2jhg - Revision history

OCA at 14:48, 13 December 2023

2023-12-13T14:48:29Z

←Older revision		Revision as of 14:48, 13 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IBO:2~~-~~METHYLPROPANAMIDE'>IBO</scene>~~, ~~<scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBO:2-METHYLPROPANAMIDE'>IBO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [https://pdbe.org/2jhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [https://www.ebi.ac.uk/pdbsum/2jhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [https://pdbe.org/2jhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [https://www.ebi.ac.uk/pdbsum/2jhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ADH1E_HORSE ADH1E_HORSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adolph~~, H W~~]]	+	[[Category: Adolph HW]]
-	[[Category: Cedergren-Zeppezauer~~, E S~~]]	+	[[Category: Cedergren-Zeppezauer ES]]
-	[[Category: Dauter, Z]]	+	[[Category: Dauter Z]]
-	[[Category: Lamzin~~, V S~~]]	+	[[Category: Lamzin VS]]
-	[[Category: Meijers, R]]	+	[[Category: Meijers R]]
-	[[Category: Wilson~~, K S]]~~	+	[[Category: Wilson KS]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Inhibition]]~~	+
-	~~[[Category: Metal coordination]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 10:07, 12 May 2021

2021-05-12T10:07:38Z

←Older revision		Revision as of 10:07, 12 May 2021
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	<StructureSection load='2jhg' size='340' side='right'caption='[[2jhg]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='2jhg' size='340' side='right'caption='[[2jhg]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JHG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBO:2-METHYLPROPANAMIDE'>IBO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBO:2-METHYLPROPANAMIDE'>IBO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [~~http~~://pdbe.org/2jhg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jhg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [https://pdbe.org/2jhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [https://www.ebi.ac.uk/pdbsum/2jhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:24, 24 July 2019

2019-07-24T07:24:08Z

←Older revision		Revision as of 07:24, 24 July 2019
Line 1:		Line 1:

	==Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase==		==Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase==
-	<StructureSection load='2jhg' size='340' side='right' caption='[[2jhg]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='2jhg' size='340' side='right'caption='[[2jhg]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHG FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]	+	*[[Alcohol dehydrogenase 3D structures\|Alcohol dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
	[[Category: Adolph, H W]]		[[Category: Adolph, H W]]
	[[Category: Cedergren-Zeppezauer, E S]]		[[Category: Cedergren-Zeppezauer, E S]]

OCA at 06:40, 11 July 2018

2018-07-11T06:40:43Z

←Older revision		Revision as of 06:40, 11 July 2018
Line 1:		Line 1:
-	==~~STRUCTURAL EVIDENCE FOR A LIGAND COORDINATION SWITCH IN LIVER ALCOHOL DEHYDROGENASE~~==	+
		+	==Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase==
	<StructureSection load='2jhg' size='340' side='right' caption='[[2jhg]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='2jhg' size='340' side='right' caption='[[2jhg]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [http://pdbe.org/2jhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [http://www.ebi.ac.uk/pdbsum/2jhg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [http://pdbe.org/2jhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [http://www.ebi.ac.uk/pdbsum/2jhg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhg ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 42:		Line 43:
	[[Category: Meijers, R]]		[[Category: Meijers, R]]
	[[Category: Wilson, K S]]		[[Category: Wilson, K S]]
		+	[[Category: Acetylation]]
	[[Category: Inhibition]]		[[Category: Inhibition]]
	[[Category: Metal coordination]]		[[Category: Metal coordination]]
Line 47:		Line 49:
	[[Category: Nad]]		[[Category: Nad]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
		+	[[Category: Zinc]]

OCA at 08:36, 7 February 2016

2016-02-07T08:36:40Z

←Older revision		Revision as of 08:36, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jhg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:41, 9 September 2015

2015-09-09T23:41:42Z

←Older revision		Revision as of 23:41, 9 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [http://www.ebi.ac.uk/pdbsum/2jhg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [http://pdbe.org/2jhg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [http://www.ebi.ac.uk/pdbsum/2jhg PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jhg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:28, 19 January 2015

2015-01-19T17:28:34Z

←Older revision		Revision as of 17:28, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBO:2-METHYLPROPANAMIDE'>IBO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBO:2-METHYLPROPANAMIDE'>IBO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [http://www.ebi.ac.uk/pdbsum/2jhg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [http://www.ebi.ac.uk/pdbsum/2jhg PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
-	[[Category: Adolph, H W.]]	+	[[Category: Adolph, H W]]
-	[[Category: Cedergren-Zeppezauer, E S.]]	+	[[Category: Cedergren-Zeppezauer, E S]]
-	[[Category: Dauter, Z.]]	+	[[Category: Dauter, Z]]
-	[[Category: Lamzin, V S.]]	+	[[Category: Lamzin, V S]]
-	[[Category: Meijers, R.]]	+	[[Category: Meijers, R]]
-	[[Category: Wilson, K S~~.]]~~	+	[[Category: Wilson, K S]]
-	~~[[Category: Alcohol dehydrogenase~~]]	+
	[[Category: Inhibition]]		[[Category: Inhibition]]
	[[Category: Metal coordination]]		[[Category: Metal coordination]]

