2iy7 - Revision history

OCA at 13:07, 26 July 2023

2023-07-26T13:07:07Z

←Older revision		Revision as of 13:07, 26 July 2023
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	<StructureSection load='2iy7' size='340' side='right'caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2iy7' size='340' side='right'caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacterium_multocidum"_lehmann_and_neumann_1899 "bacterium multocidum" lehmann and neumann 1899~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pasteurella_multocida Pasteurella multocida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CSF:CYTIDINE~~-~~5-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC+ACID'>CSF</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSF:CYTIDINE-5-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC+ACID'>CSF</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [https://pdbe.org/2iy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [https://www.ebi.ac.uk/pdbsum/2iy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iy7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [https://pdbe.org/2iy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [https://www.ebi.ac.uk/pdbsum/2iy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iy7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q15KI8_PASMD Q15KI8_PASMD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacterium multocidum lehmann and neumann 1899]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cho, H S~~]]	+	[[Category: Pasteurella multocida]]
-	[[Category: ~~Kim, D U~~]]	+	[[Category: Cho HS]]
-	[[Category: ~~Cmp-3fneuac]]~~	+	[[Category: Kim DU]]
-	~~[[Category: Hypothetical protein]]~~	+
-	~~[[Category: Sialyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 20:43, 20 October 2021

2021-10-20T20:43:13Z

←Older revision		Revision as of 20:43, 20 October 2021
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	<StructureSection load='2iy7' size='340' side='right'caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2iy7' size='340' side='right'caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_multocidum"_lehmann_and_neumann_1899 "bacterium multocidum" lehmann and neumann 1899]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_multocidum"_lehmann_and_neumann_1899 "bacterium multocidum" lehmann and neumann 1899]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSF:CYTIDINE-5-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC+ACID'>CSF</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSF:CYTIDINE-5-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC+ACID'>CSF</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [~~http~~://pdbe.org/2iy7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2iy7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2iy7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [https://pdbe.org/2iy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [https://www.ebi.ac.uk/pdbsum/2iy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iy7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Sialyltransferase\|Sialyltransferase]]	+	*[[Sialyltransferase 3D structures\|Sialyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:36, 10 October 2019

2019-10-10T05:36:58Z

←Older revision		Revision as of 05:36, 10 October 2019
Line 1:		Line 1:

	==crystal structure of the sialyltransferase PM0188 with CMP-3FNeuAc==		==crystal structure of the sialyltransferase PM0188 with CMP-3FNeuAc==
-	<StructureSection load='2iy7' size='340' side='right' caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='2iy7' size='340' side='right'caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_multocidum"_lehmann_and_neumann_1899 "bacterium multocidum" lehmann and neumann 1899]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_multocidum"_lehmann_and_neumann_1899 "bacterium multocidum" lehmann and neumann 1899]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bacterium multocidum lehmann and neumann 1899]]		[[Category: Bacterium multocidum lehmann and neumann 1899]]
		+	[[Category: Large Structures]]
	[[Category: Cho, H S]]		[[Category: Cho, H S]]
	[[Category: Kim, D U]]		[[Category: Kim, D U]]

OCA at 07:12, 11 July 2018

2018-07-11T07:12:44Z

←Older revision		Revision as of 07:12, 11 July 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE~~ PM0188 ~~WITH~~ CMP-~~3FNEUAC~~==	+
		+	==crystal structure of the sialyltransferase PM0188 with CMP-3FNeuAc==
	<StructureSection load='2iy7' size='340' side='right' caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2iy7' size='340' side='right' caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [http://pdbe.org/2iy7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [http://www.ebi.ac.uk/pdbsum/2iy7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [http://pdbe.org/2iy7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [http://www.ebi.ac.uk/pdbsum/2iy7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iy7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 2iy7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2iy7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sialyltransferase\|Sialyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:35, 11 September 2015

2015-09-11T22:35:24Z

←Older revision		Revision as of 22:35, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2iy7' size='340' side='right' caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2iy7' size='340' side='right' caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pasteurella_multocida Pasteurella multocida~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_multocidum"_lehmann_and_neumann_1899 "bacterium multocidum" lehmann and neumann 1899]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSF:CYTIDINE-5-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC+ACID'>CSF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSF:CYTIDINE-5-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC+ACID'>CSF</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [http://www.ebi.ac.uk/pdbsum/2iy7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [http://pdbe.org/2iy7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [http://www.ebi.ac.uk/pdbsum/2iy7 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2iy7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pasteurella multocida~~]]	+	[[Category: Bacterium multocidum lehmann and neumann 1899]]
	[[Category: Cho, H S]]		[[Category: Cho, H S]]
	[[Category: Kim, D U]]		[[Category: Kim, D U]]

OCA at 17:04, 19 January 2015

2015-01-19T17:04:23Z

←Older revision		Revision as of 17:04, 19 January 2015
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Pasteurella multocida]]		[[Category: Pasteurella multocida]]
-	[[Category: Cho, H S.]]	+	[[Category: Cho, H S]]
-	[[Category: Kim, D U.]]	+	[[Category: Kim, D U]]
	[[Category: Cmp-3fneuac]]		[[Category: Cmp-3fneuac]]
	[[Category: Hypothetical protein]]		[[Category: Hypothetical protein]]
	[[Category: Sialyltransferase]]		[[Category: Sialyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 15:35, 12 October 2014

