2ixb - Revision history

OCA at 14:28, 13 December 2023

2023-12-13T14:28:45Z

←Older revision		Revision as of 14:28, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2ixb' size='340' side='right'caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ixb' size='340' side='right'caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_13253 Atcc 13253~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ixa\|2ixa]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [https://pdbe.org/2ixb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [https://www.ebi.ac.uk/pdbsum/2ixb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [https://pdbe.org/2ixb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [https://www.ebi.ac.uk/pdbsum/2ixb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GH109_ELIME GH109_ELIME]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Alpha-N-acetylgalactosaminidase]]~~	+	[[Category: Elizabethkingia meningoseptica]]
-	~~[[Category: Atcc 13253~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bourne, Y]]	+	[[Category: Bourne Y]]
-	[[Category: Clausen, H]]	+	[[Category: Clausen H]]
-	[[Category: Henrissat, B]]	+	[[Category: Henrissat B]]
-	[[Category: Liu~~, Q P~~]]	+	[[Category: Liu QP]]
-	[[Category: Sulzenbacher, G]]	+	[[Category: Sulzenbacher G]]
-	~~[[Category: A-eco conversion]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: N-acetylgalactosaminidase]]~~	+
-	~~[[Category: Nad~~]]	+

OCA at 20:43, 20 October 2021

2021-10-20T20:43:11Z

←Older revision		Revision as of 20:43, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2ixb' size='340' side='right'caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ixb' size='340' side='right'caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_13253 Atcc 13253]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_13253 Atcc 13253]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ixa\|2ixa]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [~~http~~://pdbe.org/2ixb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ixb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [https://pdbe.org/2ixb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [https://www.ebi.ac.uk/pdbsum/2ixb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:48, 11 December 2019

2019-12-11T19:48:47Z

←Older revision		Revision as of 19:48, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of N-ACETYLGALACTOSAMINIDASE in complex with GalNAC==		==Crystal structure of N-ACETYLGALACTOSAMINIDASE in complex with GalNAC==
-	<StructureSection load='2ixb' size='340' side='right' caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2ixb' size='340' side='right'caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_13253 Atcc 13253]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_13253 Atcc 13253]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXB FirstGlance]. <br>
Line 34:		Line 34:
	[[Category: Alpha-N-acetylgalactosaminidase]]		[[Category: Alpha-N-acetylgalactosaminidase]]
	[[Category: Atcc 13253]]		[[Category: Atcc 13253]]
		+	[[Category: Large Structures]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Clausen, H]]		[[Category: Clausen, H]]

OCA at 05:33, 8 March 2018

2018-03-08T05:33:54Z

←Older revision		Revision as of 05:33, 8 March 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ N-ACETYLGALACTOSAMINIDASE ~~IN COMPLEX WITH GALNAC~~==	+
		+	==Crystal structure of N-ACETYLGALACTOSAMINIDASE in complex with GalNAC==
	<StructureSection load='2ixb' size='340' side='right' caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ixb' size='340' side='right' caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [http://pdbe.org/2ixb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [http://www.ebi.ac.uk/pdbsum/2ixb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [http://pdbe.org/2ixb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [http://www.ebi.ac.uk/pdbsum/2ixb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ixb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:14, 11 September 2015

2015-09-11T17:14:35Z

←Older revision		Revision as of 17:14, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ixb' size='340' side='right' caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ixb' size='340' side='right' caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Elizabethkingia_meningoseptica Elizabethkingia meningoseptica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_13253 Atcc 13253]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [http://www.ebi.ac.uk/pdbsum/2ixb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [http://pdbe.org/2ixb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [http://www.ebi.ac.uk/pdbsum/2ixb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ixb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Alpha-N-acetylgalactosaminidase]]		[[Category: Alpha-N-acetylgalactosaminidase]]
-	[[Category: ~~Elizabethkingia meningoseptica~~]]	+	[[Category: Atcc 13253]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Clausen, H]]		[[Category: Clausen, H]]

OCA at 14:38, 19 January 2015

2015-01-19T14:38:17Z

←Older revision		Revision as of 14:38, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [http://www.ebi.ac.uk/pdbsum/2ixb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [http://www.ebi.ac.uk/pdbsum/2ixb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Alpha-N-acetylgalactosaminidase]]		[[Category: Alpha-N-acetylgalactosaminidase]]
	[[Category: Elizabethkingia meningoseptica]]		[[Category: Elizabethkingia meningoseptica]]
-	[[Category: Bourne, Y.]]	+	[[Category: Bourne, Y]]
-	[[Category: Clausen, H.]]	+	[[Category: Clausen, H]]
-	[[Category: Henrissat, B.]]	+	[[Category: Henrissat, B]]
-	[[Category: Liu, Q P.]]	+	[[Category: Liu, Q P]]
-	[[Category: Sulzenbacher, G.]]	+	[[Category: Sulzenbacher, G]]
	[[Category: A-eco conversion]]		[[Category: A-eco conversion]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: N-acetylgalactosaminidase]]		[[Category: N-acetylgalactosaminidase]]
	[[Category: Nad]]		[[Category: Nad]]

