2ixn - Revision history

OCA at 09:31, 9 May 2024

2024-05-09T09:31:40Z

←Older revision		Revision as of 09:31, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2ixn' size='340' side='right'caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ixn' size='340' side='right'caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2ixo\|2ixo]]~~, [[~~2ixp~~\|~~2ixp~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [https://pdbe.org/2ixn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [https://www.ebi.ac.uk/pdbsum/2ixn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [https://pdbe.org/2ixn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [https://www.ebi.ac.uk/pdbsum/2ixn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTPA2_YEAST PTPA2_YEAST]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.<ref>PMID:11262194</ref> <ref>PMID:11134337</ref> <ref>PMID:12952889</ref> <ref>PMID:15447631</ref> <ref>PMID:15689491</ref> <ref>PMID:16380387</ref>	+	[https://www.uniprot.org/uniprot/PTPA2_YEAST PTPA2_YEAST] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.<ref>PMID:11262194</ref> <ref>PMID:11134337</ref> <ref>PMID:12952889</ref> <ref>PMID:15447631</ref> <ref>PMID:15689491</ref> <ref>PMID:16380387</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barford, D]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Goris, J]]	+	[[Category: Barford D]]
-	[[Category: Jordens, J]]	+	[[Category: Goris J]]
-	[[Category: Leulliot, N]]	+	[[Category: Jordens J]]
-	[[Category: Quevillon-Cheruel, S]]	+	[[Category: Leulliot N]]
-	[[Category: Schiltz, M]]	+	[[Category: Quevillon-Cheruel S]]
-	[[Category: Tilbeurgh, H ~~Van~~]]	+	[[Category: Schiltz M]]
-	[[Category: Vicentini, G]]	+	[[Category: Van Tilbeurgh H]]
-	~~[[Category: Isomerase]]~~	+	[[Category: Vicentini G]]
-	~~[[Category: Pp2a phosphatase activator prolyl isomerase ptpa~~]]	+

OCA at 07:56, 19 January 2022

2022-01-19T07:56:30Z

←Older revision		Revision as of 07:56, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2ixn' size='340' side='right'caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ixn' size='340' side='right'caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2IXN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ixo\|2ixo]], [[2ixp\|2ixp]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [~~http~~://pdbe.org/2ixn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ixn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [https://pdbe.org/2ixn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [https://www.ebi.ac.uk/pdbsum/2ixn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTPA2_YEAST PTPA2_YEAST]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.<ref>PMID:11262194</ref> <ref>PMID:11134337</ref> <ref>PMID:12952889</ref> <ref>PMID:15447631</ref> <ref>PMID:15689491</ref> <ref>PMID:16380387</ref>	+	[[https://www.uniprot.org/uniprot/PTPA2_YEAST PTPA2_YEAST]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.<ref>PMID:11262194</ref> <ref>PMID:11134337</ref> <ref>PMID:12952889</ref> <ref>PMID:15447631</ref> <ref>PMID:15689491</ref> <ref>PMID:16380387</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:34, 15 April 2020

2020-04-15T07:34:13Z

←Older revision		Revision as of 07:34, 15 April 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2==		==CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2==
-	<StructureSection load='2ixn' size='340' side='right' caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2ixn' size='340' side='right'caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IXN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IXN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://pdbe.org/2ixn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://pdbe.org/2ixn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Barford, D]]		[[Category: Barford, D]]
	[[Category: Goris, J]]		[[Category: Goris, J]]

OCA at 06:26, 11 July 2018

2018-07-11T06:26:03Z

←Older revision		Revision as of 06:26, 11 July 2018
Line 1:		Line 1:
-	==CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR ~~YPA2~~ PTPA2==	+
		+	==CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2==
	<StructureSection load='2ixn' size='340' side='right' caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ixn' size='340' side='right' caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://pdbe.org/2ixn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://pdbe.org/2ixn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:27, 9 February 2016

2016-02-09T05:27:27Z

←Older revision		Revision as of 05:27, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ixn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:04, 10 September 2015

2015-09-10T19:04:41Z

←Older revision		Revision as of 19:04, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ixn' size='340' side='right' caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2ixn' size='340' side='right' caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://pdbe.org/2ixn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2ixn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Barford, D]]		[[Category: Barford, D]]
	[[Category: Goris, J]]		[[Category: Goris, J]]

