2jiy - Revision history

OCA at 06:41, 1 May 2024

2024-05-01T06:41:59Z

←Older revision		Revision as of 06:41, 1 May 2024
Line 3:		Line 3:
	<StructureSection load='2jiy' size='340' side='right'caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jiy' size='340' side='right'caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"rhodococcus_capsulatus"_molisch_1907 "rhodococcus capsulatus" molisch 1907~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JIY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [https://pdbe.org/2jiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [https://www.ebi.ac.uk/pdbsum/2jiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jiy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [https://pdbe.org/2jiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [https://www.ebi.ac.uk/pdbsum/2jiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jiy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RCEH_RHOSH RCEH_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[https://www.uniprot.org/uniprot/RCEM_RHOSH RCEM_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[https://www.uniprot.org/uniprot/RCEL_RHOSH RCEL_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.	+	[https://www.uniprot.org/uniprot/RCEH_CERSP RCEH_CERSP] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jiy ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jiy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	X-ray crystallography has been used to investigate the extent of structural changes in mutants of the purple bacterial reaction center that assemble without a particular ubiquinone or bacteriopheophytin cofactor. In the case of the bacteriopheophytin-exclusion mutant, in which Ala M149 was replaced by Trp (AM149W), the quality of protein crystals was improved over that seen in previous work by minimizing illumination, time, and temperature during the purification protocol and carrying out crystal growth at 4 degrees C after overnight incubation at 18 degrees C. The X-ray crystal structure of the AM149W mutant, determined to a resolution of 2.2 A, showed very little change in protein structure despite the absence of the bacteriopheophytin cofactor. Changes in the electron density map in the region of the cofactor binding site could be accounted for by changes in the conformation of the phytol side chains of adjacent cofactors and the presence of a buried water molecule. Residues lining the vacated binding pocket did not show any significant changes in conformation or increases in disorder as assessed through crystallographic atomic displacement parameters (B-factors). The X-ray crystal structure of a reaction center lacking the primary acceptor ubiquinone through mutation of Ala M248 to Trp (AM248W) was also determined, to a resolution of 2.8 A. Again, despite the absence of an internal cofactor only very minor changes in protein structure were observed. This is in contrast to a previous report on a reaction center lacking this ubiquinone through mutation of Ala M260 to Trp (AM260W) where more extensive changes in structure were apparent. All three mutant reaction centers showed a decrease in thermal stability when housed in the native membrane, but this decrease was smaller for the AM260W mutant than the AM248W complex, possibly due to beneficial effects of the observed changes in protein structure. The lack of major changes in protein structure despite the absence of large internal cofactors is discussed in terms of protein rigidity, the protective influence of the adaptable membrane environment, and the role of small molecules and ions as packing material in the internal cavities created by this type of mutation.
-
-	Structural responses to cavity-creating mutations in an integral membrane protein.,Fyfe PK, Potter JA, Cheng J, Williams CM, Watson AJ, Jones MR Biochemistry. 2007 Sep 18;46(37):10461-72. Epub 2007 Aug 21. PMID:17711306<ref>PMID:17711306</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2jiy" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rhodococcus capsulatus molisch 1907~~]]	+	[[Category: Cereibacter sphaeroides]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cheng, J]]	+	[[Category: Cheng J]]
-	[[Category: Fyfe~~, P K~~]]	+	[[Category: Fyfe PK]]
-	[[Category: Jones~~, M R~~]]	+	[[Category: Jones MR]]
-	[[Category: Potter~~, J A~~]]	+	[[Category: Potter JA]]
-	[[Category: Watson~~, A J~~]]	+	[[Category: Watson AJ]]
-	[[Category: Williams~~, C M]]~~	+	[[Category: Williams CM]]
-	~~[[Category: Bacteriochlorophyll]]~~	+
-	~~[[Category: Chlorophyll]]~~	+
-	~~[[Category: Chromophore]]~~	+
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Photosynthesis]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 08:12, 19 January 2022