OCA at 08:23, 30 September 2014

2014-09-30T08:23:16Z

←Older revision		Revision as of 08:23, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ixb.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF N-ACETYLGALACTOSAMINIDASE IN COMPLEX WITH GALNAC==
		+	<StructureSection load='2ixb' size='340' side='right' caption='[[2ixb]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixa\|2ixa]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixb RCSB], [http://www.ebi.ac.uk/pdbsum/2ixb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Enzymatic removal of blood group ABO antigens to develop universal red blood cells (RBCs) was a pioneering vision originally proposed more than 25 years ago. Although the feasibility of this approach was demonstrated in clinical trials for group B RBCs, a major obstacle in translating this technology to clinical practice has been the lack of efficient glycosidase enzymes. Here we report two bacterial glycosidase gene families that provide enzymes capable of efficient removal of A and B antigens at neutral pH with low consumption of recombinant enzymes. The crystal structure of a member of the alpha-N-acetylgalactosaminidase family reveals an unusual catalytic mechanism involving NAD+. The enzymatic conversion processes we describe hold promise for achieving the goal of producing universal RBCs, which would improve the blood supply while enhancing the safety of clinical transfusions.

-	~~{{STRUCTURE_2ixb\| PDB=2ixb \| SCENE= }}~~	+	Bacterial glycosidases for the production of universal red blood cells.,Liu QP, Sulzenbacher G, Yuan H, Bennett EP, Pietz G, Saunders K, Spence J, Nudelman E, Levery SB, White T, Neveu JM, Lane WS, Bourne Y, Olsson ML, Henrissat B, Clausen H Nat Biotechnol. 2007 Apr;25(4):454-64. Epub 2007 Apr 1. PMID:17401360<ref>PMID:17401360</ref>

-	~~===CRYSTAL STRUCTURE OF N-ACETYLGALACTOSAMINIDASE IN COMPLEX WITH GALNAC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17401360}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ixb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017401360<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alpha-N-acetylgalactosaminidase]]		[[Category: Alpha-N-acetylgalactosaminidase]]
	[[Category: Elizabethkingia meningoseptica]]		[[Category: Elizabethkingia meningoseptica]]

OCA: Protected "2ixb" [edit=sysop:move=sysop]

2013-01-07T10:47:54Z

Protected "2ixb" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:47, 7 January 2013

OCA at 10:47, 7 January 2013

2013-01-07T10:47:52Z

←Older revision		Revision as of 10:47, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2ixb.png\|left\|200px]]		[[Image:2ixb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ixb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2ixb\| PDB=2ixb \| SCENE= }}		{{STRUCTURE_2ixb\| PDB=2ixb \| SCENE= }}

	===CRYSTAL STRUCTURE OF N-ACETYLGALACTOSAMINIDASE IN COMPLEX WITH GALNAC===		===CRYSTAL STRUCTURE OF N-ACETYLGALACTOSAMINIDASE IN COMPLEX WITH GALNAC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17401360}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17401360 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17401360}}		{{ABSTRACT_PUBMED_17401360}}

	==About this Structure==		==About this Structure==
-	~~2IXB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA].	+	[[2ixb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17401360~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017401360</ref><references group="xtra"/>
	[[Category: Alpha-N-acetylgalactosaminidase]]		[[Category: Alpha-N-acetylgalactosaminidase]]
	[[Category: Elizabethkingia meningoseptica]]		[[Category: Elizabethkingia meningoseptica]]
Line 35:		Line 23:
	[[Category: N-acetylgalactosaminidase]]		[[Category: N-acetylgalactosaminidase]]
	[[Category: Nad]]		[[Category: Nad]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:38:37 2009''

OCA at 09:38, 22 March 2009

2009-03-22T09:38:37Z

←Older revision		Revision as of 09:38, 22 March 2009
Line 12:		Line 12:
	===CRYSTAL STRUCTURE OF N-ACETYLGALACTOSAMINIDASE IN COMPLEX WITH GALNAC===		===CRYSTAL STRUCTURE OF N-ACETYLGALACTOSAMINIDASE IN COMPLEX WITH GALNAC===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_17401360}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17401360 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17401360}}

	==About this Structure==		==About this Structure==
	2IXB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA].		2IXB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_meningoseptica Elizabethkingia meningoseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:17401360</ref><references group="xtra"/>
	[[Category: Alpha-N-acetylgalactosaminidase]]		[[Category: Alpha-N-acetylgalactosaminidase]]
	[[Category: Elizabethkingia meningoseptica]]		[[Category: Elizabethkingia meningoseptica]]
Line 27:		Line 36:
	[[Category: Nad]]		[[Category: Nad]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Feb 18 04:30~~:38 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:38:37 2009''