2jrc - Revision history

OCA at 10:11, 20 December 2023

2023-12-20T10:11:45Z

←Older revision		Revision as of 10:11, 20 December 2023
Line 1:		Line 1:

	==Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.==		==Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.==
-	<StructureSection load='2jrc' size='340' side='right'caption='[[2jrc~~]], [[NMR_Ensembles_of_Models \| 40 NMR models~~]]' scene=''>	+	<StructureSection load='2jrc' size='340' side='right'caption='[[2jrc]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jrc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis~~ Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jrc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRC FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>pth ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=1773 Mycobacterium tuberculosis])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [https://pdbe.org/2jrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [https://www.ebi.ac.uk/pdbsum/2jrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [https://pdbe.org/2jrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [https://www.ebi.ac.uk/pdbsum/2jrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).	+	[https://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aminoacyl-tRNA hydrolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Mycobacterium tuberculosis]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Arora, A]]	+	[[Category: Arora A]]
-	[[Category: Jain, A]]	+	[[Category: Jain A]]
-	[[Category: Pathak~~, P P~~]]	+	[[Category: Pathak PP]]
-	[[Category: Pulavarti~~, S V.S R.K]]~~	+	[[Category: Pulavarti SVSRK]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mycobacterium tuberculosis h37rv]]~~	+
-	~~[[Category: Pth]]~~	+
-	~~[[Category: Solution structure~~]]	+

OCA at 07:54, 7 April 2021

2021-04-07T07:54:13Z

←Older revision		Revision as of 07:54, 7 April 2021
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.==		==Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.==
-	<StructureSection load='2jrc' size='340' side='right' caption='[[2jrc]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>	+	<StructureSection load='2jrc' size='340' side='right'caption='[[2jrc]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2jrc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2JRC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2jrc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JRC FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [~~http~~://pdbe.org/2jrc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2jrc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [https://pdbe.org/2jrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [https://www.ebi.ac.uk/pdbsum/2jrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrc ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).	+	[[https://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
		+	[[Category: Large Structures]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Arora, A]]		[[Category: Arora, A]]

OCA at 07:17, 11 July 2018

2018-07-11T07:17:00Z

←Older revision		Revision as of 07:17, 11 July 2018
Line 1:		Line 1:
		+	{{Large structure}}
	==Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.==		==Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.==
	<StructureSection load='2jrc' size='340' side='right' caption='[[2jrc]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>		<StructureSection load='2jrc' size='340' side='right' caption='[[2jrc]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [http://pdbe.org/2jrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [http://www.ebi.ac.uk/pdbsum/2jrc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [http://pdbe.org/2jrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [http://www.ebi.ac.uk/pdbsum/2jrc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jrc ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jrc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jrc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:42, 7 February 2016

2016-02-07T21:42:50Z

←Older revision		Revision as of 21:42, 7 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jrc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:12, 10 September 2015

2015-09-10T05:12:54Z

←Older revision		Revision as of 05:12, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [http://www.ebi.ac.uk/pdbsum/2jrc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [http://pdbe.org/2jrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [http://www.ebi.ac.uk/pdbsum/2jrc PDBsum]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).		[[http://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2jrc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:25, 24 December 2014

2014-12-24T18:25:37Z

←Older revision		Revision as of 18:25, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2jrc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2jrc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [http://www.ebi.ac.uk/pdbsum/2jrc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [http://www.ebi.ac.uk/pdbsum/2jrc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTH_MYCTU PTH_MYCTU]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Arora, A.]]	+	[[Category: Arora, A]]
-	[[Category: Jain, A.]]	+	[[Category: Jain, A]]
-	[[Category: Pathak, P P.]]	+	[[Category: Pathak, P P]]
-	[[Category: Pulavarti, S V.S R.K.]]	+	[[Category: Pulavarti, S V.S R.K]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
	[[Category: Pth]]		[[Category: Pth]]
	[[Category: Solution structure]]		[[Category: Solution structure]]

