2j7q - Revision history

OCA at 08:31, 15 November 2023

2023-11-15T08:31:24Z

←Older revision		Revision as of 08:31, 15 November 2023
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	<StructureSection load='2j7q' size='340' side='right'caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2j7q' size='340' side='right'caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~] and [https://en.wikipedia.org/wiki/~~Muhv1 Muhv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Murid_betaherpesvirus_1 Murid betaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=~~PG4~~:~~TETRAETHYLENE+GLYCOL~~'>~~PG4~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</div></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [https://pdbe.org/2j7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [https://www.ebi.ac.uk/pdbsum/2j7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [https://pdbe.org/2j7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [https://www.ebi.ac.uk/pdbsum/2j7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7q ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UBC_HUMAN UBC_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Muhv1~~]]	+	[[Category: Murid betaherpesvirus 1]]
-	[[Category: Frijns, E]]	+	[[Category: Frijns E]]
-	[[Category: Gaudet, R]]	+	[[Category: Gaudet R]]
-	[[Category: Kattenhorn~~, L M~~]]	+	[[Category: Kattenhorn LM]]
-	[[Category: Ploegh~~, H L~~]]	+	[[Category: Ploegh HL]]
-	[[Category: Schlieker, C]]	+	[[Category: Schlieker C]]
-	[[Category: Weihofen~~, W A]]~~	+	[[Category: Weihofen WA]]
-	~~[[Category: Covalent enzyme-ligand complex]]~~	+
-	~~[[Category: Cysteine protease]]~~	+
-	~~[[Category: Deubiquitinating enzyme]]~~	+
-	~~[[Category: Herpesviridae]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Papain-like fold~~]]	+

OCA at 08:03, 19 January 2022

2022-01-19T08:03:42Z

←Older revision		Revision as of 08:03, 19 January 2022
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	<StructureSection load='2j7q' size='340' side='right'caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2j7q' size='340' side='right'caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [~~http~~://pdbe.org/2j7q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j7q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [https://pdbe.org/2j7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [https://www.ebi.ac.uk/pdbsum/2j7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[~~Ubiquitin~~\|~~Ubiquitin~~]]	+	*[[3D structures of ubiquitin\|3D structures of ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:43, 15 April 2020

2020-04-15T07:43:02Z

←Older revision		Revision as of 07:43, 15 April 2020
Line 1:		Line 1:

	==Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate==		==Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate==
-	<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2j7q' size='340' side='right'caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://pdbe.org/2j7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://pdbe.org/2j7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Muhv1]]		[[Category: Muhv1]]
	[[Category: Frijns, E]]		[[Category: Frijns, E]]

OCA at 07:17, 11 July 2018

2018-07-11T07:17:50Z

←Older revision		Revision as of 07:17, 11 July 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE UBIQUITIN~~-~~SPECIFIC PROTEASE ENCODED BY MURINE CYTOMEGALOVIRUS TEGUMENT PROTEIN~~ M48 ~~IN COMPLEX WITH A UBQUITIN~~-~~BASED SUICIDE SUBSTRATE~~==	+
		+	==Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate==
	<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://pdbe.org/2j7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://pdbe.org/2j7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7q ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j7q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/2j7q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:50, 8 February 2016

2016-02-08T06:50:31Z

←Older revision		Revision as of 06:50, 8 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j7q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:58, 10 September 2015

2015-09-10T08:58:38Z

←Older revision		Revision as of 08:58, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Murid_herpesvirus_1 Murid herpesvirus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Muhv1 Muhv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://pdbe.org/2j7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2j7q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
-	[[Category: ~~Murid herpesvirus 1~~]]	+	[[Category: Muhv1]]
	[[Category: Frijns, E]]		[[Category: Frijns, E]]
	[[Category: Gaudet, R]]		[[Category: Gaudet, R]]

OCA at 21:26, 24 December 2014

2014-12-24T21:26:07Z

←Older revision		Revision as of 21:26, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Murid herpesvirus 1]]		[[Category: Murid herpesvirus 1]]
-	[[Category: Frijns, E.]]	+	[[Category: Frijns, E]]
-	[[Category: Gaudet, R.]]	+	[[Category: Gaudet, R]]
-	[[Category: Kattenhorn, L M.]]	+	[[Category: Kattenhorn, L M]]
-	[[Category: Ploegh, H L.]]	+	[[Category: Ploegh, H L]]
-	[[Category: Schlieker, C.]]	+	[[Category: Schlieker, C]]
-	[[Category: Weihofen, W A.]]	+	[[Category: Weihofen, W A]]
	[[Category: Covalent enzyme-ligand complex]]		[[Category: Covalent enzyme-ligand complex]]
	[[Category: Cysteine protease]]		[[Category: Cysteine protease]]

