2jmu - Revision history

OCA at 10:07, 20 December 2023

2023-12-20T10:07:38Z

←Older revision		Revision as of 10:07, 20 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JMU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JMU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [https://pdbe.org/2jmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [https://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmu ProSAT], [https://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [https://pdbe.org/2jmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [https://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmu ProSAT], [https://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:30, 14 June 2023

2023-06-14T08:30:40Z

←Older revision		Revision as of 08:30, 14 June 2023
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	==NMR structure of the mouse thiamine triphosphatase==		==NMR structure of the mouse thiamine triphosphatase==
-	<StructureSection load='2jmu' size='340' side='right'caption='[[2jmu~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2jmu' size='340' side='right'caption='[[2jmu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JMU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JMU FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [https://pdbe.org/2jmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [https://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmu ProSAT], [https://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [https://pdbe.org/2jmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [https://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmu ProSAT], [https://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/THTPA_MOUSE THTPA_MOUSE]] Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity).	+	[https://www.uniprot.org/uniprot/THTPA_MOUSE THTPA_MOUSE] Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Thiamine-triphosphatase]]~~	+	[[Category: Markley JL]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Song J]]
-	[[Category: Markley~~, J L~~]]	+
-	[[Category: Song, J]]	+
-	~~[[Category: Cesg]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Thiamine triphosphatase~~]]	+

OCA at 08:29, 10 November 2021

2021-11-10T08:29:22Z

←Older revision		Revision as of 08:29, 10 November 2021
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	<StructureSection load='2jmu' size='340' side='right'caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jmu' size='340' side='right'caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JMU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JMU FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [~~http~~://pdbe.org/2jmu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmu ProSAT], [~~http~~://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [https://pdbe.org/2jmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [https://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmu ProSAT], [https://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/THTPA_MOUSE THTPA_MOUSE]] Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity).	+	[[https://www.uniprot.org/uniprot/THTPA_MOUSE THTPA_MOUSE]] Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:23, 5 February 2020

2020-02-05T08:23:25Z

←Older revision		Revision as of 08:23, 5 February 2020
Line 1:		Line 1:

	==NMR structure of the mouse thiamine triphosphatase==		==NMR structure of the mouse thiamine triphosphatase==
-	<StructureSection load='2jmu' size='340' side='right' caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2jmu' size='340' side='right'caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JMU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JMU FirstGlance]. <br>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Thiamine-triphosphatase]]		[[Category: Thiamine-triphosphatase]]

OCA at 06:29, 11 July 2018

2018-07-11T06:29:45Z

←Older revision		Revision as of 06:29, 11 July 2018
Line 1:		Line 1:
		+
	==NMR structure of the mouse thiamine triphosphatase==		==NMR structure of the mouse thiamine triphosphatase==
	<StructureSection load='2jmu' size='340' side='right' caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jmu' size='340' side='right' caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [http://pdbe.org/2jmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [http://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [http://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [http://pdbe.org/2jmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [http://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmu ProSAT], [http://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jmu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jmu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:46, 10 February 2016

2016-02-10T05:46:56Z

←Older revision		Revision as of 05:46, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jmu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:57, 11 September 2015

2015-09-11T05:57:07Z

←Older revision		Revision as of 05:57, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2jmu' size='340' side='right' caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2jmu' size='340' side='right' caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JMU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JMU FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [http://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [http://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [http://pdbe.org/2jmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [http://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [http://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jmu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Thiamine-triphosphatase]]		[[Category: Thiamine-triphosphatase]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 12:14, 25 December 2014

2014-12-25T12:14:02Z

←Older revision		Revision as of 12:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JMU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JMU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [http://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [http://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [http://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [http://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/THTPA_MOUSE THTPA_MOUSE]] Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Thiamine-triphosphatase]]		[[Category: Thiamine-triphosphatase]]
-	[[Category: ~~CESG, Center for Eukaryotic~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Markley, J L.]]	+	[[Category: Markley, J L]]
-	[[Category: Song, J~~.]]~~	+	[[Category: Song, J]]
-	~~[[Category: Center for eukaryotic structural genomic~~]]	+
	[[Category: Cesg]]		[[Category: Cesg]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi]]~~	+
-	~~[[Category: Structural genomic~~]]	+
	[[Category: Thiamine triphosphatase]]		[[Category: Thiamine triphosphatase]]

OCA at 09:12, 30 September 2014

2014-09-30T09:12:52Z

←Older revision		Revision as of 09:12, 30 September 2014
Line 1:		Line 1:
-	[[~~Image~~:2jmu.~~png\|left~~\|200px]]	+	==NMR structure of the mouse thiamine triphosphatase==
		+	<StructureSection load='2jmu' size='340' side='right' caption='[[2jmu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2jmu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JMU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Thtpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jmu RCSB], [http://www.ebi.ac.uk/pdbsum/2jmu PDBsum], [http://www.topsan.org/Proteins/CESG/2jmu TOPSAN]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jmu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian soluble thiamine triphosphatase (ThTPase) is a 25-kDa cytosolic enzyme that specifically catalyzes the conversion of thiamine triphosphate (ThTP) to thiamine diphosphate and has an absolute requirement for divalent cations. We have investigated the kinetic properties of recombinant mouse thiamine triphosphatase (mThTPase) and determined its solution structure by NMR spectroscopy. Residues responsible for binding Mg(2+) and ThTP were determined from NMR titration experiments. The binding of Mg(2+) induced only a minor local conformational change, whereas ThTP binding was found to cause a more global conformational change. We derived a structural model for the mThTPase.ThTP.Mg(2+) ternary complex and concluded from this that whereas free mThTPase has an open cleft fold, the enzyme in the ternary complex adopts a tunnel fold. Our results provide a functional rationale for a number of conserved residues and suggest an essential role for Mg(2+) in catalysis. We propose a mechanism underlying the high substrate specificity of mThTPase and discuss the possible role of water molecules in enzymatic catalysis.

-	~~{{STRUCTURE_2jmu\| PDB=2jmu \| SCENE= }}~~	+	Structural basis for the catalytic mechanism of mammalian 25-kDa thiamine triphosphatase.,Song J, Bettendorff L, Tonelli M, Markley JL J Biol Chem. 2008 Apr 18;283(16):10939-48. Epub 2008 Feb 14. PMID:18276586<ref>PMID:18276586</ref>

-	~~===NMR structure~~ of the ~~mouse thiamine triphosphatase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18276586}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2jmu]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2JMU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018276586<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Thiamine-triphosphatase]]		[[Category: Thiamine-triphosphatase]]

OCA: Protected "2jmu" [edit=sysop:move=sysop]

2013-01-07T11:29:10Z

Protected "2jmu" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:29, 7 January 2013