2j5z - Revision history

OCA at 14:35, 13 December 2023

2023-12-13T14:35:50Z

←Older revision		Revision as of 14:35, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2j5z' size='340' side='right'caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='2j5z' size='340' side='right'caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.73Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [https://pdbe.org/2j5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [https://www.ebi.ac.uk/pdbsum/2j5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [https://pdbe.org/2j5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [https://www.ebi.ac.uk/pdbsum/2j5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5z ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[https://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>	+	[https://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[https://omim.org/entry/613860 613860]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.<ref>PMID:11907111</ref>	+	[https://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.<ref>PMID:11907111</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gaboriaud, C]]	+	[[Category: Gaboriaud C]]
-	[[Category: Garlatti, V]]	+	[[Category: Garlatti V]]
-	~~[[Category: Collagen]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Immunology]]~~	+
-	~~[[Category: Lectin~~]]	+

OCA at 11:24, 31 March 2021

2021-03-31T11:24:57Z

OCA at 07:26, 3 April 2019

2019-04-03T07:26:26Z

←Older revision		Revision as of 07:26, 3 April 2019
Line 1:		Line 1:

	==H-ficolin complexed to galactose==		==H-ficolin complexed to galactose==
-	<StructureSection load='2j5z' size='340' side='right' caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>	+	<StructureSection load='2j5z' size='340' side='right'caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gaboriaud, C]]		[[Category: Gaboriaud, C]]
	[[Category: Garlatti, V]]		[[Category: Garlatti, V]]

OCA at 06:56, 11 July 2018

2018-07-11T06:56:54Z

←Older revision		Revision as of 06:56, 11 July 2018
Line 1:		Line 1:
-	==H-~~FICOLIN COMPLEXED TO GALACTOSE~~==	+
		+	==H-ficolin complexed to galactose==
	<StructureSection load='2j5z' size='340' side='right' caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='2j5z' size='340' side='right' caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [http://pdbe.org/2j5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [http://www.ebi.ac.uk/pdbsum/2j5z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [http://pdbe.org/2j5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [http://www.ebi.ac.uk/pdbsum/2j5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5z ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j5z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j5z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:21, 8 February 2016

2016-02-08T20:21:52Z

←Older revision		Revision as of 20:21, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j5z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:04, 10 September 2015

2015-09-10T15:04:07Z

←Older revision		Revision as of 15:04, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2j5z' size='340' side='right' caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='2j5z' size='340' side='right' caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [http://www.ebi.ac.uk/pdbsum/2j5z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [http://pdbe.org/2j5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [http://www.ebi.ac.uk/pdbsum/2j5z PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2j5z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gaboriaud, C]]		[[Category: Gaboriaud, C]]
	[[Category: Garlatti, V]]		[[Category: Garlatti, V]]

OCA at 16:49, 19 January 2015

2015-01-19T16:49:55Z

←Older revision		Revision as of 16:49, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [http://www.ebi.ac.uk/pdbsum/2j5z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [http://www.ebi.ac.uk/pdbsum/2j5z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[http://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>		[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[http://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Gaboriaud, C.]]	+	[[Category: Gaboriaud, C]]
-	[[Category: Garlatti, V.]]	+	[[Category: Garlatti, V]]
	[[Category: Collagen]]		[[Category: Collagen]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 09:35, 30 September 2014