OCA at 03:57, 29 September 2014

2014-09-29T03:57:21Z

←Older revision		Revision as of 03:57, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jhg.~~png~~\|~~left~~\|200px]]	+	==STRUCTURAL EVIDENCE FOR A LIGAND COORDINATION SWITCH IN LIVER ALCOHOL DEHYDROGENASE==
		+	<StructureSection load='2jhg' size='340' side='right' caption='[[2jhg]], [[Resolution\|resolution]] 1.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IBO:2-METHYLPROPANAMIDE'>IBO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a71\|1a71]], [[1a72\|1a72]], [[1adb\|1adb]], [[1adc\|1adc]], [[1adf\|1adf]], [[1adg\|1adg]], [[1axe\|1axe]], [[1axg\|1axg]], [[1bto\|1bto]], [[1het\|1het]], [[1heu\|1heu]], [[1hf3\|1hf3]], [[1hld\|1hld]], [[1ju9\|1ju9]], [[1lde\|1lde]], [[1ldy\|1ldy]], [[1mg0\|1mg0]], [[1mgo\|1mgo]], [[1n8k\|1n8k]], [[1n92\|1n92]], [[1p1r\|1p1r]], [[1qlh\|1qlh]], [[1qlj\|1qlj]], [[1qv6\|1qv6]], [[1qv7\|1qv7]], [[1ye3\|1ye3]], [[2jhf\|2jhf]], [[2ohx\|2ohx]], [[2oxi\|2oxi]], [[3bto\|3bto]], [[5adh\|5adh]], [[6adh\|6adh]], [[7adh\|7adh]], [[8adh\|8adh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jhg RCSB], [http://www.ebi.ac.uk/pdbsum/2jhg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The use of substrate analogues as inhibitors provides a way to understand and manipulate enzyme function. Here we report two 1 A resolution crystal structures of liver alcohol dehydrogenase in complex with NADH and two inhibitors: dimethyl sulfoxide and isobutyramide. Both structures present a dynamic state of inhibition. In the dimethyl sulfoxide complex structure, the inhibitor is caught in transition on its way to the active site using a flash-freezing protocol and a cadmium-substituted enzyme. One inhibitor molecule is partly located in the first and partly in the second coordination sphere of the active site metal. A hydroxide ion bound to the active site metal lies close to the pyridine ring of NADH, which is puckered in a twisted boat conformation. The cadmium ion is coordinated by both the hydroxide ion and the inhibitor molecule, providing structural evidence of a coordination switch at the active site metal ion. The structure of the isobutyramide complex reveals the partial formation of an adduct between the isobutyramide inhibitor and NADH. It provides evidence of the contribution of a shift from the keto to the enol tautomer during aldehyde reduction. The different positions of the inhibitors further refine the knowledge of the dynamics of the enzyme mechanism and explain how the crowded active site can facilitate the presence of a substrate and a metal-bound hydroxide ion.

-	~~{{STRUCTURE_2jhg\| PDB=2jhg \| SCENE= }}~~	+	Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase.,Meijers R, Adolph HW, Dauter Z, Wilson KS, Lamzin VS, Cedergren-Zeppezauer ES Biochemistry. 2007 May 8;46(18):5446-54. Epub 2007 Apr 13. PMID:17429946<ref>PMID:17429946</ref>

-	~~===STRUCTURAL EVIDENCE FOR A LIGAND COORDINATION SWITCH IN LIVER ALCOHOL DEHYDROGENASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17429946}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jhg]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Equus_caballus Equus caballus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA].~~	+

	==See Also==		==See Also==
	*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]		*[[Alcohol dehydrogenase\|Alcohol dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017429946<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Alcohol dehydrogenase]]		[[Category: Alcohol dehydrogenase]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]

OCA at 06:07, 20 October 2012

2012-10-20T06:07:46Z

←Older revision		Revision as of 06:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2jhg]] is a 2 chain structure ~~of [[Alcohol dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA].	+	[[2jhg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHG OCA].

	==See Also==		==See Also==

OCA: Protected "2jhg" [edit=sysop:move=sysop]

2012-07-25T12:12:50Z

Protected "2jhg" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:12, 25 July 2012