2014-10-12T15:35:57Z

←Older revision		Revision as of 15:35, 12 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2iy7.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188 WITH CMP-3FNEUAC==
		+	<StructureSection load='2iy7' size='340' side='right' caption='[[2iy7]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2iy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pasteurella_multocida Pasteurella multocida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IY7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSF:CYTIDINE-5-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC+ACID'>CSF</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c83\|2c83]], [[2c84\|2c84]], [[2ex0\|2ex0]], [[2ex1\|2ex1]], [[2iy8\|2iy8]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iy7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iy7 RCSB], [http://www.ebi.ac.uk/pdbsum/2iy7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'-monophosphonuraminic acid (CMP-NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition, cell differentiation and receptor-ligand interactions, little is known about their catalytic mechanism. Here, we report the X-ray crystal structures of PM0188 in the presence of an acceptor sugar and a donor sugar analogue, revealing the precise mechanism of sialic acid transfer. Site-directed mutagenesis, kinetic assays, and structural analysis show that Asp141, His311, Glu338, Ser355 and Ser356 are important catalytic residues; Asp141 is especially crucial as it acts as a general base. These complex structures provide insights into the mechanism of sialyltransferases and the structure-based design of specific inhibitors.

-	~~{{STRUCTURE_2iy7\| PDB=2iy7 \| SCENE= }}~~	+	Structural analysis of sialyltransferase PM0188 from Pasteurella multocida complexed with donor analogue and acceptor sugar.,Kim DU, Yoo JH, Lee YJ, Kim KS, Cho HS BMB Rep. 2008 Jan 31;41(1):48-54. PMID:18304450<ref>PMID:18304450</ref>

-	~~===CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188 WITH CMP-3FNEUAC===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18304450}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2iy7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pasteurella_multocida Pasteurella multocida]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018304450<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Pasteurella multocida]]		[[Category: Pasteurella multocida]]
	[[Category: Cho, H S.]]		[[Category: Cho, H S.]]

OCA: Protected "2iy7" [edit=sysop:move=sysop]

2013-01-07T12:00:48Z

Protected "2iy7" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:00, 7 January 2013

OCA at 12:00, 7 January 2013

2013-01-07T12:00:46Z

←Older revision		Revision as of 12:00, 7 January 2013
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-	{{Seed}}
	[[Image:2iy7.png\|left\|200px]]		[[Image:2iy7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2iy7", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2iy7\| PDB=2iy7 \| SCENE= }}		{{STRUCTURE_2iy7\| PDB=2iy7 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188 WITH CMP-3FNEUAC===		===CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188 WITH CMP-3FNEUAC===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18304450}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18304450 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18304450}}		{{ABSTRACT_PUBMED_18304450}}

	==About this Structure==		==About this Structure==
-	~~2IY7 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Pasteurella_multocida Pasteurella multocida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA].	+	[[2iy7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pasteurella_multocida Pasteurella multocida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IY7 OCA].

	==Reference==		==Reference==
-	~~Structural analysis of sialyltransferase PM0188 from Pasteurella multocida complexed with donor analogue and acceptor sugar., Kim DU, Yoo JH, Lee YJ, Kim KS, Cho HS, BMB Rep. 2008 Jan 31;41(1):48-54.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~18304450 18304450]~~	+	<ref group="xtra">PMID:018304450</ref><references group="xtra"/>
	[[Category: Pasteurella multocida]]		[[Category: Pasteurella multocida]]
-	[[Category: Single protein]]
	[[Category: Cho, H S.]]		[[Category: Cho, H S.]]
	[[Category: Kim, D U.]]		[[Category: Kim, D U.]]
Line 32:		Line 19:
	[[Category: Sialyltransferase]]		[[Category: Sialyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:46:18 2008''

OCA at 09:46, 29 July 2008

2008-07-29T09:46:20Z

←Older revision		Revision as of 09:46, 29 July 2008
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-	[[Image:2iy7.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2iy7.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2iy7\| PDB=2iy7 \| SCENE= }}		{{STRUCTURE_2iy7\| PDB=2iy7 \| SCENE= }}

-	~~'''~~CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188 WITH CMP-3FNEUAC~~'''~~	+	===CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188 WITH CMP-3FNEUAC===


-	~~==Overview==~~	+	<!--
-	~~PM0188 is a newly identified sialyltransferase from P. multocida which transfers sialic acid from cytidine 5'~~-~~monophosphonuraminic acid (CMP~~-~~NeuAc) to an acceptor sugar. Although sialyltransferases are involved in important biological functions like cell-cell recognition~~, ~~cell differentiation and receptor-ligand interactions, little is known about their catalytic mechanism. Here~~, ~~we report~~ the ~~X-ray crystal structures of PM0188 in~~ the ~~presence of an acceptor sugar and a donor sugar analogue, revealing the precise mechanism of sialic acid transfer~~. ~~Site-directed mutagenesis~~, ~~kinetic assays, and structural analysis show that Asp141, His311, Glu338, Ser355 and Ser356 are important catalytic residues; Asp141~~ is ~~especially crucial as it acts as a general base~~. ~~These complex structures provide insights into the mechanism of sialyltransferases and the structure~~-~~based design of specific inhibitors.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_18304450}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18304450 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18304450}}

	==About this Structure==		==About this Structure==
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	[[Category: Sialyltransferase]]		[[Category: Sialyltransferase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 08~~:04:04 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:46:18 2008''