OCA at 04:44, 25 December 2014

2014-12-25T04:44:37Z

←Older revision		Revision as of 04:44, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTPA2_YEAST PTPA2_YEAST]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.<ref>PMID:11262194</ref> <ref>PMID:11134337</ref> <ref>PMID:12952889</ref> <ref>PMID:15447631</ref> <ref>PMID:15689491</ref> <ref>PMID:16380387</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Barford, D.]]	+	[[Category: Barford, D]]
-	[[Category: Goris, J.]]	+	[[Category: Goris, J]]
-	[[Category: Jordens, J.]]	+	[[Category: Jordens, J]]
-	[[Category: Leulliot, N.]]	+	[[Category: Leulliot, N]]
-	[[Category: Quevillon-Cheruel, S.]]	+	[[Category: Quevillon-Cheruel, S]]
-	[[Category: Schiltz, M.]]	+	[[Category: Schiltz, M]]
-	[[Category: Tilbeurgh, H Van.]]	+	[[Category: Tilbeurgh, H Van]]
-	[[Category: Vicentini, G.]]	+	[[Category: Vicentini, G]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Pp2a phosphatase activator prolyl isomerase ptpa]]		[[Category: Pp2a phosphatase activator prolyl isomerase ptpa]]

OCA at 07:38, 30 September 2014

2014-09-30T07:38:14Z

←Older revision		Revision as of 07:38, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2ixn.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR YPA2 PTPA2==
		+	<StructureSection load='2ixn' size='340' side='right' caption='[[2ixn]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IXN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ixo\|2ixo]], [[2ixp\|2ixp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ixn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ixn RCSB], [http://www.ebi.ac.uk/pdbsum/2ixn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PTPA, an essential and specific activator of protein phosphatase 2A (PP2A), functions as a peptidyl prolyl isomerase (PPIase). We present here the crystal structures of human PTPA and of the two yeast orthologs (Ypa1 and Ypa2), revealing an all alpha-helical protein fold that is radically different from other PPIases. The protein is organized into two domains separated by a groove lined by highly conserved residues. To understand the molecular mechanism of PTPA activity, Ypa1 was cocrystallized with a proline-containing PPIase peptide substrate. In the complex, the peptide binds at the interface of a peptide-induced dimer interface. Conserved residues of the interdomain groove contribute to the peptide binding site and dimer interface. Structure-guided mutational studies showed that in vivo PTPA activity is influenced by mutations on the surface of the peptide binding pocket, the same mutations that also influenced the in vitro activation of PP2Ai and PPIase activity.

-	~~{{STRUCTURE_2ixn\| PDB=2ixn \| SCENE= }}~~	+	Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.,Leulliot N, Vicentini G, Jordens J, Quevillon-Cheruel S, Schiltz M, Barford D, van Tilbeurgh H, Goris J Mol Cell. 2006 Aug 4;23(3):413-24. PMID:16885030<ref>PMID:16885030</ref>

-	~~===CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR YPA2 PTPA2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_16885030}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2ixn]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:016885030<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Barford, D.]]		[[Category: Barford, D.]]

OCA: Protected "2ixn" [edit=sysop:move=sysop]

2013-01-07T12:48:09Z

Protected "2ixn" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:48, 7 January 2013

OCA at 12:48, 7 January 2013

2013-01-07T12:48:06Z

←Older revision		Revision as of 12:48, 7 January 2013
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-	{{Seed}}
	[[Image:2ixn.png\|left\|200px]]		[[Image:2ixn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2ixn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2ixn\| PDB=2ixn \| SCENE= }}		{{STRUCTURE_2ixn\| PDB=2ixn \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR YPA2 PTPA2===		===CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR YPA2 PTPA2===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_16885030}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 16885030 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_16885030}}		{{ABSTRACT_PUBMED_16885030}}

	==About this Structure==		==About this Structure==
-	~~2IXN~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA].	+	[[2ixn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXN OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~16885030~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:016885030</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Barford, D.]]		[[Category: Barford, D.]]
Line 35:		Line 23:
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Pp2a phosphatase activator prolyl isomerase ptpa]]		[[Category: Pp2a phosphatase activator prolyl isomerase ptpa]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:50:08 2009''