2022-01-19T08:12:06Z

←Older revision		Revision as of 08:12, 19 January 2022
Line 3:		Line 3:
	<StructureSection load='2jiy' size='340' side='right'caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jiy' size='340' side='right'caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"rhodococcus_capsulatus"_molisch_1907 "rhodococcus capsulatus" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2JIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"rhodococcus_capsulatus"_molisch_1907 "rhodococcus capsulatus" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JIY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [~~http~~://pdbe.org/2jiy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jiy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jiy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [https://pdbe.org/2jiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [https://www.ebi.ac.uk/pdbsum/2jiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jiy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RCEH_RHOSH RCEH_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[~~http~~://www.uniprot.org/uniprot/RCEM_RHOSH RCEM_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[~~http~~://www.uniprot.org/uniprot/RCEL_RHOSH RCEL_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.	+	[[https://www.uniprot.org/uniprot/RCEH_RHOSH RCEH_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[https://www.uniprot.org/uniprot/RCEM_RHOSH RCEM_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[https://www.uniprot.org/uniprot/RCEL_RHOSH RCEL_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:52, 15 April 2020

2020-04-15T07:52:49Z

←Older revision		Revision as of 07:52, 15 April 2020
Line 1:		Line 1:

	==PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M149 REPLACED WITH TRP (CHAIN M, AM149W)==		==PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M149 REPLACED WITH TRP (CHAIN M, AM149W)==
-	<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2jiy' size='340' side='right'caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodococcus_capsulatus"_molisch_1907 "rhodococcus capsulatus" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodococcus_capsulatus"_molisch_1907 "rhodococcus capsulatus" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JIY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://pdbe.org/2jiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jiy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://pdbe.org/2jiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jiy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Rhodococcus capsulatus molisch 1907]]		[[Category: Rhodococcus capsulatus molisch 1907]]
		+	[[Category: Large Structures]]
	[[Category: Cheng, J]]		[[Category: Cheng, J]]
	[[Category: Fyfe, P K]]		[[Category: Fyfe, P K]]

OCA at 06:59, 11 July 2018

2018-07-11T06:59:33Z

←Older revision		Revision as of 06:59, 11 July 2018
Line 1:		Line 1:
		+
	==PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M149 REPLACED WITH TRP (CHAIN M, AM149W)==		==PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M149 REPLACED WITH TRP (CHAIN M, AM149W)==
	<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://pdbe.org/2jiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://pdbe.org/2jiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jiy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jiy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jiy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:22, 9 February 2016

2016-02-09T15:22:18Z

←Older revision		Revision as of 15:22, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jiy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:32, 10 September 2015

2015-09-10T23:32:39Z

←Older revision		Revision as of 23:32, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodobacter_sphaeroides Rhodobacter sphaeroides~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JIY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodococcus_capsulatus"_molisch_1907 "rhodococcus capsulatus" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JIY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://pdbe.org/2jiy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jiy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rhodobacter sphaeroides~~]]	+	[[Category: Rhodococcus capsulatus molisch 1907]]
	[[Category: Cheng, J]]		[[Category: Cheng, J]]
	[[Category: Fyfe, P K]]		[[Category: Fyfe, P K]]

OCA at 07:41, 25 December 2014

2014-12-25T07:41:54Z

←Older revision		Revision as of 07:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JIY FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JIY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RCEH_RHOSH RCEH_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[http://www.uniprot.org/uniprot/RCEM_RHOSH RCEM_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis. [[http://www.uniprot.org/uniprot/RCEL_RHOSH RCEL_RHOSH]] The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Rhodobacter sphaeroides]]		[[Category: Rhodobacter sphaeroides]]
-	[[Category: Cheng, J.]]	+	[[Category: Cheng, J]]
-	[[Category: Fyfe, P K.]]	+	[[Category: Fyfe, P K]]
-	[[Category: Jones, M R.]]	+	[[Category: Jones, M R]]
-	[[Category: Potter, J A.]]	+	[[Category: Potter, J A]]
-	[[Category: Watson, A J.]]	+	[[Category: Watson, A J]]
-	[[Category: Williams, C M.]]	+	[[Category: Williams, C M]]
	[[Category: Bacteriochlorophyll]]		[[Category: Bacteriochlorophyll]]
	[[Category: Chlorophyll]]		[[Category: Chlorophyll]]

