2jid - Revision history

OCA at 08:11, 19 January 2022

2022-01-19T08:11:19Z

←Older revision		Revision as of 08:11, 19 January 2022
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	<StructureSection load='2jid' size='340' side='right'caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2jid' size='340' side='right'caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [~~http~~://pdbe.org/2jid PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jid PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jid ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [https://pdbe.org/2jid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [https://www.ebi.ac.uk/pdbsum/2jid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jid ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>	+	[[https://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:52, 15 April 2020

2020-04-15T07:52:06Z

←Older revision		Revision as of 07:52, 15 April 2020
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	==Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine==		==Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine==
-	<StructureSection load='2jid' size='340' side='right' caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2jid' size='340' side='right'caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JID FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://pdbe.org/2jid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jid ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://pdbe.org/2jid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jid ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
-	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]	+	*[[Dipeptidyl peptidase 3D structures\|Dipeptidyl peptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hennig, M]]		[[Category: Hennig, M]]
	[[Category: Luebbers, T]]		[[Category: Luebbers, T]]

OCA at 07:18, 11 July 2018

2018-07-11T07:18:27Z

←Older revision		Revision as of 07:18, 11 July 2018
Line 1:		Line 1:
		+
	==Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine==		==Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine==
	<StructureSection load='2jid' size='340' side='right' caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2jid' size='340' side='right' caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://pdbe.org/2jid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://pdbe.org/2jid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jid ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jid_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jid_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jid ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:18, 11 September 2015

2015-09-11T07:18:41Z

←Older revision		Revision as of 07:18, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jid' size='340' side='right' caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2jid' size='340' side='right' caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://pdbe.org/2jid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jid" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hennig, M]]		[[Category: Hennig, M]]
	[[Category: Luebbers, T]]		[[Category: Luebbers, T]]

OCA at 13:07, 25 December 2014

2014-12-25T13:07:59Z

←Older revision		Revision as of 13:07, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JID FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JID FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hennig, M.]]	+	[[Category: Hennig, M]]
-	[[Category: Luebbers, T.]]	+	[[Category: Luebbers, T]]
-	[[Category: Stihle, M.]]	+	[[Category: Stihle, M]]
-	[[Category: Thoma, R.]]	+	[[Category: Thoma, R]]
	[[Category: Aminopeptidase]]		[[Category: Aminopeptidase]]
	[[Category: B-propeller]]		[[Category: B-propeller]]

OCA at 04:19, 29 September 2014

2014-09-29T04:19:47Z

←Older revision		Revision as of 04:19, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2jid.~~png~~\|~~left~~\|200px]]	+	==Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine==
		+	<StructureSection load='2jid' size='340' side='right' caption='[[2jid]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JID FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GVB:(3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE'>GVB</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j2e\|1j2e]], [[1n1m\|1n1m]], [[1nu6\|1nu6]], [[1nu8\|1nu8]], [[1pfq\|1pfq]], [[1r9m\|1r9m]], [[1r9n\|1r9n]], [[1rwq\|1rwq]], [[1tk3\|1tk3]], [[1tkr\|1tkr]], [[1u8e\|1u8e]], [[1w1i\|1w1i]], [[1wcy\|1wcy]], [[1x70\|1x70]], [[2ajl\|2ajl]], [[2bgn\|2bgn]], [[2bgr\|2bgr]], [[2bub\|2bub]], [[2g5p\|2g5p]], [[2g5t\|2g5t]], [[2g63\|2g63]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jid RCSB], [http://www.ebi.ac.uk/pdbsum/2jid PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jid_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR could be transferred to the 2-aminobenzo[a]quinolizine series, leading to highly active DPP-IV inhibitors.

-	~~{{STRUCTURE_2jid\| PDB=2jid \| SCENE= }}~~	+	1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors.,Lubbers T, Bohringer M, Gobbi L, Hennig M, Hunziker D, Kuhn B, Loffler B, Mattei P, Narquizian R, Peters JU, Ruff Y, Wessel HP, Wyss P Bioorg Med Chem Lett. 2007 Jun 1;17(11):2966-70. Epub 2007 Mar 25. PMID:17418568<ref>PMID:17418568</ref>

-	~~===Human Dipeptidyl peptidase IV in complex with 1-(3~~,~~4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17418568}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2jid]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA].~~	+

	==See Also==		==See Also==
	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]		*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017418568<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 17:03, 20 October 2012

2012-10-20T17:03:06Z

←Older revision		Revision as of 17:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2jid]] is a 2 chain structure ~~of [[Dipeptidyl peptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA].	+	[[2jid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA].

	==See Also==		==See Also==

OCA at 05:10, 29 August 2012

2012-08-29T05:10:44Z

←Older revision		Revision as of 05:10, 29 August 2012
Line 3:		Line 3:
	{{STRUCTURE_2jid\| PDB=2jid \| SCENE= }}		{{STRUCTURE_2jid\| PDB=2jid \| SCENE= }}

-	===~~HUMAN DIPEPTIDYL PEPTIDASE~~ IV ~~IN COMPLEX WITH~~ 1-(3,4-~~DIMETHOXY~~-~~PHENYL~~)-3-M-~~TOLYL~~-~~PIPERIDINE~~-4-~~YLAMINE~~===	+	===Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine===

		+	{{ABSTRACT_PUBMED_17418568}}

	==About this Structure==		==About this Structure==
Line 11:		Line 12:
	==See Also==		==See Also==
	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]		*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:017418568</ref><references group="xtra"/>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "2jid" [edit=sysop:move=sysop]

2012-07-26T23:40:21Z

Protected "2jid" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:40, 26 July 2012

OCA at 23:40, 26 July 2012

2012-07-26T23:40:19Z

←Older revision		Revision as of 23:40, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jid.png\|left\|200px]]		[[Image:2jid.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jid", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jid\| PDB=2jid \| SCENE= }}		{{STRUCTURE_2jid\| PDB=2jid \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~2JID~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA].	+	[[2jid]] is a 2 chain structure of [[Dipeptidyl peptidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JID OCA].
		+
		+	==See Also==
		+	*[[Dipeptidyl peptidase\|Dipeptidyl peptidase]]
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 34:		Line 30:
	[[Category: Structure based design]]		[[Category: Structure based design]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:00:10 2009''