2==		==Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2==
-	<StructureSection load='2ion' size='340' side='right' caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>	+	<StructureSection load='2ion' size='340' side='right'caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ION FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ION FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iol\|2iol]], [[2ios\|2ios]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [~~http~~://pdbe.org/2ion PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ion PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ion ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [https://pdbe.org/2ion PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [https://www.ebi.ac.uk/pdbsum/2ion PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ion ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.	+	[[https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref>	+	[[https://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2ion_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2ion_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 2ion" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ion" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: LaRonde-LeBlanc, N A]]		[[Category: LaRonde-LeBlanc, N A]]

OCA at 08:33, 18 October 2017

2017-10-18T08:33:20Z

←Older revision		Revision as of 08:33, 18 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2==		==Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2==
	<StructureSection load='2ion' size='340' side='right' caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='2ion' size='340' side='right' caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [http://pdbe.org/2ion PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [http://www.ebi.ac.uk/pdbsum/2ion PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [http://pdbe.org/2ion PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [http://www.ebi.ac.uk/pdbsum/2ion PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ion ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 2ion" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2ion" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:24, 9 February 2016

2016-02-09T10:24:26Z

←Older revision		Revision as of 10:24, 9 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ion ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:20, 10 September 2015

2015-09-10T21:20:19Z

←Older revision		Revision as of 21:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ion' size='340' side='right' caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='2ion' size='340' side='right' caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ION FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ION FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [http://www.ebi.ac.uk/pdbsum/2ion PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [http://pdbe.org/2ion PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [http://www.ebi.ac.uk/pdbsum/2ion PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ion" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: LaRonde-LeBlanc, N A]]		[[Category: LaRonde-LeBlanc, N A]]
	[[Category: Wlodawer, A]]		[[Category: Wlodawer, A]]
	[[Category: Alpha-helical]]		[[Category: Alpha-helical]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]

OCA at 08:41, 16 January 2015

2015-01-16T08:41:15Z

←Older revision		Revision as of 08:41, 16 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ION FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ION FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [http://www.ebi.ac.uk/pdbsum/2ion PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [http://www.ebi.ac.uk/pdbsum/2ion PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.		[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: LaRonde-LeBlanc, N A.]]	+	[[Category: LaRonde-LeBlanc, N A]]
-	[[Category: Wlodawer, A.]]	+	[[Category: Wlodawer, A]]
	[[Category: Alpha-helical]]		[[Category: Alpha-helical]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]

OCA at 10:15, 30 September 2014

2014-09-30T10:15:21Z

←Older revision		Revision as of 10:15, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2ion\| PDB=2ion \| SCENE= }}~~	+	==Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2==
-	===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2===	+	<StructureSection load='2ion' size='340' side='right' caption='[[2ion]], [[Resolution\|resolution]] 1.57Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17060447}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2ion]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ION FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iol\|2iol]], [[2ios\|2ios]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pdcd4, MA-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ion FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ion OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ion RCSB], [http://www.ebi.ac.uk/pdbsum/2ion PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.		[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/2ion_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G. These interactions are mediated through two MA3 domains on the Pdcd4 molecule and result in inhibition of protein synthesis. We have solved the high-resolution crystal structure of the C-terminal MA3 (cMA3) domain of Pdcd4 in several crystal forms and demonstrated its similarity to the MA3 domain of eIF4G. As predicted by the structure, the cMA3 domain competes with eIF4Gc for binding to eIF4A and surprisingly is sufficient to inhibit translation initiation. Mutations that abolish eIF4A binding negate both functions of the cMA3. Interestingly mutations in the Akt phosphorylation site influenced neither cMA3 binding to eIF4A nor its ability to inhibit translation initiation. Finally, our structural analysis reveals MA3 domains to be a novel subfamily of VHS domains.

-	~~==Function==~~	+	Structural basis for inhibition of translation by the tumor suppressor Pdcd4.,LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH Mol Cell Biol. 2007 Jan;27(1):147-56. Epub 2006 Oct 23. PMID:17060447<ref>PMID:17060447</ref>
-	~~[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits~~ translation ~~initiation and cap-dependent translation. May excert its function~~ by ~~hindering~~ the ~~interaction between EIF4A1 and EIF4G~~. ~~Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down~~-~~regulates the expression of MAP4K1~~, ~~thus inhibiting events important in driving invasion~~, ~~namely~~, ~~MAPK85 activation and consequent JUN-dependent transcription~~. ~~May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter~~-~~induced neoplastic transformation~~. ~~Binds RNA~~.~~<ref>PMID:12482958</ref><ref>PMID:12894233</ref><ref>~~PMID:~~16024603</ref>~~<ref>PMID:17060447</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2ion]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Cell death protein\|Cell death protein]]		*[[Cell death protein\|Cell death protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017060447</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: LaRonde-LeBlanc, N A.]]		[[Category: LaRonde-LeBlanc, N A.]]

OCA at 06:16, 25 March 2013

2013-03-25T06:16:15Z

←Older revision		Revision as of 06:16, 25 March 2013
Line 1:		Line 1:
-	[[Image:2ion.png\|left\|200px]]
-
	{{STRUCTURE_2ion\| PDB=2ion \| SCENE= }}		{{STRUCTURE_2ion\| PDB=2ion \| SCENE= }}
-
	===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2===		===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2===
		+	{{ABSTRACT_PUBMED_17060447}}

-	~~{{ABSTRACT_PUBMED_17060447}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref><ref>PMID:12894233</ref><ref>PMID:16024603</ref><ref>PMID:17060447</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017060447</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017060447</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: LaRonde-LeBlanc, N A.]]		[[Category: LaRonde-LeBlanc, N A.]]

OCA: Protected "2ion" [edit=sysop:move=sysop]

2012-10-20T13:34:08Z

Protected "2ion" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:34, 20 October 2012

OCA at 13:34, 20 October 2012

2012-10-20T13:34:06Z

←Older revision		Revision as of 13:34, 20 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ion.png\|left\|200px]]		[[Image:2ion.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ion", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ion\| PDB=2ion \| SCENE= }}		{{STRUCTURE_2ion\| PDB=2ion \| SCENE= }}

	===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2===		===Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17060447}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17060447 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17060447}}		{{ABSTRACT_PUBMED_17060447}}

	==About this Structure==		==About this Structure==
-	~~2ION~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA].	+	[[2ion]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ION OCA].
		+
		+	==See Also==
		+	*[[Cell death protein\|Cell death protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17060447~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017060447</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: LaRonde-LeBlanc, N A.]]		[[Category: LaRonde-LeBlanc, N A.]]
	[[Category: Wlodawer, A.]]		[[Category: Wlodawer, A.]]
	[[Category: Alpha-helical]]		[[Category: Alpha-helical]]
-		+	[[Category: Antitumor protein]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 09:07:10 2009''~~	+