OCA at 09:01, 3 October 2014

2014-10-03T09:01:02Z

←Older revision		Revision as of 09:01, 3 October 2014
Line 2:		Line 2:
	<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. <br>	+	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JIY FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene><br>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>
	<table>		<table>
Line 24:		Line 23:
	Structural responses to cavity-creating mutations in an integral membrane protein.,Fyfe PK, Potter JA, Cheng J, Williams CM, Watson AJ, Jones MR Biochemistry. 2007 Sep 18;46(37):10461-72. Epub 2007 Aug 21. PMID:17711306<ref>PMID:17711306</ref>		Structural responses to cavity-creating mutations in an integral membrane protein.,Fyfe PK, Potter JA, Cheng J, Williams CM, Watson AJ, Jones MR Biochemistry. 2007 Sep 18;46(37):10461-72. Epub 2007 Aug 21. PMID:17711306<ref>PMID:17711306</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:43, 1 May 2014

2014-05-01T09:43:29Z

←Older revision		Revision as of 09:43, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2jiy' size='340' side='right' caption='[[2jiy]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. <br>	+	<table><tr><td colspan='2'>[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. <br>
-	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene><br>
-	<b>[[Related_structure\|Related:]]</b> [[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]<br>	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span></td></tr>
		+	<table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
-	[[Image:Consurf_key_small.gif\|right]]	+	[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
Line 17:		Line 18:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	X-ray crystallography has been used to investigate the extent of structural changes in mutants of the purple bacterial reaction center that assemble without a particular ubiquinone or bacteriopheophytin cofactor. In the case of the bacteriopheophytin-exclusion mutant, in which Ala M149 was replaced by Trp (AM149W), the quality of protein crystals was improved over that seen in previous work by minimizing illumination, time, and temperature during the purification protocol and carrying out crystal growth at 4 degrees C after overnight incubation at 18 degrees C. The X-ray crystal structure of the AM149W mutant, determined to a resolution of 2.2 A, showed very little change in protein structure despite the absence of the bacteriopheophytin cofactor. Changes in the electron density map in the region of the cofactor binding site could be accounted for by changes in the conformation of the phytol side chains of adjacent cofactors and the presence of a buried water molecule. Residues lining the vacated binding pocket did not show any significant changes in conformation or increases in disorder as assessed through crystallographic atomic displacement parameters (B-factors). The X-ray crystal structure of a reaction center lacking the primary acceptor ubiquinone through mutation of Ala M248 to Trp (AM248W) was also determined, to a resolution of 2.8 A. Again, despite the absence of an internal cofactor only very minor changes in protein structure were observed. This is in contrast to a previous report on a reaction center lacking this ubiquinone through mutation of Ala M260 to Trp (AM260W) where more extensive changes in structure were apparent. All three mutant reaction centers showed a decrease in thermal stability when housed in the native membrane, but this decrease was smaller for the AM260W mutant than the AM248W complex, possibly due to beneficial effects of the observed changes in protein structure. The lack of major changes in protein structure despite the absence of large internal cofactors is discussed in terms of protein rigidity, the protective influence of the adaptable membrane environment, and the role of small molecules and ions as packing material in the internal cavities created by this type of mutation.		X-ray crystallography has been used to investigate the extent of structural changes in mutants of the purple bacterial reaction center that assemble without a particular ubiquinone or bacteriopheophytin cofactor. In the case of the bacteriopheophytin-exclusion mutant, in which Ala M149 was replaced by Trp (AM149W), the quality of protein crystals was improved over that seen in previous work by minimizing illumination, time, and temperature during the purification protocol and carrying out crystal growth at 4 degrees C after overnight incubation at 18 degrees C. The X-ray crystal structure of the AM149W mutant, determined to a resolution of 2.2 A, showed very little change in protein structure despite the absence of the bacteriopheophytin cofactor. Changes in the electron density map in the region of the cofactor binding site could be accounted for by changes in the conformation of the phytol side chains of adjacent cofactors and the presence of a buried water molecule. Residues lining the vacated binding pocket did not show any significant changes in conformation or increases in disorder as assessed through crystallographic atomic displacement parameters (B-factors). The X-ray crystal structure of a reaction center lacking the primary acceptor ubiquinone through mutation of Ala M248 to Trp (AM248W) was also determined, to a resolution of 2.8 A. Again, despite the absence of an internal cofactor only very minor changes in protein structure were observed. This is in contrast to a previous report on a reaction center lacking this ubiquinone through mutation of Ala M260 to Trp (AM260W) where more extensive changes in structure were apparent. All three mutant reaction centers showed a decrease in thermal stability when housed in the native membrane, but this decrease was smaller for the AM260W mutant than the AM248W complex, possibly due to beneficial effects of the observed changes in protein structure. The lack of major changes in protein structure despite the absence of large internal cofactors is discussed in terms of protein rigidity, the protective influence of the adaptable membrane environment, and the role of small molecules and ions as packing material in the internal cavities created by this type of mutation.
Line 23:		Line 25:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:04, 30 April 2014

