2j88 - Revision history

OCA at 14:38, 13 December 2023

2023-12-13T14:38:12Z

←Older revision		Revision as of 14:38, 13 December 2023
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	<StructureSection load='2j88' size='340' side='right'caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2j88' size='340' side='right'caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Apime Apime~~] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J88 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Apis_mellifera Apis mellifera] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J88 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1fcq\|1fcq]]~~, [[~~1fcu~~\|~~1fcu~~]]~~, [[1fcv\|1fcv]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.~~1.35 3.2.1.35] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [https://pdbe.org/2j88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [https://www.ebi.ac.uk/pdbsum/2j88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j88 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [https://pdbe.org/2j88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [https://www.ebi.ac.uk/pdbsum/2j88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j88 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HUGA_APIME HUGA_APIME]] Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides (By similarity).	+	[https://www.uniprot.org/uniprot/HUGA_APIME HUGA_APIME] Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Apime]]~~	+	[[Category: Apis mellifera]]
-	~~[[Category: Hydrolase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Markovic-Housley, Z]]	+	[[Category: Markovic-Housley Z]]
-	[[Category: Padavattan, S]]	+	[[Category: Padavattan S]]
-	[[Category: Schirmer, T]]	+	[[Category: Schirmer T]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Glycosidase family 56]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 08:04, 19 January 2022

2022-01-19T08:04:02Z

←Older revision		Revision as of 08:04, 19 January 2022
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	<StructureSection load='2j88' size='340' side='right'caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2j88' size='340' side='right'caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Apime Apime] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J88 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Apime Apime] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J88 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [~~http~~://pdbe.org/2j88 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j88 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j88 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [https://pdbe.org/2j88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [https://www.ebi.ac.uk/pdbsum/2j88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j88 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HUGA_APIME HUGA_APIME]] Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides (By similarity).	+	[[https://www.uniprot.org/uniprot/HUGA_APIME HUGA_APIME]] Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:43, 15 April 2020

2020-04-15T07:43:25Z

←Older revision		Revision as of 07:43, 15 April 2020
Line 1:		Line 1:

	==Hyaluronidase in complex with a monoclonal IgG Fab fragment==		==Hyaluronidase in complex with a monoclonal IgG Fab fragment==
-	<StructureSection load='2j88' size='340' side='right' caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='2j88' size='340' side='right'caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Apime Apime] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2J88 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Apime Apime] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J88 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://pdbe.org/2j88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j88 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://pdbe.org/2j88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j88 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Hyaluronidase\|Hyaluronidase]]	+	*[[Hyaluronidase 3D structures\|Hyaluronidase 3D structures]]
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
Line 39:		Line 39:
	[[Category: Apime]]		[[Category: Apime]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Markovic-Housley, Z]]		[[Category: Markovic-Housley, Z]]

OCA at 06:33, 11 July 2018

2018-07-11T06:33:12Z

←Older revision		Revision as of 06:33, 11 July 2018
Line 1:		Line 1:
		+
	==Hyaluronidase in complex with a monoclonal IgG Fab fragment==		==Hyaluronidase in complex with a monoclonal IgG Fab fragment==
	<StructureSection load='2j88' size='340' side='right' caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2j88' size='340' side='right' caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://pdbe.org/2j88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://pdbe.org/2j88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j88 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j88_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j88_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:
	==See Also==		==See Also==
	*[[Hyaluronidase\|Hyaluronidase]]		*[[Hyaluronidase\|Hyaluronidase]]
-	*[[Monoclonal ~~Antibody~~\|Monoclonal ~~Antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:16, 7 February 2016

2016-02-07T06:16:17Z

←Older revision		Revision as of 06:16, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j88 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:38, 9 September 2015

2015-09-09T22:38:29Z

←Older revision		Revision as of 22:38, 9 September 2015
Line 5:		Line 5:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://pdbe.org/2j88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2j88" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:33, 24 December 2014

2014-12-24T08:33:47Z

←Older revision		Revision as of 08:33, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Apime Apime] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J88 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Apime Apime] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J88 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HUGA_APIME HUGA_APIME]] Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Markovic-Housley, Z.]]	+	[[Category: Markovic-Housley, Z]]
-	[[Category: Padavattan, S.]]	+	[[Category: Padavattan, S]]
-	[[Category: Schirmer, T.]]	+	[[Category: Schirmer, T]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]
	[[Category: Glycosidase family 56]]		[[Category: Glycosidase family 56]]
-	[[Category: Hydrolase]]
	[[Category: Immunoglobulin domain]]		[[Category: Immunoglobulin domain]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 05:14, 3 October 2014

