2iwr - Revision history

OCA at 14:27, 13 December 2023

2023-12-13T14:27:53Z

←Older revision		Revision as of 14:27, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2iwr' size='340' side='right'caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2iwr' size='340' side='right'caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IWR FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=CAF:S~~-~~DIMETHYLARSINOYL-CYSTEINE'>CAF</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2bmj\|2bmj]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [https://pdbe.org/2iwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [https://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [https://pdbe.org/2iwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [https://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AGAP2_HUMAN AGAP2_HUMAN] GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.<ref>PMID:12640130</ref> <ref>PMID:14761976</ref> <ref>PMID:15118108</ref> <ref>PMID:16079295</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith, C]]	+	[[Category: Arrowsmith C]]
-	[[Category: Doyle~~, D A~~]]	+	[[Category: Doyle DA]]
-	[[Category: Edwards, A]]	+	[[Category: Edwards A]]
-	[[Category: Elkins~~, J M~~]]	+	[[Category: Elkins JM]]
-	[[Category: Papagrigoriou, E]]	+	[[Category: Papagrigoriou E]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Soundararajan M]]
-	[[Category: Soundararajan, M]]	+	[[Category: Sundstrom M]]
-	[[Category: Sundstrom, M]]	+	[[Category: Weigelt J]]
-	[[Category: Weigelt, J]]	+	[[Category: Yang X]]
-	[[Category: Yang, X]]	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Ank repeat]]~~	+
-	~~[[Category: Centg1]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Gtpase activation]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Oncogene]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 07:55, 19 January 2022

2022-01-19T07:55:52Z

←Older revision		Revision as of 07:55, 19 January 2022
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	<StructureSection load='2iwr' size='340' side='right'caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2iwr' size='340' side='right'caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IWR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bmj\|2bmj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [~~http~~://pdbe.org/2iwr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [https://pdbe.org/2iwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [https://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:33, 15 April 2020

2020-04-15T07:33:39Z

←Older revision		Revision as of 07:33, 15 April 2020
Line 1:		Line 1:

	==Gtpase Like Domain Of Centaurin Gamma 1 (Human)==		==Gtpase Like Domain Of Centaurin Gamma 1 (Human)==
-	<StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='2iwr' size='340' side='right'caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IWR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://pdbe.org/2iwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://pdbe.org/2iwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Doyle, D A]]		[[Category: Doyle, D A]]

OCA at 07:07, 11 July 2018

2018-07-11T07:07:54Z

←Older revision		Revision as of 07:07, 11 July 2018
Line 1:		Line 1:
		+
	==Gtpase Like Domain Of Centaurin Gamma 1 (Human)==		==Gtpase Like Domain Of Centaurin Gamma 1 (Human)==
	<StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://pdbe.org/2iwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://pdbe.org/2iwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 41:		Line 42:
	[[Category: Weigelt, J]]		[[Category: Weigelt, J]]
	[[Category: Yang, X]]		[[Category: Yang, X]]
		+	[[Category: Alternative splicing]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
	[[Category: Centg1]]		[[Category: Centg1]]
Line 52:		Line 54:
	[[Category: Oncogene]]		[[Category: Oncogene]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Transport]]		[[Category: Transport]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 15:39, 9 February 2016

2016-02-09T15:39:52Z

←Older revision		Revision as of 15:39, 9 February 2016
Line 5:		Line 5:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://pdbe.org/2iwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iwr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2iwr" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:56, 22 April 2015

2015-04-22T06:56:47Z

←Older revision		Revision as of 06:56, 22 April 2015
Line 1:		Line 1:
-	==~~GTPASE LIKE DOMAIN OF CENTAURIN GAMMA~~ 1 (~~HUMAN~~)==	+	==Gtpase Like Domain Of Centaurin Gamma 1 (Human)==
	<StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IWR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>
Line 29:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C]]		[[Category: Arrowsmith, C]]
	[[Category: Doyle, D A]]		[[Category: Doyle, D A]]