OCA at 11:25, 3 October 2014

2014-10-03T11:25:51Z

←Older revision		Revision as of 11:25, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. <br>	+	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J7Q FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>
	<table>		<table>
Line 25:		Line 24:
	Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.,Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL Mol Cell. 2007 Mar 9;25(5):677-87. PMID:17349955<ref>PMID:17349955</ref>		Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes.,Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL Mol Cell. 2007 Mar 9;25(5):677-87. PMID:17349955<ref>PMID:17349955</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Ubiquitin\|Ubiquitin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:58, 1 May 2014

2014-05-01T09:58:24Z

←Older revision		Revision as of 09:58, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2j7q' size='340' side='right' caption='[[2j7q]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. <br>	+	<table><tr><td colspan='2'>[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. <br>
-	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
-	<b>[[Non-Standard_Residue\|NonStd Res:]]</b> <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene><br>	+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<b>[[Related_structure\|Related:]]</b> [[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]<br>	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	All members of the herpesviridae contain within their large tegument protein a cysteine protease module that displays deubiquitinating activity. We report the crystal structure of the cysteine protease domain of murine cytomegalovirus M48 (M48(USP)) in a complex with a ubiquitin (Ub)-based suicide substrate. M48(USP) adopts a papain-like fold, with the active-site cysteine forming a thioether linkage to the suicide substrate. The Ub core participates in an extensive hydrophobic interaction with an exposed beta hairpin loop of M48(USP). This Ub binding mode contributes to Ub specificity and is distinct from that observed in other deubiquitinating enzymes. Both the arrangement of active-site residues and the architecture of the interface with Ub lead us to classify this domain as the founding member of a previously unknown class of deubiquitinating enzymes.		All members of the herpesviridae contain within their large tegument protein a cysteine protease module that displays deubiquitinating activity. We report the crystal structure of the cysteine protease domain of murine cytomegalovirus M48 (M48(USP)) in a complex with a ubiquitin (Ub)-based suicide substrate. M48(USP) adopts a papain-like fold, with the active-site cysteine forming a thioether linkage to the suicide substrate. The Ub core participates in an extensive hydrophobic interaction with an exposed beta hairpin loop of M48(USP). This Ub binding mode contributes to Ub specificity and is distinct from that observed in other deubiquitinating enzymes. Both the arrangement of active-site residues and the architecture of the interface with Ub lead us to classify this domain as the founding member of a previously unknown class of deubiquitinating enzymes.
Line 24:		Line 26:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:24, 30 April 2014

2014-04-30T10:24:00Z

←Older revision		Revision as of 10:24, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. <br>		[[2j7q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Q OCA]. <br>
-	<b>Related:</b> [[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]<br>	+	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
		+	<b>[[Non-Standard_Residue\|NonStd Res:]]</b> <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene><br>
		+	<b>[[Related_structure\|Related:]]</b> [[1c3t\|1c3t]], [[1d3z\|1d3z]], [[1f9j\|1f9j]], [[1fxt\|1fxt]], [[1g6j\|1g6j]], [[1gjz\|1gjz]], [[1nbf\|1nbf]], [[1ogw\|1ogw]], [[1q5w\|1q5w]], [[1s1q\|1s1q]], [[1sif\|1sif]], [[1tbe\|1tbe]], [[1ubi\|1ubi]], [[1ubq\|1ubq]], [[1xd3\|1xd3]], [[1xqq\|1xqq]], [[1yx5\|1yx5]], [[1yx6\|1yx6]], [[1zgu\|1zgu]], [[2ayo\|2ayo]], [[2bgf\|2bgf]], [[2fcm\|2fcm]], [[2fcn\|2fcn]], [[2fcq\|2fcq]], [[2fcs\|2fcs]], [[2fuh\|2fuh]], [[2g45\|2g45]], [[2gbk\|2gbk]], [[2gbm\|2gbm]], [[2gbn\|2gbn]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j7q RCSB], [http://www.ebi.ac.uk/pdbsum/2j7q PDBsum]</span><br>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|right]]		[[Image:Consurf_key_small.gif\|right]]