2014-09-30T09:35:34Z

←Older revision		Revision as of 09:35, 30 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2j5z~~\| ~~PDB~~=2j5z \| ~~SCENE~~= }}	+	==H-FICOLIN COMPLEXED TO GALACTOSE==
-	===H-~~FICOLIN COMPLEXED TO GALACTOSE~~===	+	<StructureSection load='2j5z' size='340' side='right' caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17215869}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [http://www.ebi.ac.uk/pdbsum/2j5z PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[http://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.<ref>PMID:11907111</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j5z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Innate immunity relies critically upon the ability of a few pattern recognition molecules to sense molecular markers on pathogens, but little is known about these interactions at the atomic level. Human L- and H-ficolins are soluble oligomeric defence proteins with lectin-like activity, assembled from collagen fibers prolonged by fibrinogen-like recognition domains. The X-ray structures of their trimeric recognition domains, alone and in complex with various ligands, have been solved to resolutions up to 1.95 and 1.7 A, respectively. Both domains have three-lobed structures with clefts separating the distal parts of the protomers. Ca(2+) ions are found at sites homologous to those described for tachylectin 5A (TL5A), an invertebrate lectin. Outer binding sites (S1) homologous to the GlcNAc-binding pocket of TL5A are present in the ficolins but show different structures and specificities. In L-ficolin, three additional binding sites (S2-S4) surround the cleft. Together, they define an unpredicted continuous recognition surface able to sense various acetylated and neutral carbohydrate markers in the context of extended polysaccharides such as 1,3-beta-D-glucan, as found on microbial or apoptotic surfaces.

-	~~==Disease==~~	+	Structural insights into the innate immune recognition specificities of L- and H-ficolins.,Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869<ref>PMID:17215869</ref>
-	~~[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are~~ the ~~cause~~ of ~~ficolin 3 deficiency (FCN3D) [MIM:[http://omim.org/entry/613860 613860]]~~. ~~FCN3D is a disorder characterized by immunodeficiency~~, ~~recurrent infections~~, ~~brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes~~, ~~normal~~ T-~~cell responses~~, ~~and normal antibodies~~, ~~but a selective deficient antibody response to pneumococcal polysaccharide vaccine~~.<ref>PMID:~~19535802~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] May function in innate immunity through activation~~ of the ~~lectin complement pathway~~. ~~Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from~~ S.~~typhimurium and S.minnesota~~.<~~ref~~>~~PMID:11907111~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA].	+

	==See Also==		==See Also==
	*[[Ficolin\|Ficolin]]		*[[Ficolin\|Ficolin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017215869</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gaboriaud, C.]]		[[Category: Gaboriaud, C.]]

OCA at 21:04, 24 March 2013

2013-03-24T21:04:16Z

←Older revision		Revision as of 21:04, 24 March 2013
Line 1:		Line 1:
-	[[Image:2j5z.png\|left\|200px]]
-
	{{STRUCTURE_2j5z\| PDB=2j5z \| SCENE= }}		{{STRUCTURE_2j5z\| PDB=2j5z \| SCENE= }}
-
	===H-FICOLIN COMPLEXED TO GALACTOSE===		===H-FICOLIN COMPLEXED TO GALACTOSE===
		+	{{ABSTRACT_PUBMED_17215869}}

-	~~{{ABSTRACT_PUBMED_17215869}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[http://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.<ref>PMID:11907111</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017215869</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017215869</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Gaboriaud, C.]]		[[Category: Gaboriaud, C.]]

OCA at 11:21, 20 October 2012

2012-10-20T11:21:36Z

←Older revision		Revision as of 11:21, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2j5z]] is a 3 chain structure ~~of [[Ficolin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA].	+	[[2j5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA].

	==See Also==		==See Also==

←Older revision		Revision as of 11:24, 31 March 2021
Line 3:		Line 3:
	<StructureSection load='2j5z' size='340' side='right'caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='2j5z' size='340' side='right'caption='[[2j5z]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j5z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J5Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1la5\|1la5]], [[2j60\|2j60]], [[2j64\|2j64]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [~~http~~://pdbe.org/2j5z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j5z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5z OCA], [https://pdbe.org/2j5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j5z RCSB], [https://www.ebi.ac.uk/pdbsum/2j5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5z ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[~~http~~://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>	+	[[https://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D) [MIM:[https://omim.org/entry/613860 613860]]. FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.<ref>PMID:19535802</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.<ref>PMID:11907111</ref>	+	[[https://www.uniprot.org/uniprot/FCN3_HUMAN FCN3_HUMAN]] May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.<ref>PMID:11907111</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]