OCA at 15:51, 19 January 2015

2015-01-19T15:51:30Z

←Older revision		Revision as of 15:51, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IWR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IWR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C.]]	+	[[Category: Arrowsmith, C]]
-	[[Category: Doyle, D A.]]	+	[[Category: Doyle, D A]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Elkins, J M.]]	+	[[Category: Elkins, J M]]
-	[[Category: Papagrigoriou, E.]]	+	[[Category: Papagrigoriou, E]]
-	[[Category: ~~Sgc,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Soundararajan, M.]]	+	[[Category: Soundararajan, M]]
-	[[Category: Sundstrom, M.]]	+	[[Category: Sundstrom, M]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Yang, X.]]	+	[[Category: Yang, X]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
	[[Category: Centg1]]		[[Category: Centg1]]
Line 53:		Line 53:
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structual genomics consortium]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 08:58, 30 September 2014

2014-09-30T08:58:33Z

←Older revision		Revision as of 08:58, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2iwr.~~png~~\|~~left~~\|200px]]	+	==GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)==
		+	<StructureSection load='2iwr' size='340' side='right' caption='[[2iwr]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IWR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bmj\|2bmj]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iwr RCSB], [http://www.ebi.ac.uk/pdbsum/2iwr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Centaurins are a family of proteins that contain GTPase-activating protein domains, with the gamma family members containing in addition a GTPase-like domain. Centaurins reside mainly in the nucleus and are known to activate phosphoinositide 3-kinase, a key regulator of cell proliferation, motility and vesicular trafficking. In the present study, using X-ray structural analysis, enzymatic assays and nucleotide-binding studies, we show that, for CENTG1 (centaurin gamma-1) the GTPase-like domain has broader trinucleotide specificity. Alterations within the G4 motif of CENTG1 from the highly conserved NKXD found in typical GTPases to TQDR result in the loss of specificity, a lower affinity for the nucleotides and higher turnover rates. These results indicate that the centaurins could be more accurately classified as NTPases and point to alternative mechanisms of cell signalling control.

-	~~{{STRUCTURE_2iwr\| PDB=2iwr \| SCENE= }}~~	+	The centaurin gamma-1 GTPase-like domain functions as an NTPase.,Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA Biochem J. 2007 Feb 1;401(3):679-88. PMID:17037982<ref>PMID:17037982</ref>

-	~~===GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17037982}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2iwr]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017037982<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]

OCA: Protected "2iwr" [edit=sysop:move=sysop]

2013-01-07T11:18:27Z

Protected "2iwr" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:18, 7 January 2013

OCA at 11:18, 7 January 2013

2013-01-07T11:18:24Z

←Older revision		Revision as of 11:18, 7 January 2013
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-	{{Seed}}
	[[Image:2iwr.png\|left\|200px]]		[[Image:2iwr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2iwr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2iwr\| PDB=2iwr \| SCENE= }}		{{STRUCTURE_2iwr\| PDB=2iwr \| SCENE= }}

	===GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)===		===GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17037982}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17037982 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17037982}}		{{ABSTRACT_PUBMED_17037982}}

	==About this Structure==		==About this Structure==
-	~~2IWR~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA].	+	[[2iwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWR OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17037982~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017037982</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C.]]		[[Category: Arrowsmith, C.]]
Line 35:		Line 23:
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
	[[Category: Yang, X.]]		[[Category: Yang, X.]]
-	[[Category: Alternative splicing]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
	[[Category: Centg1]]		[[Category: Centg1]]
Line 47:		Line 34:
	[[Category: Oncogene]]		[[Category: Oncogene]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
-	[[Category: Polymorphism]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Sgc]]		[[Category: Sgc]]
Line 54:		Line 40:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	[[Category: Transport]]		[[Category: Transport]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:53:51 2009''