2014-04-30T10:04:40Z

←Older revision		Revision as of 10:04, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. <br>		[[2jiy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIY OCA]. <br>
-	<b>Related:</b> [[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]<br>	+	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=BCL:BACTERIOCHLOROPHYLL+A'>BCL</scene>, <scene name='pdbligand=BPH:BACTERIOPHEOPHYTIN+A'>BPH</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SPN:SPEROIDENONE'>SPN</scene>, <scene name='pdbligand=U10:UBIQUINONE-10'>U10</scene><br>
		+	<b>[[Related_structure\|Related:]]</b> [[1aig\|1aig]], [[1aij\|1aij]], [[1ds8\|1ds8]], [[1dv3\|1dv3]], [[1dv6\|1dv6]], [[1e14\|1e14]], [[1e6d\|1e6d]], [[1f6n\|1f6n]], [[1fnp\|1fnp]], [[1fnq\|1fnq]], [[1jgw\|1jgw]], [[1jgx\|1jgx]], [[1jgy\|1jgy]], [[1jgz\|1jgz]], [[1jh0\|1jh0]], [[1k6l\|1k6l]], [[1k6n\|1k6n]], [[1kby\|1kby]], [[1l9b\|1l9b]], [[1l9j\|1l9j]], [[1m3x\|1m3x]], [[1mps\|1mps]], [[1ogv\|1ogv]], [[1pcr\|1pcr]], [[1pss\|1pss]], [[1pst\|1pst]], [[1qov\|1qov]], [[1rg5\|1rg5]], [[1rgn\|1rgn]], [[1rqk\|1rqk]], [[1rvj\|1rvj]], [[1ry5\|1ry5]], [[1rzh\|1rzh]], [[1rzz\|1rzz]], [[1s00\|1s00]], [[1umx\|1umx]], [[1yst\|1yst]], [[1z9j\|1z9j]], [[1z9k\|1z9k]], [[2bnp\|2bnp]], [[2bns\|2bns]], [[2boz\|2boz]], [[2gmr\|2gmr]], [[2j8c\|2j8c]], [[2j8d\|2j8d]], [[2rcr\|2rcr]], [[2uws\|2uws]], [[2uwt\|2uwt]], [[2uwu\|2uwu]], [[2uwv\|2uwv]], [[2uww\|2uww]], [[2ux3\|2ux3]], [[2ux4\|2ux4]], [[2ux5\|2ux5]], [[2uxj\|2uxj]], [[2uxk\|2uxk]], [[2uxl\|2uxl]], [[2uxm\|2uxm]], [[4rcr\|4rcr]], [[2jj0\|2jj0]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jiy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jiy RCSB], [http://www.ebi.ac.uk/pdbsum/2jiy PDBsum]</span><br>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|right]]		[[Image:Consurf_key_small.gif\|right]]