OCA at 09:03, 30 September 2014

2014-09-30T09:03:38Z

←Older revision		Revision as of 09:03, 30 September 2014
Line 1:		Line 1:
-	~~{{Large~~ structure}}	+	==Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.==
-	~~{{STRUCTURE_2jrc\| PDB~~=2jrc \| ~~SCENE~~= }}	+	<StructureSection load='2jrc' size='340' side='right' caption='[[2jrc]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>
-	===~~Solution~~ structure ~~of Peptidyl-tRNA Hydrolase~~ from Mycobacterium tuberculosis ~~H37Rv~~.===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_18342886}}~~	+	<table><tr><td colspan='2'>[[2jrc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JRC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jrc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jrc RCSB], [http://www.ebi.ac.uk/pdbsum/2jrc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/2jrc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Eubacterial peptidyl-tRNA hydrolase is an essential enzyme that hydrolyzes peptidyl-tRNAs that are released into the cytoplasm because of premature termination of translation, expression of minigenes, and action of lincosamide and macrolide antibiotics. This averts the arrest of protein synthesis caused by depletion of free tRNA. Recently, we demonstrated that Mycobacterium tuberculosis peptidyl-tRNA hydrolase (MtPth) is present in the cytosol of mycobacterium and is capable of hydrolyzing peptidyl-tRNA. Here, we present the solution structure of MtPth, which is the first solution structure for this family of proteins. MtPth typically consists of seven-stranded mixed beta-sheet surrounded by six alpha-helices. The backbone dynamics for this enzyme were probed by measuring (15)N relaxation parameters and these were analyzed with model-free formalism and reduced spectral density mapping analysis. Overall, the protein molecule has tau(m) of 9.67+/-0.02 ns. The (15)N relaxation data analysis reveals that while majority of the protein backbone is rigid to motions, a short segment consisting of enzymatically critical residue H22, the loop-helix cover over the active site crevice, and the C-terminal helical hairpin exhibit motions on the milli-to microsecond timescale, all of which are linked to interaction with the substrate peptidyl-tRNA.

-	~~==About this Structure==~~	+	Solution structure and dynamics of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis H37Rv.,Pulavarti SV, Jain A, Pathak PP, Mahmood A, Arora A J Mol Biol. 2008 Apr 18;378(1):165-77. Epub 2008 Feb 21. PMID:18342886<ref>PMID:18342886</ref>
-	~~[[2jrc]] is a 1 chain~~ structure ~~with sequence~~ from ~~[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis~~ Mycobacterium tuberculosis]. ~~Full experimental information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2JRC OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:018342886~~</~~ref~~><~~references group="xtra"~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Peptidyl-tRNA hydrolase\|Peptidyl-tRNA hydrolase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 08:40, 11 March 2013

2013-03-11T08:40:24Z

←Older revision		Revision as of 08:40, 11 March 2013
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-	~~[[Image:2jrc.png\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_2jrc\| PDB=2jrc \| SCENE= }}		{{STRUCTURE_2jrc\| PDB=2jrc \| SCENE= }}
-
	===Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.===		===Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.===
-
	{{ABSTRACT_PUBMED_18342886}}		{{ABSTRACT_PUBMED_18342886}}

OCA: Protected "2jrc" [edit=sysop:move=sysop]

2013-01-07T11:22:45Z

Protected "2jrc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:22, 7 January 2013

OCA at 11:22, 7 January 2013

2013-01-07T11:22:42Z

←Older revision		Revision as of 11:22, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2jrc.png\|left\|200px]]		[[Image:2jrc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2jrc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2jrc\| PDB=2jrc \| SCENE= }}		{{STRUCTURE_2jrc\| PDB=2jrc \| SCENE= }}

	===Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.===		===Solution structure of Peptidyl-tRNA Hydrolase from Mycobacterium tuberculosis H37Rv.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18342886}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18342886 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18342886}}		{{ABSTRACT_PUBMED_18342886}}

	==About this Structure==		==About this Structure==
-	~~2JRC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA].	+	[[2jrc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JRC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18342886~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018342886</ref><references group="xtra"/>
	[[Category: Aminoacyl-tRNA hydrolase]]		[[Category: Aminoacyl-tRNA hydrolase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 32:		Line 20:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mycobacterium tuberculosis h37rv]]		[[Category: Mycobacterium tuberculosis h37rv]]
-	[[Category: Nmr]]
	[[Category: Pth]]		[[Category: Pth]]
	[[Category: Solution structure]]		[[Category: Solution structure]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:41:24 2009''