2014-10-03T05:14:56Z

←Older revision		Revision as of 05:14, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2j88\| PDB=2j88 \| SCENE= }}~~	+	==Hyaluronidase in complex with a monoclonal IgG Fab fragment==
-	===Hyaluronidase in complex with a monoclonal IgG Fab fragment===	+	<StructureSection load='2j88' size='340' side='right' caption='[[2j88]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17374540}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Apime Apime] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J88 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fcq\|1fcq]], [[1fcu\|1fcu]], [[1fcv\|1fcv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.35 3.2.1.35] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j88 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j88 RCSB], [http://www.ebi.ac.uk/pdbsum/2j88 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j88_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The major allergens of honeybee venom, hyaluronidase (Hyal) and phospholipase A2, can induce life-threatening IgE-mediated allergic reactions in humans. Although conventional immunotherapy is effective, up to 40% of patients develop allergic side effects including anaphylaxis and thus, there is a need for an improved immunotherapy. A murine monoclonal anti-Hyal IgG1 antibody (mAb 21E11), that competed for Hyal binding with IgEs from sera of bee venom allergic patients, was raised. The fragment of these IgG antibodies which bind to antigen (Fab) was produced and complexed (1:1) with Hyal. The crystal structure determination of Hyal/Fab 21E11 complex (2.6 A) enabled the identification of the Hyal-IgG interface which provides indirect information on the Hyal-IgE interaction (B-cell epitope). The epitope is composed of a linear array of nine residues (Arg138, His141-Arg148) located at the tip of a helix-turn-helix motive which protrudes away from the globular core and fits tightly into the deep surface pocket formed by the residues from the six complementarity determining regions (CDRs) of the Fab. The epitope is continuous and yet its conformation appears to be essential for Ab recognition, since the synthetic 15-mer peptide comprising the entire epitope (Arg138-Glu152) is neither recognized by mAb 21E11 nor by human IgEs. The structure of the complex provides the basis for the rational design of Hyal derivatives with reduced allergenic activity, which could be used in the development of safer allergen-specific immunotherapy.

-	~~==Function==~~	+	Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab.,Padavattan S, Schirmer T, Schmidt M, Akdis C, Valenta R, Mittermann I, Soldatova L, Slater J, Mueller U, Markovic-Housley Z J Mol Biol. 2007 May 4;368(3):742-52. Epub 2007 Feb 22. PMID:17374540<ref>PMID:17374540</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/HUGA_APIME HUGA_APIME]] Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2j88]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Apime Apime] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Hyaluronidase\|Hyaluronidase]]		*[[Hyaluronidase\|Hyaluronidase]]
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:017374540</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Apime]]		[[Category: Apime]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 08:02, 5 February 2014

2014-02-05T08:02:58Z

←Older revision		Revision as of 08:02, 5 February 2014
Line 1:		Line 1:
-	[[Image:2j88.png\|left\|200px]]
-
	{{STRUCTURE_2j88\| PDB=2j88 \| SCENE= }}		{{STRUCTURE_2j88\| PDB=2j88 \| SCENE= }}
		+	===Hyaluronidase in complex with a monoclonal IgG Fab fragment===
		+	{{ABSTRACT_PUBMED_17374540}}

-	===~~HYALURONIDASE IN COMPLEX WITH A MONOCLONAL IGG FAB FRAGMENT~~===	+	==Function==
-		+	[[http://www.uniprot.org/uniprot/HUGA_APIME HUGA_APIME]] Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides (By similarity).
-	~~{{ABSTRACT_PUBMED_17374540}}~~	+

	==About this Structure==		==About this Structure==
-	[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Apis_mellifera Apis mellifera~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA].	+	[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Apime Apime] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA].

	==See Also==		==See Also==
Line 15:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017374540</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017374540</ref><references group="xtra"/><references/>
-	[[Category: ~~Apis mellifera~~]]	+	[[Category: Apime]]
-	[[Category: ~~Hyaluronoglucosaminidase~~]]	+	[[Category: Hydrolase]]
		+	[[Category: Mus musculus]]
	[[Category: Markovic-Housley, Z.]]		[[Category: Markovic-Housley, Z.]]
	[[Category: Padavattan, S.]]		[[Category: Padavattan, S.]]

OCA at 05:49, 20 October 2012

2012-10-20T05:49:29Z

←Older revision		Revision as of 05:49, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2j88]] is a 3 chain structure ~~of [[Hyaluronidase]] and [[Monoclonal Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Apis_mellifera Apis mellifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA].	+	[[2j88]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Apis_mellifera Apis mellifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J88 OCA].

	==See Also==		==See Also==